Hydrocortisone 21-hemisuccinate sodium salt - ≥98% , Glucocorticoid receptor agonist, CAS No.125-04-2, Glucocorticoid receptor agonist

CAS: 125-04-2 Cat. No.: H329245 Molecular Weight: 484.51 EC Number: 204-725-5

GRADE & PURITY ≥98%

Synonyms

C08178 | Idrocortisone B. I. L. | H 2270 | Hydrocortisone 21-sodium succinate | Hydrocortisone sodium succinate (USP:BAN:JAN) | Sinsurrene | Sodium hydrocortisone 21-succinate | 21-succinate | A-hydroCort | BSPBio_000696 | Hydrocortisone succinate,sodium

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Hydrocortisone 21-hemisuccinate sodium salt is a water-soluble form of the endogenous hormone cortisol. Hydrocortisone 21-hemisuccinate sodium salt is useful for epithelial and endothelial adherent cell culture applications. Since Hydrocortisone 21-hemisuccinate sodium salt can bind to glucocorticoid receptors, the transcription of anti-inflammatory nand immunosuppressive mediators can be initiated. Hydrocortisone 21-hemisuccinate sodium salt will also inhibit proinflammatory cytokine activity.

Specifications

Synonyms

C08178 | Idrocortisone B. I. L. | H 2270 | Hydrocortisone 21-sodium succinate | Hydrocortisone sodium succinate (USP:BAN:JAN) | Sinsurrene | Sodium hydrocortisone 21-succinate | 21-succinate | A-hydroCort | BSPBio_000696 | Hydrocortisone succinate, sodium

Specifications & Purity

≥98%

Source

Synthetic

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Mechanism of action

Glucocorticoid receptor agonist

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 488200567
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488200567
• Canonical Smiles: CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)COC(=O)CCC(=O)[O-])O)C)O.[Na+]
• IUPAC Name: sodium;4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate
• InChIKey: HHZQLQREDATOBM-CODXZCKSSA-M
• INCHI: 1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1
• Isomeric SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)COC(=O)CCC(=O)[O-])O)C)O.[Na+]
• WGK Germany: 3
• RTECS: GM9015000
• Molecular Weight: 484.51
• Reaxy-Rn: 37058057
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37058057&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Class Steroids and steroid derivatives
      • Subclass Pregnane steroids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Class: Steroids and steroid derivatives
• Subclass: Pregnane steroids
• Intermediate Tree Nodes: Not available
• Direct Parent: Gluco/mineralocorticoids, progestogins and derivatives
• Alternative Parents: 20-oxosteroids 11-beta-hydroxysteroids 17-hydroxysteroids 3-oxo delta-4-steroids Delta-4-steroids Alpha-acyloxy ketones Cyclohexenones Dicarboxylic acids and derivatives Tertiary alcohols Alpha-hydroxy ketones Secondary alcohols Cyclic alcohols and derivatives Carboxylic acid esters Carboxylic acid salts Carboxylic acids Hydrocarbon derivatives Organic zwitterions Organic sodium salts Organic oxides
• Molecular Framework: Aliphatic homopolycyclic compounds
• Substituents: Progestogin-skeleton - 20-oxosteroid - 3-oxo-delta-4-steroid - 3-oxosteroid - Hydroxysteroid - 17-hydroxysteroid - 11-hydroxysteroid - 11-beta-hydroxysteroid - Oxosteroid - Delta-4-steroid - Cyclohexenone - Alpha-acyloxy ketone - Dicarboxylic acid or derivatives - Alpha-hydroxy ketone - Cyclic alcohol - Tertiary alcohol - Carboxylic acid ester - Carboxylic acid salt - Cyclic ketone - Ketone - Secondary alcohol - Organic alkali metal salt - Carboxylic acid - Carboxylic acid derivative - Organic salt - Organic sodium salt - Organic oxide - Organic oxygen compound - Carbonyl group - Organic zwitterion - Alcohol - Organooxygen compound - Hydrocarbon derivative - Aliphatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety.
• External Descriptors: organic molecular entity

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)

Discover Target: HIF1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

Discover Target: PMP22

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

Discover Target: IDH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)

Explore this target

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RAW264.7 (28094 Activities)

Explore this target

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FTL Ferritin light chain (43324 Activities)

Discover Target: FTL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in Water: 50 mg/mL
• Sensitivity: Moisture sensitive
• Molecular Weight: 484.500 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 484.207 Da
• Monoisotopic Mass: 484.207 Da
• Topological Polar Surface Area: 141.000 Ų
• Heavy Atom Count: 34
• Formal Charge: 0
• Complexity: 915.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 7
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Yunyan Tang, Hongfang Li, Jianhua Tang, Lei Hu, Feifei Ma, Yanmiao Liu, Fushan Tang.  (2024)  Effects of total saikosaponins on CYP3A4 and CYP1A2 in HepaRG cells.  Experimental and Therapeutic Medicine,  27  (5): (1-8).  [PMID:38590569] [10.3892/etm.2024.12505]