pathway
- Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2. (1)
- Protein modification; peptidyl-diphthamide biosynthesis. (7)
- Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. (1)
- Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. (1)
- Lipid metabolism; bile acid biosynthesis. (3)
- Hormone biosynthesis; cholecalciferol biosynthesis. (2)
- Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5. (4)
- Protein modification; protein ubiquitination. (399)
- Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3. (3)
- Lipid metabolism; sphingolipid metabolism. (15)
- Protein modification; protein glycosylation. (148)
- tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. (4)
- Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6. (1)
- Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6. (1)
- Lipid metabolism; fatty acid beta-oxidation. (13)
- Lipid metabolism; C21-steroid hormone metabolism. (1)
- Cofactor degradation; phylloquinone degradation. (2)
- Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2. (1)
- Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. (1)
- Cofactor biosynthesis; ubiquinone biosynthesis. (11)
- Sphingolipid metabolism; galactosylceramide biosynthesis. (2)
- Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3. (1)
- Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 3/3. (1)
- Lipid metabolism; polyunsaturated fatty acid biosynthesis. (7)
- Cofactor biosynthesis; molybdopterin biosynthesis. (5)
- Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1. (2)
- Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1. (2)
- Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1. (1)
- Lipid metabolism; fatty acid biosynthesis. (15)
- Glycan metabolism; heparan sulfate biosynthesis. (11)
- Hormone biosynthesis; thyroid hormone biosynthesis. (3)
- Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1. (2)
- Sulfur metabolism; glutathione metabolism. (6)
- Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. (1)
- Lipid metabolism; leukotriene D4 biosynthesis. (1)
- Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3. (4)
- Amino-acid metabolism; lysine degradation. (1)
- Amino-acid metabolism; tryptophan metabolism. (1)
- Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1. (2)
- Protein biosynthesis; polypeptide chain elongation. (1)
- Steroid biosynthesis; estrogen biosynthesis. (5)
- Protein modification; eIF5A hypusination. (2)
- Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1. (1)
- Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. (1)
- Hormone biosynthesis; testosterone biosynthesis. (1)
- Carbohydrate biosynthesis; gluconeogenesis. (10)
- Protein modification; protein sumoylation. (17)
- Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. (1)
- Lipid metabolism; fatty acid metabolism. (7)
- Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6. (1)
- Lipid metabolism; leukotriene B4 degradation. (1)
- Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6. (1)
- Lipid metabolism. (3)
- Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from malonyl-CoA: step 1/1. (1)
- Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2. (2)
- Carbohydrate metabolism; tricarboxylic acid cycle. (2)
- Steroid biosynthesis; cholesterol biosynthesis. (4)
- Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6. (1)
- Amine and polyamine biosynthesis; histamine biosynthesis; histamine from L-histidine: step 1/1. (1)
- Lipid metabolism; glycerolipid metabolism. (2)
- Glycerolipid metabolism; triacylglycerol biosynthesis. (5)
- Glycan metabolism; chondroitin sulfate biosynthesis. (4)
- Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3. (2)
- Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2. (2)
- Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 2/2. (1)
- Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. (1)
- Membrane lipid metabolism; sphingolipid biosynthesis. (1)
- Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1. (1)
- Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. (1)
- Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2. (1)
- Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1. (1)
- Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. (1)
- Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. (2)
- Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. (1)
- Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. (1)
- Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. (1)
- Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3. (1)
- Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. (4)
- Phospholipid metabolism; phosphatidylserine biosynthesis. (2)
- Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. (1)
- Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. (1)
- Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1. (1)
- Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. (2)
- Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2. (1)
- Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. (3)
- Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. (1)
- Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. (1)
- Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1. (1)
- Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. (1)
- Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2. (1)
- Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1. (1)
- Energy metabolism; sulfur metabolism. (1)
- Organosulfur degradation. (1)
- Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. (2)
- Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. (1)
- Amine and polyamine biosynthesis; spermine biosynthesis; spermine from spermidine: step 1/1. (1)
- Amino-acid degradation; 4-aminobutanoate degradation. (1)
- Protein modification; sulfatase oxidation. (1)
- Steroid metabolism; cholesterol metabolism. (2)
- Quinol/quinone metabolism; menaquinone biosynthesis. (1)
- tRNA modification; wybutosine-tRNA(Phe) biosynthesis. (6)
- Protein modification; protein neddylation. (4)
- Pigment biosynthesis; melanin biosynthesis. (2)
- Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. (1)
- Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2. (1)
- Pyrimidine metabolism; dTTP biosynthesis. (2)
- Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1. (1)
- Protein modification; carbohydrate sulfation. (3)
- Glycan metabolism; heparin biosynthesis. (5)
- Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. (1)
- Cofactor biosynthesis; iron-sulfur cluster biosynthesis. (2)
- Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3. (1)
- Carbohydrate metabolism; hexose metabolism. (5)
- Glycan biosynthesis; hyaluronan biosynthesis. (3)
- Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. (3)
- Carbohydrate metabolism; galactose metabolism. (3)
- Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis. (1)
- Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. (1)
- Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2. (1)
- Organic acid metabolism; glycolate degradation; 3-phospho-D-glycerate from glycolate: step 1/4. (1)
- Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. (1)
- Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3. (2)
- Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1. (2)
- Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3. (1)
- Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4. (1)
- Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3. (1)
- Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1. (1)
- Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. (1)
- Amino-acid degradation; L-valine degradation. (3)
- Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4. (1)
- Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. (2)
- Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 2/2. (1)
- Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1. (1)
- Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1. (1)
- Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3. (1)
- Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1. (2)
- Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6. (1)
- Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. (1)
- Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1. (2)
- Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. (1)
- Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. (3)
- Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2. (1)
- Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2. (1)
- Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3. (1)
- Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1. (1)
- tRNA modification; N(7)-methylguanine-tRNA biosynthesis. (2)
- Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2. (2)
- Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2. (2)
- Amine and polyamine degradation; spermine degradation. (1)
- Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2. (1)
- Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. (1)
- Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1. (1)
- Amine and polyamine biosynthesis; carnitine biosynthesis. (3)
- Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1. (2)
- Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1. (2)
- Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. (1)
- Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5. (1)
- Amine and polyamine degradation; sarcosine degradation; formaldehyde and glycine from sarcosine: step 1/1. (1)
- Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. (2)
- Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3. (1)
- Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. (1)
- Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3. (1)
- Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3. (1)
- Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1. (1)
- Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. (22)
- Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 1/2. (1)
- Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis. (3)
- Catecholamine biosynthesis; (R)-adrenaline biosynthesis; (R)-adrenaline from (R)-noradrenaline: step 1/1. (1)
- Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6. (1)
- Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. (1)
- Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1. (1)
- Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2. (2)
- Cofactor metabolism; retinol metabolism. (8)
- Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2. (1)
- Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3. (1)
- Sulfur metabolism; sulfate assimilation. (2)
- Flavonoid metabolism; quercetin degradation. (1)
- Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. (6)
- Glycerolipid metabolism; triacylglycerol degradation. (3)
- Phospholipid metabolism. (1)
- Glycerolipid metabolism. (1)
- Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. (3)
- Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. (2)
- Genetic information processing; DNA replication. (3)
- Amino-sugar metabolism; N-acetylneuraminate degradation. (4)
- Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. (9)
- Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1. (3)
- Lipid metabolism; prostaglandin biosynthesis. (4)
- Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3. (2)
- Lipid metabolism; phospholipid metabolism. (7)
- Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2. (1)
- Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. (1)
- Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. (1)
- Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2. (2)
- Phospholipid metabolism; phosphatidylcholine biosynthesis. (1)
- Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3. (1)
- Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. (1)
- Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. (1)
- Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. (5)
- Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. (2)
- Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3. (1)
- Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3. (1)
- Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2. (1)
- Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3. (2)
- Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7. (1)
- Glycan metabolism; N-glycan degradation. (2)
- Cofactor biosynthesis; adenosylcobalamin biosynthesis. (2)
- Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis. (5)
- Lipid metabolism; leukotriene A4 biosynthesis. (1)
- Glycan biosynthesis; glycogen metabolism. (3)
- Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2. (1)
- Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2. (1)
- Lipid metabolism; leukotriene B4 biosynthesis. (1)
- Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2. (1)
- Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6. (1)
- Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 2/2. (1)
- Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2. (1)
- Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1. (1)
- One-carbon metabolism; tetrahydrofolate interconversion. (7)
- Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6. (1)
- Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 3/6. (1)
- Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1. (3)
- Amino-acid biosynthesis; beta-alanine biosynthesis. (2)
- Porphyrin-containing compound metabolism; protoheme degradation. (1)
- Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2. (1)
- Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. (2)
- Lipid metabolism; steroid biosynthesis. (3)
- Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 3/3. (1)
- Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1. (1)
- Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1. (2)
- Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5. (1)
- Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6. (1)
- Energy metabolism; oxidative phosphorylation. (1)
- Siderophore biosynthesis. (1)
- Sphingolipid metabolism. (1)
- Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3. (1)
- Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. (3)
- Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. (3)
- Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1. (1)
- Secondary metabolite metabolism; quinolate metabolism. (1)
- Lipid metabolism; mitochondrial fatty acid beta-oxidation. (5)
- Carbohydrate metabolism; pyruvate metabolism. (1)
- Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. (1)
- Lipid metabolism; peroxisomal fatty acid beta-oxidation. (2)
- Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. (2)
- Glycerolipid metabolism; ether lipid biosynthesis. (1)
- Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6. (1)
- Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6. (1)
- Steroid hormone biosynthesis. (1)
- Steroid metabolism. (1)
- Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. (4)
- Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. (3)
- Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. (1)
- Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2. (1)
- Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1. (2)
- Carbohydrate degradation; glycolysis. (1)
- Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1. (1)
- Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2. (1)
- Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3. (1)
- Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. (1)
- Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. (1)
- Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 4/6. (1)
- Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1. (1)
- Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. (1)
- Nitrogen metabolism; urea cycle; L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1. (1)
- Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. (3)
- Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1. (1)
- Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. (1)
- Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. (1)
- Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1. (2)
- Protein degradation; proteasomal ubiquitin-dependent pathway. (2)
- Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1. (2)
- Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. (1)
- Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1. (1)
- Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2. (1)
- Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. (1)
- Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1. (1)
- Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. (1)
- Membrane lipid metabolism; glycerophospholipid metabolism. (1)
- Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2. (3)
- Signal transduction; phosphatidylinositol signaling pathway. (3)
- Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. (2)
- Glycan biosynthesis; glycogen biosynthesis. (5)
- Purine metabolism; guanine degradation; xanthine from guanine: step 1/1. (1)
- Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. (4)
- Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. (1)
- Glycan metabolism; N-glycan metabolism. (2)
- Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. (1)
- Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1. (1)
- Carbohydrate acid metabolism; D-gluconate degradation. (1)
- Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. (4)
- Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1. (1)
- Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. (1)
- Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2. (1)
- Amino-sugar metabolism; N-acetylneuraminate biosynthesis. (2)
- Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1. (2)
- Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2. (1)
- Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2. (1)
- Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1. (1)
- Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 1/2. (1)
- Amine and polyamine metabolism; spermine metabolism. (1)
- Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 1/2. (1)
- Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. (3)
- Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2. (1)
- Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2. (1)
- Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. (1)
- Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1. (1)
- Nitrogen metabolism; urea cycle; L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1. (1)
- Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 4/6. (1)
- Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5. (1)
- Cofactor biosynthesis; NAD(+) biosynthesis. (2)
- Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. (1)
- Carbohydrate metabolism; fructose metabolism. (1)
- Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1. (1)
- Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1. (1)
- Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. (1)
- Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. (1)
- Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1. (1)
- Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1. (3)
- Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. (3)
- Purine metabolism; purine nucleoside salvage. (1)
- Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1. (1)
- Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1. (1)
- Amino-sugar metabolism; N-acetylneuraminate metabolism. (1)
- Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. (1)
- Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1. (1)
- Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1. (1)
- Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6. (1)
- PI3K-Akt signaling pathway (3965)
- Alanine, aspartate and glutamate metabolism (36)
- Central carbon metabolism in cancer (69)
- Folate biosynthesis (27)
- Complement and coagulation cascades (278)
- Citrate cycle (TCA cycle) (30)
- Axon guidance (713)
- Platinum drug resistance (75)
- EGFR tyrosine kinase inhibitor resistance (79)
- Endocrine resistance (100)
- Tryptophan metabolism (138)
- Prion diseases (36)
- Histidine metabolism (23)
- Inflammatory mediator regulation of TRP channels (102)
- Glycosphingolipid biosynthesis - ganglio series (15)
- Non-small cell lung cancer (1743)
- Platelet activation (126)
- Cell adhesion molecules (CAMs) (227)
- Chronic myeloid leukemia (77)
- ECM-receptor interaction (88)
- Gastric cancer (148)
- Focal adhesion (741)
- Protein export (23)
- Pyruvate metabolism (80)
- Adherens junction (71)
- mTOR signaling pathway (218)
- GnRH secretion (64)
- Parathyroid hormone synthesis, secretion and action (110)
- Cortisol synthesis and secretion (68)
- Relaxin signaling pathway (132)
- Aldosterone synthesis and secretion (101)
- Nucleotide excision repair (156)
- Regulation of lipolysis in adipocytes (58)
- Retinol metabolism (65)
- Oxytocin signaling pathway (155)
- Adipocytokine signaling pathway (69)
- T cell receptor signaling pathway (102)
- Circadian rhythm (30)
- B cell receptor signaling pathway (176)
- Inflammatory bowel disease (IBD) (77)
- Fc epsilon RI signaling pathway (66)
- Fc gamma R-mediated phagocytosis (91)
- Kaposi sarcoma-associated herpesvirus infection (252)
- TGF-beta signaling pathway (754)
- Arginine and proline metabolism (48)
- Ubiquinone and other terpenoid-quinone biosynthesis (11)
- Choline metabolism in cancer (97)
- Gastric acid secretion (78)
- Salmonella infection (80)
- Pyrimidine metabolism (159)
- Glycolysis / Gluconeogenesis (68)
- Fructose and mannose metabolism (33)
- Yersinia infection (121)
- Legionellosis (56)
- Glycosylphosphatidylinositol (GPI)-anchor biosynthesis (25)
- Inositol phosphate metabolism (122)
- Glycerolipid metabolism (61)
- Ether lipid metabolism (46)
- Glycerophospholipid metabolism (96)
- Synaptic vesicle cycle (78)
- Long-term potentiation (90)
- Retrograde endocannabinoid signaling (148)
- Neurotrophin signaling pathway (119)
- Longevity regulating pathway (89)
- Glutamatergic synapse (116)
- GABAergic synapse (89)
- Serotonergic synapse (115)
- Dopaminergic synapse (135)
- Antifolate resistance (31)
- Melanoma (73)
- Allograft rejection (432)
- Graft-versus-host disease (120)
- Pertussis (75)
- Type II diabetes mellitus (353)
- Insulin resistance (108)
- Non-alcoholic fatty liver disease (NAFLD) (150)
- AGE-RAGE signaling pathway in diabetic complications (100)
- Cushing syndrome (158)
- Bladder cancer (446)
- Fanconi anemia pathway (136)
- Butanoate metabolism (28)
- Proximal tubule bicarbonate reclamation (23)
- Steroid hormone biosynthesis (59)
- Cell cycle (1515)
- PD-L1 expression and PD-1 checkpoint pathway in cancer (88)
- Oocyte meiosis (125)
- beta-Alanine metabolism (33)
- Dilated cardiomyopathy (DCM) (98)
- HIF-1 signaling pathway (109)
- Viral myocarditis (138)
- JAK-STAT signaling pathway (161)
- Renin-angiotensin system (23)
- Phenylalanine metabolism (23)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) (77)
- Endocytosis (309)
- Staphylococcus aureus infection (103)
- D-Glutamine and D-glutamate metabolism (5)
- Longevity regulating pathway - multiple species (62)
- D-Arginine and D-ornithine metabolism (1)
- Long-term depression (61)
- Tight junction (169)
- Small cell lung cancer (1948)
- Chemokine signaling pathway (673)
- Systemic lupus erythematosus (108)
- Acute myeloid leukemia (66)
- Human T-cell leukemia virus 1 infection (300)
- Vibrio cholerae infection (53)
- Glutathione metabolism (95)
- Protein digestion and absorption (95)
- Ribosome biogenesis in eukaryotes (77)
- Fat digestion and absorption (41)
- Nicotinate and nicotinamide metabolism (36)
- Ferroptosis (245)
- GnRH signaling pathway (95)
- Bile secretion (75)
- Lysine degradation (59)
- Vitamin digestion and absorption (24)
- Sulfur relay system (9)
- Propanoate metabolism (34)
- Ubiquitin mediated proteolysis (136)
- Phenylalanine, tyrosine and tryptophan biosynthesis (5)
- Renal cell carcinoma (68)
- Breast cancer (147)
- Type I diabetes mellitus (122)
- ErbB signaling pathway (1924)
- Phagosome (230)
- Starch and sucrose metabolism (34)
- Peroxisome (83)
- Protein processing in endoplasmic reticulum (165)
- Autophagy - animal (137)
- Lysosome (123)
- Alzheimer disease (171)
- Amyotrophic lateral sclerosis (ALS) (137)
- Base excision repair (105)
- Carbohydrate digestion and absorption (42)
- Apoptosis - multiple species (33)
- Vasopressin-regulated water reabsorption (47)
- Huntington disease (312)
- Biosynthesis of unsaturated fatty acids (27)
- Gap junction (91)
- FoxO signaling pathway (129)
- African trypanosomiasis (35)
- TNF signaling pathway (112)
- Rheumatoid arthritis (103)
- Asthma (42)
- Hypertrophic cardiomyopathy (HCM) (90)
- RNA degradation (78)
- Circadian entrainment (100)
- Amoebiasis (104)
- Pantothenate and CoA biosynthesis (19)
- mRNA surveillance pathway (88)
- RNA transport (157)
- Ribosome (134)
- Regulation of actin cytoskeleton (883)
- SNARE interactions in vesicular transport (34)
- One carbon pool by folate (19)
- Malaria (47)
- Autophagy - other (32)
- Mitophagy - animal (65)
- p53 signaling pathway (74)
- Epithelial cell signaling in Helicobacter pylori infection (70)
- Maturity onset diabetes of the young (26)
- Cysteine and methionine metabolism (49)
- Mucin type O-glycan biosynthesis (30)
- Various types of N-glycan biosynthesis (39)
- N-Glycan biosynthesis (50)
- Other glycan degradation (18)
- AMPK signaling pathway (120)
- Steroid biosynthesis (36)
- Other types of O-glycan biosynthesis (22)
- Mannose type O-glycan biosynthesis (23)
- Necroptosis (151)
- Carbon metabolism (117)
- Selenocompound metabolism (17)
- Thermogenesis (1264)
- Glucagon signaling pathway (109)
- Signaling pathways regulating pluripotency of stem cells (139)
- ABC transporters (45)
- Basal cell carcinoma (63)
- Aminoacyl-tRNA biosynthesis (44)
- Cardiac muscle contraction (86)
- Hepatocellular carcinoma (168)
- Nicotine addiction (40)
- Thyroid hormone signaling pathway (119)
- Adrenergic signaling in cardiomyocytes (152)
- Prostate cancer (97)
- Riboflavin metabolism (8)
- Basal transcription factors (44)
- RNA polymerase (32)
- Hippo signaling pathway (154)
- Hippo signaling pathway - multiple species (28)
- Endometrial cancer (1123)
- Chagas disease (American trypanosomiasis) (104)
- Glycine, serine and threonine metabolism (40)
- C-type lectin receptor signaling pathway (104)
- Calcium signaling pathway (195)
- Synthesis and degradation of ketone bodies (19)
- Toll-like receptor signaling pathway (621)
- NOD-like receptor signaling pathway (174)
- cAMP signaling pathway (217)
- Cytosolic DNA-sensing pathway (773)
- Mismatch repair (38)
- VEGF signaling pathway (119)
- Apelin signaling pathway (136)
- Phosphonate and phosphinate metabolism (6)
- Estrogen signaling pathway (798)
- Fatty acid metabolism (233)
- Fluid shear stress and atherosclerosis (138)
- 2-Oxocarboxylic acid metabolism (17)
- Vascular smooth muscle contraction (135)
- Autoimmune thyroid disease (130)
- Fatty acid degradation (44)
- Metabolic pathways (1433)
- Metabolism of xenobiotics by cytochrome P450 (73)
- Drug metabolism - other enzymes (77)
- Drug metabolism - cytochrome P450 (69)
- Endocrine and other factor-regulated calcium reabsorption (53)
- Oxidative phosphorylation (245)
- Vitamin B6 metabolism (9)
- Porphyrin and chlorophyll metabolism (41)
- Aldosterone-regulated sodium reabsorption (37)
- DNA replication (225)
- Hepatitis C (154)
- alpha-Linolenic acid metabolism (24)
- Renin secretion (72)
- Arachidonic acid metabolism (121)
- Linoleic acid metabolism (28)
- Tuberculosis (189)
- Terpenoid backbone biosynthesis (21)
- Collecting duct acid secretion (27)
- Th17 cell differentiation (119)
- Th1 and Th2 cell differentiation (104)
- Rap1 signaling pathway (213)
- Ras signaling pathway (230)
- Salivary secretion (90)
- Valine, leucine and isoleucine biosynthesis (4)
- Pancreatic secretion (103)
- MAPK signaling pathway (2206)
- Fatty acid elongation (27)
- Natural killer cell mediated cytotoxicity (195)
- Leishmaniasis (87)
- Fatty acid biosynthesis (59)
- Mineral absorption (53)
- Cholesterol metabolism (51)
- IL-17 signaling pathway (92)
- Toxoplasmosis (124)
- Taurine and hypotaurine metabolism (11)
- Primary bile acid biosynthesis (17)
- Sphingolipid signaling pathway (119)
- Phosphatidylinositol signaling system (99)
- Phospholipase D signaling pathway (149)
- Primary immunodeficiency (36)
- Caffeine metabolism (5)
- Bacterial invasion of epithelial cells (73)
- Purine metabolism (188)
- PPAR signaling pathway (305)
- Shigellosis (67)
- Amphetamine addiction (71)
- Pathogenic Escherichia coli infection (307)
- Homologous recombination (130)
- Proteoglycans in cancer (201)
- Chemical carcinogenesis (80)
- Prolactin signaling pathway (1345)
- MicroRNAs in cancer (161)
- Antigen processing and presentation (156)
- Wnt signaling pathway (1310)
- Viral carcinogenesis (251)
- Transcriptional misregulation in cancer (172)
- Spliceosome (133)
- Hepatitis B (160)
- Parkinson disease (231)
- Glycosphingolipid biosynthesis - globo and isoglobo series (15)
- Sphingolipid metabolism (137)
- Glycosphingolipid biosynthesis - lacto and neolacto series (27)
- Measles (138)
- Nitrogen metabolism (17)
- Pathways in cancer (532)
- Human papillomavirus infection (399)
- Neuroactive ligand-receptor interaction (338)
- Osteoclast differentiation (127)
- Ascorbate and aldarate metabolism (26)
- Galactose metabolism (31)
- Valine, leucine and isoleucine degradation (48)
- Human immunodeficiency virus 1 infection (276)
- Influenza A (179)
- Hematopoietic cell lineage (108)
- Neomycin, kanamycin and gentamicin biosynthesis (5)
- Tyrosine metabolism (44)
- cGMP-PKG signaling pathway (166)
- Amino sugar and nucleotide sugar metabolism (48)
- Biosynthesis of amino acids (74)
- Apoptosis (1245)
- NF-kappa B signaling pathway (99)
- Arginine biosynthesis (26)
- Pentose phosphate pathway (63)
- Cytokine-cytokine receptor interaction (290)
- Viral protein interaction with cytokine and cytokine receptor (98)
- Cellular senescence (392)
- Biotin metabolism (3)
- Cholinergic synapse (112)
- Lipoic acid metabolism (3)
- Human cytomegalovirus infection (293)
