Microcrystalline Cellulose - ChP, JP, Ph.Eur., E 460(i), FCC, NF , CAS No.9004-34-6

CAS: 9004-34-6 Cat. No.: M489093 Formula: (C₆H₁₀O₅)_n EC Number: 232-674-9 PubChem CID: 16211032

GRADE & PURITY ChP, JP, Ph.Eur., E 460(i), FCC, NF

Synonyms

(5S)-6-(hydroxymethyl)-5-{[(2S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxane-2,3,4-triol | Diethylaminoethyl cellulose | Cellulosepulver | Express-Ion(TM) exchanger?? D free base, 60-130 mum | DEAE-CELLULOSE | EN300-381040 | (6S)-2-(HYDROXYMETHYL

Storage

Room temperature

Shipped In

Normal

Overview

Microcrystalline cellulose is very strong and chemically inert, so it is a very ideal carrier. API layered microcrystalline cellulose can be filled into capsules or pressed into tablets. They have a very tight particle size distribution, which can better control and improve the consistency of API release between batches. The uniformity of particle size minimizes the risk of packaging or tablet pressing, resulting in higher uniformity of API content. In addition, different APIs can be used in a variety of concentrates and combined with pellet core coating in a unit dose.

Product specifications

SKU	Average Particle Size by Laser Diffraction (µm)	Bulk Density (g/mL)	Main Application
M489093-01	15	max 0.26	Very fine grade, which gives a pleasant mouth feeling, masks bitter tastes and supports flavors.
M489093-02	65	0.26–0.31	Fine standard MCC grade, especially suited for wet granulation, roller compaction and spheronization. Very high compactibility.
M489093-03	65	0.26-0.34	Same quality as grade 101/50M, but very low moisture content (< 1.5 %) for processing water-sensitive actives.
M489093-04	65	0.35-0.46	Same quality as grade 101, but increased bulk density and improved flow properties.
M489093-05	130	0.28-0.33	Medium size standard MCC grade, suited for the majority of directly compressible actives. Combines good flow and high compactibility.
M489093-06	130	0.30-0.36	Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives
M489093-07	130	0.35-0.50	Same quality to grade 102/90M, but increased bulk density and improved flow properties. Especially suited for high speed tableting and processing high density actives.
M489093-08	170/175	0.28-0.34	Coarse, DC-grade MCC.
M489093-09	180	0.30-0.36	Coarse grade MCC, combines good compactibility and high binding capacity with outstanding flow. Provides good content uniformity at low weight variation – even when used with low concentrations of fine actives.
M489093-10	170	0.32-0.40	Same quality to grade 12, but very low moisture content (<1.5 %) for processing water-sensitive actives.
M489093-11	250	0.31-0.37	Large size MCC grade with excellent flow properties for a variety of direct compression formulations.
M489093-12	250	0.33-0.40	Same quality to grades 200/LP200, but very low moisture content (<1.5 %) for processing water-sensitive actives.
M489093-13	220	0.20-0.37	Coarse grained microcrystalline cellulose has good compressibility and adhesion, and good fluidity. Even for active ingredients with low content and fine particle size, tablets with good content uniformity and small differences in tablet weight can be obtained.

Benefits

1.High compactability,

2.Robust tablets with low friability,

3.High production yields,

4.Practically inert – compatible with most APIs,

5.Created from sustainable organic materials,

6.Contains no additives, impurities, or irradiated components,

7.Advanced carton packaging design for fast NIR identification.

Specifications

Synonyms

(5S)-6-(hydroxymethyl)-5-{[(2S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxane-2,3,4-triol | Diethylaminoethyl cellulose | Cellulosepulver | Express-Ion(TM) exchanger?? D free base, 60-130 mum | DEAE-CELLULOSE | EN300-381040 | (6S)-2-(HYDROXYMETHYL

Specifications & Purity

ChP, JP, Ph.Eur., E 460(i), FCC, NF

Storage

Room temperature

Shipped In

Normal

Grade

ChP, E 460(i), FCC, JP, NF, Ph.Eur.

