Minoxidil(U10858) - Moligand™, ≥98%(HPLC)(T) , Activator of K ir6.1;Activator of K ir6.2, CAS No.38304-91-5, Activator of K ir6.1;Activator of K ir6.2

CAS: 38304-91-5 Cat. No.: M158689 Molecular Weight: 209.25 Beilstein Registry Number: 25(5)12,317 EC Number: 253-874-2

GRADE & PURITY Moligand™, ≥98%(HPLC)(T)

Synonyms

pyrimidin-1(2H)-ol | Women''''s rogaine | 3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine | SCHEMBL29698 | Spectrum3_000509 | 2,4-Diamino-6-piperidinopyrimidine 3-oxide | 3-hydroxy-2-imino-6-(1-piperidyl)pyrimidin-4-amine | Minoxidil (U-10858) | U-10,

Storage

Room temperature,Argon charged

Shipped In

Normal

Overview

Minoxidil is used as antihypertensive, antialopecia agent. . It is administered orally for the treatment of severe hypertension and used topically to promote the regrowth of hair in male and female pattern baldness.

Specifications

Synonyms

pyrimidin-1(2H)-ol | Women''''s rogaine | 3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine | SCHEMBL29698 | Spectrum3_000509 | 2, 4-Diamino-6-piperidinopyrimidine 3-oxide | 3-hydroxy-2-imino-6-(1-piperidyl)pyrimidin-4-amine | Minoxidil (U-10858) | U-10,

Specifications & Purity

Moligand™, ≥98%(HPLC)(T)

Biochemical and Physiological Mechanisms

Antihypertensive. Antialopecia agent. Kir6 channel (KATP) activator.

Storage

Room temperature, Argon charged

Shipped In

Normal

Grade

Moligand™

Action Type

ACTIVATOR

Mechanism of action

Activator of K ir6.1;Activator of K ir6.2

Purity

≥98%(HPLC)(T)

Names and Identifiers

• Pubchem Sid: 488179821
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488179821
• Canonical Smiles: C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O
• IUPAC Name: 3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine
• InChIKey: ZIMGGGWCDYVHOY-UHFFFAOYSA-N
• INCHI: 1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
• Isomeric SMILES: C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O
• WGK Germany: 3
• RTECS: UV8200000
• Molecular Weight: 209.25
• Beilstein: 25(5)12,317
• Reaxy-Rn: 656915
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=656915&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Class Organonitrogen compounds
      • Subclass Amines
        • Level5 Tertiary amines
          • Level6 Tertiary alkylarylamines
            • Level7 Dialkylarylamines

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Class: Organonitrogen compounds
• Subclass: Amines
• Intermediate Tree Nodes: Tertiary amines - Tertiary alkylarylamines
• Direct Parent: Dialkylarylamines
• Alternative Parents: Aminopyrimidines and derivatives Piperidines Imidolactams Hydropyrimidines Heteroaromatic compounds Azacyclic compounds Primary amines Organopnictogen compounds Organic oxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Dialkylarylamine - Aminopyrimidine - Imidolactam - Pyrimidine - Piperidine - Hydropyrimidine - Heteroaromatic compound - Azacycle - Organoheterocyclic compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Primary amine - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as dialkylarylamines. These are aliphatic aromatic amines in which the amino group is linked to two aliphatic chains and one aromatic group.
• External Descriptors: a small molecule

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

KCNJ8 Tbio ATP-sensitive inward rectifier potassium channel 8 (0 Activities)

Discover Target: KCNJ8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNJ11 Tclin ATP-sensitive inward rectifier potassium channel 11 (0 Activities)

Discover Target: KCNJ11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solvent:ethanol, Max Conc. mg/mL: 5.23, Max Conc. mM: 25; Solvent:DMSO, Max Conc. mg/mL: 5.23, Max Conc. mM: 25 with gentle warming
• Sensitivity: Air sensitive
• Melt Point(°C): 272-274 °C
• Molecular Weight: 209.250 g/mol
• XLogP3: 1.200
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 209.128 Da
• Monoisotopic Mass: 209.128 Da
• Topological Polar Surface Area: 88.900 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 329.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Yu Cai, Liying Xin, Hui Li, Peng Sun, Chao Liu, Liang Fang.  (2023)  Mussel-inspired controllable drug release hydrogel for transdermal drug delivery: Hydrogen bond and ion-dipole interactions.  JOURNAL OF CONTROLLED RELEASE,      [PMID:37972766] [10.1016/j.jconrel.2023.11.016]

2. Peixin Li, Yanfang Sun, Lei Nie, Amin Shavandi, Khaydar E. Yunusov, Yinjian Hua, Guohua Jiang.  (2023)  Fabrication of carboxymethyl cellulose/hyaluronic acid/polyvinylpyrrolidone composite pastes incorporation of minoxidil-loaded ferulic acid-derived lignin nanoparticles and valproic acid for treatment of androgenetic alopecia.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:37517761] [10.1016/j.ijbiomac.2023.126013]

