GRADE & PURITY 10mM in DMSO

Synonyms

NSC 293099 | [1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Magnolol Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation.
In vitro

Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. Magnolol has a more potent enhancing effect on GABA_A receptor alpha2 subunit. Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml.

In vivo

LD50: Mice 2200mg/kg (i.g.).
Cell Data

cell lines：LNCaP/AR prostate cancer cell line

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

NSC 293099 | [1, 1'-Biphenyl]-2, 2'-diol, 5, 5'-di-2-propen-1-yl-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O
• WGK Germany: 3
• RTECS: DV5105500
• UN Number: 3077
• Molecular Weight: 266.33
• Beilstein: 6(4)6918
• Reaxy-Rn: 1982224
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1982224&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 100 mg/mL (148.9 mM); Ethanol: 4 mg/mL (5.95 mM); Water: Insoluble
• Boil Point(°C): 180 °C/1 mmHg
• Melt Point(°C): 101 °C

References

1. Jietao Liu, Shenye Qu, Tao Wang, Bin Yang, Xiang Liu, Gaoxue Wang, Pengfei Li, Qing Yu, Fei Ling.  (2023)  Nanosuspensions as an approach for improved solubility and anti-Ichthyophthirius multifiliis activity of magnolol.  AQUACULTURE,      [PMID:] [10.1016/j.aquaculture.2023.740133]

2. Zhao Zhang, Jing Li, Gaoxue Wang, Fei Ling.  (2023)  The oral protective efficacy of magnolol against Aeromonas hydrophila and A. veronii infection via enhancing anti-inflammatory ability in goldfish (Carassius auratus).  JOURNAL OF FISH DISEASES,  46  (12): (1413-1423).  [PMID:37705318] [10.1111/jfd.13859]

3. Mo Feixu, Long Youhua, Li Ming, Ding Yi, Wu Shuai, Li Rongyu.  (2023)  Effect of enzyme-response Mag@CMCS@CPSG film on rice sheath blight disease (caused by Rhizoctonia solani) control and rice quality.  Frontiers in Sustainable Food Systems,      [PMID:] [10.3389/fsufs.2023.1204698]

4. Guoyu Wei, Wei Zhao, Anlong Hu, Mingjian Ren, Yunxiao Huang, Huayang Xu.  (2023)  Identification of a New Pathogenic fungi Causing Sorghum Leaf Spot Disease and Its Management Using Natural Product and Microorganisms.  Microorganisms,  11  (6): (1431).  [PMID:37374932] [10.3390/microorganisms11061431]

5. Tong Yin-Chao, Zhang Yi-Ning, Li Peng-Cheng, Cao Ya-Li, Ding Dong-Zhao, Yang Yang, Lin Qing-Yi, Gao Yi-Nuo, Sun Shao-Qiang, Fan Yun-Peng, Liu Ying-Qiu, Qing Su-Zhu, Ma Wu-Ren, Zhang Wei-Min.  (2023)  Detection of antibiotic-resistant canine origin Escherichia coli and the synergistic effect of magnolol in reducing the resistance of multidrug-resistant Escherichia coli.  Frontiers in Veterinary Science,      [PMID:37008355] [10.3389/fvets.2023.1104812]

6. Feixu Mo, Wenzhi Li, Youhua Long, Rongyu Li, Yi Ding, Ming Li.  (2023)  Magnolol Loaded on Carboxymethyl Chitosan Particles Improved the Antimicrobial Resistance and Storability of Kiwifruits.  Foods,  12  (6): (1149).  [PMID:36981076] [10.3390/foods12061149]

7. Weizhen Wang, Linan He, Zhuzhu Zhang, Wenzhi Li, Jia Chen, Tingting Chen, Youhua Long.  (2023)  Activity of the botanical compound thymol against kiwifruit rot caused by Fusarium tricinctum and the underlying mechanisms.  PEST MANAGEMENT SCIENCE,      [PMID:36864770] [10.1002/ps.7431]