Names and Identifiers

IUPAC Name

(6S)-2-(hydroxymethyl)-6-[(3S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol

InChIKey

GUBGYTABKSRVRQ-WFVLMXAXSA-N

INCHI

1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3?,4?,5?,6?,7?,8?,9?,10-,11?,12+/m1/s1

Isomeric SMILES

C(C1[C@H](C(C(C(O1)O)O)O)O[C@H]2C(C(C(C(O2)CO)O)O)O)O

WGK Germany

3

RTECS

FJ5691460

PubChem CID

16211032

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Class Organooxygen compounds
      • Subclass Carbohydrates and carbohydrate conjugates
        • Level5 Glycosyl compounds
          • Level6 O-glycosyl compounds

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Class: Organooxygen compounds
• Subclass: Carbohydrates and carbohydrate conjugates
• Intermediate Tree Nodes: Glycosyl compounds
• Direct Parent: O-glycosyl compounds
• Alternative Parents: Disaccharides Oxanes Secondary alcohols Hemiacetals Polyols Oxacyclic compounds Acetals Primary alcohols Hydrocarbon derivatives
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: O-glycosyl compound - Disaccharide - Oxane - Secondary alcohol - Hemiacetal - Oxacycle - Organoheterocyclic compound - Polyol - Acetal - Hydrocarbon derivative - Primary alcohol - Alcohol - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as o-glycosyl compounds. These are glycoside in which a sugar group is bonded through one carbon to another group via a O-glycosidic bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Molecular Weight: 342.300 g/mol
• XLogP3: -4.700
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 4
• Exact Mass: 342.116 Da
• Monoisotopic Mass: 342.116 Da
• Topological Polar Surface Area: 190.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 382.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 8
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Application Protocols

No item-specific validated protocols were provided. The following general procedures (literature) can guide use; adjust to your equipment and scale.

• Aqueous dispersion for rheology studies:

  • Pre-wet MCC with a small portion of water or glycerol to reduce floating.
  • Add gradually to vortexing water under high shear (rotor–stator). Target 1–10% w/w solids depending on viscosity needs.
  • Mix 10–30 min until uniform; defoam as needed. Allow to equilibrate to release entrained air before measurements.

• Direct compression blend preparation:

  • Equilibrate MCC to controlled RH (e.g., 30–50% RH) for 24 h.
  • Sieve to break soft agglomerates; blend with actives and lubricants using low-shear to prevent over-lubrication. Evaluate blend flow and compressibility.

• Support impregnation (for catalysis/materials):

  • Prepare solution of active species; add to MCC by incipient wetness or immersion.
  • Age to equilibrate, then dry under vacuum at ≤60 °C. Optional reduction/activation step per catalyst chemistry.

For application-specific parameters (particle size, moisture, compaction profile), Not specified for this item; refer to CoA/Spec Sheet and SDS.

Biological Roles

This section summarizes general biochemistry of cellulose; it does not imply biological activity for therapeutic use.

• Cellulose in nature (literature):

  • Primary structural polysaccharide in plant cell walls, composed of β(1→4)-D-glucan chains packed into microfibrils that provide tensile strength.
  • Produced by plants, some algae, and certain bacteria (e.g., Gluconacetobacter xylinus produces bacterial cellulose with distinct crystallinity and purity).

• Interaction with biological systems (literature):

  • Indigestible by humans due to lack of cellulases; acts as insoluble dietary fiber. Certain microbes express cellulases enabling cellulose degradation to glucose.
  • Exhibits low bioavailability and minimal systemic absorption; generally regarded as biologically inert in mammalian systems.

• Relevance to research:

  • Serves as an inert matrix for immobilization of enzymes or cells, offering high surface area and mechanical stability.
  • Can be chemically modified (e.g., carboxymethylation) to introduce charges or functional groups for bioseparations and biosensing.

• Physicochemical determinants:

  • Degree of polymerization and crystallinity influence swelling, porosity, and accessibility to enzymes and reagents.
  • Surface hydroxyl density enables hydrogen bonding and adsorption of biomacromolecules; surface treatments can tune nonspecific binding.

Note: No item-specific biological testing is provided for this SKU. For research use only.

Buffer Applications

MCC is not a buffering agent and does not establish defined pH ranges. However, it can be used within buffered systems as an inert structural/rheological component.

