Laccase, CAS No.80498-15-3

CAS: 80498-15-3 Cat. No.: L1506448 EC Number: 617-092-9

GRADE & PURITY EnzymoPure™, ≥1 U/mg; from Aspergillus sp.

Accession #

P17489

Bioactivity

≥1 U/mg Liquid

Overview

  The key enzyme activity in this product is provided by laccase.Laccase oxidizes various phenols, anilines, benzenols, metal ion complexes and other compounds to quinones or other oxidized compounds, accompanied by the reduction of oxygen molecules to water.

Ingredients 

Ingredient	Approx. % (w/w)
Water, CAS no. 7732-18-5	66
Propylene glycol, CAS no. 57-55-6	25
Sucrose/Dextrose, CAS no. 57-50-1/50-99-7	4
Laccase, CAS no. 80498-15-3*	3
Glycine (Aminoacetic acid), CAS no. 56-40-6	2

*Defined as enzyme concentration (on a dry matter basis) 

GMO Status

This product is not a genetically modified organism.Enzyme preparations are produced by microbial fermentation, but the microorganisms are not present in the final product. The production strain has been improved by modern biotechnology methods.

Safety and Handling Precautions

Enzymes are proteins. Inhalation of dust or aerosols may cause sensitization and may lead to allergic reactions in sensitized individuals.Some enzymes may irritate the skin, eyes and mucous membranes after prolonged contact.

Specifications

Product Name

Laccase, CAS No.80498-15-3

Synonyms

urishiol oxidase | Uroshiol oxidase | Denilite IIS | yA

Grade

EnzymoPure™

Specifications & Purity

EnzymoPure™, ≥1 U/mg; from Aspergillus sp.

Bioactivity

≥1 U/mg Liquid

Accession #

P17489

CAS

80498-15-3

Enzyme Commission Number

EC 1.10.3.2

Molecule Type

Enzyme

Storage and Shipping

Concentration

≥1 U/mg; from Aspergillus sp.

Storage

Store at 2-8°C,Protected from light,Desiccated,Do not freeze

Shipped In

Wet ice,Do not freeze

Stability And Storage

Store at 2-8℃ long term (12 months). Upon receipt, it is recommended to aliquot. Do not freeze. Store in the dark. Desiccated.

Unit definition

1 laccase unit (LAMU) is the amount of enzyme needed to convert 1 μmol syringaldazine per minute under the given analytical conditions.

References

1. Jishao Jiang, Zhuyu Tang, Kai Liu, Shipeng Wang, Yunbei Li, Jinghua Lv, Xu Yan, Dong Liu, Parag Bhople, Ke Cheng.  (2025)  A novel two-stage laccase application strategy to maintain enzyme activity and promote pharmaceuticals and personal care products degradation during sewage sludge composting.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2025.118877]

2. Yaping Ma, Minchang Liu, Ruifang Gu, Rongya Zhang, Xiaomei Ji, Juan Zhang, Wu Wen, Zheng Peng.  (2025)  Optimization of the scale-up production process for high-yield laccase from white-rot fungi.  Frontiers in Bioengineering and Biotechnology,      [PMID:40895717] [10.3389/fbioe.2025.1631687]

3. Xia Zunbin, Zuo Wei, Li Haiying, Qiu Liewei, Mu Ruihua, Wang Qian, Liu Hongchen, Wang Huixin, Hui Yuchen.  (2023)  Wearable cellulose textile matrix self-powered biosensor sensing lactate in human sweat.  JOURNAL OF APPLIED ELECTROCHEMISTRY,      [PMID:] [10.1007/s10800-023-02010-x]

4. Guolin Zheng, Zhe Jiang, Yifan Cui, Man Zhou, Yuanyuan Yu, Ping Wang, Qiang Wang.  (2023)  Near-infrared light-enhanced enzymatic activity of laccase-platinum nanoparticles as a biosensor for colorimetric and visible detection of ascorbic acid.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.146097]

5. Fenghong Deng, Shunjing Luo, Xiuting Hu, Chengmei Liu.  (2023)  Preparation, structural characterization and properties of feruloyl oligosaccharide–rice protein hydrolysate conjugates.  FOOD RESEARCH INTERNATIONAL,      [PMID:38163734] [10.1016/j.foodres.2023.113844]

6. Jing Zhu, Hongwei Jiang, Wenwu Wang.  (2023)  Colorimetric sensor array for discriminating and determinating phenolic pollutants basing on different ratio of ligands in Cu/MOFs.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:37647664] [10.1016/j.jhazmat.2023.132418]