3. Meirong Yin, Yongnian Zeng, Han-Qing Liu, Wen Zhang, Chenyuan Wang, Chuang Chen, Wei Li.  (2023)  Dissolving Microneedle Patch Integrated with Microspheres for Long-Acting Hair Regrowth Therapy.  ACS Applied Materials & Interfaces,      [PMID:36975753] [10.1021/acsami.2c22814]

4. Qi Tian, Peng Quan, Liang Fang, Hui Xu, Chao Liu.  (2021)  A molecular mechanism investigation of the transdermal/topical absorption classification system on the basis of drug skin permeation and skin retention.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:34506925] [10.1016/j.ijpharm.2021.121082]

5. Huanzhu Qian, Zhen Ye, Yu Hu, Liulin Chen, Linzhen Li, Kaihua Qin, Qiaobo Ye, Xiaohong Zuo.  (2025)  Dahuang-Gancao Decoction Ameliorates Testosterone-Induced Androgenetic Alopecia in Mice.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:39800247] [10.1016/j.jep.2025.119347]

6. Mbituyimana Bricard, Fu Lina, Wang Hao, Qi Fuyu, Jiang Yuchi, Meng Fanbo, Wu Min, Shi Zhijun, Yang Guang.  (2025)  Glutamic acid-loaded separable microneedle composite for long-acting hair regeneration treatment.  Advanced Composites and Hybrid Materials,  8  (2): (1-17).  [PMID:] [10.1007/s42114-025-01287-0]

7. Yan-Wen Ding, Yang Li, Zhi-Wei Zhang, Jin-Wei Dao, Dai-Xu Wei.  (2024)  Hydrogel forming microneedles loaded with VEGF and Ritlecitinib/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment.  Bioactive Materials,      [PMID:38699241] [10.1016/j.bioactmat.2024.04.020]

8. Shuting Zhang, Hong Zhou, Xuan Chen, Shasha Zhu, Dan Chen, Dan Luo, Siyuan Chen, Wei Liu.  (2024)  Microneedle Delivery Platform Integrated with Codelivery Nanoliposomes for Effective and Safe Androgenetic Alopecia Treatment.  ACS Applied Materials & Interfaces,      [PMID:38507687] [10.1021/acsami.3c16608]

9. Jiajia Wang, Yucen Cai, Lin Lei, Feng Zeng, Qi Liu, Yunqiang Xiang, Xinyuan Fu, Zhangyou Yang, Jing Luo.  (2025)  A mesoporous polydopamine-mediated programmed drug release hydrogel for burn wound treatment.  Materials Today Communications,      [PMID:] [10.1016/j.mtcomm.2025.113552]

10. Xueyang Wang, Xiaojie Ju, Chunyan He.  (2025)  Nitric Oxide Donor and Minoxidil Co-Loaded Microneedles Improving Hair Loss Treatment.  MACROMOLECULAR BIOSCIENCE,      [PMID:40765394] [10.1002/mabi.202500225]

11. Zheng Xing, Xiaoxiao Zhang, Chen Zhao, Li Zhang, Song Qian, Yun Chu, Wenhao Yang, Yuhui Wang, Jiang Xia, Jianhao Wang.  (2025)  Microenvironment-Responsive Recombinant Collagen XVII-Based Composite Microneedles for the Treatment of Androgenetic Alopecia.  Acta Biomaterialia,      [PMID:40389048] [10.1016/j.actbio.2025.05.039]

12. Zheng Xing, Wenhao Yang, Chen Zhao, Yuhui Wang, Xiaolian Jiang, Song Qian, Yun Chu, Jiang Xia, Cheng Wang, Jianhao Wang.  (2025)  Borate-modified recombinant type XVII collagen microneedles loaded with IGF-1 for the treatment of androgenetic alopecia.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40398062] [10.1016/j.ijbiomac.2025.144460]

13. Zhiqing Liu, Wenhua Huang, Shanhua Xu, Meilan Nan, Xian Cui, Yue Wang, Zhehu Jin, Wan Meng, Jingbi Meng, Longquan Pi.  (2025)  Using a Natural Clay Mineral as an Active Drug Carrier to Promote Hair Growth.  Pharmaceuticals,  19  (1): (11).  [PMID:41599612] [10.3390/ph19010011]

14. Lingyun Zhao, Anqi Li, Shijing Chen, Wei Hua, Ru Dai, Lingyu Pan, Meng Hu, Nan Huang, Runke Zhou, Yuanyuan Han, Lidan Xiong, Li Li.  (2026)  Extracellular vesicles of human transformed skin-derived precursors containing miR-221-3p promote hair growth through DKK2-mediated Wnt/β-catenin signaling.  Bioengineering & Translational Medicine,      [PMID:] [10.1002/btm2.70130]

15. Ma Tianyu, Li Qiang, Chen Xingwu, Dong Jixiang, Jiang Yuqing, Li Shanshan.  (2026)  Hydrogel microneedle delivery of a palmitoylated peptide promotes hair regeneration via dual activation of Wnt/β-catenin and cAMP–PKA signaling.  JOURNAL OF NANOBIOTECHNOLOGY,      [PMID:] [10.1186/s12951-026-04542-8]