- Notch signaling pathway (533)
- Non-homologous end-joining (13)
- Epstein-Barr virus infection (279)
- Thyroid cancer (37)
- Taste transduction (83)
- Glioma (76)
- Olfactory transduction (441)
- Pancreatic cancer (76)
- Thyroid hormone synthesis (77)
- Colorectal cancer (87)
- Phototransduction (28)
- Morphine addiction (94)
- Proteasome (46)
- RIG-I-like receptor signaling pathway (69)
- Glyoxylate and dicarboxylate metabolism (30)
- Sulfur metabolism (10)
- Alcoholism (151)
- Cocaine addiction (52)
- Pentose and glucuronate interconversions (33)
- Ovarian steroidogenesis (51)
- Insulin signaling pathway (137)
- Insulin secretion (89)
- Melanogenesis (104)
- Intestinal immune network for IgA production (59)
- Thiamine metabolism (17)
- Leukocyte transendothelial migration (112)
- Herpes simplex virus 1 infection (567)
- Glycosaminoglycan degradation (19)
- Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate (20)
- Glycosaminoglycan biosynthesis - keratan sulfate (14)
- Glycosaminoglycan biosynthesis - heparan sulfate / heparin (24)
- Progesterone-mediated oocyte maturation (96)
- Hedgehog signaling pathway (334)
- Adrenaline and noradrenaline biosynthesis (27)
- Alpha adrenergic receptor signaling pathway (23)
- Alzheimer disease-amyloid secretase pathway (63)
- Alzheimer disease-presenilin pathway (110)
- Angiogenesis (420)
- Apoptosis signaling pathway (107)
- Axon guidance mediated by semaphorins (19)
- Axon guidance mediated by Slit/Robo (18)
- Axon guidance mediated by netrin (30)
- B cell activation (54)
- Blood coagulation (38)
- Cadherin signaling pathway (150)
- Cholesterol biosynthesis (37)
- Circadian clock system (9)
- Cytoskeletal regulation by Rho GTPase (70)
- EGF receptor signaling pathway (114)
- untitled (102)
- FAS signaling pathway (37)
- FGF signaling pathway (159)
- General transcription by RNA polymerase I (15)
- General transcription regulation (30)
- Glycolysis (86)
- Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway (150)
- Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway (118)
- Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction (33)
- Hypoxia response via HIF activation (19)
- Inflammation mediated by chemokine and cytokine signaling pathway (196)
- Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade (29)
- Insulin/IGF pathway-protein kinase B signaling cascade (23)
- Integrin signalling pathway (166)
- Interferon-gamma signaling pathway (28)
- Interleukin signaling pathway (80)
- Ionotropic glutamate receptor pathway (42)
- JAK/STAT signaling pathway (15)
- Metabotropic glutamate receptor group III pathway (65)
- Metabotropic glutamate receptor group II pathway (42)
- Metabotropic glutamate receptor group I pathway (24)
- Muscarinic acetylcholine receptor 1 and 3 signaling pathway (54)
- Muscarinic acetylcholine receptor 2 and 4 signaling pathway (53)
- Nicotinic acetylcholine receptor signaling pathway (86)
- Oxidative stress response (45)
- PDGF signaling pathway (125)
- PI3 kinase pathway (43)
- Plasminogen activating cascade (16)
- TCA cycle (10)
- T cell activation (62)
- Toll receptor signaling pathway (44)
- Transcription regulation by bZIP transcription factor (47)
- mRNA splicing (194)
- p53 pathway (102)
- Ubiquitin proteasome pathway (44)
- ATP synthesis (2)
- Acetate utilization (3)
- Adenine and hypoxanthine salvage pathway (6)
- Alanine biosynthesis (2)
- Allantoin degradation (1)
- Aminobutyrate degradation (1)
- Androgen/estrogene/progesterone biosynthesis (9)
- Ascorbate degradation (1)
- Asparagine and aspartate biosynthesis (1)
- Coenzyme A biosynthesis (17)
- Cysteine biosynthesis (1)
- De novo purine biosynthesis (26)
- De novo pyrimidine deoxyribonucleotide biosynthesis (12)
- De novo pyrimidine ribonucleotides biosythesis (10)
- Flavin biosynthesis (2)
- Tetrahydrofolate biosynthesis (5)
- Formyltetrahydroformate biosynthesis (6)
- Fructose galactose metabolism (9)
- Glutamine glutamate conversion (4)
- Heme biosynthesis (32)
- Isoleucine biosynthesis (3)
- Leucine biosynthesis (2)
- Lipoate_biosynthesis (1)
- Mannose metabolism (6)
- Methionine biosynthesis (1)
- Methylcitrate cycle (2)
- Methylmalonyl pathway (8)
- N-acetylglucosamine metabolism (6)
- O-antigen biosynthesis (3)
- Ornithine degradation (3)
- Pyridoxal-5-phosphate biosynthesis (2)
- Phenylethylamine degradation (3)
- Pyridoxal phosphate salvage pathway (2)
- S-adenosylmethionine biosynthesis (3)
- Salvage pyrimidine deoxyribonucleotides (3)
- Salvage pyrimidine ribonucleotides (8)
- Serine glycine biosynthesis (3)
- Succinate to proprionate conversion (3)
- Threonine biosynthesis (1)
- Triacylglycerol metabolism (2)
- Valine biosynthesis (3)
- Xanthine and guanine salvage pathway (4)
- 5-Hydroxytryptamine biosynthesis (3)
- 5-Hydroxytryptamine degredation (18)
- 5HT1 type receptor mediated signaling pathway (42)
- 5HT2 type receptor mediated signaling pathway (46)
- 5HT3 type receptor mediated signaling pathway (13)
- 5HT4 type receptor mediated signaling pathway (31)
- Beta1 adrenergic receptor signaling pathway (32)
- Beta2 adrenergic receptor signaling pathway (24)
- Beta3 adrenergic receptor signaling pathway (26)
- Cortocotropin releasing factor receptor signaling pathway (30)
- Gamma-aminobutyric acid synthesis (5)
- Histamine H1 receptor mediated signaling pathway (41)
- Histamine H2 receptor mediated signaling pathway (24)
- Histamine synthesis (1)
- Oxytocin receptor mediated signaling pathway (46)
- P53 pathway feedback loops 1 (6)
- Ras Pathway (70)
- Thyrotropin-releasing hormone receptor signaling pathway (56)
- Vasopressin synthesis (11)
- Vitamin D metabolism and pathway (8)
- p53 pathway by glucose deprivation (21)
- p53 pathway feedback loops 2 (43)
- 5-arachidonylglycerol_biosynthesis (7)
- Anandamide_degradation (1)
- Bupropion_degradation (1)
- Endogenous_cannabinoid_signaling (24)
- GABA-B_receptor_II_signaling (35)
- Synaptic_vesicle_trafficking (21)
- Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin (35)
- PNAT (51)
- Enkephalin release (33)
- Nicotine_degradation (9)
- Opioid proenkephalin pathway (30)
- Opioid proopiomelanocortin pathway (30)
- p38 MAPK pathway (32)
- Nicotine pharmacodynamics pathway (28)
- Gastrin_CCK2R_240212 (147)
- adenine and adenosine salvage I (1)
- Succinic acid + Ubiquinone = Fumaric acid + Ubiquinol ( Arginine and Proline metabolism ) (2)
- Regulation of Androgen receptor activity (54)
- IL-3 signaling pathway(JAK1 JAK2 STAT5) ( IL-3 signaling(JAK1 JAK2 STAT5) ) (7)
- Raf activation signaling (through Grb2 and Sos) ( CD4 T cell receptor signaling ) (9)
- VEGFR1 specific signals (26)
- Leptin (98)
- 3-Hydroxy-propanoyl-CoA = Propenoyl-CoA + H2O ( Propanoate metabolism ) (3)
- IFN-gamma pathway (40)
- IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1) ( CD4 T cell receptor signaling ) (10)
- T cell receptor signaling (PLC gamma, PKC, Ras and IKK-NF-kappaB cascade) ( CD4 T cell receptor signaling (NF-kB cascade) ) (40)
- IL5 (59)
- Fc-epsilon receptor I signaling in mast cells (64)
- Regulation of RAC1 activity (39)
- NADP+ + GDP-L-fucose = NADPH + GDP-4-dehydro-6-deoxy-D-mannose ( Fructose and Mannose metabolism ) (1)
- IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1) ( CD4 T cell receptor signaling (NF-kB cascade) ) (10)
- Xenopus axis formation Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) (28)
- JNK cascade ( Toll-like receptor signaling pathway (through JNK cascade) ) (18)
- sucrose degradation V (mammalian) (6)
- Cytosolic calcium ion concentration elevation (through IP3 receptor) ( GPCR GroupI metabotropic glutamate receptor signaling pathway ) (2)
- Secretory pathway of Hh ( Hedgehog signaling pathway ) (8)
- Butanoate metabolism ( Butanoate metabolism ) (4)
- EGF signaling pathway ( EGF signaling pathway Diagram ) (13)
- VEGF and VEGFR signaling network (10)
- D-Glucose 6-phosphate = D-Fructose 6-phosphate ( Fructose and Mannose metabolism ) (1)
- thio-molybdenum cofactor biosynthesis (1)
- ATP + Pyruvic acid + CO2 + H2O = ADP + Oxaloacetic acid + Orthophosphate ( Citrate cycle ) (1)
- GMCSF-mediated signaling events (38)
- (R)-Methyl-malonyl-CoA = (S)-Methyl-malonyl-CoA ( Propanoate metabolism ) (1)
- EPHB forward signaling (40)
- Beta catenin degradation signaling (Drosophila) ( Drosophila Wingless/Wnt signaling pathway Diagram ) (1)
- DNA-PK pathway in nonhomologous end joining (13)
- Galactose metabolism ( Galactose metabolism ) (6)
- D-myo-inositol-5-phosphate metabolism (19)
- AKT(PKB) activation signaling ( PDGF signaling pathway ) (14)
- S1P2 pathway (26)
- AlphaE beta7 integrin cell surface interactions (3)
- Beta catenin degradation signaling (Canonical) ( Mammalian Wnt signaling pathway Diagram ) (8)
- NADP+ + D-Glucose = NADPH + D-Glucono-1,5-lactone ( Pentose phosphate cycle ) (1)
- creatine-phosphate biosynthesis (4)
- IL-12 signaling pathway(JAK2 TYK2 STAT4) ( IL-12 signaling(JAK2 TYK2 STAT4) ) (7)
- 3-Hydroxy-isopentyl-CoA = 3-Methylbut-2-enoyl-CoA + H2O ( Valine,Leucine and Isoleucine degradation ) (3)
- a4b7 Integrin signaling (8)
- Signaling by Aurora kinases (3)
- G alpha s GDP-GTP exchange signaling ( GPCR signaling (cholera toxin) ) (35)
- D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis (3)
- glutamate removal from folates (1)
- Notch secretory pathway (Mammal) ( Notch signaling pathway Diagram ) (2)
- Angiopoietin receptor Tie2-mediated signaling (50)
- sulfate activation for sulfonation (2)
- NAD+ + (S)-Malic acid = NADH + Pyruvic acid + CO2 ( Pyruvate metabolism ) (3)
- Nicotinate and Nicotinamide metabolism ( Nicotinate and Nicotinamide metabolism ) (18)
- dermatan sulfate degradation (metazoa) (4)
- BMP2 signaling pathway(through Smad) ( TGF-beta_BMP Diagram(MolecularVariation) ) (13)
- Inosine + Orthophosphate = Hypoxanthine + D-Ribose 1-phosphate ( Purine nucleotides and Nucleosides metabolism ) (1)
- glycine degradation (creatine biosynthesis) (2)
- S-methyl-5'-thioadenosine degradation II (1)
- UTP + D-Glucose 1-phosphate = Pyrophosphate + UDP-D-glucose ( Galactose metabolism ) (1)
- AMP + Pyrophosphate = Adenine + D-5-Phospho-ribosyl 1-diphosphate ( Purine nucleotides and Nucleosides metabolism ) (2)
- Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) (47)
- D-Ribose 1-phosphate = D-Ribose 5-phosphate ( Pentose phosphate cycle ) (1)
- Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) (56)
- AKT(PKB)-Bad signaling ( Insulin receptor signaling (Mammal) ) (11)
- IL4-mediated signaling events (66)
- Gene expression of c-FLIP ( TNFR1 signaling pathway ) (3)
- ATP + CoA + Citric acid = ADP + Acetyl-CoA + Oxaloacetic acid + Orthophosphate ( Citrate cycle ) (1)
- Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta) ( GPCR GroupI metabotropic glutamate receptor signaling pathway ) (18)
- methylglyoxal degradation III (3)
- Beta1 integrin cell surface interactions (70)
- purine nucleotides de novo biosynthesis II (11)
- histamine biosynthesis (1)
- ATP + Pyruvic acid + CO2 + H2O = ADP + Oxaloacetic acid + Orthophosphate ( Glycolysis and Gluconeogenesis ) (1)
- 5,6-Dihydro-thymine + H2O = 3-Ureido-2-methyl-propanoic acid ( Pyrimidine Nucleotides and Nucleosides metabolism ) (1)
- IFN alpha signaling pathway(JAK1 TYK2 STAT1) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) (17)
- UDP-D-xylose and UDP-D-glucuronate biosynthesis (2)
- ERK cascade ( Integrin signaling pathway ) (10)
- EGF signaling pathway (D. melanogaster) ( EGF signaling pathway Diagram ) (7)
- heme biosynthesis II (9)
- glycine biosynthesis III (2)
- 5-Formimino-tetrahydro-folic acid = 5,10-Methenyl-tetrahydro-folic acid + NH3 ( Folate metabolism ) (1)
- Negative regulation of (G alpha i GDP-GTP exchange signaling) ( GPCR signaling (G alpha i) ) (21)
- Mammalian Hh signaling pathway ( Hedgehog signaling pathway ) (6)
- EPO signaling pathway (34)
- ErbB1 downstream signaling (102)
- Notch secretory pathway ( Notch signaling pathway Diagram ) (5)
- Lysine degradation ( Lysine degradation ) (6)
- Notch degradation signaling ( Notch signaling pathway Diagram ) (5)
- Visual signal transduction: Rods (24)
- Succinyl-CoA + Dihydro-lipoamide = CoA + S-Succinyl-dihydro-lipoamide ( Citrate cycle ) (1)
- threonine degradation II (1)
- Hedgehog (39)
- S1P1 pathway (20)
- BMP2 signaling pathway(through TAK1) ( BMP2 signaling(through TAK1) ) (8)
- ERK cascade ( EGF signaling pathway Diagram ) (6)
- guanine and guanosine salvage I (2)
- Negative regulation of (Dimerization of STAT) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) (3)
- Insulin Pathway (47)
- IL-13 signaling pathway(JAK1 TYK2 STAT6) ( IL-13 signaling(JAK1 TYK2 STAT6) ) (10)
- Calcineurin activation signaling ( CD4 T cell receptor signaling ) (4)
- (S)-3-Hydroxy-3-methyl-glutaryl-CoA = 3-Methyl-glutaconyl-CoA + H2O ( Valine,Leucine and Isoleucine degradation ) (1)
- EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) (12)
- Adenylate cyclase inactivation signaling ( GPCR signaling (G alpha i) ) (12)
- Endogenous TLR signaling (24)
- Plasma membrane estrogen receptor signaling (42)
- CDP-diacylglycerol biosynthesis I (19)
- TGF beta receptor I degradation signaling ( TGF-beta_super_family_signaling_pathway(canonical) ) (43)
- Canonical Wnt signaling pathway (21)
- phenylalanine degradation I (aerobic) (4)
- inosine-5'-phosphate biosynthesis II (3)
- D-Ribose 5-phosphate = D-Ribulose 5-phosphate ( Pentose phosphate cycle ) (1)
- Activation of Smo ( Hedgehog signaling pathway ) (4)
- colanic acid building blocks biosynthesis (13)
- CoA + GTP + Succinic acid = Succinyl-CoA + GDP + Orthophosphate ( Citrate cycle ) (2)
- NAD+ + 3,4-Dihydroxy-phenyl-acetaldehyde + H2O = NADH + 3,4-Dihydroxy-phenyl-acetic acid ( Tyrosine metabolism ) (4)
- Porphyrin_metabolism ( Porphyrin metabolism ) (7)
- Heterotrimeric GPCR signaling pathway (through Adenosine G alpha s) ( GPCR Adenosine A2A receptor signaling pathway ) (9)
- Signaling without Hh ( Hedgehog signaling pathway ) (13)
- AKT(PKB) activation signaling ( Insulin receptor signaling ) (7)
- Regulation of p38-alpha and p38-beta (31)
- superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism (20)
- D-Glucose 6-phosphate = D-Fructose 6-phosphate ( Pentose phosphate cycle ) (1)
- IL8- and CXCR1-mediated signaling events (29)
- E2F transcription factor network (77)
- Beta3 integrin cell surface interactions (44)
- IL2 signaling events mediated by PI3K (35)
- Stabilization and accumulation of cytoplasmic beta-catenin (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) (12)
- ERK cascade ( PDGF signaling pathway ) (13)
- 5-Formimino-tetrahydro-folic acid + L-Glutamic acid = L-Tetrahydro-folic acid + N-Formimino-L-glutamic acid ( Histidine degradation ) (1)
- Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s) ( GPCR signaling (cholera toxin) ) (12)
- 3-phosphoinositide degradation (21)
- Glypican 2 network (2)
- (S)-3-Hydroxy-butanoyl-CoA = Crotonoyl-CoA + H2O ( Lysine degradation ) (3)
- IMP + H2O = 5'-Phospho-ribosyl-4-carboxamido-5-formamido-imidazole ( Purine nucleotides and Nucleosides metabolism ) (1)
