Resiquimod - Moligand™, ≥98%(HPLC) , Agonist of TLR7;Agonist of TLR8, CAS No.144875-48-9, Agonist of TLR7;Agonist of TLR8

Name: Resiquimod - Moligand™, ≥98%(HPLC) , Agonist of TLR7;Agonist of TLR8, CAS No.144875-48-9, Agonist of TLR7;Agonist of TLR8
Brand: Aladdin Scientific
SKU: R131891
Availability: InStock

CAS: 144875-48-9 Cat. No.: R131891 Formula: C₁₇H₂₂N₄O₂ Molecular Weight: 314.38 PubChem CID: 159603

1 Citations COA

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Resiquimod - Moligand™, ≥98%(HPLC) CAS No(144875-48-9) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY Moligand™ ? ≥98%(HPLC)

Synonyms

R848 | R 848 | S 28463 | R-848 | Resiquimod [INN] | 1-(4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol. | 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol | s28463 | R848;S28463 | Resiquimod (GMP

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Specifications Product Properties Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates (CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Documents & Articles Citations of This Product Solution Calculators Reviews

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Why this grade

Moligand™, ≥98%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms

Specifications & Purity

Moligand™, ≥98%(HPLC)

Biochemical and Physiological Mechanisms

Toll-like receptor 7 (TLR7) agonist. Induces upregulation of IL-6, IL-12, IFN-γand iNOS expression in mouse bone marrow-derived macrophages (BMMs). Inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Also

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of TLR7;Agonist of TLR8

Purity

≥98%(HPLC)

Product Properties

ALogP

1.3

Names and Identifiers

Pubchem Sid

528776396

Canonical Smiles

CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N

IUPAC Name

1-[4-amino-2-(ethoxymethyl)imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol

InChIKey

BXNMTOQRYBFHNZ-UHFFFAOYSA-N

INCHI

1S/C17H22N4O2/c1-4-23-9-13-20-14-15(21(13)10-17(2,3)22)11-7-5-6-8-12(11)19-16(14)18/h5-8,22H,4,9-10H2,1-3H3,(H2,18,19)

Isomeric SMILES

CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N

WGK Germany

RTECS

NJ5911320

PubChem CID

159603

Molecular Weight

314.38

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

<<<<<<< HEAD Download SDS → ======= Download SDS → >>>>>>> release248-p3

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Quinolines and derivatives
    - Subclass Imidazoquinolines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Quinolines and derivatives
Subclass	Imidazoquinolines
Intermediate Tree Nodes	Not available
Direct Parent	Imidazoquinolines
Alternative Parents	Aminoquinolines and derivatives Imidazo-[4,5-c]pyridines Aminopyridines and derivatives N-substituted imidazoles Imidolactams Benzenoids Tertiary alcohols Heteroaromatic compounds Dialkyl ethers Azacyclic compounds Primary amines Organopnictogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Imidazoquinoline - Aminoquinoline - Imidazopyridine - Imidazo-[4,5-c]pyridine - Aminopyridine - Imidolactam - Benzenoid - Pyridine - N-substituted imidazole - Azole - Imidazole - Heteroaromatic compound - Tertiary alcohol - Dialkyl ether - Ether - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Amine - Alcohol - Organopnictogen compound - Organic oxygen compound - Primary amine - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as imidazoquinolines. These are aromatic heterocyclic compounds containing an imidazole ring fused to a quinoline ring system. In some configurations, the imidazole ring shares a nitrogen atom with the quinoline moiety.
External Descriptors	imidazoquinoline
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

TLR8 Tchem Toll-like receptor 8 (1 Activities)

Discover Target: TLR8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TLR7 Tclin Toll-like receptor 7 (5 Activities)

Discover Target: TLR7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HEK293 (82097 Activities)

Lot Number	Certificate Type	Date	Item
A2510173	Certificate of Analysis	Oct 09, 2026	R131891
G2409131	Certificate of Analysis	Apr 07, 2026	R131891
G2409130	Certificate of Analysis	Apr 07, 2026	R131891
J2527660	Certificate of Analysis	Oct 15, 2025	R131891
J2527659	Certificate of Analysis	Oct 15, 2025	R131891
J2527658	Certificate of Analysis	Oct 15, 2025	R131891
J2527626	Certificate of Analysis	Oct 15, 2025	R131891
E2620019	Certificate of Analysis	Oct 15, 2025	R131891
C2624071	Certificate of Analysis	Oct 15, 2025	R131891
A2622009	Certificate of Analysis	Oct 15, 2025	R131891
H2331037	Certificate of Analysis	Jun 10, 2025	R131891
G2401033	Certificate of Analysis	Jul 10, 2024	R131891
G2409127	Certificate of Analysis	Jun 22, 2024	R131891
G2409128	Certificate of Analysis	Jun 22, 2024	R131891
G2409129	Certificate of Analysis	Jun 22, 2024	R131891
F2414041	Certificate of Analysis	Jun 20, 2024	R131891
H2222101	Certificate of Analysis	Jun 20, 2024	R131891
H2222106	Certificate of Analysis	Jun 20, 2024	R131891
H2222107	Certificate of Analysis	Jun 20, 2024	R131891
D2416463	Certificate of Analysis	Mar 11, 2024	R131891
D2428397	Certificate of Analysis	Mar 11, 2024	R131891
H2222098	Certificate of Analysis	Aug 02, 2022	R131891
I2305257	Certificate of Analysis	Aug 02, 2022	R131891

Solubility	Solvent:DMSO, Max Conc. mg/mL: 31.44, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 15.72, Max Conc. mM: 50
Sensitivity	Moisture sensitive；Heat sensitive
Melt Point(°C)	193℃
Molecular Weight	314.400 g/mol
XLogP3	1.300
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	314.174 Da
Monoisotopic Mass	314.174 Da
Topological Polar Surface Area	86.200 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	406.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Resiquimod - Moligand™, ≥98%(HPLC) , Agonist of TLR7;Agonist of TLR8, CAS No.144875-48-9, Agonist of TLR7;Agonist of TLR8

Storage & shipping

Quality documents

Literature proof

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

📚 Citations by Application

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