JC124 - ≥97% , CAS No.1638611-48-9

CAS: 1638611-48-9 Cat. No.: J650458 Molecular Weight: 382.86

GRADE & PURITY ≥97%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects.

In Vitro

JC124 shows selective inhibition of NLRP3 inflammasome formation and activation of caspase-1, and reduction of IL-1β both in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

JC124 (100 mg/kg; i.p.; 4 doses; 30 min post-injury, 6, 24, and 30 h after TBI) treatment significantly decreases the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume. JC124 also significantly reduces protein expression levels of NLRP3, ASC, IL-1 beta, TNFα, iNOS, and caspase-1 . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult male Sprague-Dawley rats (3-4-months-old) bearing traumatic brain injury (TBI) Dosage: 100 mg/kg Administration: i.p.; 4 doses; 30 min post-injury, 6, 24, and 30 h after TBI Result: Significantly decreased the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume.

Form:Solid

Specifications

Specifications & Purity

≥97%

Biochemical and Physiological Mechanisms

JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥97%

Names and Identifiers

• Molecular Weight: 382.86

Chemical and Physical Properties

• Solubility: DMSO : 250 mg/mL (652.98 mM; ultrasonic and adjust pH to 3 with HCl)