• Practical uses in buffered media (literature):

  • Suspension aid/viscosity builder in buffered aqueous systems; helps maintain uniform dispersions of insoluble actives or particles.
  • Solid support for immobilization in biocatalysis carried out in buffered solutions; surface functionalization (e.g., activation with epoxides) enables covalent attachment of proteins.

• Operational tips:

  • Wet-out in the buffer under high shear to minimize agglomerates; pre-blending with a humectant or small amount of surfactant can improve dispersion.
  • Buffer salts can screen electrostatic interactions and influence dispersion stability; assess ionic strength effects experimentally.

For formulating buffer recipes or pH control, use dedicated buffering agents (e.g., phosphate, HEPES, Tris).

Green Alternatives

MCC itself is a bio-based, renewable material with low toxicity and broad regulatory acceptance. Still, selection among cellulosic and non-cellulosic options should weigh sustainability, performance, and process compatibility.

• Why MCC is “green” (general):

  • Derived from plant biomass; nonvolatile, nonpetroleum binder/filler.
  • Enables solvent-free direct compression in formulations, reducing wet granulation solvent use.

• Alternatives and trade-offs (literature):

  • Starch/Native fibers: Renewable and inexpensive; higher moisture sensitivity and lower mechanical reinforcement vs MCC.
  • Cellulose derivatives (HPMC, CMC): Offer solubility and film formation; additional chemical processing and potential organic solvents in manufacture.
  • Mineral fillers (talc, CaCO3): Inert and low-cost; nonrenewable and do not contribute to wicking/disintegration.
  • Nanocellulose (CNC/CNF): Superior reinforcement at lower loadings; higher energy processing and different rheology/health considerations for nanoscale particulates.

• Comparison snapshot (literature, qualitative):

  • MCC vs HPMC: Insoluble, better for direct compression and rapid disintegration vs HPMC’s film-forming, sustained-release roles.
  • MCC vs PLA microspheres: MCC is non-thermoplastic and processable at ambient, avoiding melt processing energy.

• Process greener choices:

  • Favor aqueous dispersion and high-shear wetting over organic solvent use.
  • When derivatization is needed, consider ionic liquid or NaOH/urea systems with solvent recovery plans; assess lifecycle and safety.

Pharmaceutical Uses

No therapeutic claims are made. The following describes excipient roles consistent with the compendial grades indicated for this item.

• Compendial status (from Product Data): ChP, JP, Ph.Eur., E 460(i), FCC, NF.

• Typical excipient functions (literature):

  • Binder and diluent for direct compression tablets; enhances compactability and hardness at low lubricant sensitivity.
  • Disintegrant via capillary wicking, promoting rapid tablet breakup.
  • Suspension stabilizer and viscosity modifier in oral liquids and topical vehicles (with appropriate particle size/colloidal processing).

• Process considerations (literature):

  • Moisture content critically affects flow, compaction, and lubrication; equilibrate to controlled RH and monitor Loss on Drying per monograph.
  • Particle size distribution drives blend uniformity and content uniformity; select grade tailored to direct compression vs. wet granulation.
  • Compatibility is generally good; monitor for interactions with strong oxidizers or reducing sugars under stress conditions.

• Regulatory/formulation context:

  • Multipharmacopeial conformity supports use in method development, DoE studies, and scale-up simulations in regulated environments. For research use only for this SKU; confirm compliance and CoA specifications for any intended application.

Physical Properties

Item-specific specs were not provided. The following are typical literature characteristics of microcrystalline cellulose; they are NOT product specifications.

• Appearance: Typically a white, odorless, free-flowing powder (literature).
• Density:
  • True density ~1.50–1.60 g/cm³ (literature range, varies with crystallinity).
  • Bulk density widely grade-dependent (literature; consult CoA for this item).
• Solubility (literature):
  • Insoluble in water and most organic solvents.
  • Dispersible in water as a suspension; swells slightly. Forms stable aqueous suspensions under shear when colloidally processed.
  • Soluble in specific cellulose solvents (e.g., DMAc/LiCl, NMMO, certain ionic liquids), enabling homogeneous derivatization.
• Hygroscopicity (literature):
  • Moisture sorption typical of polysaccharides; equilibrates with ambient relative humidity. Water content affects flow, compressibility, and rheology.
• Particle characteristics (literature):
  • Particle size and degree of polymerization are grade-specific and control flowability and compressibility; not specified for this item.
• Thermal behavior (literature):
  • Decomposition onset typically ~260–300 °C under inert atmosphere; no true melting point.
• pKa/logP (not applicable):
  • Polyhydroxy polymer; pKa/logP not defined as for small molecules.

