GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.≥99%
Moligand™,≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at 2-8°C,Protected from light,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans , improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway
In Vitro
Licarin B (5 μM, 10 μM, 15 μM. 8 days) moderately increases TG accumulation during adipogenic differentiation and showed partial PPARg agonist activity in 3T3-L1 preadipocytes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: 3T3-L1 cell. Concentration: 1-500 μM. Incubation Time: 48 h. Result: Did not cause significant cell death up to 500 μM concentration. Cell Viability AssayCell Line: 3T3-L1 cell. Concentration: 5 μM, 10 μM, 15 μM. Incubation Time: 8 days (replaced every 2 days). Result: LB at 15 μM concentration significantly promoted adipocyte differentiation and caused intracellular TG accumulation.
Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans , improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway.
Storage
Store at 2-8°C,Protected from light,Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
This compound belongs to the class of organic compounds known as 2-arylbenzofuran flavonoids. These are phenylpropanoids containing the 2-phenylbenzofuran moiety.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
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Application Protocols
No manufacturer-validated protocols are provided for this item. The following generic protocols can serve as starting points for small-molecule screening and analytical use. Adapt and validate for your system.
Stock preparation for screening:
Dissolve Licarin B in anhydrous DMSO to 10–50 mM under low light. Vortex/sonicate briefly. Filter through a 0.22 µm PTFE syringe filter if particulate remains.
Aliquot into low-bind, amber vials or 96/384-well source plates. Overlay with argon and store at 2–8°C short term or at –20°C for longer term if compatible.
Assay dilution:
Add DMSO stock to buffer to reach desired final concentration keeping DMSO ≤1–2% v/v. Mix immediately and inspect for precipitation. Include vehicle controls.
LC–MS reference standard:
Prepare 0.1–1.0 mg/mL solutions in MeOH or ACN (with 0.1% formic acid if needed). Record retention time on your system, collect MS/MS spectrum to add to internal libraries.
Stability check:
Incubate working solutions at assay temperature and sample at 0, 2, 4, 24 h for HPLC purity assessment. Protect from light throughout.
Note: These are general best practices; consult the batch CoA/Spec Sheet for any item-specific recommendations.
Biological Roles
General literature context (not item-specific claims):
Licarin-type molecules are commonly categorized as lignans/neolignans, which are plant-derived phenylpropanoid dimers. In planta, such metabolites are implicated in ecological interactions and defense, frequently accumulating in seeds, bark, or essential oil–rich tissues.
Structural motifs in neolignans (e.g., multiple aryl–O substituents) confer lipophilicity and the potential to interact with biological membranes and proteins; binding is often driven by aromatic and hydrogen-bonding interactions. Exact targets for Licarin B, if any, should be established experimentally.
Research implications:
As Moligand-grade small molecules, licarin scaffolds can be incorporated into screening decks to sample natural-product–like chemical space, complementing synthetic libraries dominated by rule-of-five space. Such scaffolds may exhibit different 3D shapes and stereochemical richness compared with flat heteroaromatics.
For systems biology and metabolomics, authentic standards like Licarin B can support retention index alignment, tandem MS spectral libraries, and cross-laboratory comparability.
Caveats:
No medical or clinical utility is implied. Any biological activity must be verified in the intended model system with appropriate controls, concentration ranges, and counter-screens for assay interference (e.g., redox cycling, fluorescence quenching).
Batch-specific form (free base, solvate, polymorph) and purity can influence apparent activity; consult the CoA/Spec Sheet and confirm by orthogonal analytical methods prior to mechanistic studies.
Buffer Applications
This product is a hydrophobic small molecule, not a buffering reagent. It does not serve as a pH buffer or classical additive for buffer capacity.
Practical notes for using in buffered assays:
Prepare concentrated DMSO stocks and dilute into the desired buffer (e.g., PBS, HEPES, Tris) ensuring the final DMSO content is within assay tolerance (commonly ≤1–2% v/v).