8. Chen Kai, Qin Ting, Pan Liangkun, Bing Xuwen, Xi Bingwen, Xie Jun.  (2023)  Effects of glycyrrhetinic acid β on growth and virulence of Aeromonas hydrophila.  Frontiers in Microbiology,      [PMID:36846766] [10.3389/fmicb.2023.1043838]

9. Ziyu Liu, Xiaoli Wang, Xingyue Zhu, Yazhou Tian, Jue Cheng, Junying Zhang.  (2022)  Phase Change Energy Storage Material with Photocuring, Photothermal Conversion, and Self-Cleaning Performance via a Two-Layer Structure.  ACS Applied Materials & Interfaces,      [PMID:36514297] [10.1021/acsami.2c18748]

10. Xin-Yuan Jiang, Zong-Yi Ren, Nian-Kun Zhang, Ke-Chen Yang, Gao-Xue Wang, Hai-Feng Jiang.  (2022)  Screening and evaluating honokiol from Magnolia officinalis against Nocardia seriolae infection in largemouth bass (Micropterus Salmoides).  JOURNAL OF FISH DISEASES,  45  (11): (1599-1607).  [PMID:35801398] [10.1111/jfd.13683]

11. Ziyu Liu, Xingyue Zhu, Yazhou Tian, Kaiyun Zhou, Jue Cheng, Junying Zhang.  (2022)  Bio-based recyclable Form-Stable phase change material based on thermally reversible Diels–Alder reaction for sustainable thermal energy storage.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2022.137749]

12. Wenwen Guo, Fuwei Liang, Shun Chen, Kejing Yu, Jie Sun, Zengyuan Pang, Bin Fei.  (2022)  Magnolol-derived thiol-ene photo-polymerized membranes with intrinsic anti-flammability and high transparency.  COMPOSITES PART B-ENGINEERING,      [PMID:] [10.1016/j.compositesb.2022.110074]

13. Wenwen Guo, Fuwei Liang, Shun Chen, Diantang Zhang, Wenbing Li, Kun Qian, Yang Xu, Bin Fei.  (2022)  Synthesis of magnolol-derived bisphosphate for fabrication of bismaleimide resins with intrinsic anti-flammability and smoke suppression.  POLYMER DEGRADATION AND STABILITY,      [PMID:] [10.1016/j.polymdegradstab.2022.110002]

14. Feixu Mo, Xianfeng Hu, Yi Ding, Rongyu Li, Youhua Long, Xiaomao Wu, Ming Li.  (2021)  Naturally produced magnolol can significantly damage the plasma membrane of Rhizoctonia solani.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,      [PMID:34446208] [10.1016/j.pestbp.2021.104942]

15. Xueying Song, Liu Liu, Xiaoxia Wu, Yongfeng Liu, Jialu Yuan.  (2021)  Chitosan-Based Functional Films Integrated with Magnolol: Characterization, Antioxidant and Antimicrobial Activity and Pork Preservation.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  22  (15): (7769).  [PMID:34360535] [10.3390/ijms22157769]

16. Na Teng, Shimin Yang, Jinyue Dai, Shuaipeng Wang, Jun Zhao, Jin Zhu, Xiaoqing Liu.  (2019)  Making Benzoxazine Greener and Stronger: Renewable Resource, Microwave Irradiation, Green Solvent, and Excellent Thermal Properties.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.9b00607]

17. Jie Cheng, Shuqi Dong, Litao Yi, Di Geng, Qing Liu.  (2018)  Magnolol abrogates chronic mild stress-induced depressive-like behaviors by inhibiting neuroinflammation and oxidative stress in the prefrontal cortex of mice.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:29627576] [10.1016/j.intimp.2018.03.031]

