Pyridoxine hydrochloride - analytical standard,Moligand™ , CAS No.58-56-0

CAS: 58-56-0 Cat. No.: V108690 Molecular Weight: 205.64 Beilstein Registry Number: 3632435 EC Number: 200-386-2 PubChem CID: 6019

GRADE & PURITY Analytical standard, Moligand™

Synonyms

Paxadon | PYRIDOXINE HYDROCHLORIDE [USP-RS] | Pyridoxol (hydrochloride);Vitamin B6 (hydrochloride) | Pyridoxol (hydrochloride) | Alestrol | Beesix | PYRIDOXINE HYDROCHLORIDE [USP MONOGRAPH] | Pyridoxine hydrogen chloride | Adermine hydrochloride | Hexabio

Storage

Protected from light,Room temperature,Desiccated

Shipped In

Normal

Overview

Odorless. Slightly salty and bitter taste. Gradually deteriorates when exposed to light. Stable in air. 1g dissolves in about 4.5ml of water and 90ml of ethanol, slightly soluble in acetone, insoluble in ether and chloroform. pH of 10% aqueous solution is 3.2. Acidic aqueous solutions are stable, even when heated to 120°C (decomposes and sublimes). Maximum absorption wavelengths: (0.1mol/L hydrochloric acid) 290nm (ε840), (phosphate buffer, pH7) 253, 325nm (ε3700, 7100). Low toxicity, median lethal dose (rats, oral) 4000mg/kg. Used in biochemical research.

Specifications

Synonyms

Paxadon | PYRIDOXINE HYDROCHLORIDE [USP-RS] | Pyridoxol (hydrochloride);Vitamin B6 (hydrochloride) | Pyridoxol (hydrochloride) | Alestrol | Beesix | PYRIDOXINE HYDROCHLORIDE [USP MONOGRAPH] | Pyridoxine hydrogen chloride | Adermine hydrochloride | Hexabio

Specifications & Purity

analytical standard, Moligand™

Biochemical and Physiological Mechanisms

Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

Storage

Protected from light, Room temperature, Desiccated

Shipped In

Normal

Grade

Analytical standard, Moligand™

Names and Identifiers

• Canonical Smiles: CC1=NC=C(C(=C1O)CO)CO.Cl
• IUPAC Name: 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol;hydrochloride
• InChIKey: ZUFQODAHGAHPFQ-UHFFFAOYSA-N
• INCHI: 1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H
• Isomeric SMILES: CC1=NC=C(C(=C1O)CO)CO.Cl
• WGK Germany: 2
• RTECS: UV1350000
• Alternate CAS: 65-23-6
• PubChem CID: 6019
• Molecular Weight: 205.64
• Beilstein: 3632435

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Pyridines and derivatives
      • Subclass Pyridoxines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Pyridines and derivatives
• Subclass: Pyridoxines
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyridoxines
• Alternative Parents: Methylpyridines Hydroxypyridines Heteroaromatic compounds Azacyclic compounds Primary alcohols Organopnictogen compounds Organonitrogen compounds Hydrochlorides Hydrocarbon derivatives Aromatic alcohols
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyridoxine - Hydroxypyridine - Methylpyridine - Heteroaromatic compound - Azacycle - Hydrocarbon derivative - Organic oxygen compound - Alcohol - Hydrochloride - Aromatic alcohol - Organic nitrogen compound - Primary alcohol - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as pyridoxines. These are pyridoxal derivatives in which the carbaldehyde group at position 2 of the pyridoxal moiety is replaced by a hydroxymethyl group.
• External Descriptors: hydrochloride

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

AR Tclin Androgen Receptor (11781 Activities)

Discover Target: AR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

Discover Target: TP53

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Light Sensitive
• Melt Point(°C): 207°C
• Molecular Weight: 205.640 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 205.051 Da
• Monoisotopic Mass: 205.051 Da
• Topological Polar Surface Area: 73.600 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 142.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Ziyuan Deng, Chengling Lai, Jun Zhang, Fan Sun, Danting Li, Peiying Hao, Xuping Shentu, Kun Pang, Xiaoping Yu.  (2023)  Effects of Secondary Metabolites of Rice on Brown Planthopper and Its Symbionts.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  25  (1): (386).  [PMID:38203556] [10.3390/ijms25010386]