For exact values relevant to this SKU, including moisture content or particle size distribution, Not specified for this item; refer to CoA/Spec Sheet.

Quality & Grades

Item-specific grade designations (from Product Data): ChP, JP, Ph.Eur., E 460(i), FCC, NF.

• What these grades indicate (general context):

  • Ph.Eur., JP, ChP, and NF monographs define identity, purity, and functional tests (e.g., identification, degree of polymerization ranges, moisture, residue on ignition/ash, heavy metals limits, microbial quality, pH of dispersion, etc.).
  • FCC certifies suitability for food use with compendial quality attributes.
  • E 460(i) corresponds to the EU food additive code for microcrystalline cellulose, distinguishing it from powdered cellulose (E 460(ii)).

• Implications for this item:

  • Multipharmacopeial listing supports use across pharmaceutical, nutraceutical, and food research where compendial compliance is required for method development, excipient screening, and process simulation. It does not confer clinical use; Research Use Only applies.

• Stabilizers/processing aids:

  • Not specified for this item; refer to CoA/Spec Sheet. MCC is typically additive-free, but some grades may be co-processed; verify if critical to your application.

• Functional performance considerations (general):

  • Compendial tests often include bulk/tapped density, flow characteristics, particle size, and compressibility indices that impact blending, direct compression, and suspension rheology.
  • Select grade based on intended unit operation (direct compression vs. wet granulation vs. suspension). For this SKU, specific performance attributes are Not specified for this item; refer to CoA/Spec Sheet.

Reaction & Applications

MCC serves primarily as an inert, renewable, microstructured scaffold and excipient, with growing roles in materials science and green chemistry.

• Materials/formulation applications (literature):

  • Direct compression aid and binder in solid compacts; enhances tablet hardness and disintegration kinetics via capillary wicking.
  • Rheology modifier and stabilizer for aqueous suspensions, coatings, and 3D-printing pastes; imparts thixotropy when properly dispersed.
  • Reinforcing fiber in polymer composites (PLA, PHA, epoxies), improving modulus and reducing density.

• Catalysis/support (literature):

  • Solid support for immobilized catalysts or reagents (e.g., sulfonated cellulose as a solid acid; metal nanoparticles anchored on cellulose fibrils) enabling heterogeneous processing and simplified separations.

• Chromatography/filtration (literature):

  • Component of stationary phases or as a filtration aid where inert, fibrous microstructure is advantageous.

• Green chemistry utility (literature):

  • Renewable carbon feedstock; MCC can be converted to platform chemicals (e.g., levulinic acid, HMF via derivatization routes) or functionalized to cellulose esters/ethers under heterogeneous or homogeneous conditions.

• Practical tips:

  • For heterogeneous reactions on MCC, ensure thorough impregnation (incipient wetness or solvent exchange) and controlled drying to maintain dispersion of active species.
  • Moisture content significantly affects flow and compaction; equilibrate material to controlled RH for reproducible processing in formulation studies.

No manufacturer-specific application text was provided; the above expands on typical MCC uses relevant to materials science and formulation research.

Reaction Conditions

The following are general literature conditions for modifying or using MCC as a substrate/support; they are not specifications for this product.

• Esterification/Etherification (literature):

  • Heterogeneous acetylation: Acetic anhydride with catalytic sulfuric acid or DMAP in acetic acid or mixed solvent; 25–60 °C; control degree of substitution by stoichiometry/time.
  • Homogeneous derivatization: Dissolve MCC in DMAc/LiCl (e.g., 8–10% LiCl after activation and solvent exchange) or ionic liquids (e.g., [BMIM]Cl). Carry out etherification with alkyl halides/epoxides or esterification with acid chlorides at 25–80 °C.

• Oxidation (literature):

  • TEMPO/NaBr/NaOCl system in water at pH ~10–11, 0–25 °C, selectively oxidizes C6 primary alcohol to carboxylate; subsequent crosslinking yields hydrogels.