Pre-wet dilution: Add the DMSO stock into an intermediate of buffer + co-solvent (e.g., buffer containing 10–20% EtOH or DMSO) before final dilution to minimize precipitation; validate this with the assay system.
Surfactants: Low levels of non-ionic surfactants (e.g., 0.01–0.05% Tween-20 or Pluronic F-68) can reduce aggregation/precipitation artifacts; verify compatibility with target assays.
No buffer capacity ranges, pKa pairs, or recipe tables are applicable to this item.
Green Alternatives
As Licarin B is a discrete small molecule rather than a process solvent or reagent used in bulk, “green alternatives” primarily concern handling media and workflows around it rather than substitution of the compound itself.
Greener handling considerations (general):
Prefer DMSO or ethanol for stock solutions where compatible, as these are broadly accepted and easier to manage in waste streams than DMF/NMP.
For chromatographic purification or analytical runs (if applicable), consider greener solvent systems such as ethanol/heptane or EtOAc/EtOH in place of acetonitrile or dichloromethane when resolution permits.
Minimize solvent volumes by preparing concentrated stocks and using microscale assay formats (384/1536-well) to reduce overall solvent consumption.
Implement light- and oxygen-minimizing practices (amber vials, argon headspace) to extend compound lifetime and reduce repurification needs, thereby lowering resource use.
Illustrative comparison (handling solvents):
DMSO (preferred for assays) vs DMF/NMP (higher hazard profiles): DMSO typically offers a better balance of solvency and operator safety in bioassays; DMF/NMP may be reserved for synthetic or analytical contexts where necessary.
Ethanol vs acetonitrile: Ethanol is renewable and less toxic; however, ACN often gives superior chromatographic performance. Evaluate method feasibility before switching.
Because Licarin B is being used for research discovery rather than scale manufacturing, the dominant green-chemistry levers are solvent choice, miniaturization, and compound lifecycle management rather than substitution.
Pharmaceutical Uses
No pharmacopeial or excipient status is provided for this item. Licarin B is offered for research use only and is not intended for clinical or diagnostic applications.
Potential roles in a pharmaceutical R&D context (non-clinical, general):
Reference standard: For analytical method development (HPLC/UPLC–MS) and natural product QC where licarin-type compounds are relevant.
Discovery screening: Inclusion in HTS or focused libraries to explore natural-product–like chemical space and assess ligandability of targets.
ADME method controls (exploratory): May serve as a case compound for assay development (e.g., solubility, permeability, microsomal stability) when building internal capability; any data generated are method-development artifacts, not product specifications.
Regulatory and quality notes:
No USP/EP/JP monographs are indicated. Any use in regulated environments requires internal qualification using the batch-specific CoA/SDS and appropriate method validation.
Impurities, residual solvents, and solid-state form for this item are Not specified for this item; refer to CoA/Spec Sheet.
Physical Properties
Item-specific physicochemical specifications were not provided. Do not treat the following general remarks as specifications.
Appearance: Not specified for this item; refer to CoA/Spec Sheet.
Melting point: Not specified for this item; refer to CoA/Spec Sheet. (Neolignans are often solids; literature values vary by congener.)
Boiling point: Not applicable/rarely reported for complex lignans due to thermal lability; item-specific BP not specified.
Density: Not specified for this item; refer to CoA/Spec Sheet.
Refractive index: Not applicable (typically a solid); not specified.
LogP/logD: Not specified for this item; refer to CoA/Spec Sheet. (Neolignans are generally lipophilic, literature trend only.)
pKa: Not specified for this item; refer to CoA/Spec Sheet. (Phenolic/benzylic functionalities may exhibit weak acidity; literature trend only.)
Aqueous solubility: Not specified for this item; refer to CoA/Spec Sheet. General expectation for lignans is very low water solubility; use of co-solvents recommended.
Organic solvent solubility (general guidance): Frequently soluble in DMSO and moderately soluble in DMF, MeOH/EtOH (with warming), acetone, ethyl acetate, and other mid-polar organics. Verify with a small-scale solubility screen.
