≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature,Desiccated Ships FedEx DG Service Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 13 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Piperazine hexahydrate may be used as a standard for the determination of piperazine in pharmaceutical preparations using colorimetric technique
| Canonical Smiles | C1CNCCN1.O.O.O.O.O.O |
|---|---|
| IUPAC Name | piperazine;hexahydrate |
| InChIKey | AVRVZRUEXIEGMP-UHFFFAOYSA-N |
| INCHI | 1S/C4H10N2.6H2O/c1-2-6-4-3-5-1;;;;;;/h5-6H,1-4H2;6*1H2 |
| Isomeric SMILES | C1CNCCN1.O.O.O.O.O.O |
| WGK Germany | 1 |
| RTECS | TM0850000 |
| UN Number | 2579 |
| Molecular Weight | 194.23 |
| Beilstein | 4455527 |
| Reaxy-Rn | 4455527 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4455527&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Diazinanes |
| Subclass | Piperazines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Piperazines |
| Alternative Parents | Dialkylamines Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aliphatic heteromonocyclic compounds |
| Substituents | Piperazine - Azacycle - Secondary amine - Secondary aliphatic amine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organonitrogen compound - Amine - Aliphatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as piperazines. These are compounds containing a piperazine ring, which is a saturated aliphatic six-member heterocyclic with two nitrogen atoms at positions 1 and 4, as well as four carbon atoms. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 C2204631 | Certificate of Analysis | Dec 12, 2025 | P105279 |
| F2118343 | Certificate of Analysis | Apr 03, 2025 | P105279 |
| F2118346 | Certificate of Analysis | Apr 03, 2025 | P105279 |
| F2404370 | Certificate of Analysis | Apr 10, 2024 | P105279 |
| F2404371 | Certificate of Analysis | Apr 10, 2024 | P105279 |
| F2404416 | Certificate of Analysis | Apr 10, 2024 | P105279 |
| F2404417 | Certificate of Analysis | Apr 10, 2024 | P105279 |
| I2423643 | Certificate of Analysis | Apr 10, 2024 | P105279 |
| C2204577 | Certificate of Analysis | Dec 16, 2021 | P105279 |
| E2310036 | Certificate of Analysis | Mar 03, 2021 | P105279 |
| J2326057 | Certificate of Analysis | Mar 03, 2021 | P105279 |
| Solubility | Soluble in water; Soluble in Alcohol; Very slightly soluble in Ether |
|---|---|
| Sensitivity | Moisture and Light sensitive |
| Flash Point(°F) | 87℃ |
| Flash Point(°C) | 87℃ |
| Boil Point(°C) | 145-156°C |
| Melt Point(°C) | 41-45°C |
| Molecular Weight | 194.230 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 8 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 0 |
| Exact Mass | 194.148 Da |
| Monoisotopic Mass | 194.148 Da |
| Topological Polar Surface Area | 30.100 Ų |
| Heavy Atom Count | 12 |
| Formal Charge | 0 |
| Complexity | 26.500 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 7 |
| 1. Jie Zhang, Rui Shen, Xu Zhang, Gen Li, Xi Wang. (2023) A pharmaceutical cocrystal of apigenin with piperazine: Preparation, structural characterization, and dissolution performance. JOURNAL OF MOLECULAR STRUCTURE, [PMID:] [10.1016/j.molstruc.2023.137027] |
| 2. Zhiwen Li, Yanchao Xu, Liguo Shen, Renjie Li, Yang Jiao, Hongjun Lin, Chuyang Y. Tang. (2023) Nano-wrinkled polyamide membrane preparation via heterogeneous surface-regulated interfacial polymerization for enhanced desalination performance. DESALINATION, [PMID:] [10.1016/j.desal.2023.116801] |
