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Hydroxypropylmethylcellulose(HPMC) - Substitution type 2208, viscosity: 4000mPa. s, methoxy group: 19-24%; Hydroxypropyl group: 4.0-12% , CAS No.9004-65-3

CAS: 9004-65-3 Cat. No.: H108824 EC Number: 618-389-6 PubChem CID: 206257985
252 Citations COA
Hydroxypropylmethylcellulose(HPMC) - Substitution type 2208, viscosity: 4000mPa. s, methoxy group: 19-24%; Hydroxypropyl group: 4.0-12% CAS No(9004-65-3) by Aladdin Scientific
AVAILABLE TO ORDER
GRADE & PURITY Substitution type 2208, viscosity: 4000mPa. s, methoxy group: 19-24%; Hydroxypropyl group: 4.0-12%
Synonyms
HPMC MHPC Hydroxypropyl Methyl Cellulose
Storage
Room temperature,Argon charged
Shipped In
Normal
★
Size
USA
Germany (EU)*
Price
Qty
50g
H108824-50g
Made to order · 8–12 wks
$12.90
100g
H108824-100g
4 In stock
—
$19.90
500g
H108824-500g
2 In stock
1 In stock
$64.90
Enter a quantity for the sizes you want to add.
Bulk / Custom
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Overview Specifications Names and Identifiers Documentation Advanced Data Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Documents & Articles Citations of This Product Solution Calculators Reviews
🧪
Why this grade

Substitution type 2208, viscosity: 4000mPa. s, methoxy group: 19-24%; Hydroxypropyl group: 4.0-12% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Room temperature,Argon charged Ships Normal Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 252 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Features and advantages:

Dissolves in water, undergoes reversible gelation upon heating, non-ionic, does not complex with ionic species and is surface active and enzyme resistant. Solutions are pseudoplastic.

Specifications

Synonyms
HPMC MHPC Hydroxypropyl Methyl Cellulose
Specifications & Purity
Substitution type 2208, viscosity: 4000mPa. s, methoxy group: 19-24%; Hydroxypropyl group: 4.0-12%
Storage
Room temperature,Argon charged
Shipped In
Normal
Names and Identifiers
Pubchem Sid
508815929
WGK Germany
1
PubChem CID
206257985