- dermatan sulfate biosynthesis (late stages) (4)
- Negative feedback regulation of FGF8 signaling by Mkp3 (Xenopus) ( FGF signaling pathway ) (3)
- ATP + dADP = ADP + dATP ( Purine nucleotides and Nucleosides metabolism ) (7)
- Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram ) (56)
- (S)-3-Hydroxy-2-methyl-butanoyl-CoA = 2-Methylbut-2-enoyl-CoA + H2O ( Valine,Leucine and Isoleucine degradation ) (3)
- Validated transcriptional targets of AP1 family members Fra1 and Fra2 (37)
- D-myo-inositol (1,3,4)-trisphosphate biosynthesis (15)
- Tryptophan degradation ( Tryptophan degradation ) (60)
- Drosophila Notch signaling pathway ( Notch signaling pathway Diagram ) (4)
- Regulation of nuclear SMAD2/3 signaling (82)
- PLK1 signaling events (48)
- 2 Farnesyl diphosphate + NADPH => NADP+ + Squalene + 2 Pyrophosphate ( Steroids metabolism ) (1)
- UTP + AMP = UDP + ADP ( Pyrimidine Nucleotides and Nucleosides metabolism ) (1)
- 4-hydroxyphenylpyruvate biosynthesis (1)
- Heterotrimeric GPCR signaling pathway (through G alpha q, PLC beta and ERK cascade) ( GPCR signaling (G alpha q) ) (235)
- Nephrin/Neph1 signaling in the kidney podocyte (28)
- ketolysis (6)
- (S)-Malic acid = Fumaric acid + H2O ( Arginine and Proline metabolism ) (1)
- Rap1 activation signaling (through cAMP and Epac) ( GPCR signaling (G alpha s, Epac and ERK) ) (4)
- E-cadherin signaling in the nascent adherens junction (37)
- lanosterol biosynthesis (1)
- IL-6 signaling pathway(JAK1 JAK2 STAT3) ( IL-6 signaling(JAK1 JAK2 STAT3) ) (6)
- ATR signaling pathway (39)
- Syndecan-1-mediated signaling events (42)
- IL23-mediated signaling events (37)
- Signaling events mediated by Stem cell factor receptor (c-Kit) (53)
- ATP + ADP = ADP + ATP ( Purine nucleotides and Nucleosides metabolism ) (7)
- Prolactin (104)
- glutathione-mediated detoxification I (25)
- Pyruvic acid + Enzyme N6-(lipoyl)lysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2 ( Pyruvate metabolism ) (3)
- arginine degradation I (arginase pathway) (4)
- Integrin-linked kinase signaling (46)
- Nongenotropic Androgen signaling (31)
- CD40/CD40L signaling (36)
- spermidine biosynthesis I (2)
- Posttranslational regulation of adherens junction stability and dissassembly (50)
- superpathway of serine and glycine biosynthesis I (5)
- Validated transcriptional targets of TAp63 isoforms (54)
- Coregulation of Androgen receptor activity (61)
- JNK signaling in the CD4+ TCR pathway (14)
- Raf activation signaling (through Grb2 and Sos) ( JAK-STAT pathway and regulation pathway Diagram ) (9)
- FOXM1 transcription factor network (40)
- Guanosine + Orthophosphate = Guanine + D-Ribose 1-phosphate ( Purine nucleotides and Nucleosides metabolism ) (1)
- Drosophila Wingless/Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) (9)
- CXCR4-mediated signaling events (87)
- 5,6-Dihydro-uracil + H2O = Ureido-propanoic acid ( Pyrimidine Nucleotides and Nucleosides metabolism ) (1)
- Succinic acid + Ubiquinone = Fumaric acid + Ubiquinol ( Tyrosine metabolism ) (2)
- ATP + dCMP = ADP + dCDP ( Pyrimidine Nucleotides and Nucleosides metabolism ) (1)
- Direct p53 effectors (137)
- NAD+ + 4-Hydroxy-phenyl-acetaldehyde + H2O = NADH + 4-Hydroxy-phenyl-acetic acid ( Tyrosine metabolism ) (4)
- BMP Signalling Pathway (6)
- TPO signaling pathway(JAK2 STAT3) ( TPO signaling(JAK2 STAT3) ) (4)
- L-Serine + Pyruvic acid = Hydroxy-pyruvic acid + L-Alanine ( Glycine and Serine metabolism ) (1)
- Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s) ( GPCR signaling (G alpha s, PKA and ERK) ) (12)
- Butanoyl-CoA + Acceptor = Crotonoyl-CoA + Reduced acceptor ( Butanoate metabolism ) (1)
- B-Raf activation signaling ( GPCR signaling (G alpha s, Epac and ERK) ) (3)
- alpha-tocopherol degradation (1)
- Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) (8)
- Growth hormone signaling pathway(JAK2 STAT5) ( Growth hormone signaling(JAK2 STAT5) ) (9)
- D-Fructose 1,6-bisphosphate = Dihydroxy-acetone phosphate + D-Glyceraldehyde 3-phosphate ( Pentose phosphate cycle ) (3)
- PDGFR-beta signaling pathway (125)
- D-glucuronate degradation I (2)
- Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s) ( GPCR Dopamine D1like receptor signaling pathway ) (45)
- Caspase3 activation signaling ( TNFR1 signaling pathway ) (4)
- amb2 Integrin signaling (32)
- oxidized GTP and dGTP detoxification (1)
- L-carnitine biosynthesis (3)
- Syndecan-2-mediated signaling events (38)
- Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) (178)
- urea cycle (16)
- NF-kB signaling ( IL-1 signaling pathway (through NF-kappaB) ) (12)
- anandamide degradation (2)
- glutamate degradation X (2)
- Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) (56)
- leukotriene biosynthesis (7)
- IL-4 signaling pathway(JAK1 JAK3 STAT6) ( IL-4 signaling(JAK1 JAK3 STAT6) ) (7)
- FGF signaling pathway (D. melanogaster tracheal cells) ( FGF signaling pathway ) (7)
- Phospholipase C gamma signaling ( CD4 T cell receptor signaling (JNK cascade) ) (5)
- tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate (4)
- Signaling events mediated by VEGFR1 and VEGFR2 (66)
- trehalose degradation II (trehalase) (4)
- Deoxy-inosine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Hypoxanthine ( Purine nucleotides and Nucleosides metabolism ) (1)
- AP-1 transcription factor network (71)
- folate polyglutamylation (5)
- 2-Oxo-glutaric acid + L-Cysteine = L-Glutamic acid + 3-Mercapto-pyruvic acid ( Methionine and Cysteine metabolism ) (2)
- NADPH + Cholesterol + O2 = NADP+ + 7-Hydroxy-cholesterol + H2O ( Steroids metabolism ) (1)
- (S)-2,3-Epoxy-squalene = Lanosterol ( Steroids metabolism ) (1)
- NAD+ + (R)-Lactic acid = NADH + Pyruvic acid ( Glycolysis and Gluconeogenesis ) (1)
- Stabilization and accumulation of cytoplasmic beta-catenin (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) (24)
- Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) (47)
- Toll-like receptor signaling pathway (through JNK cascade)(Canonical) ( Toll-like receptor signaling pathway (through JNK cascade) ) (14)
- Choloyl-CoA + Taurine = CoA + Taurocholic acid ( Methionine and Cysteine metabolism ) (1)
- thyroid hormone biosynthesis (2)
- ERK cascade ( FGF signaling pathway ) (42)
- tetrapyrrole biosynthesis II (5)
- TCR signaling in naïve CD4+ T cells (69)
- IGF1 pathway (30)
- NAD+ + D-Glycerate 3-phosphate = NADH + 3-Phospho-hydroxy-pyruvic acid ( Glycine and Serine metabolism ) (1)
- D-Fructose 6-phosphate + D-Glyceraldehyde 3-phosphate = D-Erythrose 4-phosphate + D-Xylulose 5-phosphate ( Pentose phosphate cycle ) (3)
- ERK cascade ( CD4 T cell receptor signaling (ERK cascade) ) (10)
- NAD+ + 2-Hydroxy-butanoic acid = NADH + 2-Oxo-butanoic acid ( Propanoate metabolism ) (4)
- glucose and glucose-1-phosphate degradation (5)
- Raf activation signaling (through Grb2 and Sos) ( B cell receptor signaling ) (9)
- ATP + D-Ribose 5-phosphate = AMP + D-5-Phospho-ribosyl 1-diphosphate ( Pyrimidine Nucleotides and Nucleosides metabolism ) (2)
- ATP + dUDP = ADP + dUTP ( Pyrimidine Nucleotides and Nucleosides metabolism ) (7)
- MAP kinase cascade (1)
- regulation of target gene expression by AP-1 ( IL-1 signaling pathway (through JNK cascade) ) (3)
- 2 Acetyl-CoA = CoA + Acetoacetyl-CoA ( Tryptophan degradation ) (2)
- ERK cascade ( GPCR GroupI metabotropic glutamate receptor signaling pathway ) (7)
- AKT(PKB)-Bad signaling ( Insulin receptor signaling ) (11)
- PDGFR-alpha signaling pathway (22)
- methylglyoxal degradation VI (1)
- EPHA2 forward signaling (19)
- Signaling with high concentrations of Hh ( Hedgehog signaling pathway ) (2)
- ErbB2/ErbB3 signaling events (41)
- ATP + CoA + Citric acid = ADP + Acetyl-CoA + Oxaloacetic acid + Orthophosphate ( Lysine degradation ) (1)
- ketogenesis (6)
- (R)-Methyl-malonyl-CoA = Succinyl-CoA ( Propanoate metabolism ) (1)
- AKT(PKB)-GSK3beta signaling ( Insulin receptor signaling ) (6)
- ATP + dIDP = ADP + dITP ( Purine nucleotides and Nucleosides metabolism ) (7)
- Rap1 activation signaling (through cAMP, PKA, Cbl and C3G) ( GPCR Adenosine A2A receptor signaling pathway ) (11)
- pyridoxal 5'-phosphate salvage pathway (2)
- ATP + D-Glycerate 3-phosphate = ADP + 1,3-Bisphospho-D-glyceric acid ( Glycolysis and Gluconeogenesis ) (2)
- Inactivation of Ptc by Hh ( Hedgehog signaling pathway ) (9)
- Calcineurin-regulated NFAT-dependent transcription in lymphocytes (47)
- ATP + GDP = ADP + GTP ( Purine nucleotides and Nucleosides metabolism ) (7)
- Caspase3 activation signaling ( Fas signaling pathway ) (4)
- AKT(PKB) activation signaling ( Insulin receptor signaling (Mammal) ) (13)
- diphthamide biosynthesis (1)
- Thrombin/protease-activated receptor (PAR) pathway (1)
- Citric acid = Isocitric acid ( Citrate cycle ) (4)
- Stabilization and accumulation of cytoplasmic beta-catenin (Canonical) ( Mammalian Wnt signaling pathway Diagram ) (24)
- (S)-reticuline biosynthesis II (1)
- Thymidine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Thymine ( Pyrimidine Nucleotides and Nucleosides metabolism ) (1)
- 2-Oxo-glutaric acid + L-Cysteine = L-Glutamic acid + 3-Mercapto-pyruvic acid ( Glycine and Serine metabolism ) (2)
- NAD+ + Isocitric acid = NADH + 2-Oxo-glutaric acid + CO2 ( Citrate cycle ) (3)
- VEGF signaling pathway ( VEGF signaling pathway ) (183)
- noradrenaline and adrenaline degradation (10)
- BCR signaling pathway (67)
- FOXA1 transcription factor network (45)
- serotonin and melatonin biosynthesis (10)
- Internalization of ErbB1 (38)
- trans, trans-farnesyl diphosphate biosynthesis (4)
- purine nucleotides degradation II (aerobic) (12)
- Wnt secretory pathway (Canonical) ( Canonical Wnt signaling pathway Diagram ) (19)
- arginine degradation VI (arginase 2 pathway) (6)
- Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) (8)
- Gene expression of Mkp3 ( FGF signaling pathway ) (1)
- Negative feedback regulation of FGF8 signaling by Sprouty1 (Xenopus) ( FGF signaling pathway ) (3)
- Cytokine receptor degradation signaling ( JAK-STAT pathway and regulation pathway Diagram ) (40)
- chondroitin sulfate degradation (metazoa) (6)
- PLK2 and PLK4 events (2)
- Succinic acid + Ubiquinone = Fumaric acid + Ubiquinol ( Citrate cycle ) (2)
- oleate biosynthesis II (animals) (8)
- Nicotinate D-ribonucleoside + Orthophosphate = Nicotinic acid + D-Ribose 1-phosphate ( Nicotinate and Nicotinamide metabolism ) (1)
- Hh signaling pathway ( Hedgehog signaling pathway ) (5)
- superpathway of cholesterol biosynthesis (27)
- Visual signal transduction: Cones (24)
- Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) (80)
- NAD+ + (R)-3-Hydroxy-butanoic acid = NADH + Acetoacetic acid ( Butanoate metabolism ) (1)
- NAD+ + L-Glutamic acid + H2O = NADH + 2-Oxo-glutaric acid + NH3 ( Arginine and Proline metabolism ) (4)
- Notch degradation signaling (C. elegans) ( Notch signaling pathway Diagram ) (4)
- Gene expression of Sprouty1 ( FGF signaling pathway ) (1)
- JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) (96)
- Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) (47)
- Validated targets of C-MYC transcriptional activation (80)
- ERK cascade ( GPCR signaling (G alpha q) ) (7)
- ATP + L-Glutamic acid + NH3 = ADP + L-Glutamine + Orthophosphate ( Glutamic acid and Glutamine metabolism ) (1)
- Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) (8)
- pentose phosphate pathway (non-oxidative branch) (6)
- sorbitol degradation I (1)
- urate biosynthesis/inosine 5'-phosphate degradation (7)
- AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) (173)
- uridine-5'-phosphate biosynthesis (2)
- spermine and spermidine degradation I (5)
- IL12-mediated signaling events (62)
- phenylethylamine degradation I (4)
- CD4 T cell receptor signaling (through Vav, Rac and JNK cascade ( CD4 T cell receptor signaling (JNK cascade) ) (40)
- NAD+ + 3-Mercapto-lactic acid = NADH + 3-Mercapto-pyruvic acid ( Methionine and Cysteine metabolism ) (4)
- Sumoylation by RanBP2 regulates transcriptional repression (15)
- IKK-NFkB cascade ( TNFR1 signaling pathway ) (11)
- Toll-like receptor signaling pathway (p38 cascade) ( Toll-like receptor signaling pathway (p38 cascade) ) (14)
- lysine degradation II (3)
- EGFR1 (472)
- tyrosine degradation I (5)
- NAD+ + 3-Methoxy-4-hydroxy-phenyl-glycolaldehyde + H2O = NADH + 3-Methoxy-4-hydroxy-mandelic acid ( Tyrosine metabolism ) (4)
- NAD+ + CoA + (S)-Methyl-malonate semialdehyde => NADH + Propanoyl-CoA + CO2 ( Valine,Leucine and Isoleucine degradation ) (1)
- Atypical NF-kappaB pathway (14)
- TCR (258)
- methylthiopropionate biosynthesis (1)
- fatty acid alpha-oxidation III (3)
- ATP + D-Ribose 5-phosphate = AMP + D-5-Phospho-ribosyl 1-diphosphate ( Purine nucleotides and Nucleosides metabolism ) (4)
- L-Alanine + Glyoxylic acid = Pyruvic acid + Glycine ( Alanine,Aspartic acid and Asparagine metabolism ) (2)
- IKK-NF-kappaB cascade ( B cell receptor signaling ) (8)
- IL27-mediated signaling events (26)
- D-Glucose 1-phosphate = D-Glucose 6-phosphate ( Glycolysis and Gluconeogenesis ) (1)
- TCR signaling in naïve CD8+ T cells (56)
- IMP + Pyrophosphate = Hypoxanthine + D-5-Phospho-ribosyl 1-diphosphate ( Purine nucleotides and Nucleosides metabolism ) (1)
- NAD+ + (S)-3-Hydroxy-butanoyl-CoA = NADH + Acetoacetyl-CoA ( Butanoate metabolism ) (4)
- cholesterol biosynthesis I (13)
- Alanine,Aspartic acid and Asparagine metabolism ( Alanine,Aspartic acid and Asparagine metabolism ) (12)
- IGF1 signaling pathway ( IGF1 signaling pathway ) (27)
- p38 cascade ( BMP2 signaling(through TAK1) ) (8)
- NAD+ + Acetaldehyde + H2O = NADH + Acetic acid ( Pyruvate metabolism ) (7)
- taurine biosynthesis (2)
- Fas signaling pathway ( Fas signaling pathway ) (21)
- NAD+ + (S)-3-Hydroxy-butanoyl-CoA = NADH + Acetoacetyl-CoA ( Tryptophan degradation ) (4)
- Signaling events mediated by the Hedgehog family (24)
- D-Fructose 1-phosphate = Dihydroxy-acetone phosphate + D-Glyceraldehyde ( Fructose and Mannose metabolism ) (3)
- p38 MAPK signaling pathway (527)
- Ras signaling in the CD4+ TCR pathway (14)
- glutamate biosynthesis II (2)
- NAD+ + D-Sorbitol = NADH + D-Fructose ( Fructose and Mannose metabolism ) (1)
- Adenosine + Orthophosphate = Adenine + D-Ribose 1-phosphate ( Purine nucleotides and Nucleosides metabolism ) (1)
- Adenylate cyclase activation signaling ( GPCR signaling (G alpha i) ) (11)
- CXCR3-mediated signaling events (38)
- L-Arginine + Glycine = L-Ornithine + Guanidino-acetic acid ( Glycine and Serine metabolism ) (1)
- all-trans-decaprenyl diphosphate biosynthesis (2)
- IL-7 (28)
- Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) (8)
- Wnt secretory pathway (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) (19)
- Pentose phosphate cycle ( Pentose phosphate cycle ) (10)
- D-Mannose 6-phosphate = D-Fructose 6-phosphate ( Fructose and Mannose metabolism ) (1)
- L-cysteine degradation III (1)
- AKT(PKB)-mTOR signaling ( Insulin receptor signaling (Mammal) ) (15)
- ALK2 signaling events (11)
- citrulline degradation (1)
- TGF_beta_Receptor (220)