7. Guolin Zheng, Yifan Cui, Zhe Jiang, Man Zhou, Yuanyuan Yu, Ping Wang, Qiang Wang.  (2023)  Superhydrophobic, photothermal, and UV-resistant coatings obtained by polydimethylsiloxane treating self-healing hydrophobic chitosan-tannic acid surface for oil/water separation.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.145258]

8. Guolin Zheng, Yifan Cui, Zhe Jiang, Man Zhou, Ping Wang, Yuanyuan Yu, Qiang Wang.  (2023)  Boosting laccase activity by synergistic drive of near infrared laser, surfactant, and sodium chloride for healthcare coatings with UV resistance, anti-oxidation, and photothermal conversion.  PROGRESS IN ORGANIC COATINGS,      [PMID:] [10.1016/j.porgcoat.2023.107838]

9. Jing Wang, Yumin Song, Futong Cui, Wenbin Wu, Haodong Zhu, Xiaoping Li, Kunyong Kang.  (2023)  Preparation and characterization of nanocellulose fiber (CNF) by biological enzymatic method.  JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS,      [PMID:] [10.1177/08927057231180479]

10. Xushuo Yuan, Wentao Yao, Decai Ji, Li Liu, Yanfei Lin, Heyang Zeng, Tao Jin, Kaimeng Xu, Guanben Du, Lianpeng Zhang.  (2023)  Synthesis of corn bract cellulose-based Au3+ fluorescent probe and its application in composite membranes.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:37105254] [10.1016/j.ijbiomac.2023.124600]

11. Lili Zheng, Minghan She, Binling Ai, Yang Yang, Xiaoyan Zheng, Shenwan Wang, Dao Xiao, Zhiguo Jiang, Zhanwu Sheng.  (2023)  Construction and properties of an amyloid fiber ferulic acid chitosan double network hydrogel and its inhibition of AGEs activity.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2023.108536]

12. Xushuo Yuan, Jiaxin Zhao, Xiaoxiao Wu, Wentao Yao, Haiyang Guo, Decai Ji, Qingkai Yu, Liwen Luo, Xiaoping Li, Lianpeng Zhang.  (2022)  Extraction of Corn Bract Cellulose by the Ammonia-Coordinated Bio-Enzymatic Method.  Polymers,  15  (1): (206).  [PMID:36616555] [10.3390/polym15010206]

13. Jiaxin Zhao, Xiaoxiao Wu, Xushuo Yuan, Xinjie Yang, Haiyang Guo, Wentao Yao, Decai Ji, Xiaoping Li, Lianpeng Zhang.  (2022)  Nanocellulose and Cellulose Making with Bio-Enzymes from Different Particle Sizes of Neosinocalamus Affinis.  Coatings,  12  (11): (1734).  [PMID:] [10.3390/coatings12111734]

14. Fan Shuang, Chang Wei, Fei Cheng, Zhang Zhongguo, Hou Bingbing, Shi Zhuxuan, Wang Huixin, Hui Yuchen.  (2022)  Stretchable and bendable textile matrix based on cellulose fibers for wearable self-powered glucose biosensors.  CELLULOSE,  29  (16): (8919-8935).  [PMID:] [10.1007/s10570-022-04820-2]

15. Yuchen Hui, Huixin Wang, Wei Zuo, Xiaoyan Ma.  (2021)  Spider nest shaped multi-scale three-dimensional enzymatic electrodes for glucose/oxygen biofuel cells.  INTERNATIONAL JOURNAL OF HYDROGEN ENERGY,      [PMID:] [10.1016/j.ijhydene.2021.11.210]

16. Xu Weiqing, Kang Yikun, Jiao Lei, Wu Yu, Yan Hongye, Li Jinli, Gu Wenling, Song Weiyu, Zhu Chengzhou.  (2020)  Tuning Atomically Dispersed Fe Sites in Metal–Organic Frameworks Boosts Peroxidase-Like Activity for Sensitive Biosensing.  Nano-Micro Letters,  12  (1): (1-12).  [PMID:34138213] [10.1007/s40820-020-00520-3]

17. Jingjing Yuan, Lin Wang, Bo Xu, Ping Wang, Jiugang Yuan, Yuanyuan Yu, Chao Deng, Qiang Wang.  (2020)  Enzymatic deposition of PPy onto cPEG-grafted silk fibroin membrane to achieve conductivity.  NEW JOURNAL OF CHEMISTRY,  44  (17): (7042-7050).  [PMID:] [10.1039/D0NJ00772B]