2. Naymul Karim, Mohammad Rezaul Islam Shishir, Tao Bao, Wei Chen.  (2021)  Effect of cold plasma pretreated hot-air drying on the physicochemical characteristics, nutritional values and antioxidant activity of shiitake mushroom.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,  101  (15): (6271-6280).  [PMID:33949697] [10.1002/jsfa.11296]

3. Yue Zhao, Zuhao Li, Qiuju Li, Longfei Yang, Hou Liu, Ruyue Yan, Lizhi Xiao, He Liu, Jingcheng Wang, Bai Yang, Quan Lin.  (2020)  Transparent Conductive Supramolecular Hydrogels with Stimuli-Responsive Properties for On-Demand Dissolvable Diabetic Foot Wound Dressings.  MACROMOLECULAR RAPID COMMUNICATIONS,  41  (24): (2000441).  [PMID:33089609] [10.1002/marc.202000441]

4. Dandan Han, Tarak Karmakar, Fei Liu, Yan Wang, Weiwei Tang, Junbo Gong.  (2019)  Uncovering the Role of Surfactants in Controlling the Crystal Growth of Pyridoxine Hydrochloride.  CRYSTAL GROWTH & DESIGN,      [PMID:] [10.1021/acs.cgd.9b01134]

5. Xinyu Gao, Jiahao Niu, Zhengjian Xiao, Da Rong, Mingming Yu, Sherwin K B Sy, Cong Wang, Zhihua Lv.  (2025)  The Application of Quantitative 1H-NMR for the Determination of Melatonin and Vitamin B6 in Commercial Melatonin Products.  MOLECULES,  30  (14): (2942).  [PMID:40733207] [10.3390/molecules30142942]

6. Lifen Meng, Yinying Zhang, Mengting Su.  (2025)  Preparation and application of Mn, Si-CQDs in Vitamin B6 and in vitro activity analysis.  CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,      [PMID:] [10.1016/j.cjac.2025.100634]

7. Yong Hu, Hai-Long Wu, Xiao-Li Yin, Hui-Wen Gu, Rong Xiao, Li-Xia Xie, Zhi Liu, Huan Fang, Li Wang, Ru-Qin Yu.  (2017)  Rapid and interference-free analysis of nine B-group vitamins in energy drinks using trilinear component modeling of liquid chromatography-mass spectrometry data.  TALANTA,      [PMID:29332787] [10.1016/j.talanta.2017.12.036]

8. Kangyuan Qu, Siyuan Xiong, Caiqian Huang, Xiaoxia Jiang, Lixia Tian, Shiwei Xie.  (2024)  Dietary supplementation of ornithine improved the growth, immune response and acute NH3 stress tolerance of Pacific white shrimp, Penaeus vannamei.  Aquaculture Reports,      [PMID:] [10.1016/j.aqrep.2024.102095]

9. Qiang Wan, Rong Li, Meiping Ren, Gang Ke.  (2025)  Hydrothermally Synthesized Boletus Brucella-derived Carbon Quantum Dots as a Fluorescent Probe for the Detection of Vitamin B2.  Current Nanoscience,  21  (1): (92-98).  [PMID:] [10.2174/0115734137259719230921065320]

10. Haolin Zhang, Jingjing Zhang, Hui Cao, Petra Högger, Randolph Arroo, Mohamed A. Farag, Avi Shpigelman, Jianbo Xiao, Chunlin Li.  (2025)  Amination of Flavonoids Possessing a Pyrogallol Group in Cell Culture Medium at 37°C.  Food Frontiers,  6  (2): (1058-1078).  [PMID:] [10.1002/fft2.70002]

11. Wen Jianzhong, Li Wenqian, Wang Zhijuan, Zhang Luchun, Huang Yating, Weng Mengjie, Chen Ye, Hou Zuyao, Zhang Meijia, Chen Yuezhou.  (2025)  Vitamin B6 promotes the activation of primordial follicles through the PI3K/Akt signaling pathway.  Journal of Ovarian Research,  18  (1): (296).  [PMID:41408298] [10.1186/s13048-025-01882-1]

12. Qin Zhou, Yushi Wei, Yijing Liao, Deming Gong, Guowen Zhang.  (2026)  Inhibition effect of vitamin B6 on α-glucosidase and mechanism of its synergistic inhibition with liquiritigenin.  FOOD CHEMISTRY,      [PMID:41592502] [10.1016/j.foodchem.2026.148130]