- B cell receptor signaling pathway ( B cell receptor signaling ) (63)
- NADH + (S)-1-Pyrroline-5-carboxylic acid = NAD+ + L-Proline ( Arginine and Proline metabolism ) (2)
- Beta2 integrin cell surface interactions (29)
- AndrogenReceptor (164)
- ERK cascade ( GPCR signaling (G alpha s, PKA and ERK) ) (5)
- RhoA signaling pathway (46)
- Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, p38 cascade) ( Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, p38 cascade) ) (14)
- D-Glycerate 2-phosphate = Phosphoenol-pyruvic acid + H2O ( Glycolysis and Gluconeogenesis ) (3)
- ATP + IDP = ADP + ITP ( Purine nucleotides and Nucleosides metabolism ) (7)
- PKA activation signaling ( GPCR Dopamine D1like receptor signaling pathway ) (9)
- Signaling events regulated by Ret tyrosine kinase (39)
- Presenilin action in Notch and Wnt signaling (46)
- N6-Acetyl-L-lysine + 2-Oxo-glutaric acid = 6-Acetamido-2-oxo-hexanoic acid + L-Glutamic acid ( Lysine degradation ) (1)
- UDP-D-glucose = UDP-D-galactose ( Galactose metabolism ) (1)
- PRPP biosynthesis I (3)
- Gene expression by FOXO ( Insulin receptor signaling ) (4)
- 2-Oxo-glutaric acid + 4-Amino-butanoic acid = L-Glutamic acid + Succinate semialdehyde ( Arginine and Proline metabolism ) (1)
- Steroids metabolism ( Steroids metabolism ) (10)
- BMP signaling in Drosophila (dorsolateral) ( BMP signaling in Drosophila ) (7)
- salvage pathways of pyrimidine ribonucleotides (16)
- BMP signaling pathway ( BMP signaling in Drosophila ) (34)
- ceramide biosynthesis (5)
- protein citrullination (5)
- Arf1 pathway (28)
- phosphatidylethanolamine biosynthesis II (6)
- glutathione biosynthesis (3)
- L-dopa degradation (1)
- IL-1_signaling(through_IKK-NFkB_cascade)(canonical) ( IL-1 signaling pathway (through NF-kappaB) ) (15)
- Stabilization and accumulation of cytoplasmic beta-catenin (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) (24)
- D-Glucose 6-phosphate = D-Fructose 6-phosphate ( Glycolysis and Gluconeogenesis ) (1)
- gluconeogenesis I (22)
- Beta catenin degradation signaling (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) (3)
- 5'-Orotidylic acid + Pyrophosphate = Orotic acid + D-5-Phospho-ribosyl 1-diphosphate ( Pentose phosphate cycle ) (1)
- PLC beta signaling ( GPCR signaling (G alpha q) ) (5)
- Proteoglycan syndecan-mediated signaling events (4)
- AKT(PKB) activation signaling ( Insulin receptor signaling (D. melanogaster) ) (1)
- 5'-Phospho-ribosyl-4-carboxamido-5-amino-imidazole + Pyrophosphate = 5-Amino-4-imidazole-carboxyamide + D-5-Phospho-ribosyl 1-diphosphate ( Purine nucleotides and Nucleosides metabolism ) (1)
- ATP + CDP = ADP + CTP ( Pyrimidine Nucleotides and Nucleosides metabolism ) (7)
- 2-Methyl-propanoyl-CoA + Acceptor = 2-Methylprop-2-enoyl-CoA + Reduced acceptor ( Valine,Leucine and Isoleucine degradation ) (3)
- FoxO family signaling (50)
- IL8-mediated signaling events (1)
- IL6-mediated signaling events (48)
- Raf activation signaling (through RasGRP) ( CD4 T cell receptor signaling (ERK cascade) ) (8)
- NAD+ + (S)-Lactic acid = NADH + Pyruvic acid ( Glycolysis and Gluconeogenesis ) (4)
- Notch degradation signaling (Mammal) ( Notch signaling pathway Diagram ) (5)
- NAD+ + 2-Propyn-1-al + H2O = NADH + Propiolic acid ( Propanoate metabolism ) (7)
- AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) ) (173)
- NAD+ + L-2-Amino-adipate 6-semialdehyde + H2O = NADH + L-2-Amino-adipic acid ( Lysine degradation ) (1)
- ATM pathway (34)
- CD28 signaling ( CD4 T cell receptor signaling ) (17)
- Arf6 signaling events (36)
- ALK1 signaling events (26)
- T cell receptor signaling pathway ( CD4 T cell receptor signaling ) (43)
- D-Glucosamine 6-phosphate + H2O = D-Fructose 6-phosphate + NH3 ( Fructose and Mannose metabolism ) (1)
- TNFR1 signaling pathway ( TNFR1 signaling pathway ) (15)
- JNK cascade ( Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, JNK cascade) ) (12)
- 5'-Phospho-ribosyl-5-amino-imidazole-4-carboxylic acid = 5'-Phospho-ribosyl-5-amino-imidazole + CO2 ( Purine nucleotides and Nucleosides metabolism ) (1)
- ATP + dCDP = ADP + dCTP ( Pyrimidine Nucleotides and Nucleosides metabolism ) (7)
- NAD salvage pathway III (5)
- S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation (4)
- Negative regulation of (G alpha i GDP-GTP exchange signaling) ( GPCR signaling (pertussis toxin) ) (21)
- 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) (15)
- Alpha4 beta1 integrin signaling events (34)
- D-Mannose 1-phosphate = D-Mannose 6-phosphate ( Fructose and Mannose metabolism ) (3)
- TWEAK (35)
- alanine biosynthesis II (2)
- G alpha i GDP-GTP exchange signaling ( GPCR signaling (pertussis toxin) ) (36)
- ATP + Creatine = ADP + N-Phospho-creatine ( Arginine and Proline metabolism ) (4)
- Beta catenin degradation signaling (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) (8)
- Propanoyl-CoA + Acceptor = Propenoyl-CoA + Reduced acceptor ( Valine,Leucine and Isoleucine degradation ) (2)
- CMP-N-acetylneuraminate biosynthesis I (eukaryotes) (4)
- asparagine biosynthesis I (1)
- TSLP (24)
- CoA + ATP + Succinic acid = Succinyl-CoA + ADP + Orthophosphate ( Citrate cycle ) (1)
- dolichyl-diphosphooligosaccharide biosynthesis (9)
- NAD+ + (S)-3-Hydroxy-2-methyl-butanoyl-CoA = NADH + 2-Methyl-3-acetoacetyl-CoA ( Valine,Leucine and Isoleucine degradation ) (4)
- Rapid glucocorticoid signaling (10)
- NAD+ + (S)-3-Hydroxy-butanoyl-CoA = NADH + Acetoacetyl-CoA ( Lysine degradation ) (3)
- Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) (8)
- Ephrin B reverse signaling (26)
- epoxysqualene biosynthesis (2)
- 2 Acetyl-CoA = CoA + Acetoacetyl-CoA ( Citrate cycle ) (2)
- Signaling events mediated by focal adhesion kinase (63)
- Caspase8 activation signaling ( Fas signaling pathway ) (2)
- Negative regulation of (G alpha GDP-GTP exchange signaling) ( GPCR signaling (G alpha s, PKA and ERK) ) (20)
- Alternative NF-kappaB pathway (6)
- Nectin adhesion pathway (30)
- Beta catenin degradation signaling (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) (8)
- NAD+ + 4-Trimethyl-ammonio-butanal + H2O = NADH + 4-Trimethyl-ammonio-butanoic acid ( Lysine degradation ) (8)
- p73 transcription factor network (80)
- EphrinA-EPHA pathway (8)
- ERK cascade ( HGF signaling pathway ) (6)
- S1P5 pathway (8)
- ERK cascade ( Insulin receptor signaling ) (8)
- pyrimidine ribonucleotides interconversion (13)
- L-Glutamine + D-Fructose 6-phosphate = L-Glutamic acid + D-Glucosamine 6-phosphate ( Fructose and Mannose metabolism ) (2)
- 4-aminobutyrate degradation I (2)
- 3-Methyl-butanoyl-CoA + Acceptor = 3-Methylbut-2-enoyl-CoA + Reduced acceptor ( Valine,Leucine and Isoleucine degradation ) (2)
- Rap1 activation signaling (through cAMP, PKA, Cbl and C3G) ( GPCR signaling (G alpha s, PKA and ERK) ) (11)
- NAD+ + (S)-Malic acid = NADH + Pyruvic acid + CO2 ( Glycolysis and Gluconeogenesis ) (3)
- IL-1 signaling pathway (through p38 cascade) ( IL-1 signaling pathway (through p38 cascade) ) (14)
- PDGF signaling pathway (Mammal) ( PDGF signaling pathway ) (29)
- dolichol and dolichyl phosphate biosynthesis (3)
- ERK cascade ( JAK-STAT pathway and regulation pathway Diagram ) (7)
- Acetyl-CoA + Dihydro-lipoamide = CoA + 6-S-Acetyl-dihydro-lipoamide ( Pyruvate metabolism ) (2)
- uracil degradation II (reductive) (8)
- (S)-Dihydro-orotic acid + H2O = N-Carbamoyl-L-aspartic acid ( Pyrimidine Nucleotides and Nucleosides metabolism ) (1)
- Validated nuclear estrogen receptor alpha network (65)
- Neurotrophic factor-mediated Trk receptor signaling (63)
- NADH + 1,3-Bisphospho-D-glyceric acid = NAD+ + D-Glyceraldehyde 3-phosphate + Orthophosphate ( Glycolysis and Gluconeogenesis ) (2)
- IL-1_signaling(through_JNK_cascade)(canonical) ( IL-1 signaling pathway (through JNK cascade) ) (14)
- Negative feedback regulation of FGF8 signaling by Mkp3 (Mouse) ( FGF signaling pathway ) (2)
- GMP + Pyrophosphate = Guanine + D-5-Phospho-ribosyl 1-diphosphate ( Purine nucleotides and Nucleosides metabolism ) (2)
- B-Raf activation signaling ( GPCR Adenosine A2A receptor signaling pathway ) (3)
- Alpha6Beta4Integrin (74)
- Signaling without Wnt (Drosophila) ( Drosophila Wingless/Wnt signaling pathway Diagram ) (4)
- Notch secretory pathway (Drosophila) ( Notch signaling pathway Diagram ) (1)
- ID (38)
- alanine degradation III (2)
- NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde (5)
- Calcineurin activation signaling ( CD4 T cell receptor signaling (JNK cascade) ) (4)
- Syndecan-3-mediated signaling events (23)
- KitReceptor (104)
- JNK cascade ( TNFR1 signaling pathway ) (14)
- NAD+ + 5,10-Methylene-tetrahydro-folic acid = NADH + 5,10-Methenyl-tetrahydro-folic acid ( Folate metabolism ) (1)
- TGF beta signaling pathway(through TAK1) ( TGF-beta signaling(through TAK1) ) (8)
- Integrin signaling pathway ( Integrin signaling pathway ) (123)
- p38 cascade ( IL-1 signaling pathway (through p38 cascade) ) (26)
- C-MYC pathway (25)
- Syndecan-4-mediated signaling events (32)
- S1P4 pathway (14)
- Gene expression of smad7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) ) (14)
- Nicotinamide D-ribonucleotide + ATP = NAD+ + Pyrophosphate ( Nicotinate and Nicotinamide metabolism ) (2)
- Beta catenin degradation signaling (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) (8)
- Fructose and Mannose metabolism ( Fructose and Mannose metabolism ) (13)
- ATP + UDP = ADP + UTP ( Pyrimidine Nucleotides and Nucleosides metabolism ) (7)
- SHP2 signaling (60)
- NADP+ + Cholesterol = NADPH + 7-Dehydro-cholesterol ( Steroids metabolism ) (1)
- IL5-mediated signaling events (14)
- Regulation of cytoplasmic and nuclear SMAD2/3 signaling (17)
- HIV-1 Nef: Negative effector of Fas and TNF-alpha (33)
- Acetyl-CoA + Dihydro-lipoamide = CoA + 6-S-Acetyl-dihydro-lipoamide ( Butanoate metabolism ) (2)
- tryptophan degradation III (eukaryotic) (11)
- L-Arginino-succinic acid = L-Arginine + Fumaric acid ( Arginine and Proline metabolism ) (1)
- IL-23 signaling pathway(JAK2 TYK2 STAT3 STAT4) ( IL-23 signaling(JAK2 TYK2 STAT3 STAT4) ) (6)
- Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling (JNK cascade) ) (5)
- ATP + dUMP = ADP + dUDP ( Pyrimidine Nucleotides and Nucleosides metabolism ) (1)
- Raf activation signaling (through Grb2 and Sos) ( CD4 T cell receptor signaling (ERK cascade) ) (9)
- ATP + CMP = ADP + CDP ( Pyrimidine Nucleotides and Nucleosides metabolism ) (1)
- D-Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate = D-Ribose 5-phosphate + D-Xylulose 5-phosphate ( Pentose phosphate cycle ) (3)
- IFN alpha signaling pathway(JAK1 TYK2 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) (17)
- Signaling events mediated by HDAC Class II (43)
- NAD+ + Dihydro-lipoamide = NADH + Lipoamide ( Pyruvate metabolism ) (1)
- L-Alanine + 2-Oxo-glutaric acid = Pyruvic acid + L-Glutamic acid ( Glycolysis and Gluconeogenesis ) (2)
- Endothelins (64)
- Gene expression of MuRF1 by FOXO ( Insulin receptor signaling (Mammal) ) (4)
- Mammalian Notch signaling pathway ( Notch signaling pathway Diagram ) (15)
- PAR1-mediated thrombin signaling events (43)
- Alpha6 beta4 integrin-ligand interactions (11)
- calcium transport I (5)
- L-serine degradation (2)
- Wnt secretory pathway (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) (19)
- N-Ribosyl-nicotinamide + Orthophosphate = Nicotinamide + D-Ribose 1-phosphate ( Nicotinate and Nicotinamide metabolism ) (1)
- Trk receptor signaling mediated by PI3K and PLC-gamma (36)
- UTP + D-Glucose 1-phosphate = Pyrophosphate + UDP-D-glucose ( Glycolysis and Gluconeogenesis ) (1)
- S1P3 pathway (25)
- ErbB receptor signaling network (15)
- tryptophan degradation X (mammalian, via tryptamine) (5)
- (S)-3-Hydroxy-3-methyl-glutaryl-CoA = Acetyl-CoA + Acetoacetic acid ( Valine,Leucine and Isoleucine degradation ) (1)
- Canonical Notch signaling pathway ( Notch signaling pathway Diagram ) (19)
- Canonical NF-kappaB pathway (24)
- G alpha s GDP-GTP exchange signaling ( GPCR Adenosine A2A receptor signaling pathway ) (5)
- Circadian rhythm pathway (17)
- IL-10 signaling pathway(JAK1 TYK2 STAT3) ( IL-10 signaling(JAK1 TYK2 STAT3) ) (6)
- Regulation of RhoA activity (48)
- NADH repair (3)
- regulation of target gene expression by AP-1 ( IL-1 signaling pathway (through p38 cascade) ) (1)
- (S)-Malic acid = Fumaric acid + H2O ( Citrate cycle ) (1)
- spermine biosynthesis (2)
- triacylglycerol biosynthesis (27)
- Aurora A signaling (33)
- Wnt secretory pathway (Mammal) ( Mammalian Wnt signaling pathway Diagram ) (19)
- Histidine degradation ( Histidine degradation ) (18)
- JNK cascade ( PDGF signaling pathway ) (8)
- adenine and adenosine salvage III (4)
- N-acetylglucosamine degradation II (4)
- glutathione redox reactions I (9)
- Gene expression of smad6/7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) ) (8)
- thymine degradation (8)
- choline biosynthesis III (9)
- fatty acid biosynthesis initiation II (3)
- sphingomyelin metabolism (8)
- Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) (56)
- ethanol degradation IV (7)
- Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling ) (236)
- Malonyl-CoA = Acetyl-CoA + CO2 ( Pyruvate metabolism ) (1)
- dopamine degradation (8)
- Alpha9 beta1 integrin signaling events (25)
- Ephrin A reverse signaling (3)
- formaldehyde oxidation II (glutathione-dependent) (2)
- Signaling events mediated by HDAC Class I (74)
- ATF-2 transcription factor network (59)
- EPHA forward signaling (33)
- tetrahydrobiopterin biosynthesis I (3)
- 2-Oxo-glutaric acid + L-Cysteine-sulfinic acid = L-Glutamic acid + 3-Sulfinyl-pyruvic acid ( Methionine and Cysteine metabolism ) (2)
- IL6 (85)
- selenocysteine biosynthesis II (archaea and eukaryotes) (6)
- NAD+ + (S)-Malic acid = NADH + Oxaloacetic acid ( Citrate cycle ) (2)
- Succinyl-CoA + Acetoacetic acid = Succinic acid + Acetoacetyl-CoA ( Valine,Leucine and Isoleucine degradation ) (1)
- PLC beta signaling ( GPCR GroupI metabotropic glutamate receptor signaling pathway ) (5)
- ceramide degradation (1)
- UDP-D-glucose + D-Galactose 1-phosphate = D-Glucose 1-phosphate + UDP-D-galactose ( Galactose metabolism ) (1)
- Signaling mediated by p38-gamma and p38-delta (11)
- RANKL (84)
- Caspase8 activation signaling ( TNFR1 signaling pathway ) (2)
- IFN alpha signaling pathway((JAK1 TYK2 STAT1 STAT2) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) (19)
- RXR and RAR heterodimerization with other nuclear receptor (26)
- D-myo-inositol (1,4,5)-trisphosphate biosynthesis (25)
- IKK activation signaling (through PKC beta and CARMA1:BCL10:MALT1) ( B cell receptor signaling ) (10)
- Ci/Gli processing signaling ( Hedgehog signaling pathway ) (17)
- Glypican pathway (3)
- mevalonate pathway I (12)
- Calcium signaling in the CD4+ TCR pathway (26)
- CD28 signaling ( CD4 T cell receptor signaling (NF-kB cascade) ) (14)
- Regulation of CDC42 activity (31)
- LPA receptor mediated events (65)
- ATP + L-Glutamic acid + NH3 = ADP + L-Glutamine + Orthophosphate ( Arginine and Proline metabolism ) (1)
