Potent, selective dopamine D 1 receptor antagonist (K i = 124 nM). Lower affinity for D 2 and D 3 receptors. Potent 5-HT 1A receptor antagonist (K i = 340 nM). Adrenergic, anti-arrhythmic, antihypertensive and antipsychotic agent. Active in vivo and in vi
Storage
Room temperature
Shipped In
Normal
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This compound belongs to the class of organic compounds known as protoberberine alkaloids and derivatives. These are alkaloids with a structure based on a protoberberine moiety, which consists of a 5,6-dihydrodibenzene moiety fused to a quinolizinium and forming 5,6-Dihydrodibenzo(a,g)quinolizinium skeleton.
External Descriptors
Isoquinoline alkaloids
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Jiawen Ai, Weize Zhao, Quan Yu, Xiang Qian, Jianhua Zhou, Xinming Huo, Fei Tang. (2023) SR-Unet: A Super-Resolution Algorithm for Ion Trap Mass Spectrometers Based on the Deep Neural Network. ANALYTICAL CHEMISTRY, [PMID:37963290][10.1021/acs.analchem.3c04172]
2.Yingchun Chen, Cui Li, Yaodong Yi, Weijuan Du, Huidi Jiang, Su Zeng, Hui Zhou. (2020) Organic Cation Transporter 1 and 3 Contribute to the High Accumulation of Dehydrocorydaline in the Heart. DRUG METABOLISM AND DISPOSITION, 48 (10):(1074-1083). [PMID:32723846][10.1124/dmd.120.000025]
3.Liping Li, Yayun Weng, Wei Wang, Mengru Bai, Hongmei Lei, Hui Zhou, Huidi Jiang. (2017) Multiple organic cation transporters contribute to the renal transport of sulpiride. BIOPHARMACEUTICS & DRUG DISPOSITION, 38 (9):(526-534). [PMID:28926871][10.1002/bdd.2104]
4.Hai-Xia GE, Jian ZHANG, Kun QIAN, Bo-Yang YU, Xiao-Ping CHEN. (2016) Diversity synthesis of tetrahydroprotoberberines glycosides by combined chemical and microbial catalysis. Chinese Journal of Natural Medicines, [PMID:28236408][10.1016/S1875-5364(16)30093-0]
5.Xu Zhu, Shufang Wu, Chunlan Li, Maotian Xu, Baoxian Ye. (2023) Electrochemical Detection of Levo-Tetrahydropalmatine Based on DNA Modified Electrode. International Journal of Electrochemical Science, [PMID:][10.1016/S1452-3981(23)08118-X]
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