GRADE & PURITY 10mM in Ethanol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

MZP-54 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4 , with a K d of 4 nM for Brd4 BD2 .

In Vitro

MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology, with a K d of 4 nM for Brd4 BD2 . MZP-54 binds to VHL-EloC-EloB protein (VCB) with a K d of 105 ± 24 nM. MZP-54 shows an inhibitory activity against MV4;11 and HL60 cells, with pEC 50 s of 7.08 ± 0.05 and 6.37 ± 0.03, respectively. MZP-54 also exhibits high depletion of cMyc levels. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:VHL BRD4 BD2 4 nM (Kd)

Specifications

Specifications & Purity

10mM in Ethanol

Biochemical and Physiological Mechanisms

MZP-54 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4 , with a K d of 4 nM for Brd4 BD2 .

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: C[C@H]1C[C@H](C2=C(N1C(=O)C)C=CC(=C2)C3=CC=C(C=C3)C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@@H](C[C@H]4C(=O)NCC5=CC=C(C=C5)C6=C(N=CS6)C)O)C(C)(C)C)NC7=CC=C(C=C7)Cl
• Alternate CAS: 2010159-47-2
• PubChem CID: 122551841
• Molecular Weight: 1036.67

Associated Targets(Human)

BRD4 Tchem Bromodomain-containing protein 4 (1 Activities)

Discover Target: BRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)