- ErbB4 signaling events (35)
- Caspase9 activation signaling ( TNFR1 signaling pathway ) (3)
- IL2-mediated signaling events (54)
- stearate biosynthesis I (animals) (13)
- D-Fructose 1,6-bisphosphate = Dihydroxy-acetone phosphate + D-Glyceraldehyde 3-phosphate ( Glycolysis and Gluconeogenesis ) (3)
- thiosulfate disproportionation III (rhodanese) (1)
- FGF8 signaling pathway(Xenopus) ( FGF signaling pathway ) (18)
- Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) (14)
- PKA activation signaling ( GPCR signaling (cholera toxin) ) (18)
- Nicotinamide D-ribonucleotide + Pyrophosphate = Nicotinamide + D-5-Phospho-ribosyl 1-diphosphate ( Nicotinate and Nicotinamide metabolism ) (1)
- androgen biosynthesis (18)
- Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) (19)
- Acetyl-CoA + Glycine = CoA + L-2-Amino-3-oxo-butanoic acid ( Glycine and Serine metabolism ) (1)
- NAD+ + 3-Methoxy-4-hydroxy-phenyl-acetaldehyde + H2O = NADH + Homovanillic acid ( Tyrosine metabolism ) (4)
- ERK cascade ( CD4 T cell receptor signaling ) (7)
- Negative regulation of (nuclear import of R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) (11)
- aspartate biosynthesis (3)
- Degradation of beta catenin (18)
- L-Arginine + Glycine = L-Ornithine + Guanidino-acetic acid ( Arginine and Proline metabolism ) (1)
- Aminosugars metabolism ( Aminosugars metabolism ) (9)
- JNK cascade ( IL-1 signaling pathway (through JNK cascade) ) (30)
- UDP-N-acetyl-D-glucosamine biosynthesis II (5)
- 2-Oxo-glutaric acid + L-Cysteic acid = L-Glutamic acid + 3-Sulfo-pyruvic acid ( Methionine and Cysteine metabolism ) (2)
- Raf activation signaling (through RasGRP) ( CD4 T cell receptor signaling ) (7)
- ATP + dGDP = ADP + dGTP ( Purine nucleotides and Nucleosides metabolism ) (7)
- D-myo-inositol (1,4,5)-trisphosphate degradation (13)
- glycolysis I (22)
- pyruvate fermentation to lactate (5)
- L-Alanine + 2-Oxo-glutaric acid = Pyruvic acid + L-Glutamic acid ( Alanine,Aspartic acid and Asparagine metabolism ) (2)
- adenine and adenosine salvage VI (1)
- cysteine biosynthesis/homocysteine degradation (2)
- Negative regulation of (G alpha s GDP-GTP exchange signaling) ( GPCR signaling (cholera toxin) ) (20)
- fatty acid activation (8)
- purine ribonucleosides degradation to ribose-1-phosphate (3)
- FGF signaling pathway ( FGF signaling pathway ) (44)
- TGF beta receptor complex degradation signaling ( TGF-beta_super_family_signaling_pathway(canonical) ) (48)
- guanosine nucleotides degradation III (4)
- phosphatidylethanolamine biosynthesis III (1)
- Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) (47)
- Wnt secretory pathway (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) (19)
- glutamate dependent acid resistance (2)
- 2-Oxo-glutaric acid + beta-Alanine = L-Glutamic acid + Malonate semialdehyde ( Pyrimidine Nucleotides and Nucleosides metabolism ) (1)
- NGF signaling pathway ( NGF signaling pathway ) (16)
- Prostaglandin and Leukotriene metabolism ( Prostaglandin and Leukotriene metabolism ) (22)
- Regulation of Ras family activation (31)
- 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA (1)
- NAD+ + Dihydro-lipoylprotein = NADH + Lipoylprotein ( Glycine and Serine metabolism ) (1)
- fatty acid alpha-oxidation II (10)
- cholesterol biosynthesis III (via desmosterol) (13)
- NAD+ + (S)-3-Hydroxy-2-methyl-propanoic acid = NADH + (S)-Methyl-malonate semialdehyde ( Valine,Leucine and Isoleucine degradation ) (4)
- G alpha i GDP-GTP exchange signaling ( GPCR signaling (G alpha i) ) (36)
- Methionine and Cysteine metabolism ( Methionine and Cysteine metabolism ) (16)
- SnoN degradation signaling ( TGF-beta_super_family_signaling_pathway(canonical) ) (38)
- NAD+ + (S)-Lactic acid = NADH + Pyruvic acid ( Pyruvate metabolism ) (4)
- JNK cascade ( TGF-beta signaling(through TAK1) ) (6)
- IL1-mediated signaling events (34)
- T cell receptor signaling (PLC gamma, PKC, Ras and ERK cascade) ( CD4 T cell receptor signaling (ERK cascade) ) (37)
- Plexin-D1 Signaling (24)
- glutamine degradation I (3)
- Adenylo-succinic acid = AMP + Fumaric acid ( Purine nucleotides and Nucleosides metabolism ) (1)
- IL2 (81)
- GDP-L-fucose biosynthesis II (from L-fucose) (2)
- Regulation of retinoblastoma protein (67)
- (S)-3-Hydroxy-3-methyl-glutaryl-CoA = Acetyl-CoA + Acetoacetic acid ( Pyruvate metabolism ) (1)
- Insulin receptor signaling ( Insulin receptor signaling ) (55)
- glycogen degradation II (7)
- Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram ) (56)
- arginine biosynthesis IV (6)
- Integrins in angiogenesis (66)
- L-2-Amino-adipic acid + 2-Oxo-glutaric acid = 2-Oxo-adipic acid + L-Glutamic acid ( Lysine degradation ) (1)
- Propanoyl-CoA + Acceptor = Propenoyl-CoA + Reduced acceptor ( Propanoate metabolism ) (2)
- regulation of target gene expression by AP-1 ( Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, JNK cascade) ) (1)
- BMP signaling in Drosophila ( BMP signaling in Drosophila ) (7)
- alanine biosynthesis III (1)
- GDP-glucose biosynthesis (5)
- NAD+ + Succinate semialdehyde + H2O = NADH + Succinic acid ( Glutamic acid and Glutamine metabolism ) (1)
- superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) (14)
- TNFalpha (270)
- ethanol degradation II (6)
- flavin biosynthesis IV (mammalian) (2)
- D-Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate = D-Erythrose 4-phosphate + D-Fructose 6-phosphate ( Pentose phosphate cycle ) (1)
- IFN alpha signaling pathway(JAK1 TYK2 STAT1 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) (18)
- dTMP de novo biosynthesis (4)
- phosphatidylglycerol biosynthesis II (non-plastidic) (20)
- tRNA splicing (5)
- thiamin salvage III (1)
- D-Glycerate 2-phosphate = D-Glycerate 3-phosphate ( Glycolysis and Gluconeogenesis ) (3)
- putrescine degradation III (10)
- ERK cascade ( Insulin receptor signaling (Mammal) ) (8)
- Rapoport-Luebering glycolytic shunt (4)
- ALK1 pathway (3)
- N-cadherin signaling events (33)
- glycerol-3-phosphate shuttle (2)
- AKT(PKB) activation signaling ( IGF1 signaling pathway ) (7)
- Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta) ( GPCR signaling (G alpha q) ) (20)
- L-cysteine degradation I (2)
- IL12 signaling mediated by STAT4 (33)
- Vitamin B6 metabolism ( Vitamin B6 metabolism ) (4)
- Stabilization and accumulation of cytoplasmic beta-catenin (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) (24)
- Phenylalanine degradation ( Phenylalanine degradation ) (6)
- 2-Oxo-glutaric acid + L-Aspartic acid = L-Glutamic acid + Oxaloacetic acid ( Alanine,Aspartic acid and Asparagine metabolism ) (2)
- TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_super_family_signaling_pathway(canonical) ) (51)
- Citric acid = cis-Aconitic acid + H2O ( Citrate cycle ) (4)
- IL2 signaling events mediated by STAT5 (30)
- AKT(PKB)-GSK3beta signaling ( Insulin receptor signaling (Mammal) ) (6)
- putrescine biosynthesis III (2)
- 1,25-dihydroxyvitamin D3 biosynthesis (3)
- (S)-3-Hydroxy-2-methyl-propanoyl-CoA = 2-Methylprop-2-enoyl-CoA + H2O ( Valine,Leucine and Isoleucine degradation ) (3)
- NAD+ + Dihydro-lipoamide = NADH + Lipoamide ( Citrate cycle ) (1)
- glutaryl-CoA degradation (5)
- D-Glycerate 2-phosphate = Phosphoenol-pyruvic acid + H2O ( Citrate cycle ) (3)
- AKT(PKB)-TOR signaling ( Insulin receptor signaling ) (15)
- Class I PI3K signaling events mediated by Akt (35)
- IL9 (24)
- tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde (5)
- glutamine biosynthesis I (1)
- Stabilization and accumulation of cytoplasmic beta-catenin (Mammal) ( Mammalian Wnt signaling pathway Diagram ) (24)
- Noncanonical Wnt signaling pathway (33)
- glycogen degradation III (9)
- cardiolipin biosynthesis II (2)
- NAD salvage pathway II (12)
- 4-hydroxybenzoate biosynthesis (1)
- 2-Methyl-butanoyl-CoA + Acceptor = 2-Methylbut-2-enoyl-CoA + Reduced acceptor ( Valine,Leucine and Isoleucine degradation ) (3)
- Xanthosine + Orthophosphate = Xanthine + D-Ribose 1-phosphate ( Purine nucleotides and Nucleosides metabolism ) (1)
- 2-Oxo-glutaric acid + L-Isoleucine = L-Glutamic acid + (R)-2-Oxo-3-methyl-pentanoic acid ( Valine,Leucine and Isoleucine degradation ) (2)
- Cytosolic calcium ion concentration elevation (through IP3 receptor) ( VEGF signaling pathway ) (2)
- 2-Oxo-glutaric acid + L-Phenylalanine = L-Glutamic acid + Phenyl-pyruvic acid ( Phenylalanine degradation ) (3)
- Caspase Cascade in Apoptosis (57)
- Class I PI3K signaling events (46)
- NAD phosphorylation and dephosphorylation (4)
- Validated transcriptional targets of deltaNp63 isoforms (48)
- N-acetylglucosamine degradation I (3)
- Notch (76)
- Glutamic acid and Glutamine metabolism ( Glutamic acid and Glutamine metabolism ) (10)
- xanthine and xanthosine salvage (1)
- Heterotrimeric GPCR signaling pathway (through G alpha s ACs Epac BRaf and ERKcascade) ( GPCR signaling (G alpha s, Epac and ERK) ) (233)
- N-Acetyl-D-glucosamine = N-Acetyl-D-mannosamine ( Aminosugars metabolism ) (1)
- CDC42 signaling events (71)
- JNK cascade ( CD4 T cell receptor signaling (JNK cascade) ) (12)
- Osteopontin-mediated events (32)
- Negative regulation of (transcription by R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) (21)
- Uridine + Orthophosphate = Uracil + D-Ribose 1-phosphate ( Pyrimidine Nucleotides and Nucleosides metabolism ) (1)
- G alpha s GDP-GTP exchange signaling ( GPCR signaling (G alpha q) ) (35)
- gamma-glutamyl cycle (13)
- serine biosynthesis (12)
- p38 cascade ( TGF-beta signaling(through TAK1) ) (8)
- Nicotinate D-ribonucleotide + ATP = Deamido-NAD+ + Pyrophosphate ( Nicotinate and Nicotinamide metabolism ) (2)
- heme biosynthesis from uroporphyrinogen-III I (4)
- Deoxy-uridine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Uracil ( Pyrimidine Nucleotides and Nucleosides metabolism ) (1)
- 5,10-Methenyl-tetrahydro-folic acid + H2O = 10-Formyl-tetrahydro-folic acid ( Folate metabolism ) (3)
- BMP signaling in Drosophila (dorsal midline) ( BMP signaling in Drosophila ) (7)
- FOXA transcription factor networks (3)
- 4-hydroxy-2-nonenal detoxification (5)
- ERK cascade ( IGF1 signaling pathway ) (8)
- ATP + D-Ribose 5-phosphate = AMP + D-5-Phospho-ribosyl 1-diphosphate ( Pentose phosphate cycle ) (4)
- Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) (47)
- Downstream signaling in naïve CD8+ T cells (65)
- Signaling with Hh ( Hedgehog signaling pathway ) (4)
- acyl carrier protein metabolism (1)
- Gli processing signaling ( Hedgehog signaling pathway ) (15)
- RAC1 signaling pathway (54)
- (S)-Dihydro-orotic acid + O2 = Orotic acid + H2O2 ( Pyrimidine Nucleotides and Nucleosides metabolism ) (1)
- Ceramide signaling pathway (49)
- Signaling events mediated by HDAC Class III (27)
- p38 signaling mediated by MAPKAP kinases (21)
- glutamate degradation III (via 4-aminobutyrate) (4)
- superoxide radicals degradation (5)
- N-Acetyl-D-glucosamine 1-phosphate = N-Acetyl-D-glucosamine 6-phosphate ( Aminosugars metabolism ) (1)
- ERK cascade ( NGF signaling pathway ) (8)
- 2-Oxo-glutaric acid + L-Valine = L-Glutamic acid + 3-Methyl-2-oxo-butanoic acid ( Valine,Leucine and Isoleucine degradation ) (2)
- D-Glucose 1-phosphate = D-Glucose 6-phosphate ( Galactose metabolism ) (1)
- D-mannose degradation (1)
- p75(NTR)-mediated signaling (74)
- Lissencephaly gene (LIS1) in neuronal migration and development (28)
- Tyrosine metabolism ( Tyrosine metabolism ) (15)
- B-Raf activation signaling ( GPCR signaling (G alpha s, PKA and ERK) ) (3)
- acetyl-CoA biosynthesis III (from citrate) (1)
- fatty acid beta-oxidation III (unsaturated, odd number) (3)
- NAD+ + CoA + (S)-Methyl-malonate semialdehyde => NADH + Propanoyl-CoA + CO2 ( Propanoate metabolism ) (1)
- Reelin signaling pathway (28)
- 2 Acetyl-CoA = CoA + Acetoacetyl-CoA ( Pyruvate metabolism ) (2)
- BCR (161)
- S-adenosyl-L-methionine biosynthesis (3)
- tyrosine biosynthesis IV (1)
- regulation of target gene expression by AP-1 ( Toll-like receptor signaling pathway (through JNK cascade) ) (1)
- Arginine and Proline metabolism ( Arginine and Proline metabolism ) (29)
- superpathway of inositol phosphate compounds (68)
- zymosterol biosynthesis (6)
- NAD biosynthesis III (4)
- E-cadherin signaling in keratinocytes (21)
- L-Tetrahydro-folic acid + L-Serine = 5,10-Methylene-tetrahydro-folic acid + Glycine + H2O ( Glycine and Serine metabolism ) (2)
- Beta catenin degradation signaling (Canonical) ( Canonical Wnt signaling pathway Diagram ) (8)
- ATP + UMP = ADP + UDP ( Pyrimidine Nucleotides and Nucleosides metabolism ) (1)
- L-glutamine biosynthesis II (tRNA-dependent) (2)
- FGF8 signaling pathway(Mouse) ( FGF signaling pathway ) (20)
- Insulin-mediated glucose transport (27)
- ERK cascade ( B cell receptor signaling ) (7)
- IFN gamma signaling pathway(JAK1 JAK2 STAT1) ( IFN gamma signaling(JAK1 JAK2 STAT1) ) (6)
- ATP + dTMP = ADP + dTDP ( Pyrimidine Nucleotides and Nucleosides metabolism ) (1)
- Signaling mediated by p38-alpha and p38-beta (35)
- p38 cascade ( Toll-like receptor signaling pathway (p38 cascade) ) (20)
- 5-Formimino-tetrahydro-folic acid + L-Glutamic acid = L-Tetrahydro-folic acid + N-Formimino-L-glutamic acid ( Folate metabolism ) (1)
- Phospholipase C gamma signaling ( CD4 T cell receptor signaling ) (5)
- 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) (3)
- citrulline-nitric oxide cycle (5)
- Polo-like kinase signaling events in the cell cycle (4)
- 2-Oxo-glutaric acid + 4-Amino-butanoic acid = L-Glutamic acid + Succinate semialdehyde ( Glutamic acid and Glutamine metabolism ) (1)
- D-Mannose 6-phosphate = D-Fructose 6-phosphate ( Aminosugars metabolism ) (1)
- ATP + dGMP = ADP + dGDP ( Purine nucleotides and Nucleosides metabolism ) (1)
- Negative regulation of (Binding of GPCR ligand and GPCR) ( GPCR signaling (pertussis toxin) ) (2)
- NADP+ + 5,6-Dihydro-uracil = NADPH + Uracil ( Pyrimidine Nucleotides and Nucleosides metabolism ) (1)
- Adenylo-succinic acid = AMP + Fumaric acid ( Alanine,Aspartic acid and Asparagine metabolism ) (1)
- Cytosolic calcium ion concentration elevation (through IP3 receptor) ( GPCR signaling (G alpha q) ) (2)
- Signaling events mediated by PTP1B (53)
- Glypican 1 network (26)
- L-Alanine + 2-Oxo-glutaric acid = Pyruvic acid + L-Glutamic acid ( Glutamic acid and Glutamine metabolism ) (2)
- L-Arginino-succinic acid = L-Arginine + Fumaric acid ( Alanine,Aspartic acid and Asparagine metabolism ) (1)
- Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK, TAK1 and IKK-NF-kappaB cascade)(Canonical) ( Toll-like receptor signaling pathway (trough NF-kappaB) ) (19)
- proline biosynthesis I (4)
- Glucocorticoid receptor regulatory network (85)
- salvage pathways of pyrimidine deoxyribonucleotides (5)
- ATP + GMP = ADP + GDP ( Purine nucleotides and Nucleosides metabolism ) (1)
- L-Alanine + Glyoxylic acid = Pyruvic acid + Glycine ( Glycolysis and Gluconeogenesis ) (2)
- a6b1 and a6b4 Integrin signaling (46)
- C. elegans Notch signaling pathway ( Notch signaling pathway Diagram ) (8)
- GTP + Oxaloacetic acid = GDP + Phosphoenol-pyruvic acid + CO2 ( Citrate cycle ) (2)
