HSP70-IN-1 - Moligand™,10mM in DMSO , CAS No.1268273-90-0

CAS: 1268273-90-0 Cat. No.: H655596 Formula: C₂₄H₂₈N₆O₂S Molecular Weight: 464.58 PubChem CID: 66973893

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

HSP70-IN-1 is a heat shock protein ( HSP ) inhibitor; inhibits the growth of Kasumi-1 cells with an IC 50 of 2.3 μM.

In Vitro

The heat shock protein 70 (Hsp70) is a molecular chaperone which plays an important function in protein homeostasis as well as in cell signaling and survival. Hsp70 is frequently overexpressed in cancer, where the elevated expression is furthermore believed to be a cause of or to lead to resistance to chemotherapy and other treatments. HSP70-IN-1 interferes with the formation of functional Hsp70-HOP-Hsp90 machinery by its ability to dose-dependently alter the megacomplex components and to destabilize an Hsp70-Hsp90 machinery client, Raf-1. In cells, the refolding of heat-denatured luciferase by endogenous as well as transfected Hsp70 is inhibited by HSP70-IN-1. HSP70-IN-1 also results in induction of apoptosis in cancer cells. Addition of HSP70-IN-1to cancer cells dose-dependently alters the formation of the Hsp70-HOP complex, a phenomenon associated with their destabilization and reduction in half-life. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:HSP70 Caspase-3/7 1.9 μM (IC 50 , MOLM13 cells)

Specifications

Specifications & Purity

Moligand™,10mM in DMSO

Biochemical and Physiological Mechanisms

HSP70-IN-1 is a heat shock protein ( HSP ) inhibitor; inhibits the growth of Kasumi-1 cells with an IC 50 of 2.3 μM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Names and Identifiers

Isomeric SMILES

CN1CCN(CC1)C2=NC=C(C(=N2)OCC3=CC=CC=C3)SC4=CC=CC(=C4)NC(=O)CN

PubChem CID

66973893

Molecular Weight

464.58

Frequently Asked Questions

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1268273-90-0, the molecular formula is C24H28N6O2S, and the molecular weight is 464.58 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.