Factor XIa, CAS No.37203-61-5

CAS: 37203-61-5 Cat. No.: H1443844

GRADE & PURITY Bioactive, ActiBioPure™, Native, High Performance, EnzymoPure™, ≥95%(SDS-PAGE), from Human plasma; Protein concentration: See COA

Accession #

P03951

Bioactivity

See COA

Overview

  Prepared from Human Factor XI using Human Factor Xlla. This Xlla was removed using a corn trypsin inhibitor column. Complete activation is observed by SDS-PAGE. Factor XI, through the contact factor pathway cascade, is activated to Factor XIa via Factor Xlla and High Molecular Weight Kininogen. During activation by Factor Xlla and HK, FXI undergoes proteolytic cleavage in which the Mr=80,000 chain reportedly is cleaved to a heavy and light chain with Mr of about 48,000 and 33,000. This Factor XIa is responsible for the activation of Factor IX to Factor IXa. Unlike other examples of activation of Vitamin K-dependent blood-clotting proteins, Factor XIa proteolysis of Factor IX does not require membrane surfaces.

  Extinction Coefficient (1%) = 13.1

  The above protein was purified from Human plasma units that test negative for antibodies to HBc, HCV, HIV 1/2, HTLV-I/II, and non reactive for HBsAg, HIV-1 RNA, HCV RNA, HBV DNA and Syphilis by FDA approved tests. Donors are screened for CJD. 

Specifications

Product Name

Factor XIa, CAS No.37203-61-5

Synonyms

Human Factor XIa Native Protein | Coagulation Factor XIa, Human Plasma | coagulation factor XIa | plasma thromboplastin antecedent | Coagulation factor XI | F11 | FXI | PTA

Grade

ActiBioPure™, Bioactive, High Performance, Native, EnzymoPure™

Specifications & Purity

Bioactive, ActiBioPure™, Native, High Performance, EnzymoPure™, ≥95%(SDS-PAGE), from Human plasma; Protein concentration: See COA

Biochemical and Physiological Mechanisms

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Catalytic activity: Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa. Activity regulation: Inhibited by SERPINA5.

Bioactivity

See COA

Accession #

P03951

Predicted molecular weight

160 kDa

CAS

37203-61-5

Enzyme Commission Number

EC 3.4.21.27

Molecule Type

Enzyme

Storage and Shipping

Concentration

from Human plasma; Protein concentration: See COA

Storage

Store at -80°C,Avoid repeated freezing and thawing

Shipped In

Dry ice packs + Cold packs

Stability And Storage

Store at -80℃ long term. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.