18. Hui Yuchen, Ma Xiaoyan, Qu Fengjin.  (2018)  Flexible glucose/oxygen enzymatic biofuel cells based on three-dimensional gold-coated nickel foam.  JOURNAL OF SOLID STATE ELECTROCHEMISTRY,  23  (1): (169-178).  [PMID:] [10.1007/s10008-018-4099-4]

19. Yuchen Hui, Xiaoyan Ma, Fengjin Qu, Fang Chen, Ying Chen.  (2017)  Three-Dimensional Nickel Foam Based Enzymatic Electrode and Its Glucose/O2 Biofuel Cell with High Power Density.  JOURNAL OF THE ELECTROCHEMICAL SOCIETY,  164  (13): (G112).  [PMID:] [10.1149/2.0761713jes]

20. Mufang Li, Mengying Luo, Fei Li, Wenwen Wang, Ke Liu, Qiongzhen Liu, Yuedan Wang, Zhentan Lu, Dong Wang.  (2016)  Biomimetic Copper-Based Inorganic–Protein Nanoflower Assembly Constructed on the Nanoscale Fibrous Membrane with Enhanced Stability and Durability.  Journal of Physical Chemistry C,      [PMID:] [10.1021/acs.jpcc.6b03537]

21. Zhao Li, Kanghui Ning, Ning Guo, Yuanyuan Shao, Song Li, Daoji Wu, Xiangzheng Ren, Lin Wang.  (2024)  Application of activated carbon-immobilized laccase for tetracycline degradation.  Environmental Technology & Innovation,      [PMID:] [10.1016/j.eti.2024.103873]

22. Lin Wang, Tianxin Yuan, Yan Zhang.  (2024)  Application of laccase-inorganic nanoflowers based time-temperature integrator to real-time monitor the freshness of pasteurized milk.  Food Chemistry-X,      [PMID:39525071] [10.1016/j.fochx.2024.101916]

23. Zuwei Yu, Xue Zhang, Shiyang Li, Jun Yang, Muci Wu, Qian Wu, Jingyi Wang.  (2024)  Characterization of feruloylated arabinoxylan - acorn starch double network gel composite film and its application in postharvest preservation of Agaricus bisporus.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38782312] [10.1016/j.ijbiomac.2024.132571]

24. Guobao Ning, Huan Liang, Linjiang Guo, Xiaokang Lu, Lin Xiao, Tianle Qi, Hui Zhao, Can-Peng Li.  (2024)  Chiral FeNC single-atom nanozymes with multi-enzyme activity for dye degradation.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2024.114471]

25. Lijia Li, Xumei Feng, Mengjie Geng, Fei Teng, Yang Li.  (2025)  Development of interpenetrating network gels based on co-gelation of heteroprotein aggregates and sugar beet pectin for physicochemical functional enhancement of W-O-W systems.  CARBOHYDRATE POLYMERS,      [PMID:39914963] [10.1016/j.carbpol.2025.123274]

26. Kai Li, Yuan Wang, Xiao Guo, Bo Wang.  (2024)  Effects of Lignin-Diverted Reductant with Polyphenol Oxidases on Cellulose Degradation by Wild and Mutant Types of Lytic Polysaccharide Monooxygenase.  CURRENT ISSUES IN MOLECULAR BIOLOGY,  46  (4): (3694-3712).  [PMID:38666960] [10.3390/cimb46040230]

27. Hui Yuchen, Fei Cheng, Zhang Zhongguo, Fan Shuang, Wang Huixin, Fan Wei, Chang Wei.  (2024)  Flexible and washable self-powered biosensors based on textile bioelectrodes for sensing glucose in sweat.  JOURNAL OF SOLID STATE ELECTROCHEMISTRY,      [PMID:] [10.1007/s10008-024-06133-9]

28. Hong Zhang, Zhi Wang, Fengxi Li, Lei Wang, Bo Ren.  (2024)  Immobilization of Laccase in β-Cyclodextrin Composite Hydrogel for Efficient Degradation of Dye Pollutants.  Catalysts,  14  (8): (473).  [PMID:] [10.3390/catal14080473]

29. Zhang Qi, Yang Ce, Gu Mingqi, Qin Shaoxuan, Yin Jianhua, Wang Xiangrong, Zhang Wei.  (2024)  Laccase-Catalyzed the Polymerization of Portulaca Oleracea L. Extract as a Precursor for Ecological Dyeing of Pure Cotton Fabric.  FIBERS AND POLYMERS,      [PMID:] [10.1007/s12221-024-00620-6]

