Microcrystalline Cellulose - JP, Ph.Eur., E 460(i), FCC, NF , CAS No.9004-34-6

CAS: 9004-34-6 Cat. No.: M489705 Formula: (C₆H₁₀O₅)_n EC Number: 232-674-9 PubChem CID: 16211032

GRADE & PURITY JP, Ph.Eur., E 460(i), FCC, NF

Synonyms

cellulose|DEAE-CELLULOSE|9004-34-6|(6S)-2-(hydroxymethyl)-6-[(3S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol|Diethylaminoethyl cellulose|Cellulosepulver|DEAE-Sephacel(R)|Diethylaminoethyl-Sephacel(R)|CHEBI:156274|AKOS015895024|EN300-

Storage

Room temperature

Shipped In

Normal

Overview

Microcrystalline cellulose (MCC) is an odorless, tasteless, porous white powder derived from pharmaceutical grade wood pulp. With a wide range of chemical, technical, and economic benefits, MCC is one of the most widely used binder excipients for tablet formulations.

Product specifications

SKU	Average Particle Size by Laser Diffraction (µm)	Bulk Density (g/mL)	Main Application
M489705-01	65	0.25-0.37	Fine standard MCC grade, especially suited for wet granulation, roller compaction and spheronization. Very high compactibility.
M489705-02	130	0.25-0.37	Medium size standard MCC grade, suited for the majority of directly compressible actives. Combines good flow and high compactibility.
M489705-03	130	0.25-0.37(very low moisture content ＜1.5%)	Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives.
M489705-04	130	0.38-0.50	Same quality to grade 102/90M, but increased bulk density and improved flow properties. Especially suited for high speed tableting and processing high density actives.
M489705-05	170/175	0.25-0.37	Coarse, DC-grade MCC.
M489705-06	220	0.20-0.37	Coarse grade MCC, combines good compactibility and high binding capacity with outstanding flow. Provides good content uniformity at low weight variation – even when used with low concentrations of fine actives.

Benefits

High compactability

Robust tablets with low friability

High production yields

Cost savings due to reduction in dosage levels

Compatibility with most APIs (inert)

Specifications

Synonyms

cellulose | DEAE-CELLULOSE | 9004-34-6 | (6S)-2-(hydroxymethyl)-6-[(3S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol | Diethylaminoethyl cellulose | Cellulosepulver | DEAE-Sephacel(R) | Diethylaminoethyl-Sephacel(R) | CHEBI:156274 | AKOS015895024 | EN300-

Specifications & Purity

JP, Ph.Eur., E 460(i), FCC, NF

Storage

Room temperature

Shipped In

Normal

Grade

E 460(i), FCC, JP, NF, Ph.Eur.

Names and Identifiers

Pubchem Sid

508813529

IUPAC Name

(6S)-2-(hydroxymethyl)-6-[(3S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol

InChIKey

GUBGYTABKSRVRQ-WFVLMXAXSA-N

INCHI

1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3?,4?,5?,6?,7?,8?,9?,10-,11?,12+/m1/s1

Isomeric SMILES

C(C1[C@H](C(C(C(O1)O)O)O)O[C@H]2C(C(C(C(O2)CO)O)O)O)O

WGK Germany

3

RTECS

FJ5691460

PubChem CID

16211032

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Class Organooxygen compounds
      • Subclass Carbohydrates and carbohydrate conjugates
        • Level5 Glycosyl compounds
          • Level6 O-glycosyl compounds

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Class: Organooxygen compounds
• Subclass: Carbohydrates and carbohydrate conjugates
• Intermediate Tree Nodes: Glycosyl compounds
• Direct Parent: O-glycosyl compounds
• Alternative Parents: Disaccharides Oxanes Secondary alcohols Hemiacetals Polyols Oxacyclic compounds Acetals Primary alcohols Hydrocarbon derivatives
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: O-glycosyl compound - Disaccharide - Oxane - Secondary alcohol - Hemiacetal - Oxacycle - Organoheterocyclic compound - Polyol - Acetal - Hydrocarbon derivative - Primary alcohol - Alcohol - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as o-glycosyl compounds. These are glycoside in which a sugar group is bonded through one carbon to another group via a O-glycosidic bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Molecular Weight: 342.300 g/mol
• XLogP3: -4.700
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 4
• Exact Mass: 342.116 Da
• Monoisotopic Mass: 342.116 Da
• Topological Polar Surface Area: 190.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 382.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 8
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1