Mefenamic Acid - Moligand™, 10mM in DMSO , Cyclooxygenase inhibitor, CAS No.61-68-7, Cyclooxygenase inhibitor

CAS: 61-68-7 Cat. No.: M408474 Molecular Weight: 241.29 EC Number: 200-513-1

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

CI 473, CN-35355 | Benzoic acid, 2-[(2,3-dimethylphenyl)amino]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Mefenamic Acid (CI 473, CN-35355) is a competitive inhibitor ofCOX-1andCOX-2.
In vitro

In vivo

Cell Data

cell lines：PDAC(pancreatic ductal adenocarcinoma) cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

CI 473, CN-35355 | Benzoic acid, 2-[(2, 3-dimethylphenyl)amino]-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Mefenamic Acid (CI 473, CN-35355) is a competitive inhibitor of COX-1 and COX-2.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ACTIVATOR, CHANNEL BLOCKER, INHIBITOR

Mechanism of action

Cyclooxygenase inhibitor

Product Properties

• ALogP: 5.1

Names and Identifiers

• Isomeric SMILES: CC1=C(C(=CC=C1)NC2=CC=CC=C2C(=O)O)C
• WGK Germany: 3
• RTECS: CB4550000
• Molecular Weight: 241.29
• Reaxy-Rn: 2216243
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2216243&ln=

Associated Targets(Human)

NAPRT Tchem Nicotinate phosphoribosyltransferase (2 Activities)

Discover Target: NAPRT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS1 Tclin Prostaglandin G/H synthase 1 (2 Activities)

Discover Target: PTGS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 (2 Activities)

Discover Target: PTGS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MPO Tchem Myeloperoxidase (1 Activities)

Discover Target: MPO

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1C2 Tchem Aldo-keto reductase family 1 member C2 (1 Activities)

Discover Target: AKR1C2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1C3 Tchem Aldo-keto reductase family 1 member C3 (2 Activities)

Discover Target: AKR1C3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1C1 Tchem Aldo-keto reductase family 1 member C1 (1 Activities)

Discover Target: AKR1C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 42 mg/mL (199.78 mM); Ethanol: 42 mg/mL (199.78 mM); Water: Insoluble
• Melt Point(°C): 230°C

References

1. Xinyi Wang, Shijie Xu, Lina Jia, Yujia Yang, Yu Liu, Junbo Gong, Songgu Wu.  (2019)  Drug–drug salts of mefenamic acid\tolfenamic acid and piperazine to improve physicochemical properties for potential veterinary use.  CRYSTENGCOMM,  21  (35): (5284-5291).  [PMID:] [10.1039/C9CE00781D]

2. Xinyi Wang, Yifu Chen, Junbo Gong, Jinze Hou.  (2019)  Aggregation-induced emission and polymorphism/shape/size-dependent emission behaviours of fenamates for potential drug evaluation.  ORGANIC & BIOMOLECULAR CHEMISTRY,  17  (13): (3409-3415).  [PMID:30869715] [10.1039/C9OB00338J]

3. Xinyi Wang, Dejiang Zhang, Shiyuan Liu, Yifu Chen, Lina Jia, Songgu Wu.  (2018)  Thermodynamic Study of Solubility for Imatinib Mesylate in Nine Monosolvents and Two Binary Solvent Mixtures from 278.15 to 318.15 K.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,      [PMID:] [10.1021/acs.jced.8b00551]

4. Xue Shu-Wen, Li Jing, Xu Li.  (2017)  Preparation of magnetic melamine-formaldehyde resin and its application to extract nonsteroidal anti-inflammatory drugs.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  409  (12): (3103-3113).  [PMID:28224244] [10.1007/s00216-017-0251-8]

5. Yuqing Li, Yanhua Sun, Jian Chen, Xiaohong Zhu, Hui Li, Shen Huang, Yuwei Hu, Qi Chen, Shian Zhong.  (2016)  Graphene oxide as a sacrificial material for fabricating molecularly imprinted polymers via Pickering emulsion polymerization.  RSC Advances,  6  (78): (74654-74661).  [PMID:] [10.1039/C6RA17672K]

6. Luo Zhi-yuan, Li Zhi-yong, Liu Hai-yan, Tang Min-qiong, Shi Zhi-guo.  (2015)  Click chemistry-based synthesis of water-dispersible hydrophobic magnetic nanoparticles for use in solid phase extraction of non-steroidal anti-inflammatory drugs.  MICROCHIMICA ACTA,  182  (15): (2585-2591).  [PMID:] [10.1007/s00604-015-1638-x]

7. Lian Xu, Yan Xiao, Kun Yu, Hongshuo Pan, Jiayi Xu, Yiyun Guan, Mengke Wang, Xiangyu Xu, Hao Wang.  (2025)  Machine Learning-Assisted Chemical Tongues Based on Dual-channel Inclusion Complexes for Rapid Identification of Nonsteroidal Anti-inflammatory Drugs in Food.  ACS Sensors,      [PMID:39992799] [10.1021/acssensors.4c02806]

8. Zhiyong Wu, Xinhao Wang, Lin Wang, Na Sun, Zihui Yang, Jianguo Zeng.  (2025)  Research on the metabolites and key metabolic enzymes of allocryptopine in chicken liver microsomes via stable isotope tracing technology.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:39805195] [10.1016/j.jpba.2025.116667]

9. Xueping Quan, Bing Yan.  (2023)  In Situ Generated Dye@MOF/COF Heterostructure for Fluorescence Detection of Chloroquine Phosphate and Folic Acid via Different Luminescent Channels.  ACS Applied Materials & Interfaces,      [PMID:37972380] [10.1021/acsami.3c11298]

10. Kai Ni, Bo Che, Rong Gu, Chunhong Wang, Hongyang Xu, Huiduo Li, Shiyan Cen, Mingzhi Luo, Linhong Deng.  (2024)  BitterDB database analysis plus cell stiffness screening identify flufenamic acid as the most potent TAS2R14-based relaxant of airway smooth muscle cells for therapeutic bronchodilation.  Theranostics,      [PMID:38389834] [10.7150/thno.92492]