- triacylglycerol degradation (14)
- PLC gamma signaling ( PDGF signaling pathway ) (4)
- NAD+ + Phenyl-acetaldehyde + H2O = NADH + Phenyl-acetic acid ( Phenylalanine degradation ) (4)
- (S)-3-Hydroxy-butanoyl-CoA = Crotonoyl-CoA + H2O ( Butanoate metabolism ) (3)
- IL1 (69)
- Validated targets of C-MYC transcriptional repression (63)
- Glycine and Serine metabolism ( Glycine and Serine metabolism ) (27)
- tetrahydrobiopterin biosynthesis II (3)
- Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) (8)
- Adenylate cyclase activation signaling ( GPCR signaling (pertussis toxin) ) (11)
- Stabilization and expansion of the E-cadherin adherens junction (43)
- Phospholipase C gamma signaling ( B cell receptor signaling ) (3)
- HIF-2-alpha transcription factor network (34)
- tRNA charging (38)
- 5'-Phospho-ribosyl-4-(N-succino-carboxamide)-5-amino-imidazole = 5'-Phospho-ribosyl-4-carboxamido-5-amino-imidazole + Fumaric acid ( Purine nucleotides and Nucleosides metabolism ) (1)
- VEGFR3 signaling in lymphatic endothelium (26)
- Signaling with Wnt (Drosophila) ( Drosophila Wingless/Wnt signaling pathway Diagram ) (4)
- 2-Oxo-glutaric acid + L-O-Phospho-serine = L-Glutamic acid + 3-Phospho-hydroxy-pyruvic acid ( Glycine and Serine metabolism ) (1)
- Aurora B signaling (40)
- Retinoic acid receptors-mediated signaling (30)
- NAD+ + L-Glutamic acid + H2O = NADH + 2-Oxo-glutaric acid + NH3 ( Glutamic acid and Glutamine metabolism ) (2)
- galactose degradation I (Leloir pathway) (4)
- IKK-NF-kappaB cascade ( CD4 T cell receptor signaling (NF-kB cascade) ) (8)
- ATP + dAMP = ADP + dADP ( Purine nucleotides and Nucleosides metabolism ) (4)
- JNK cascade ( EGF signaling pathway Diagram ) (4)
- Propanoate metabolism ( Propanoate metabolism ) (3)
- L-Glutamine + D-Fructose 6-phosphate = L-Glutamic acid + D-Glucosamine 6-phosphate ( Aminosugars metabolism ) (2)
- GTP + L-Fucose 1-phosphate = GDP-L-fucose + Pyrophosphate ( Fructose and Mannose metabolism ) (1)
- Negative regulation of (Phosphorylation of JAK) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) (5)
- Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) (8)
- PDGF receptor signaling network (6)
- 2-Oxo-glutaric acid + L-Tyrosine = L-Glutamic acid + 4-Hydroxy-phenyl-pyruvic acid ( Tyrosine metabolism ) (1)
- phosphatidylcholine biosynthesis I (6)
- Beta catenin degradation signaling (Mammal) ( Mammalian Wnt signaling pathway Diagram ) (8)
- IL4 (73)
- Pyrimidine Nucleotides and Nucleosides metabolism ( Pyrimidine Nucleotides and Nucleosides metabolism ) (30)
- serotonin degradation (12)
- D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis (2)
- geranylgeranyldiphosphate biosynthesis (1)
- NAD+ + 3-Methyl-imidazole acetaldehyde + H2O = NADH + 3-Methyl-imidazole-acetic acid ( Histidine degradation ) (4)
- FAS (CD95) signaling pathway (36)
- asparagine degradation I (2)
- catecholamine biosynthesis (7)
- inositol pyrophosphates biosynthesis (7)
- 3-phosphoinositide biosynthesis (27)
- PLK3 signaling events (6)
- Arf6 trafficking events (48)
- glycine biosynthesis I (2)
- adenosine nucleotides degradation II (8)
- sulfite oxidation IV (1)
- Netrin-mediated signaling events (32)
- fatty acid beta-oxidation I (18)
- Negative feedback regulation pathway of TGF beta superfamily signaling by (binding of smad6/7 and TGF beta receptor I) ( TGF-beta_super_family_signaling_pathway(canonical) ) (8)
- Deoxy-adenosine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Adenine ( Purine nucleotides and Nucleosides metabolism ) (1)
- Negative regulation of gene expression ( Insulin receptor signaling ) (7)
- regulation of target gene expression by AP-1 ( Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, p38 cascade) ) (1)
- TRAIL signaling pathway (25)
- ATP + dTDP = ADP + dTTP ( Pyrimidine Nucleotides and Nucleosides metabolism ) (7)
- Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) (47)
- Thromboxane A2 receptor signaling (56)
- PDGF signaling pathway ( PDGF signaling pathway ) (15)
- GDP-mannose biosynthesis (6)
- NAD+ + 3,4-Dihydroxy-phenyl-ethyleneglycol = NADH + 3,4-Dihydroxy-mandelaldehyde ( Tyrosine metabolism ) (8)
- ATP + GDP = ADP + GTP ( Folate metabolism ) (7)
- regulation of target gene expression by NF-kB ( IL-1 signaling pathway (through NF-kappaB) ) (3)
- Hypoxic and oxygen homeostasis regulation of HIF-1-alpha (19)
- E-cadherin signaling events (3)
- phospholipases (39)
- IKK-NF-kappaB cascade ( CD4 T cell receptor signaling ) (8)
- UTP + N-Acetyl-D-glucosamine 1-phosphate = Pyrophosphate + UDP-N-acetyl-D-glucosamine ( Aminosugars metabolism ) (1)
- Dimethylallyl diphosphate = Isopentenyl diphosphate ( Steroids metabolism ) (2)
- PKA activation signaling ( GPCR signaling (G alpha s, PKA and ERK) ) (18)
- Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through_G_alpha_s,_cholera_toxin,_adenylate_cyclase_and_cAMP) ( GPCR signaling (cholera toxin) ) (223)
- IL-7 signaling pathway(JAK1 JAK3 STAT5) ( IL-7 signaling(JAK1 JAK3 STAT5) ) (13)
- Negative feedback regulation of FGF8 signaling by Sprouty2 (Mouse) ( FGF signaling pathway ) (2)
- Integrin family cell surface interactions (26)
- Arf6 downstream pathway (15)
- ATP + Pyruvic acid + CO2 + H2O = ADP + Oxaloacetic acid + Orthophosphate ( Alanine,Aspartic acid and Asparagine metabolism ) (1)
- D-Fructose 1,6-bisphosphate = Dihydroxy-acetone phosphate + D-Glyceraldehyde 3-phosphate ( Fructose and Mannose metabolism ) (3)
- Purine nucleotides and Nucleosides metabolism ( Purine nucleotides and Nucleosides metabolism ) (85)
- (S)-Malic acid = Fumaric acid + H2O ( Tyrosine metabolism ) (1)
- myo-inositol biosynthesis (4)
- 5-aminoimidazole ribonucleotide biosynthesis I (3)
- L-Alanine + Glyoxylic acid = Pyruvic acid + Glycine ( Glycine and Serine metabolism ) (2)
- regulation of target gene expression by AP-1 ( Toll-like receptor signaling pathway (p38 cascade) ) (1)
- Citrate cycle ( Citrate cycle ) (1)
- NADP+ + D-Sorbitol = NADPH + D-Glucose ( Fructose and Mannose metabolism ) (1)
- Inositol phosphate metabolism ( Inositol phosphate metabolism ) (42)
- XMP + Pyrophosphate = Xanthine + D-5-Phospho-ribosyl 1-diphosphate ( Purine nucleotides and Nucleosides metabolism ) (1)
- glycerol degradation I (4)
- 4-hydroxyproline degradation I (1)
- sphingosine and sphingosine-1-phosphate metabolism (9)
- pentose phosphate pathway (oxidative branch) (4)
- C-MYB transcription factor network (87)
- L-dopachrome biosynthesis (1)
- pyrimidine ribonucleotides de novo biosynthesis (15)
- EphrinB-EPHB pathway (6)
- NAD+ + (R)-Lactic acid = NADH + Pyruvic acid ( Pyruvate metabolism ) (1)
- glutamate degradation II (3)
- Effects of Botulinum toxin (9)
- LPA4-mediated signaling events (16)
- HIF-1-alpha transcription factor network (67)
- LIF signaling pathway ( LIF signaling(JAK1 JAK2 STAT3) ) (10)
- (R)-S-Lactoyl-glutathione = Glutathione + Methyl-glyoxal ( Pyruvate metabolism ) (1)
- G alpha q GDP-GTP exchange signaling ( GPCR GroupI metabotropic glutamate receptor signaling pathway ) (6)
- eumelanin biosynthesis (4)
- 2 Acetyl-CoA = CoA + Acetoacetyl-CoA ( Butanoate metabolism ) (2)
- HGF signaling pathway ( HGF signaling pathway ) (30)
- Caspase9 activation signaling ( Fas signaling pathway ) (3)
- Wnt signaling network (29)
- Notch-mediated HES/HEY network (48)
- Aurora C signaling (4)
- histamine degradation (3)
- methylglyoxal degradation I (3)
- Notch secretory pathway (C. elegans) ( Notch signaling pathway Diagram ) (5)
- Succinyl-CoA + Acetoacetic acid = Succinic acid + Acetoacetyl-CoA ( Butanoate metabolism ) (1)
- Wnt secretory pathway (Canonical) ( Mammalian Wnt signaling pathway Diagram ) (19)
- Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) (49)
- Signaling events mediated by PRL (23)
- Sphingosine 1-phosphate (S1P) pathway (21)
- TSH (81)
- PAR4-mediated thrombin signaling events (15)
- Glypican 3 network (9)
- Cellular roles of Anthrax toxin (21)
- NAD biosynthesis II (from tryptophan) (26)
- histidine degradation III (7)
- Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin) ( GPCR signaling (pertussis toxin) ) (224)
- D-Glucosamine 6-phosphate + H2O = D-Fructose 6-phosphate + NH3 ( Aminosugars metabolism ) (1)
- 2-Oxo-glutaric acid + beta-Alanine = L-Glutamic acid + Malonate semialdehyde ( Alanine,Aspartic acid and Asparagine metabolism ) (1)
- FOXA2 and FOXA3 transcription factor networks (45)
- BMP receptor signaling (42)
- IL3 (84)
- cholesterol biosynthesis II (via 24,25-dihydrolanosterol) (13)
- ERK cascade ( GPCR Adenosine A2A receptor signaling pathway ) (5)
- L-Tetrahydro-folic acid + L-Serine = 5,10-Methylene-tetrahydro-folic acid + Glycine + H2O ( Folate metabolism ) (2)
- p38 cascade ( Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, p38 cascade) ) (13)
- Negative regulation of (Phosphorylation of cytokine receptor) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) (40)
- beta-alanine degradation I (2)
- oxidative ethanol degradation III (7)
- Stabilization and accumulation of cytoplasmic beta-catenin (Canonical) ( Canonical Wnt signaling pathway Diagram ) (24)
- ATP + AMP = 2 ADP ( Purine nucleotides and Nucleosides metabolism ) (4)
- Role of Calcineurin-dependent NFAT signaling in lymphocytes (51)
- 2-Oxo-glutaric acid + N2-Succinyl-L-ornithine = L-Glutamic acid + N2-Succinyl-L-glutamate 5-semialdehyde ( Arginine and Proline metabolism ) (1)
- Wnt (118)
- 2-Oxo-glutaric acid + L-erythro-4-Hydroxy-glutamic acid = L-Glutamic acid + D-4-Hydroxy-2-oxo-glutaric acid ( Arginine and Proline metabolism ) (2)
- Glycolysis and Gluconeogenesis ( Glycolysis and Gluconeogenesis ) (12)
- TGF-beta receptor signaling (148)
- Beta5 beta6 beta7 and beta8 integrin cell surface interactions (17)
- Signaling events mediated by TCPTP (40)
- 2-oxobutanoate degradation I (8)
- Class IB PI3K non-lipid kinase events (5)
- TNF receptor signaling pathway (46)
- NAD+ + 3,4-Dihydroxy-mandelaldehyde + H2O = NADH + 3,4-Dihydroxy-mandelic acid ( Tyrosine metabolism ) (4)
- JNK cascade ( CD4 T cell receptor signaling ) (10)
- L-cysteine degradation II (1)
- Regulation of Telomerase (70)
- ERK cascade ( VEGF signaling pathway ) (6)
- IL-2 signaling pathway(JAK1 JAK3 STAT5) ( IL-2 signaling(JAK1 JAK3 STAT5) ) (7)
- Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through G alpha i, adenylate cyclase and cAMP) ( GPCR signaling (G alpha i) ) (224)
- G alpha s GDP-GTP exchange signaling ( GPCR signaling (G alpha s, PKA and ERK) ) (35)
- acyl-CoA hydrolysis (3)
- aspartate degradation II (5)
- mitochondrial L-carnitine shuttle pathway (3)
- Regulation of nuclear beta catenin signaling and target gene transcription (80)
- 2-Oxo acid + L-Ornithine = L-Amino acid + L-Glutamate 5-semialdehyde ( Arginine and Proline metabolism ) (1)
- Pyruvate metabolism ( Pyruvate metabolism ) (7)
- 5'-Orotidylic acid + Pyrophosphate = Orotic acid + D-5-Phospho-ribosyl 1-diphosphate ( Pyrimidine Nucleotides and Nucleosides metabolism ) (1)
- LKB1 signaling events (43)
- IL3-mediated signaling events (27)
- CD28 signaling ( CD4 T cell receptor signaling (JNK cascade) ) (3)
- (S)-3-Hydroxy-3-methyl-glutaryl-CoA = Acetyl-CoA + Acetoacetic acid ( Butanoate metabolism ) (1)
- molybdenum cofactor biosynthesis (12)
- lactose degradation III (2)
- Trk receptor signaling mediated by the MAPK pathway (34)
- Heterotrimeric GPCR signaling pathway (through_G alpha s_ACs_PKA_BRaf_and_ERKcascade)(canonical) ( GPCR signaling (G alpha s, PKA and ERK) ) (223)
- p63 transcription factor network (1)
- Folate metabolism ( Folate metabolism ) (16)
- BARD1 signaling events (29)
- GDP-L-fucose biosynthesis I (from GDP-D-mannose) (2)
- Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling ) (5)
- Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling (42)
- Deoxy-guanosine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Guanine ( Purine nucleotides and Nucleosides metabolism ) (1)
- JAK degradation signaling ( JAK-STAT pathway and regulation pathway Diagram ) (5)
- Adenylate cyclase inactivation signaling ( GPCR signaling (pertussis toxin) ) (12)
- 2 Acetyl-CoA = CoA + Acetoacetyl-CoA ( Lysine degradation ) (2)
- Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) (8)
- EGFR-dependent Endothelin signaling events (9)
- proline biosynthesis II (from arginine) (5)
- UDP-N-acetyl-D-galactosamine biosynthesis I (1)
- Alpha-synuclein signaling (34)
- UDP-N-acetyl-D-galactosamine biosynthesis II (9)
- IL-5 signaling pathway(JAK1 JAK2 STAT1 STAT5) ( IL-5 signaling(JAK1 JAK2 STAT1 STAT5) ) (11)
- IL8- and CXCR2-mediated signaling events (35)
- G alpha s GDP-GTP exchange signaling ( GPCR Dopamine D1like receptor signaling pathway ) (6)
- L-Glutamine + H2O = L-Glutamic acid + NH3 ( Glutamic acid and Glutamine metabolism ) (2)
- 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 ( Citrate cycle ) (1)
- Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, JNK cascade) ( Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, JNK cascade) ) (15)
- Negative regulation of gene expression ( Insulin receptor signaling (Mammal) ) (7)
- FSH (44)
- Insulin receptor signaling (Mammal) ( Insulin receptor signaling (Mammal) ) (58)
- NADP+ + 5,6-Dihydro-thymine = NADPH + Thymine ( Pyrimidine Nucleotides and Nucleosides metabolism ) (1)
- L-Arginino-succinic acid = L-Arginine + Fumaric acid ( Citrate cycle ) (1)
- Hedgehog signaling events mediated by Gli proteins (49)
- acetate conversion to acetyl-CoA (3)
- Validated nuclear estrogen receptor beta network (15)
- NADH + L-1-Pyrroline-3-hydroxy-5-carboxylic acid = NAD+ + trans-4-Hydroxy-L-proline ( Arginine and Proline metabolism ) (2)
- 2-Oxo-glutaric acid + L-Leucine = L-Glutamic acid + 4-Methyl-2-oxo-pentanoic acid ( Valine,Leucine and Isoleucine degradation ) (2)
- Valine,Leucine and Isoleucine degradation ( Valine,Leucine and Isoleucine degradation ) (16)
- Gene expression of MAFbx by FOXO ( Insulin receptor signaling (Mammal) ) (4)
- NAD+ + L-Saccharopine + H2O = NADH + L-2-Amino-adipate 6-semialdehyde + L-Glutamic acid ( Lysine degradation ) (1)
- 2-LTR circle formation (7)
- 5-Phosphoribose 1-diphosphate biosynthesis (3)
- A tetrasaccharide linker sequence is required for GAG synthesis (26)
- ABC transporter disorders (78)
- ABC transporters in lipid homeostasis (18)
- ABC-family proteins mediated transport (104)
- ABO blood group biosynthesis (3)
- ADP signalling through P2Y purinoceptor 1 (25)
- ADP signalling through P2Y purinoceptor 12 (22)
- AKT phosphorylates targets in the cytosol (14)
- AKT phosphorylates targets in the nucleus (10)
- AKT-mediated inactivation of FOXO1A (4)
- ALKBH2 mediated reversal of alkylation damage (1)
- ALKBH3 mediated reversal of alkylation damage (4)
- AMER1 mutants destabilize the destruction complex (14)
- AMPK inhibits chREBP transcriptional activation activity (8)
- APC truncation mutants are not K63 polyubiquitinated (1)
- APC truncation mutants have impaired AXIN binding (14)
- APC-Cdc20 mediated degradation of Nek2A (25)