Practical notes (general):
Prepare concentrated DMSO stocks (e.g., 10–50 mM) for screening; dilute into assay buffers with ≤1–2% final DMSO where permissible.
Gentle warming (30–40°C) and sonication can help dissolution; avoid prolonged heating or light exposure.
Quality & Grades
Grade/Purity: Moligand™
What Moligand™ typically signifies (general description):
Moligand-grade items are intended for ligand discovery, target screening, and medicinal chemistry hit-finding workflows. Emphasis is on structural integrity, suitability for biochemical assays, and practical handling for high-throughput or fragment/lead-like evaluation.
Typical expectations for Moligand-type offerings (not item-specific specifications):
High chemical purity suitable for screening and SAR development, often assessed by LC/UV/ELSD and/or LC–MS.
Documented identity (e.g., NMR/MS) and batch-specific CoA/Spec Sheet providing purity and handling notes.
Packaging oriented to small-scale use, with inert gas backfill for air/light-sensitive compounds.
Item-specific clarifications:
Purity value, water content, residual solvents, and metal limits: Not specified for this item; refer to CoA/Spec Sheet.
Stabilizers or additives: Not specified for this item; refer to CoA/Spec Sheet.
Chromatography suitability: While Moligand materials are generally compatible with HPLC/UPLC analyses, UV cutoffs or background absorbance are not specified; consult batch documentation for chromatographic baselines and detection wavelengths.
Best practices for receiving and qualifying:
Inspect vial integrity on receipt (shipped on wet ice). Allow to equilibrate to 2–8°C before opening to avoid condensation ingress. Record appearance and run a quick LC–MS confirmation if needed for screening campaigns.
Reaction & Applications
This product is primarily positioned as a screening ligand/small molecule for discovery research rather than as a commodity reagent or solvent.
Applications (research context):
Bioactivity screening: Suitable for target-agnostic or hypothesis-driven screening panels (enzyme assays, binding assays, phenotypic screens). Prepare well-characterized DMSO stocks, verify stability under assay conditions, and include vehicle controls.
Chemical biology probes (early-stage): With appropriate derivatization chemistry (if permissible), neolignan cores can be adapted into photoaffinity or biotinylated probes for pulldown/MS workflows; ensure synthetic feasibility and maintain the core scaffold.
Analytical standard: May serve as a reference standard for natural product identification, QC of plant extracts, or metabolomics libraries; confirm retention time and ionization behavior on the instrument of choice.
Practical tips:
Stability assessment: Conduct a short-term stability check (HPLC at t = 0, 24, 48 h) in the intended solvent and at typical assay temperature. Light protection and inert atmosphere are recommended per product storage guidance.
Adsorption/precipitation: Hydrophobic analytes can adsorb to plasticware or precipitate upon aqueous dilution. Use low-bind plates/tubes and keep DMSO ≥0.2–0.5% v/v when compatible.
QC before screening: Verify identity by LC–MS (single major peak, expected m/z) and purity by area%. Batch CoA should be used as the primary acceptance criterion.
Note: No manufacturer-specific application claims were provided; suggestions above are general best practices for Moligand-grade small molecules.
Reaction Conditions
No item-specific reaction condition data are provided because Licarin B is supplied as a research small molecule rather than a reagent or catalyst. The following general guidance pertains to handling during analytical or derivatization steps, not to a standardized transformation.
Dissolution for assays: Prepare 10–50 mM stocks in anhydrous DMSO under low light. If needed, gently warm (30–40°C) and sonicate to aid dissolution. Maintain an inert headspace when feasible.
Stability checks: Assess stability in assay buffer (with intended DMSO carryover) at the target temperature and time window. Analyze by HPLC at t = 0 and post-incubation to detect degradation or adsorption losses.
Derivatization (general): When performing O-acylation/alkylation or linker installation, employ mild bases (e.g., K2CO3, DIPEA) in polar aprotic solvents (DMF, acetone, MeCN) at 0–25°C initially; monitor closely by LC–MS. Oxidative elaborations (e.g., benzylic oxidation) should use controlled, chemoselective oxidants with short reaction times.