18. Zhihong Yao, Shishi Li, Zifei Qin, Xiaodan Hong, Yi Dai, Baojian Wu, Wencai Ye, Frank J. Gonzalez, Xinsheng Yao.  (2017)  Characterization of human UDP-glucuronosyltransferases responsible for glucuronidation and inhibition of norbakuchinic acid, a primary metabolite of hepatotoxicity and nephrotoxicity component bakuchiol in Psoralea corylifolia L..  RSC Advances,  7  (83): (52661-52671).  [PMID:] [10.1039/C7RA10376J]

19. Hongjun Zhang, Baoling Ju, Xiaoli Zhang, Yanfei Zhu, Ying Nie, Yuanhong Xu, Qiuxia Lei.  (2016)  Magnolol Attenuates Concanavalin A-induced Hepatic Fibrosis, Inhibits CD4+ T Helper 17 (Th17) Cell Differentiation and Suppresses Hepatic Stellate Cell Activation: Blockade of Smad3/Smad4 Signalling.  BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,  120  (6): (560-570).  [PMID:28032440] [10.1111/bcpt.12749]

20. Liu Guishen, Ma Yanhui, Hou Xiaodong, huang Yina, Chen Jianpeng, Zhan Guoqing, Li Chunya.  (2015)  Synthesis of 1-[3-(N-pyrrole)propyl]-3-[1-tert-butoxycarbonylamino-propyl]-imidazolium tetrafluoroborate ionic liquid for application in electrochemical sensing of magnolol.  IONICS,  21  (9): (2567-2574).  [PMID:] [10.1007/s11581-015-1455-6]

21. Zhenhao Li, Shun Xiao, Ni Ai, Kedi Luo, Xiaohui Fan, Yiyu Cheng.  (2014)  Derivative multiple reaction monitoring and single herb calibration approach for multiple components quantification of traditional Chinese medicine analogous formulae.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:25541090] [10.1016/j.chroma.2014.12.024]

22. Xinjian Song, Bing Wang, Yina Huang, Liqing Li, Ting Li, Chunya Li, Shenghui Zhang.  (2013)  A novel nanoporous film electrode based on electrochemical polymerization of ionic liquid and its application in sensitive determination of magnolol.  TALANTA,      [PMID:24401462] [10.1016/j.talanta.2013.11.055]

23. Ting Xu, Zhiyuan Zheng, Yong Guo, Li-Ping Bai.  (2020)  Semisynthesis of novel magnolol-based Mannich base derivatives that suppress cancer cells via inducing autophagy.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:32791403] [10.1016/j.ejmech.2020.112663]

24. Fei Yang, Zhiqiang Zhang, Shenye Qu, Gaoxue Wang, Qing Yu, Fei Ling.  (2025)  Efficient antiviral activity of a novel magnolol derivative against aquatic rhabdoviruses.  AQUACULTURE,      [PMID:] [10.1016/j.aquaculture.2025.742464]

25. Ming Li, Hua Sun, Jin-Ling Song, Xing Sun, Wei Li.  (2025)  Identification of human UDP-glucuronosyltransferases involved in I3,II8-biapigenin glucuronidation in Vitro.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:39923326] [10.1016/j.jpba.2025.116735]

26. Huifa Meng, Kaijin Chen, Chuying Li, Longfei Zhang, Yanwei He, Zining Zhao, Peixin Wu, Hai Zhu, Zhenguo Chi, Jiarui Xu, Siwei Liu, Yi Zhang.  (2025)  Innocuous solvent-based, low-temperature curable, and high transparency photosensitive polyimides developed by soluble polyimides containing bio-based magnolol moieties.  Chemical Science,      [PMID:39829980] [10.1039/D4SC07952C]

27. Safdar Ali Amur, Quratulain Khuhro, Najaf Ali Soomro, Bharat Prasad Sharma, Ahmed Nadeem, Muhammad Tariq, Hao Liang.  (2025)  Synthesis, characterization and computational study of chitosan-modified pH-responsive Mag@ZIF-8/CS drug delivery system loaded with magnolol for sustained drug release and synergistic antibacterial activity.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40107541] [10.1016/j.ijbiomac.2025.142144]