• Catalyst/support preparation (literature):

  • Impregnation of metal salts from aqueous or alcoholic solutions, followed by reduction (e.g., NaBH4) to deposit nanoparticles on cellulose; dry at ≤60 °C to preserve morphology.

• Composite fabrication (literature):

  • Polymer melt compounding at 160–200 °C with PLA/PHAs; pre-dry MCC to minimize voids. Surface compatibilizers (e.g., silanes, maleated polymers) improve dispersion.

• Analytical controls:

  • Monitor degree of substitution via 13C NMR, titration, or elemental analysis; crystallinity by XRD; thermal properties via TGA/DSC; surface area by BET.

Note: Conditions depend heavily on solvent system, activation, and target substitution; optimize empirically.

Safety & Handling

Item-specific GHS details were not provided; defer to the SDS for authoritative information.

• GHS/Classification (general guidance):

  • Many MCC grades are not classified as hazardous under GHS. Nonetheless, always review the SDS for this SKU.
  • Combustible dust hazard is possible when finely divided; avoid dust accumulation and ignition sources.

• Potential hazards (general):

  • Inhalation of dust may cause mechanical irritation to respiratory tract and eyes.
  • Dust explosion risk in confined spaces; implement appropriate housekeeping and grounding/bonding during handling.

• PPE recommendations (good laboratory practice):

  • Safety glasses, lab coat, and suitable gloves.
  • Use dust mask/respirator if airborne dust may be generated (per risk assessment/SDS).

• Handling tips:

  • Minimize dust generation; use local exhaust ventilation and closed transfer where feasible.
  • Ground/earth equipment during pneumatic transfer; use antistatic measures.

• Incompatibilities (general):

  • Strong oxidizers (risk of exothermic reaction/ignition). Avoid open flames and hot surfaces.

• First aid (overview; see SDS):

  • Inhalation: Move to fresh air; seek medical attention if symptoms persist.
  • Eye contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do.
  • Skin contact: Wash with soap and water.
  • Ingestion: Rinse mouth; seek medical advice if large quantities are involved.

• Storage per Product Data: Room temperature; keep container tightly closed in a dry place. Shipped at ambient conditions (Normal).

Solvent Selection

As a solid, insoluble biopolymer, MCC is not used as a solvent. However, understanding its interaction with liquids is crucial for dispersion, processing, and derivatization.

• Polarity/miscibility (literature):

  • Insoluble in water and most organic solvents due to strong hydrogen bonding and crystallinity.
  • Dispersible in water; forms stable suspensions under shear (especially after colloidal milling).

• Media for dispersion (literature):

  • Water: Primary medium for aqueous slurries, coatings, and rheology modification; add slowly under high shear to prevent agglomeration.
  • Hydroalcoholic systems: Reduced swelling; watch for phase separation.
  • Nonpolar media: Requires surfactants or surface-modified cellulose for stable dispersions.

• True dissolution (literature):

  • Specialized cellulose solvents enable homogeneous processing: DMAc/LiCl, N-methylmorpholine-N-oxide (NMMO), certain imidazolium-based ionic liquids, or aqueous NaOH/urea at low temperature. Each has distinct safety and processing constraints.

• When to choose MCC vs alternatives:

  • Choose MCC for inert, insoluble filler/fiber with high compressibility and wicking. Opt for soluble cellulose derivatives (e.g., HPMC, CMC) when film formation, solubility, or solution rheology is required.

• Comparative note (literature):

  • Compared to starch, MCC offers higher wet strength and lower solubility, favoring structural reinforcement; compared to talc or CaCO3, MCC improves wicking and disintegration but contributes less density.

Storage & Reconstitution

• Storage (from Product Data):

  • Room temperature. Shipped under normal ambient conditions.

• General storage guidance (literature/best practice):

  • Keep tightly closed in a clean, dry container. Protect from moisture uptake; MCC equilibrates with ambient humidity, which can alter flow and compressibility.
  • Avoid heat sources and open flames; manage combustible dust risk. Store away from strong oxidizers.

• Shelf life/quality checks:

  • Periodically verify moisture content (e.g., LOD), appearance, odor, and microbial limits per your quality system, especially after container opening.

