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· · COA & SDS available for every product · Same-day shipping on in-stock items PJ34 - Moligand™, ≥98% , Inhibitor of poly(ADP-ribose) polymerase 1, CAS No.344458-19-1, Inhibitor of poly(ADP-ribose) polymerase 1
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98% Synonyms
BRD-K11853856-003-01-3 | N~2~,N~2~-dimethyl-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)glycinamide | NA92ZAR7N2 | AS-76486 | NCGC00370866-10 | N-(5,6-dihydro-6-oxophenanthridine-2-yl)-2-(dimethylamino)acetamide | PJ34 | pj-34 | PJ34 free base | SB19292 | 2-(d
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview PJ34 is a novel potent specific inhibitor of PARP-l/2 with EC50 of 20 nM.
Specifications Synonyms
BRD-K11853856-003-01-3 | N~2~, N~2~-dimethyl-N-(6-oxo-5, 6-dihydrophenanthridin-2-yl)glycinamide | NA92ZAR7N2 | AS-76486 | NCGC00370866-10 | N-(5, 6-dihydro-6-oxophenanthridine-2-yl)-2-(dimethylamino)acetamide | PJ34 | pj-34 | PJ34 free base | SB19292 | 2-(d
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
PJ34 inhibited peroxynitrite-induced cell necrosis with EC50 of 20 nM. PJ34 provides cardioprotection by decreasing myocardial infarct size and enhancing postischemic regional and global functional recovery .Treatment with PJ34 increased NIS promoter act
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
Inhibitor of poly(ADP-ribose) polymerase 1
Names and Identifiers Pubchem Sid 504750820 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504750820 Canonical Smiles CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32 IUPAC Name 2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide InChIKey UYJZZVDLGDDTCL-UHFFFAOYSA-N INCHI 1S/C17H17N3O2/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22) Isomeric SMILES CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32 Alternate CAS 356042-41-6,344458-19-1 MeSH Entry Terms N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride;PJ 34;PJ-34;PJ34 Molecular Weight 295.34 Reaxy-Rn 9933113 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9933113&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Quinolines and derivatives Subclass Benzoquinolines Intermediate Tree Nodes Not available Direct Parent Phenanthridines and derivatives Alternative Parents Alpha amino acid amides Hydroquinolones Isoquinolones and derivatives Hydroquinolines N-arylamides Pyridinones Benzenoids Heteroaromatic compounds Trialkylamines Secondary carboxylic acid amides Lactams Azacyclic compounds Organic oxides Organopnictogen compounds Hydrocarbon derivatives Carbonyl compounds Molecular Framework Aromatic heteropolycyclic compounds Substituents Phenanthridine - Alpha-amino acid amide - Dihydroquinolone - Isoquinolone - Alpha-amino acid or derivatives - Dihydroquinoline - Isoquinoline - N-arylamide - Pyridinone - Pyridine - Benzenoid - Heteroaromatic compound - Secondary carboxylic acid amide - Tertiary aliphatic amine - Tertiary amine - Amino acid or derivatives - Carboxamide group - Lactam - Azacycle - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Carbonyl group - Organooxygen compound - Amine - Organic nitrogen compound - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as phenanthridines and derivatives. These are polycyclic compounds containing a phenanthridine moiety, which is a tricyclic system with two benzene rings joined by a pyridine forming a non-linear skeleton. Hydrogenated derivatives are also included. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility DMSO 28 mg/mL Water <1 mg/mL Ethanol <1 mg/mL Molecular Weight 295.340 g/mol XLogP3 1.700 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3 Rotatable Bond Count 3 Exact Mass 295.132 Da Monoisotopic Mass 295.132 Da Topological Polar Surface Area 61.400 Ų Heavy Atom Count 22 Formal Charge 0 Complexity 438.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
Citations of This Product References 1. Yang Yi, Wenzhe Li, Kefang Liu, Heng Xue, Rong Yu, Meng Zhang, Yang-Oujie Bao, Xinyuan Lai, Jingjing Fan, Yuxi Huang, Jing Wang, Xiaomeng Shi, Junhua Li, Hongping Wei, Kuanhui Xiang, Linjie Li, Rong Zhang, Xin Zhao, Xue Qiao, Hang Yang, Min Ye. (2023) Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation. Journal of Pharmaceutical Analysis, [PMID:37363744 ] [10.1016/j.jpha.2023.05.011 ]
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