28. Gaotian Zhai, Jiayi Shao, Jinliang Chen, Yongqiang Yang, Jien Qin, Xiaochen Wu.  (2025)  Development of a glucose-responsive smart hydrogel for diabetic wound healing.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.167205]

29. Yuhan Liu, Yu Lei, Luorui Shang, Zhaomin Yu, Li Wang, Jiabin Zhou, Guangtao Pan.  (2025)  Protective effects of Dachengqi Decoction in sepsis-associated liver injury based on network pharmacology analysis and experimental validation.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:40840728] [10.1016/j.jep.2025.120450]

30. Huawang Zhao, Naidan Zhang, Minyuan Feng, Yu Wang, Bekezela Matshazi, Haofeng Liu, Weilin Xu, Hongjun Yang.  (2025)  The forming mechanism and optimizing of natural polymer foam based on magnolol extracted from Chinese herbal medicine.  POLYMER,      [PMID:] [10.1016/j.polymer.2025.128922]

31. Lin Niu, Yu-jie Lu, Xing-wang Zu, Wen Yang, Fu-kui Shen, Yan-yan Xu, Min Jiang, Yang Xie, Su-yun Li, Jie Gao, Gang Bai.  (2023)  Magnolol alleviates pulmonary fibrosis inchronic obstructive pulmonary disease by targeting transient receptor potential vanilloid 4-ankyrin repeat domain.  PHYTOTHERAPY RESEARCH,      [PMID:37282760] [10.1002/ptr.7907]

32. Lin Niu, Jie Wang, Fukui Shen, Jie Gao, Min Jiang, Gang Bai.  (2022)  Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:35157953] [10.1016/j.jep.2022.115105]

33. Lin Niu, Shilong Wang, Yanyan Xu, Xingwang Zu, Xinyu You, Qiuyang Zhang, Pengwei Zhuang, Min Jiang, Jie Gao, Xiaotao Hou, Yanjun Zhang, Gang Bai, Jiagang Deng.  (2024)  Honokiol targeting ankyrin repeat domain of TRPV4 ameliorates endothelial permeability in mice inflammatory bowel disease induced by DSS.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:38296175] [10.1016/j.jep.2024.117825]

34. Fangyuan Wei, Caihong Shi, Hongyue Wang, Wanxuan Li, Xindi Zhang, Xiangrong Zhang.  (2025)  Zein-magnolol complexes assisted hydrogel film: Physical, antioxidant, antimicrobial properties and application on food packaging.  FOOD RESEARCH INTERNATIONAL,      [PMID:40467242] [10.1016/j.foodres.2025.116672]

35. Yane Li, Li Yao, Jiaxuan Hou, Xingyun Yuan, Yuanyuan Zhu, Zhichao Deng, Chenxi Xu, Jinxing Chen, Bingyi Chen, Jiayan Li, Yifan Me, Shuang Liu, Shaoying Lu, Mingzhen Zhang, Hui Cai.  (2026)  Harnessing the spleen–brain axis: Magnolol-loaded nanomedicine attenuates ischemic stroke via oxidative stress mitigation and monocyte/macrophage reprogramming.  Acta Pharmaceutica Sinica B,      [PMID:] [10.1016/j.apsb.2026.02.012]

36. Leyuan Huang, Xu Zhou, Guanfeng He, Haixin Li, Xiaoying Chen, Jingwen Xu, Lei Zhou.  (2026)  Magnolia officinalis Rehder & E.H.Wilson. Bark Extract and Magnolol Alleviate Allergic Rhinitis via Modulating NF-κB/MAPK Signaling.  MOLECULES,  31  (6):   [PMID:] [10.3390/molecules31061009]