Phenylbutazone - Moligand™, 10mM in DMSO , Inhibitor of COX-1;Inhibitor of COX-2, CAS No.50-33-9, Inhibitor of COX-1;Inhibitor of COX-2

CAS: 50-33-9 Cat. No.: P408411 Molecular Weight: 308.37 Beilstein Registry Number: 24(5)5,400 EC Number: 200-029-0
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GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
Synonyms
Butazolidine | 4-​butyl-​1,​2-​diphenyl-3,​5-​pyrazolidinedione
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
1ml
P408411-1ml
1

$119.90

$173.90
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Why this grade

Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 13 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

Phenylbutazone Phenylbutazone (Butazolidine) is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
In vitro


In vivo


Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥100%

Specifications

Synonyms
Butazolidine | 4-​butyl-​1, ​2-​diphenyl-3, ​5-​pyrazolidinedione
Specifications & Purity
Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms
Phenylbutazone (Butazolidine) is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of COX-1;Inhibitor of COX-2
Names and Identifiers
Isomeric SMILES CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3
WGK Germany 3
RTECS UQ8225000
UN Number 2811
Packing Group I
Molecular Weight 308.37
Beilstein 24(5)5,400
Reaxy-Rn 290080
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=290080&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Associated Targets(Human)
NAPRT Tchem Nicotinate phosphoribosyltransferase (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGS1 Tclin Prostaglandin G/H synthase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGS2 Tclin Prostaglandin G/H synthase 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
Melt Point(°C)106 °C
Documents & Articles
Citations of This Product
References
1. Wen Li, Yuzhu Fan, Chaoqun Yan, Yan Du, Tingting Liang, Chunqiang Wang, Liwei Wang, Lingling Han, Qingshan Li, Taigang Liang.  (2022)  Triptolide and methotrexate binding competitively to bovine serum albumin: A study of spectroscopic experiments, molecular docking, and molecular dynamic simulation.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2022.120300]
2. Fangwei Yang, Cheng Wang, Hang Yu, Yahui Guo, Yuliang Cheng, Weirong Yao, Yunfei Xie.  (2022)  Establishment of the thin-layer chromatography-surface-enhanced Raman spectroscopy and chemometrics method for simultaneous identification of eleven illegal drugs in anti-rheumatic health food.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2022.101842]
3. Wencheng Zhong, Xiaojian Yan, Shaohua Qu, Li Shang.  (2022)  Site-specific fabrication of gold nanocluster-based fluorescence photoswitch enabled by the dual roles of albumin proteins.  Aggregate,  (1): (e245).  [PMID:] [10.1002/agt2.245]
4. Fang Huang, Fei Pan, Li Wang, Zhang Xiao, Jinzhao He, Mei Yan, Jia Wang, Weidong Qiu, Mingxue Liu, Haiqing Dong.  (2021)  The interaction between citronellol and bovine serum albumin: Spectroscopic, computational and thermal imaging studies.  JOURNAL OF MOLECULAR STRUCTURE,      [PMID:] [10.1016/j.molstruc.2021.131986]
5. Yang Shirui, Zhang Wenxiang, Liu Zheyi, Zhai Ziyang, Hou Xudong, Wang Ping, Ge Guangbo, Wang Fangjun.  (2021)  Lysine reactivity profiling reveals molecular insights into human serum albumin–small-molecule drug interactions.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  413  (30): (7431-7440).  [PMID:34676431] [10.1007/s00216-021-03700-1]
6. Yue Wang, Wenchang Zhao, Ruixia Gao, Sameer Hussain, Yi Hao, Jiahao Tian, Shihui Chen, Yunhao Feng, Yubo Zhao, Yuyao Qu.  (2021)  Preparation of lightweight daisy-like magnetic molecularly imprinted polymers via etching synergized template immobilization for enhanced rapid detection of trace 17β-estradiol.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:34592596] [10.1016/j.jhazmat.2021.127216]
7. Tingting Guo, Xiaojuan Wang, Yang Shu, Jianhua Wang.  (2021)  Effects of alkyl side-chain length on binding with bovine serum albumin, cytotoxicity, and antibacterial properties of 1-alkyl-3-methylimidazolium dicyanamide ionic liquids.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2021.116835]
8. Hui Lv, Juanjuan Wang, Mingying Wang, Li Shen, Ling Xiao, Taijie Chen, Tingzhe Sun, Wenjuan Li, Liangliang Zhu, Xiaoke Zhang.  (2021)  Potent inhibition of tributyltin (TBT) and triphenyltin (TPT) against multiple UDP-glucuronosyltransferases (UGT): A new potential mechanism underlying endocrine disrupting actions.  FOOD AND CHEMICAL TOXICOLOGY,      [PMID:33549631] [10.1016/j.fct.2021.112039]
9. Xiangyu Cao, Zhijun Yang, Yonglin He, Ying Xia, Yin He, Jianli Liu.  (2019)  Multispectroscopic exploration and molecular docking analysis on interaction of eriocitrin with bovine serum albumin.  JOURNAL OF MOLECULAR RECOGNITION,  32  (7): (e2779).  [PMID:30701606] [10.1002/jmr.2779]
10. Miao Qin, Tianxiang Yin, Weiguo Shen.  (2016)  The Interaction Between Crystal Violet and Bovine Serum Albumin: Spectroscopic and Molecular Docking Investigations.  JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY,      [PMID:] [10.1080/01932691.2015.1073597]
11. Miao Qin, Tianxiang Yin, Shuzhen Wang, Weiguo Shen.  (2015)  Spectroscopic Investigation on the Interactions between Cationic Surfactants and Bovine Serum Albumin.  JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY,      [PMID:] [10.1080/01932691.2014.973031]
12. Ming Li, Hua Sun, Jin-Ling Song, Xing Sun, Wei Li.  (2025)  Identification of human UDP-glucuronosyltransferases involved in I3,II8-biapigenin glucuronidation in Vitro.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:39923326] [10.1016/j.jpba.2025.116735]
13. Honglong Zhang, Zhenyu Shi, Jun Ma, Fuyi Cui, Jing Zhang, Timothy J. Strathmann.  (2022)  Abatement of Organic Contaminants by Mn(VII)/TEMPOs: Effects of TEMPOs Structure, Organic Contaminant Speciation, and Active Oxidizing Species.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:35748905] [10.1021/acs.est.2c02098]
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