Prinoxodan（RGW2938） - Moligand™, ≥98% , CAS No.111786-07-3

CAS: 111786-07-3 Cat. No.: P646475 Molecular Weight: 258.28

GRADE & PURITY Moligand™, ≥98%

Synonyms

3-methyl-6-(6-oxo-4,5-dihydro-1H-pyridazin-3-yl)-1,4-dihydroquinazolin-2-one | D05612 | 6-(6-Keto-4,5-Dihydro-1H-Pyridazin-3-Yl)-3-Methyl-1,4-Dihydroquinazolin-2-One

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Prinoxodan (RGW2938) is a phosphodiesterase inhibitor.

In Vitro

Prinoxodan (RG W-2938) is an orally effective positive inotropic/vasodilator agent. Prinoxodan is a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent is examined in vitro in isolated guinea pig hearts; in the latter, Prinoxodan 5 nmol-5 μmol increases contractility in a dose-related fashion. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Prinoxodan (RG W-2938) is a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent is examined in vivo in anesthetized and conscious dogs. Prinoxodan 30-300 μg/kg administered intravenously (i.v.) to anesthetized dogs increases contractile force while decreasing arterial pressure and total peripheral resistance (TPR) in a dose-related manner. Heart rate (HR) is only slightly increased, and aortic flow is not appreciably altered. A single oral dose of Prinoxodan 0.3 mg/kg administered to conscious chronically instrumented dogs produces a marked and sustained increase in contractility 15-240 min after treatment while only slightly increasing HR. The effects of Prinoxodan 30-300 μg/kg, i.v. are studied in a mecamylamine-propranolol-induced model of heart failure. Prinoxodan effectively reverses the drug-induced heart failure by increasing myocardial contractility and decreasing arterial pressure while only slightly affecting HR. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Phosphodiesterase

Specifications

Synonyms

3-methyl-6-(6-oxo-4, 5-dihydro-1H-pyridazin-3-yl)-1, 4-dihydroquinazolin-2-one | D05612 | 6-(6-Keto-4, 5-Dihydro-1H-Pyridazin-3-Yl)-3-Methyl-1, 4-Dihydroquinazolin-2-One

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

Prinoxodan (RGW2938) is a phosphodiesterase inhibitor.

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CN1CC2=C(C=CC(=C2)C3=NNC(=O)CC3)NC1=O
• IUPAC Name: 3-methyl-6-(6-oxo-4,5-dihydro-1H-pyridazin-3-yl)-1,4-dihydroquinazolin-2-one
• InChIKey: SUCNEHPNQBBVHQ-UHFFFAOYSA-N
• INCHI: 1S/C13H14N4O2/c1-17-7-9-6-8(2-3-10(9)14-13(17)19)11-4-5-12(18)16-15-11/h2-3,6H,4-5,7H2,1H3,(H,14,19)(H,16,18)
• Isomeric SMILES: CN1CC2=C(C=CC(=C2)C3=NNC(=O)CC3)NC1=O
• Alternate CAS: 111786-07-3
• MeSH Entry Terms: 6-(3,4-dihydro-3-methyl-2-oxoquinazolinyl)-4,5-dihydro-3-pyridazinone;6-(6-(3,4-dihydro-3-methyl-2(1H)-2-oxoquinazolinyl))-4,5-dihydro-3(2H)-pyridazinone;6-DMODP;prinoxodan;RG W-2938;RGW 2938;RGW-2938
• Molecular Weight: 258.28

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Diazanaphthalenes
      • Subclass Benzodiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Diazanaphthalenes
• Subclass: Benzodiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Quinazolines
• Alternative Parents: Pyrimidones Pyridazinones Benzenoids Ureas Carboxylic acids and derivatives Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Quinazoline - Pyridazinone - Pyrimidone - Pyridazine - Pyrimidine - Benzenoid - Urea - Carboxylic acid derivative - Azacycle - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Carbonyl group - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as quinazolines. These are compounds containing a quinazoline moiety, which is made up of two fused six-member aromatic rings, a benzene ring and a pyrimidine ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Light sensitive；Heat sensitive
• Molecular Weight: 258.279 g/mol
• XLogP3: -0.300
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 258.112 Da
• Monoisotopic Mass: 258.112 Da
• Topological Polar Surface Area: 73.800 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 434.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1