N-aminopropylmorpholine - ≥98% , CAS No.123-00-2

CAS: 123-00-2 Cat. No.: A105340 Molecular Weight: 144.21 Beilstein Registry Number: 105104 EC Number: 204-590-2

GRADE & PURITY ≥98%

Synonyms

3-Morpholinopropanamine | 4-(.gamma.-Aminopropyl)morpholine | FD10554 | Tox21_302076 | InChI=1/C7H16N2O/c8-2-1-3-9-4-6-10-7-5-9/h1-8H | NAPM | 3-(morpholin-4-yl)propylamine | 3-(morpholin-4-yl)-propylamine | BRN 0105104 | STK802951 | NSC1081 | NSC-1081 |

Storage

Room temperature

Shipped In

Normal

Specifications

Synonyms

3-Morpholinopropanamine | 4-(.gamma.-Aminopropyl)morpholine | FD10554 | Tox21_302076 | InChI=1/C7H16N2O/c8-2-1-3-9-4-6-10-7-5-9/h1-8H | NAPM | 3-(morpholin-4-yl)propylamine | 3-(morpholin-4-yl)-propylamine | BRN 0105104 | STK802951 | NSC1081 | NSC-1081 |

Specifications & Purity

≥98%

Storage

Room temperature

Shipped In

Normal

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 528766163
• Canonical Smiles: C1COCCN1CCCN
• IUPAC Name: 3-morpholin-4-ylpropan-1-amine
• InChIKey: UIKUBYKUYUSRSM-UHFFFAOYSA-N
• INCHI: 1S/C7H16N2O/c8-2-1-3-9-4-6-10-7-5-9/h1-8H2
• Isomeric SMILES: C1COCCN1CCCN
• WGK Germany: 2
• RTECS: QD7700000
• UN Number: 2735
• Packing Group: I
• Molecular Weight: 144.21
• Beilstein: 105104
• Reaxy-Rn: 105104
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=105104&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Oxazinanes
      • Subclass Morpholines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Oxazinanes
• Subclass: Morpholines
• Intermediate Tree Nodes: Not available
• Direct Parent: Morpholines
• Alternative Parents: Trialkylamines Oxacyclic compounds Dialkyl ethers Azacyclic compounds Organopnictogen compounds Monoalkylamines Hydrocarbon derivatives
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Morpholine - Tertiary amine - Tertiary aliphatic amine - Dialkyl ether - Ether - Oxacycle - Azacycle - Amine - Hydrocarbon derivative - Primary amine - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Primary aliphatic amine - Organic oxygen compound - Organic nitrogen compound - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as morpholines. These are organic compounds containing a morpholine moiety, which consists of a six-member aliphatic saturated ring with the formula C4H9NO, where the oxygen and nitrogen atoms lie at positions 1 and 4, respectively.
• External Descriptors: primary amino compound - morpholines

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

PTH1R Tclin Parathyroid hormone receptor (47172 Activities)

Discover Target: PTH1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMN1 Tchem Survival motor neuron protein (34246 Activities)

Discover Target: SMN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KEAP1 Tclin Kelch-like ECH-associated protein 1 (1736 Activities)

Discover Target: KEAP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CGA Tbio Glycoprotein hormones alpha chain (29278 Activities)

Discover Target: CGA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Leishmania donovani (89745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Refractive Index: 1.4761-1.4781
• Flash Point(°F): 98 °C
• Flash Point(°C): 98°C
• Boil Point(°C): 224°C
• Melt Point(°C): -15°C
• Molecular Weight: 144.210 g/mol
• XLogP3: -0.700
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 144.126 Da
• Monoisotopic Mass: 144.126 Da
• Topological Polar Surface Area: 38.500 Ų
• Heavy Atom Count: 10
• Formal Charge: 0
• Complexity: 81.700
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

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2. Qimin Jiang, Shuyi Guan, Yunti Zhang, Yuhua Sun, Xulin Jiang.  (2022)  Targeted and fluorescence traceable multifunctional host-guest supramolecular gene delivery platform based on poly(cyclodextrin) and rhodamine conjugated disulfide-containing azobenzene-terminated branched polymer.  International Journal of Polymeric Materials and Polymeric Biomaterials,      [PMID:] [10.1080/00914037.2022.2029438]

3. Baolong Wang, Huanqin Zhao, Liying Wang, Junmin Sun, Yongfeng Zhang, Zhenzhu Cao.  (2017)  Immortal ring-opening polymerization of lactides with super high monomer to catalyst ratios initiated by zirconium and titanium complexes containing multidentate amino-bis(phenolate) ligands.  NEW JOURNAL OF CHEMISTRY,  41  (13): (5669-5677).  [PMID:] [10.1039/C7NJ00483D]

4. Zhibing Sun, Dezhong Zhou.  (2016)  PLL/PAE/DNA ternary complexes with enhanced endosomal escape ability for efficient and safe gene transfection.  NEW JOURNAL OF CHEMISTRY,  40  (11): (9806-9812).  [PMID:] [10.1039/C6NJ02639G]

5. Xinlong Liu, Yimeng Li, Xinhua Liu, Yangyang Huang, Fujun Wang, Jiafeng Li, Yuqi Guo, Xinyuan Zhu, Lijuan Zhu, Chuan Zhang.  (2025)  GalNAc End-Capped Poly(β-amino ester)s with Screened Side Chains for Efficient Gene Delivery.  Small Methods,      [PMID:40025903] [10.1002/smtd.202401286]

6. Muhammad Owais Malik, Li Wang, Haojie Yu, Muhammad Haroon, Lei Zhang, Dileep Ahmad, Khan Manqoosh Awan, Abdul Basit, Saqlain Raza.  (2026)  Synthesis, properties and application of ferrocene-based compounds as burning rate catalysts in composite solid propellant.  JOURNAL OF ORGANOMETALLIC CHEMISTRY,      [PMID:] [10.1016/j.jorganchem.2026.124132]