| 3. Yu Li, Jiangnan Li, Deliang Zhu, Guangcun Qian, Hongyan Tang. (2023) Facile dual-functionalization of NF membranes with excellent chlorine resistance and good antifouling property by in-situ grafting of zwitterions. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2023.123660] |
| 4. Yanchao Xu, Wentian Zhang, Zhiwen Li, Liguo Shen, Renjie Li, Meijia Zhang, Yang Jiao, Hongjun Lin, Chuyang Y. Tang. (2022) Enhanced water permeability in nanofiltration membranes using 3D accordion-like MXene particles with random orientation of 2D nanochannels. Journal of Materials Chemistry A, 10 (31): (16430-16438). [PMID:] [10.1039/D2TA03091H] |
| 5. Junhui Wu, Mengjiao Xia, Zhiwen Li, Liguo Shen, Renjie Li, Meijia Zhang, Yang Jiao, Yanchao Xu, Hongjun Lin. (2021) Facile preparation of polyvinylidene fluoride substrate supported thin film composite polyamide nanofiltration: Effect of substrate pore size. JOURNAL OF MEMBRANE SCIENCE, [PMID:] [10.1016/j.memsci.2021.119699] |
| 6. Wentian Zhang, Zhiwen Li, Yanchao Xu, Hongjun Lin, Liguo Shen, Renjie Li, Meijia Zhang. (2021) In situ conversion of ZnO into zeolitic imidazolate framework-8 in polyamide layers for well-structured high-permeance thin-film nanocomposite nanofiltration membranes. Journal of Materials Chemistry A, 9 (12): (7684-7691). [PMID:] [10.1039/D0TA11923G] |
| 7. Qing Kong, Hang Xu, ChenWei Liu, Guang Yang, Mingmei Ding, Wen Yang, Tao Lin, Wei Chen, Stephen Gray, Zongli Xie. (2020) Fabrication of high performance TFN membrane containing NH2-SWCNTs via interfacial regulation. RSC Advances, 10 (42): (25186-25199). [PMID:35517444] [10.1039/D0RA02947E] |
| 8. Wang Yong, Wang Jinghua, Zhang Yuan, Song Feng, Xie Yujiao, Wang Ming, Cui Hongyou, Yi Weiming. (2019) N-Doped Carbon Materials as Heterogeneous Catalysts for High Efficiency Isomerization Glucose to Fructose in Aqueous Media. CATALYSIS LETTERS, 150 (2): (493-504). [PMID:] [10.1007/s10562-019-03020-1] |
| 9. Wenguang Wang, Ru Liu, Ming Tan, Haixiang Sun, Q. Jason Niu, Tongwen Xu, Victor Nikonenko, Yang Zhang. (2019) Evaluation of the ideal selectivity and the performance of selectrodialysis by using TFC ion exchange membranes. JOURNAL OF MEMBRANE SCIENCE, [PMID:] [10.1016/j.memsci.2019.04.007] |
| 10. Yugang Huang, Laixing Pang, Hongliang Wang, Rong Zhong, Zhaohua Zeng, Jianwen Yang. (2013) Synthesis and properties of UV-curable tung oil based resins via modification of Diels–Alder reaction, nonisocyanate polyurethane and acrylates. PROGRESS IN ORGANIC COATINGS, [PMID:] [10.1016/j.porgcoat.2012.12.005] |
| 11. Weiwen Gu, Rui Wang, Huaibo Qian, Jingyu Zhang, Jiang Jing, Hongfei Li, Xiaoyu Gu, Sheng Zhang. (2025) Interaction modulation of diphosphate piperazine and melamine phosphate for enhanced water resistance and flame retardancy in polypropylene. COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING, [PMID:] [10.1016/j.compositesa.2025.109177] |
| 12. Huaibo Qian, Weiwen Gu, Jingyu Zhang, Yujia Wang, Libo Li, Qiaolian Lv, Jiang Jing, Jun Sun, Xiaoyu Gu, Sheng Zhang. (2025) Carbon dot-based nanohybrids enable polypropylene flame retardancy, UV-aging resistance, and upcycling performance. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.171862] |
| 13. Bin Hu, Yifang Hua, Xianghong Yang, Zhenhua Wang, Jun Sun, Jian Cai. (2026) A simple strategy for preparing Cu2+-doped flame retardants to enhance the fire resistance of wood. INDUSTRIAL CROPS AND PRODUCTS, [PMID:] [10.1016/j.indcrop.2026.123120] |