Purification: Normal-phase silica with EtOAc/hexanes or reverse-phase C18 with MeOH/H2O or ACN/H2O (with formic acid if needed) are common starting points; optimize gradients empirically.
These notes are general literature/practice guidance and are not specifications. For any reaction development, confirm the exact structure and functional groups of Licarin B from the CoA/SDS prior to planning conditions.
Safety & Handling
Safety information specific to this catalog item was not provided. The following are general laboratory precautions for hydrophobic, aromatic natural-product–like small molecules. Always consult the product SDS for authoritative guidance.
GHS classification, signal word, pictograms, H-statements: Not specified for this item; refer to SDS.
Likely hazards (general): Many lignan/neolignan compounds can cause eye/skin irritation and may be harmful if ingested or inhaled. Avoid dust and aerosols.
Personal protective equipment: Use lab coat, safety glasses or goggles, and appropriate chemical-resistant gloves (e.g., nitrile). Handle in a fume hood to avoid inhalation of dust or solvent vapors.
Handling practices: Protect from light. Minimize air/oxygen exposure if the compound contains air-/light-sensitive motifs; this product is supplied argon charged—maintain an inert headspace when possible.
Incompatibilities (general): Strong oxidizers, strong acids/bases that may cause decomposition or O-dealkylation. Avoid prolonged exposure to UV/visible light.
First aid (general):
Skin/eye contact: Rinse with plenty of water for at least 15 minutes; remove contaminated clothing; seek medical advice.
Inhalation: Move to fresh air; keep at rest; seek medical attention if symptoms occur.
Ingestion: Rinse mouth; do not induce vomiting; seek medical attention.
Spill/cleanup: Avoid dust formation. Collect solids by gentle sweeping; for solutions, absorb with inert material. Dispose according to local regulations.
Fire safety: Use CO2, dry chemical, or foam. Combustible organic material; burning may produce irritating fumes.
Research use only. Not for human or veterinary use.
Solvent Selection
Given the typical lipophilicity of lignan/neolignan small molecules, Licarin B is expected to behave as a low-water-solubility analyte suitable for stock preparation in polar aprotic organic solvents.
Polarity class (general): Low to moderate polarity, aromatic multi-ether framework; use mid- to high–donor number solvents to assist dissolution.
Recommended stock solvents (practical guidance):
DMSO: First-line for biological screening stocks (e.g., 10–50 mM).
DMF or NMP: Alternative for synthetic or analytical preparations when higher solubility is needed.
Methanol/ethanol or acetone/ethyl acetate: Often usable at lower concentrations with gentle warming.
Aqueous systems: Poor direct solubility is expected. For assays, dilute DMSO stocks into buffer while maintaining a low final DMSO fraction (≤1–2% v/v as assay-permitted), optionally with surfactants (e.g., 0.01–0.05% Tween-20) if validated by the assay.
Avoid: Strongly acidic/basic aqueous media that may promote hydrolysis or O-dealkylation; prolonged exposure to oxidants.
Comparison (general guidance):
DMSO vs DMF: DMSO preferred for bioassays due to lower toxicity profile in cells and routine use; DMF can improve solubility but is less favored in live-cell settings.
MeOH/EtOH vs Acetone/EtOAc: Alcohols facilitate rapid dilution into water but may still precipitate; acetone/EtOAc are excellent for sample preparation and chromatography but are poor for direct aqueous dilution.
Always verify solubility empirically at the working temperature and purity of the specific batch.
Storage & Reconstitution
Storage conditions (as provided): Store at 2–8°C, protected from light, argon charged.
Shipping: Shipped on wet ice.
Appearance: Not specified for this item; refer to CoA/Spec Sheet.
Reconstitution and handling (general best practices for small-molecule solids/solutions):
Upon receipt, allow the sealed container to equilibrate to 2–8°C to minimize condensation, then to ambient if needed before opening. Open under low light. If the vial is argon charged, minimize time open to air; re-establish an inert headspace after use.
