Mycophenolic acid - Moligand™, 10mM in DMSO , Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor, CAS No.24280-93-1, Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor

CAS: 24280-93-1 Cat. No.: M408934 Molecular Weight: 320.34 Beilstein Registry Number: 1295848 EC Number: 246-119-3

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Mycophenolate, RS-61443 | (4E)​-6-​(1,​3-​dihydro-​4-​hydroxy-​6-​methoxy-​7-​methyl-​3-​oxo-​5-​isobenzofuranyl)​-​4-​methyl-4-​hexenoic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Mycophenolic acid Mycophenolic acid (Mycophenolate, RS-61443) is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.
In vitro

Mycophenolic acid inhibits inosine-5\'-monophosphate dehydrogenase (IMPDH) by acting as a replacement for the nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule. Mycophenolic acid (MPA), an inhibitor of inosine monophosphate dehydrogenase, in nanomolar concentrations blocks proliferative responses of cultured human, mouse and rat T lymphocytes and B lymphocytes to mitogens or in mixed lymphocyte reactions. Mycophenolic acid (MPA) suppresses mixed lymphocyte reactions when added 3 days after their initiation. Mycophenolic acid also inhibits antibody formation by polyclonally activated human B lymphocytes. Mycophenolic acid is an immunosuppressive agent reversibly inhibiting proliferation of T and B lymphocytes and antibody formation, with a profile of activity different from that of other immunosuppressive drugs. Mycophenolic acid inhibits the formation of antibodies to sheep erythrocytes. Mycophenolic acid also suppresses, in a dose-related manner, the generation of cytotoxic T-lymphocytes against allogeneic cells in mice and prevents the elimination of allogeneic cells. Mycophenolic acid induces apoptosis and cell death in a large proportion of activated CD4+ T cells.

In vivo

Mycophenolic acid has lymphocyte-selective anti-proliferative effects in mice and can inhibit both cell-mediated and humoral immune responses without major side effects.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Mycophenolate, RS-61443 | (4E)​-6-​(1, ​3-​dihydro-​4-​hydroxy-​6-​methoxy-​7-​methyl-​3-​oxo-​5-​isobenzofuranyl)​-​4-​methyl-4-​hexenoic acid

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Mycophenolic acid (Mycophenolate, RS-61443) is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor

Product Properties

• ALogP: 3.2

Names and Identifiers

• Isomeric SMILES: CC1=C2COC(=O)C2=C(C(=C1OC)C/C=C(\C)/CCC(=O)O)O
• WGK Germany: 3
• RTECS: MP8050000
• Molecular Weight: 320.34
• Beilstein: 1295848
• Reaxy-Rn: 8644904
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8644904&ln=

Associated Targets(Human)

IMPDH2 Tclin Inosine-5'-monophosphate dehydrogenase 2 (24 Activities)

Discover Target: IMPDH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IMPDH1 Tclin Inosine-5'-monophosphate dehydrogenase 1 (13 Activities)

Discover Target: IMPDH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Melt Point(°C): 141-145℃

References

1. Xiangli He, Jiayan Cui, Hui Ma, Naijipu Abuduaini, Ying Huang, Lu Tang, Wanyan Wang, Yuanyuan Zhang, Yang Wang, Weiqiang Lu, Bo Feng, Jin Huang.  (2023)  Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer.  BIOCHEMICAL PHARMACOLOGY,      [PMID:37871880] [10.1016/j.bcp.2023.115868]

2. Lili Wu, Yulian Chen, Han Liu, Zhikun Zhan, Zhi Liang, Tao Zhang, Zheng Cai, Ling Ye, Menghua Liu, Jie Zhao, Shuwen Liu, Lan Tang.  (2018)  Emodin-induced hepatotoxicity was exacerbated by probenecid through inhibiting UGTs and MRP2.  TOXICOLOGY AND APPLIED PHARMACOLOGY,      [PMID:30248416] [10.1016/j.taap.2018.09.029]

3. Minhai Liu, Yan Zhang, Rui Cheng, Ting Tan, Lan Guo, Fan Liu, Yiqun Wan.  (2025)  Determination of five alternaria toxins in peppermint by dispersive solid-phase extraction coupled with ultra-high performance liquid chromatography-tandem mass spectrometry based on MOF-808-TFA.  FOOD CHEMISTRY,      [PMID:39799690] [10.1016/j.foodchem.2025.142822]

4. Xin Wang, Feiyang Pu, Xuanye Yang, Xili Feng, Jiayou Zhang, Kai Duan, Xuanxuan Nian, Zhongren Ma, Xiao-Xia Ma, Xiao-Ming Yang.  (2024)  Immunosuppressants exert antiviral effects against influenza A(H1N1)pdm09 virus via inhibition on nucleic acid synthesis, mRNA splicing and protein stability.  Virulence,      [PMID:38170681] [10.1080/21505594.2023.2301242]