• Reconstitution/dispersion (for use):

  • For aqueous slurries, add MCC slowly into vigorously agitated water to prevent lumping. High-shear mixing improves wetting and dispersion.
  • For solvent exchange or impregnation, pre-wet with a miscible intermediate (e.g., water/ethanol) as compatible with your process and safety constraints.

• Freeze–thaw:

  • Not applicable to dry powder. Aqueous dispersions may exhibit viscosity changes on freeze–thaw; test stability if relevant.

Always consult the SDS and CoA/Spec Sheet for this SKU for any item-specific limits or handling instructions not listed here. For research use only.

Structure & Identity

Microcrystalline cellulose (MCC) is a purified, partially depolymerized cellulose composed of linear β(1→4)-linked D-glucopyranose units.

• Item-specific identifiers (from Product Data):

  • CAS: 9004-34-6
  • CID: 16211032
  • InChIKey: 111548
  • SMILES: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.

• Structural features (general/literature):

  • Polymer of anhydroglucose units with repeating unit C6H10O5 (literature, repeating unit).
  • Linear polysaccharide with extensive inter- and intramolecular hydrogen bonding producing crystalline microdomains interspersed with amorphous regions.
  • “Microcrystalline” denotes controlled acid hydrolysis and mechanical processing to expose crystallites, yielding short chains and high crystallinity.

• 2D structure description (general):

  • Each monomer is a six-membered D-glucopyranose ring; β(1→4) glycosidic linkages align rings in a ribbon-like chain. Hydroxyl groups at C2, C3, and C6 project to form hydrogen-bonded networks across parallel chains, generating fibrils and microfibrils.

• Distinguishing attributes (general):

  • High surface area, low degree of polymerization relative to native cellulose, and a broad crystallinity index typical of MCC grades. These confer compressibility, wicking, and rheology-modifying behavior useful in materials and formulation science.

Synthetic Utility

While MCC is not a small-molecule reagent, it is a versatile substrate and scaffold for synthesis and materials fabrication.

• Functional handles (literature):

  • Primary and secondary alcohols at C6, C2, and C3 enable etherification and esterification (e.g., cellulose acetate, nitrate, carboxymethyl cellulose, hydroxypropyl cellulose).
  • Partial oxidation (e.g., TEMPO-mediated to C6 carboxylate) affords oxidized celluloses for ion-exchange materials and hydrogels.

• Heterogeneous derivatization (literature):

  • Conventional routes use acid chlorides/anhydrides (pyridine or DMAP catalysis) under swelling conditions or in mixed solvent systems.
  • Homogeneous modification possible after dissolution in DMAc/LiCl, NMMO, or ionic liquids, enabling controlled degree of substitution and uniformity.

• Support/templating (literature):

  • MCC as a support for reagents/catalysts (e.g., sulfonation to produce Brønsted acid catalysts) and for templating inorganic nanomaterials (silica, metal oxides) via sol–gel methods.

• Retrosynthetic value:

  • Provides a renewable, chiral, polyfunctional backbone; selective protection/activation strategies can localize modification to C6 or secondary hydroxyls.

• Processing:

  • Mechanical fibrillation or acid hydrolysis can further tailor crystallinity and surface area, influencing reactivity and uptake of reagents.

Target Specificity

Not applicable. This product is a polysaccharide material, not a biological targeting reagent. No antigen/epitope, clone, or isotype information applies.

Frequently Asked Questions

What does ChP mean?

ChP indicates that the material complies with the published monographs of the relevant pharmacopoeia (ChP). Specifications include identity, assay, impurity limits, residual solvents and other tests defined in the monograph. ChP-compliant material is suitable for pharmacopoeia-compliant pharmaceutical use, including pharmaceutical manufacturing, QC and regulatory submission.

How should this product be stored?

Store at room temperature.

What does JP mean?

JP indicates that the material complies with the published monographs of the relevant pharmacopoeia (JP). Specifications include identity, assay, impurity limits, residual solvents and other tests defined in the monograph. JP-compliant material is suitable for pharmacopoeia-compliant pharmaceutical use, including pharmaceutical manufacturing, QC and regulatory submission.

How is this product shipped?

This product ships under standard ambient conditions. No temperature-controlled packaging is required.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 9004-34-6, the molecular formula is (C6H10O5)n. InChIKey GUBGYTABKSRVRQ-WFVLMXAXSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.