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

40 results found

Lot NumberCertificate TypeDateItem
H2607640Certificate of AnalysisAug 05, 2026 H108824
H2607646Certificate of AnalysisAug 05, 2026 H108824
H2607645Certificate of AnalysisAug 05, 2026 H108824
H2607641Certificate of AnalysisAug 05, 2026 H108824
G2627263Certificate of AnalysisJul 17, 2026 H108824
G2627265Certificate of AnalysisJul 17, 2026 H108824
G2627267Certificate of AnalysisJul 17, 2026 H108824
E2609669Certificate of AnalysisApr 07, 2026 H108824
D2622338Certificate of AnalysisApr 07, 2026 H108824
D2622332Certificate of AnalysisApr 07, 2026 H108824
D2622331Certificate of AnalysisApr 07, 2026 H108824
A2621466Certificate of AnalysisJan 16, 2026 H108824
A2630572Certificate of AnalysisJan 16, 2026 H108824
A2630551Certificate of AnalysisJan 16, 2026 H108824
A2630550Certificate of AnalysisJan 16, 2026 H108824
A2630549Certificate of AnalysisJan 16, 2026 H108824
A2621483Certificate of AnalysisJan 16, 2026 H108824
A2621467Certificate of AnalysisJan 16, 2026 H108824
I2518033Certificate of AnalysisApr 17, 2025 H108824
E2512508Certificate of AnalysisApr 17, 2025 H108824
E2506191Certificate of AnalysisApr 17, 2025 H108824
E2506192Certificate of AnalysisApr 17, 2025 H108824
E2506188Certificate of AnalysisApr 17, 2025 H108824
J2422489Certificate of AnalysisOct 08, 2024 H108824
J2422483Certificate of AnalysisOct 08, 2024 H108824
J2422476Certificate of AnalysisOct 08, 2024 H108824
J2422463Certificate of AnalysisOct 08, 2024 H108824
J2422425Certificate of AnalysisOct 08, 2024 H108824
J2422424Certificate of AnalysisOct 08, 2024 H108824
E2422059Certificate of AnalysisMar 12, 2024 H108824
E2422060Certificate of AnalysisMar 12, 2024 H108824
D23211452Certificate of AnalysisMar 06, 2023 H108824
D23211442Certificate of AnalysisMar 06, 2023 H108824
D23211405Certificate of AnalysisMar 06, 2023 H108824
E2421070Certificate of AnalysisMar 21, 2022 H108824
B23011126Certificate of AnalysisMar 21, 2022 H108824
H2414028Certificate of AnalysisMar 21, 2022 H108824
F2210594Certificate of AnalysisMar 21, 2022 H108824
F2210593Certificate of AnalysisMar 21, 2022 H108824
F2210591Certificate of AnalysisMar 21, 2022 H108824
Chemical and Physical Properties
SensitivityMoisture sensitive
Documents & Articles
A Practical Guide to Fragrance Compositions: Turning a Black-Box Formula into an Engineerable System—Compatibility, Stability, Controlled Release, Traceability, and Selection
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Fragrance Fragrance composition Fragrance base
Microcrystalline Cellulose (MCC): A Comprehensive Primer and Selection Guide—Structural Features, Key Performance Metrics, and Application Scenarios
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Microcrystalline Cellulose MCC
Understanding Hydrophilic Polymers in Aqueous Systems: Hydration Mechanisms, Structural Knobs, and Task-Oriented Selection Guide (Including Tables 1–3)
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Polymer Biomedical materials Hydrophilicity hydrophilic polymers
Biomedical Polymer Insights: Role-Based Task Map, Six Key Material Levers, and a Risk-Driven Evidence Chain (including the Product Navigation Guide and Product Tables 1–3)
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Polymer Biomedical polymer Biomedical
Functional Framework of Starch Metabolism-Related Enzymes in Food Science Research and Mechanistic Analysis of Quality Regulation
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
α-amylase Rheology Starch Metabolism-Related Enzymes Food Science Research Quality-Regulation Mechanisms Glucoamylase Debranching Enzymes Transglycosylases Staling Digestive Properties
Injectable Thermosensitive Gels: Gelation Behavior, Rheological Properties, and Drug Release Characteristics
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Chitosan injectable thermosensitive gel Pluronic F-127 PLGA-PEG-PLGA gelation behavior rheological properties drug release characteristics in situ gelation
Waterborne Resin Technology Explained: Waterborne Forms, Performance Balance, and a Technology Map
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Ink Paint Film-forming resin Adhesive Waterborne Resin
Waterborne Resin Application Guide: Formulation Synergy, Troubleshooting, and Technology Development Trends
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
resin Waterborne Resin Water-based paint
Why LABSA (Sulfonic Acid) Is Commonly Used in Household Cleaning Formulations: Neutralization Mechanism, Detergency Action, and Formulation Application Points
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Anionic Surfactant Surfactants Daily Chemical Industry
From Structure to Performance: Conditioning, Film-Forming, Thickening, and Chelating Applications of Functional Ingredients in Personal Care and Home Care
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Anionic Surfactant Daily chemical formula
From Structure to Rheology: How Carbomer Forms Gel Structures and Enables Thickening, Suspension, and Auxiliary Emulsion Stabilization
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Carbomer
Thickening, Suspension, Auxiliary Stabilization, and Agglomeration Mechanisms of Xanthan Gum in Personal Care Formulations: From Molecular Structure to Processing Applications
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Xanthan Gum
From Structure to Rheology: Thickening, Stabilization, and Selection Logic of Cellulose Ethers for Personal Care Applications
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Cellulose cosmetics linear polysaccharide
Structure, Properties, and Mechanisms of Powdered Fragrances and Fragrance Delivery Materials: Stability, Release Mechanisms, and Selection Logic
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Fragrance Powdered Fragrances
Analysis of the Production Process of Hydroxypropyl Methylcellulose (HPMC) for Putty: Understanding Differences in Substitution Structure and Gelation Temperature from High-Ratio and Low-Ratio Formulations
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
HPMC Neutral putty 821 putty Ordinary interior wall putty
Why Are Daily Chemical Products Prone to Viscosity Thinning in Summer? Core Mechanisms, Troubleshooting Methods, and Solutions
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Daily chemical products Return to thinning
Types, Mechanisms of Action, Key Quality Indicators, and Selection and Application of Common Cellulose Ethers in Wall Putty
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Wall Putty Cellulose Ether
Influencing Factors and Control Strategies for Blistering in Neutral Wall Putty: An Experimental Analysis Based on HPMC Dosage, Viscosity, and Ground Calcium Carbonate Fineness
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Neutral Wall Putty Putty bubbles
How to Select Binding/Gel Materials for Neutral Wall Putty? A Comparison of Pregelatinized Starch, PVA, and Redispersible Polymer Powder Based on Four Application Trials
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
HPMC Neutral Wall Putty
Causes and Mechanism Analysis of Delamination During Sanding of Water-Resistant Putty
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Water-Resistant Putty
What Are the Differences Between Polyvinyl Alcohol 1788, 2488, and 2699? Understanding Workability, Bonding Strength, and Relative Water Resistance from the Perspective of Degree of Polymerization and Degree of Hydrolysis
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Paint Adhesive Water-soluble polymer materials Polymer materials
Why Do Rust Spots Appear on Neutral Wall Putty? Iron Sources, Moisture Migration, Oxidative Color Development, and Prevention Measures
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Neutral putty
Common Problems and Formulation Adjustment Strategies for Neutral Putty Under High Summer Temperatures
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Neutral putty
Differences and Application Selection of Cassava- and Corn-Based Pregelatinized Starch in Neutral Putty Formulations
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Neutral putty
The Role, Selection, Cracking Risk Analysis, and Dosage Control of Bentonite in Neutral Putty
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Neutral putty
What Is Direct Compression? Process Characteristics, Suitability Criteria, and Excipient Selection
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Direct Compression Wet granulation and tablet compression Dry granulation and tablet compression
Niacinamide Brightening Mechanisms and Formulation Design: Melanosome Transfer, pH Regulation, and Combination Strategies
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Niacinamide
Citations of This Product
How to Cite Aladdin Scientific Products? Citations Search
Solution Calculators
Reviews

Customer Reviews

📚 Citations by Application

Other applications141
Organic synthesis — reaction medium89
Controlled-release & nanoparticle carrier57
Topical & ophthalmic formulation12
Polymer synthesis & polymerization41
Extraction & workup solvent32
Industrial & non-pharma application20
Cell viability6
Cytotoxicity screening5
Drug / compound screening22
Nanoparticle / material biocompatibility6
Thickener / viscosity modifier12
Crystallization & recrystallization11
Film coating13
Electrochemistry & battery electrolyte15
Mucoadhesive formulation4
Spectroscopy sample preparation5
Chromatography (HPLC / GC / TLC)4
Tablet binder4
Cell proliferation3
Sustained-release matrix2
IC50 determination1
Stem cell research1
Cross-coupling reactions1
Emulsion formulation1
Food science applications1
View all 252 citations →
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View related series

Biochemical Assay Reagents (921) Cellulose (15) Hydrophilic polymers (64) Pharmaceutical excipients (17)

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