Stock solution preparation:
Dissolve in anhydrous DMSO to 10–50 mM as a master stock. Vortex/sonicate gently. If required, gently warm (≤40°C) to aid dissolution.
Optionally sterile-filter (0.22 µm PTFE) for cell-based assays.
Aliquot into amber, low-bind microtubes or plates to avoid repeated freeze–thaw and adsorption losses.
Storage of solutions:
Short term (days to weeks): 2–8°C, protected from light, under inert gas.
Longer term: –20°C to –80°C may be used if compatible; verify stability empirically. Avoid multiple freeze–thaw cycles; thaw on ice, mix, and promptly return to storage.
Solid-state storage: If supplied as a solid, keep tightly closed at 2–8°C in the dark with desiccant if available. Hygroscopicity not specified—inspect periodically for clumping or discoloration.
Research use only. Refer to the batch CoA/Spec Sheet and SDS for item-specific stability, purity, and hazard information.
Structure & Identity
Brief overview: Licarin B is a small-molecule natural-product–like compound commonly classified in the lignan/neolignan family and supplied here as a Moligand-grade screening ligand.
SKU: L651454
Product name: Licarin B
CAS: 51020-87-2
PubChem CID: 6441061 (literature identifier)
InChIKey: 67346 (as provided in Product Data)
Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
SMILES: Not specified for this item; refer to CoA/Spec Sheet.
Structural features (general, literature context):
Licarin-type compounds are typically phenylpropanoid dimers (lignans/neolignans) bearing multiple aryl ether linkages and oxygenated substituents (e.g., methoxy/methylenedioxy groups) on substituted phenyl rings; exact substitution and stereochemistry depend on the specific licarin congener. These notes are general literature descriptions and are not item-specific specifications.
Stereochemistry: literature reports for licarin congeners often include defined axial/central stereocenters; verify enantiomeric composition for this catalog item from the CoA if stereochemistry is critical.
2D structural description (general):
Two aromatic rings connected via a C–C or C–O–C framework typical of neolignans; multiple aryl O-substituents; one or more benzylic/allylic positions. Exact ring substitution pattern for Licarin B should be confirmed from the CoA/SDS or primary literature for CAS 51020-87-2.
Synthetic Utility
Licarin B is supplied as a finished small molecule for screening and analytical use; it is not typically employed as a modular building block in routine synthesis. Nevertheless, in a general natural-product chemistry context:
Derivatization opportunities (general): Phenylpropanoid-derived scaffolds often feature aryl ethers/phenolics and benzylic/allylic positions that can, in principle, be modified for SAR or probe development (e.g., selective O-alkylation/acylation, oxidative elaboration, or installation of linkers for conjugation). The exact positions available on Licarin B should be confirmed from its definitive structure (consult CoA/literature for CAS 51020-87-2).
Access to analogs: Semi-synthetic routes from closely related lignans can enable late-stage diversification. Protecting-group strategies may be required to control chemoselectivity among multiple aryl–O functionalities.
Analytical development: Even absent large-scale synthesis, the molecule is useful as a standard to calibrate separations for complex extract fractionation, guiding isolation or dereplication.
Cautions:
Over-oxidation and rearrangement are common risks under harsh conditions for lignan frameworks. Conduct small-scale scouting and monitor by LC–MS.
Stereochemical integrity (if present) should be preserved; racemization or epimerization risks should be evaluated if strongly basic or high-temperature conditions are contemplated.
Summary: treat Licarin B primarily as a screening/standard compound; any synthetic deployment should be undertaken with a clear structural map from the CoA.
Target Specificity
No target, epitope, or biological specificity has been provided for this product.
Antigen/Target: Not specified for this item; refer to CoA/Spec Sheet.
Species reactivity: Not applicable.
Clone/Isotype: Not applicable.
Context: As a Moligand-grade small molecule, Licarin B may be used in unbiased or targeted screening campaigns to empirically determine binding partners. Any target associations must be established experimentally with appropriate orthogonal validation (e.g., SPR/ITC, CETSA, chemoproteomics).
Need help choosing the grade?
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
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