30. Guolin Zheng, Zengdi Zhao, Aming Wang, Haonan Cheng, Xinjun Bao, Hengshu Zhou, Dan Zhang, Qiang Wang.  (2024)  Near infrared laser precisely controlled ultrafast superhydrophilicity-to-hydrophobicity transition of copper sulfide nanosphere coating on cellulose fiber fabric.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39694363] [10.1016/j.ijbiomac.2024.138854]

31. Guolin Zheng, Yifan Cui, Zhe Jiang, Wenda Wang, Man Zhou, Yuanyuan Yu, Ping Wang, Qiang Wang.  (2024)  Near infrared laser-mediated hydrophilicity-to-hydrophobicity switch of copper sulfide nanoflowers coating on cotton fabric.  PROGRESS IN ORGANIC COATINGS,      [PMID:] [10.1016/j.porgcoat.2024.108297]

32. Guolin Zheng, Zhe Jiang, Yifan Cui, Man Zhou, Yuanyuan Yu, Ping Wang, Qiang Wang.  (2024)  Photothermal, superhydrophobic, conductive, and anti-UV cotton fabric loaded with polydimethylsiloxane-encapsulated copper sulfide nanoflowers.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38462099] [10.1016/j.ijbiomac.2024.130650]

33. Jishao Jiang, Huilin Cui, Zhuyu Tang, Shipeng Wang, Ke Cheng, Chunyan Zhang, Tonghuan Yu, Jinghua Lv, Fuqiang Yu, Dong Liu.  (2024)  Synergistic effects of biochar and laccase on nitrogen conversation and degradations of two artificial sweeteners during the sewage sludge composting.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.155732]

34. Jiachun Wang, Juntao Hu, Wantong Jiang, Dongwei Zhu, Yinuo Yin, Yu Qin, Ao Song, Yibing Huang, Quan Luo.  (2025)  Mechanistic insights into redox-protonation coupled fluorescence switching in peptide-mediated gold nanoclusters for precision tumor imaging and resection.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:40749287] [10.1016/j.jcis.2025.138582]

35. Siyu Wu, Xiaojuan Niu, Jiali Chen, Wangni Meng, Han Tao, Jianli Zhou, Yuangen Wu.  (2025)  Design of Mn-Car multivalent laccase mimics through self-assembled coordination and its application for ultrasensitive colorimetric detection of kanamycin in food.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.114523]

36. Guolin Zheng, Wentao He, Haonan Cheng, Xinjun Bao, Anlin Zhang, Kun Wang, Bin He, Hengshu Zhou.  (2025)  Eco-friendly fabrication of photothermal, UV-resistant, and anti-oxidative coating on cotton fabric by enzymatic polymerization.  Surfaces and Interfaces,      [PMID:] [10.1016/j.surfin.2025.106675]

37. Xingdie Zhou, Zhendong Lv, Zehao Chen, Yiming Xu, Chao Lin, Li Liu, Hao Chen, Bing Niu, Wenguo Cui, Yuhui Zhang.  (2025)  Manipulation of Oxygen Tension in Damaged Regions via Hypoxia-Induced IPN Hydrogel Microspheres for Intervertebral Disc Regeneration.  Advanced Science,      [PMID:40231808] [10.1002/advs.202417570]

38. Fen Tang, Fei Ma, Du Wang, Mengxue Fang, Liangxiao Zhang, Peiwu Li, Li Yu.  (2025)  Highly efficient detoxification of aflatoxin B1 in peanut meals by attapulgite-supported laccase.  FOOD CONTROL,      [PMID:] [10.1016/j.foodcont.2025.111759]

39. Jiulong Wang, Wenjing Yuan, Xinying Duan, Wuxiong Wang, Jie Song, Shangxing Chen, Hai Luo, Ji Zhang, Zongde Wang, Shengliang Liao, Hongyan Si.  (2025)  Camphoryl thiosemicarbazide derivatives: promising multitarget fungicide candidates against Colletotrichum fructicola.  PEST MANAGEMENT SCIENCE,      [PMID:41342272] [10.1002/ps.70420]

40. Xiaolu He, Yanbao Zhao, Yuting Zhang.  (2026)  pH and enzyme responsive flower-like silica-based carriers for pesticide delivery.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2026.139911]

41. Like Wang, Bo Liu, Shuheng Wei, Yongkang Xi, Shouwei Yin.  (2026)  Compartmentalized mesoporous core–shell protein particles with hydrophobic–hydrophilic domains for synergistic adsorption and catalysis.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:] [10.1016/j.jhazmat.2026.142153]