- APC/C-mediated degradation of cell cycle proteins (87)
- APC/C:Cdc20 mediated degradation of Cyclin B (23)
- APC/C:Cdc20 mediated degradation of Securin (68)
- APC/C:Cdc20 mediated degradation of mitotic proteins (76)
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (73)
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (74)
- APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (7)
- APOBEC3G mediated resistance to HIV-1 infection (5)
- ARL13B-mediated ciliary trafficking of INPP5E (3)
- ARMS-mediated activation (7)
- ATF4 activates genes in response to endoplasmic reticulum stress (27)
- ATF6 (ATF6-alpha) activates chaperone genes (11)
- ATF6 (ATF6-alpha) activates chaperones (13)
- ATP sensitive Potassium channels (4)
- AUF1 (hnRNP D0) binds and destabilizes mRNA (56)
- AURKA Activation by TPX2 (72)
- AXIN missense mutants destabilize the destruction complex (14)
- AXIN mutants destabilize the destruction complex, activating WNT signaling (14)
- Abacavir metabolism (5)
- Abacavir transmembrane transport (5)
- Abacavir transport and metabolism (10)
- Abasic sugar-phosphate removal via the single-nucleotide replacement pathway (2)
- Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1)
- Abortive elongation of HIV-1 transcript in the absence of Tat (23)
- Acetylation (2)
- Acetylcholine Neurotransmitter Release Cycle (17)
- Acetylcholine binding and downstream events (14)
- Acetylcholine regulates insulin secretion (10)
- Acrosome Reaction and Sperm:Oocyte Membrane Binding (6)
- Activated NOTCH1 Transmits Signal to the Nucleus (31)
- Activated NTRK2 signals through CDK5 (6)
- Activated NTRK2 signals through FRS2 and FRS3 (11)
- Activated NTRK2 signals through FYN (7)
- Activated NTRK2 signals through PI3K (7)
- Activated NTRK2 signals through PLCG1 (4)
- Activated NTRK2 signals through RAS (9)
- Activated NTRK3 signals through PI3K (6)
- Activated NTRK3 signals through PLCG1 (3)
- Activated NTRK3 signals through RAS (8)
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (36)
- Activated point mutants of FGFR2 (17)
- Activation and oligomerization of BAK protein (2)
- Activation of AKT2 (4)
- Activation of AMPA receptors (4)
- Activation of AMPK downstream of NMDARs (10)
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (77)
- Activation of ATR in response to replication stress (37)
- Activation of BAD and translocation to mitochondria (15)
- Activation of BH3-only proteins (31)
- Activation of BIM and translocation to mitochondria (3)
- Activation of BMF and translocation to mitochondria (3)
- Activation of C3 and C5 (6)
- Activation of Ca-permeable Kainate Receptor (10)
- Activation of G protein gated Potassium channels (25)
- Activation of GABAB receptors (39)
- Activation of HOX genes during differentiation (90)
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (17)
- Activation of Matrix Metalloproteinases (33)
- Activation of NF-kappaB in B cells (68)
- Activation of NIMA Kinases NEK9, NEK6, NEK7 (7)
- Activation of NMDA receptors and postsynaptic events (74)
- Activation of NOXA and translocation to mitochondria (5)
- Activation of Na-permeable kainate receptors (2)
- Activation of PPARGC1A (PGC-1alpha) by phosphorylation (10)
- Activation of PUMA and translocation to mitochondria (10)
- Activation of RAC1 (13)
- Activation of RAC1 downstream of NMDARs (7)
- Activation of RAS in B cells (5)
- Activation of SMO (18)
- Activation of TRKA receptors (6)
- Activation of anterior HOX genes in hindbrain development during early embryogenesis (90)
- Activation of caspases through apoptosome-mediated cleavage (6)
- Activation of gene expression by SREBF (SREBP) (42)
- Activation of kainate receptors upon glutamate binding (30)
- Activation of the AP-1 family of transcription factors (10)
- Activation of the TFAP2 (AP-2) family of transcription factors (12)
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (61)
- Activation of the phototransduction cascade (11)
- Activation of the pre-replicative complex (33)
- Activation, myristolyation of BID and translocation to mitochondria (4)
- Activation, translocation and oligomerization of BAX (2)
- Acyl chain remodeling of CL (6)
- Acyl chain remodeling of DAG and TAG (8)
- Acyl chain remodelling of PC (27)
- Acyl chain remodelling of PE (29)
- Acyl chain remodelling of PG (18)
- Acyl chain remodelling of PI (17)
- Acyl chain remodelling of PS (22)
- Adaptive Immune System (894)
- Adenosine P1 receptors (4)
- Adenylate cyclase activating pathway (10)
- Adenylate cyclase inhibitory pathway (14)
- Adherens junctions interactions (31)
- Adrenaline signalling through Alpha-2 adrenergic receptor (3)
- Adrenaline,noradrenaline inhibits insulin secretion (28)
- Adrenoceptors (9)
- Advanced glycosylation endproduct receptor signaling (13)
- Aflatoxin activation and detoxification (20)
- Agmatine biosynthesis (2)
- Alanine metabolism (2)
- Alpha-defensins (9)
- Alpha-oxidation of phytanate (6)
- Alternative complement activation (4)
- Amine Oxidase reactions (4)
- Amine ligand-binding receptors (42)
- Amino Acid conjugation (9)
- Amino acid transport across the plasma membrane (33)
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (93)
- Amplification of signal from the kinetochores (93)
- Amyloid fiber formation (79)
- Anchoring fibril formation (7)
- Anchoring of the basal body to the plasma membrane (97)
- Antagonism of Activin by Follistatin (4)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC (92)
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (92)
- Antigen processing-Cross presentation (169)
- Antigen processing: Ubiquitination & Proteasome degradation (307)
- Antimicrobial peptides (89)
- Antiviral mechanism by IFN-stimulated genes (82)
- Apoptosis induced DNA fragmentation (13)
- Apoptotic cleavage of cell adhesion proteins (11)
- Apoptotic cleavage of cellular proteins (38)
- Apoptotic execution phase (52)
- Apoptotic factor-mediated response (16)
- Aquaporin-mediated transport (55)
- Arachidonate production from DAG (5)
- Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1)
- Aryl hydrocarbon receptor signalling (7)
- Asparagine N-linked glycosylation (286)
- Aspartate and asparagine metabolism (12)
- Assembly Of The HIV Virion (16)
- Assembly and cell surface presentation of NMDA receptors (24)
- Assembly of Viral Components at the Budding Site (2)
- Assembly of active LPL and LIPC lipase complexes (19)
- Assembly of collagen fibrils and other multimeric structures (57)
- Assembly of the ORC complex at the origin of replication (6)
- Assembly of the pre-replicative complex (69)
- Association of TriC/CCT with target proteins during biosynthesis (39)
- Astrocytic Glutamate-Glutamine Uptake And Metabolism (4)
- Asymmetric localization of PCP proteins (65)
- Attachment of GPI anchor to uPAR (7)
- Attenuation phase (26)
- Autodegradation of Cdh1 by Cdh1:APC/C (64)
- Autodegradation of the E3 ubiquitin ligase COP1 (52)
- Autointegration results in viral DNA circles (3)
- Autophagy (109)
- Axonal growth inhibition (RHOA activation) (8)
- Axonal growth stimulation (4)
- B-WICH complex positively regulates rRNA expression (61)
- BBSome-mediated cargo-targeting to cilium (23)
- BDNF activates NTRK2 (TRKB) signaling (2)
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (10)
- BMAL1:CLOCK,NPAS2 activates circadian gene expression (27)
- Base-Excision Repair, AP Site Formation (44)
- Basigin interactions (25)
- Beta defensins (36)
- Beta oxidation of butanoyl-CoA to acetyl-CoA (5)
- Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (6)
- Beta oxidation of hexanoyl-CoA to butanoyl-CoA (5)
- Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (5)
- Beta oxidation of myristoyl-CoA to lauroyl-CoA (3)
- Beta oxidation of octanoyl-CoA to hexanoyl-CoA (5)
- Beta oxidation of palmitoyl-CoA to myristoyl-CoA (3)
- Beta-catenin independent WNT signaling (146)
- Beta-catenin phosphorylation cascade (17)
- Beta-oxidation of pristanoyl-CoA (9)
- Beta-oxidation of very long chain fatty acids (11)
- Bicarbonate transporters (10)
- Bile acid and bile salt metabolism (43)
- Binding and Uptake of Ligands by Scavenger Receptors (116)
- Binding and entry of HIV virion (4)
- Binding of TCF/LEF:CTNNB1 to target gene promoters (8)
- Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (2)
- Biological oxidations (221)
- Biosynthesis of A2E, implicated in retinal degradation (1)
- Biosynthesis of D-series resolvins (4)
- Biosynthesis of DHA-derived SPMs (17)
- Biosynthesis of DHA-derived sulfido conjugates (2)
- Biosynthesis of DPA-derived SPMs (4)
- Biosynthesis of DPAn-3 SPMs (4)
- Biosynthesis of DPAn-3-derived 13-series resolvins (1)
- Biosynthesis of DPAn-3-derived maresins (2)
- Biosynthesis of DPAn-3-derived protectins and resolvins (2)
- Biosynthesis of DPAn-6 SPMs (2)
- Biosynthesis of E-series 18(R)-resolvins (4)
- Biosynthesis of E-series 18(S)-resolvins (5)
- Biosynthesis of EPA-derived SPMs (6)
- Biosynthesis of aspirin-triggered D-series resolvins (3)
- Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives (2)
- Biosynthesis of maresin conjugates in tissue regeneration (MCTR) (2)
- Biosynthesis of maresin-like SPMs (6)
- Biosynthesis of maresins (8)
- Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) (1)
- Biosynthesis of protectins (4)
- Biosynthesis of specialized proresolving mediators (SPMs) (19)
- Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (78)
- Biotin transport and metabolism (11)
- Blood group systems biosynthesis (22)
- Branched-chain amino acid catabolism (19)
- Breakdown of the nuclear lamina (3)
- Budding and maturation of HIV virion (28)
- Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (17)
- Butyrophilin (BTN) family interactions (12)
- C-type lectin receptors (CLRs) (144)
- C6 deamination of adenosine (2)
- CASP8 activity is inhibited (11)
- CD209 (DC-SIGN) signaling (21)
- CD22 mediated BCR regulation (67)
- CD28 co-stimulation (33)
- CD28 dependent PI3K/Akt signaling (22)
- CD28 dependent Vav1 pathway (12)
- CDC6 association with the ORC:origin complex (11)
- CDK-mediated phosphorylation and removal of Cdc6 (73)
- CDT1 association with the CDC6:ORC:origin complex (60)
- CHL1 interactions (9)
- CLEC7A (Dectin-1) induces NFAT activation (11)
- CLEC7A (Dectin-1) signaling (101)
- CLEC7A/inflammasome pathway (6)
- COPI-dependent Golgi-to-ER retrograde traffic (83)
- COPI-independent Golgi-to-ER retrograde traffic (34)
- COPI-mediated anterograde transport (83)
- COPII-mediated vesicle transport (68)
- COX reactions (1)
- CREB phosphorylation (7)
- CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (28)
- CREB1 phosphorylation through the activation of Adenylate Cyclase (12)
- CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (8)
- CREB3 factors activate genes (9)
- CRMPs in Sema3A signaling (16)
- CS/DS degradation (14)
- CTLA4 inhibitory signaling (21)
- CYP2E1 reactions (11)
- Ca-dependent events (36)
- Ca2+ activated K+ channels (9)
- Ca2+ pathway (61)
- CaM pathway (34)
- CaMK IV-mediated phosphorylation of CREB (10)
- Calcineurin activates NFAT (9)
- Calcitonin-like ligand receptors (11)
- Calmodulin induced events (34)
- Calnexin/calreticulin cycle (26)
- Cam-PDE 1 activation (4)
- Cap-dependent Translation Initiation (121)
- Carboxyterminal post-translational modifications of tubulin (38)
- Cardiac conduction (137)
- Cargo concentration in the ER (33)
- Cargo recognition for clathrin-mediated endocytosis (105)
- Cargo trafficking to the periciliary membrane (51)
- Carnitine synthesis (4)
- Caspase activation via Death Receptors in the presence of ligand (16)
- Caspase activation via Dependence Receptors in the absence of ligand (10)
- Caspase activation via extrinsic apoptotic signalling pathway (26)
- Caspase-mediated cleavage of cytoskeletal proteins (12)
- Cation-coupled Chloride cotransporters (7)
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A (73)
- Cell Cycle Checkpoints (272)
- Cell Cycle, Mitotic (495)
- Cell death signalling via NRAGE, NRIF and NADE (76)
- Cell junction organization (88)
- Cell redox homeostasis (2)
- Cell surface interactions at the vascular wall (211)
- Cell-Cell communication (121)
- Cell-cell junction organization (63)
- Cell-extracellular matrix interactions (16)
- Cellular hexose transport (21)
- Cellular response to heat stress (100)
- Cellular response to hypoxia (76)
- Cellular responses to external stimuli (487)
- Cellular responses to stress (392)
- Centrosome maturation (81)
- Ceramide signalling (3)
- ChREBP activates metabolic gene expression (8)
- Chaperone Mediated Autophagy (16)
- Chaperonin-mediated protein folding (96)
- Chemokine receptors bind chemokines (48)
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (13)
- Cholesterol biosynthesis via desmosterol (4)
- Cholesterol biosynthesis via lathosterol (4)
- Choline catabolism (6)
- Chondroitin sulfate biosynthesis (20)
- Chondroitin sulfate/dermatan sulfate metabolism (50)
- Chromatin modifying enzymes (238)
- Chromatin organization (238)
- Chromosome Maintenance (88)
- Chylomicron assembly (10)
- Chylomicron clearance (5)
- Chylomicron remodeling (10)
- Cilium Assembly (187)
- Circadian Clock (69)
- Citric acid cycle (TCA cycle) (22)
- Class A/1 (Rhodopsin-like receptors) (323)
- Class B/2 (Secretin family receptors) (97)
- Class C/3 (Metabotropic glutamate/pheromone receptors) (40)
- Class I MHC mediated antigen processing & presentation (437)
- Class I peroxisomal membrane protein import (20)
- Classical Kir channels (4)
- Classical antibody-mediated complement activation (83)
- Clathrin-mediated endocytosis (143)
- Cleavage of the damaged purine (37)
- Cleavage of the damaged pyrimidine (42)
- Cobalamin (Cbl, vitamin B12) transport and metabolism (19)
- Cohesin Loading onto Chromatin (10)
- Collagen biosynthesis and modifying enzymes (67)
- Collagen chain trimerization (44)
- Collagen degradation (40)
- Collagen formation (90)
- Common Pathway of Fibrin Clot Formation (22)
- Competing endogenous RNAs (ceRNAs) regulate PTEN translation (10)
- Complement cascade (133)
- Complex I biogenesis (55)
- Condensation of Prometaphase Chromosomes (11)
- Condensation of Prophase Chromosomes (43)
- Conjugation of benzoate with glycine (6)
- Conjugation of carboxylic acids (9)
- Conjugation of phenylacetate with glutamine (2)
- Conjugation of salicylate with glycine (8)
- Constitutive Signaling by AKT1 E17K in Cancer (26)
- Constitutive Signaling by Aberrant PI3K in Cancer (75)
- Constitutive Signaling by EGFRvIII (15)
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (19)
- Constitutive Signaling by NOTCH1 HD Domain Mutants (15)
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (58)
- Constitutive Signaling by NOTCH1 PEST Domain Mutants (58)
- Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant (7)
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (19)
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (42)
- Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding (33)
- Costimulation by the CD28 family (88)
- Creatine metabolism (10)
- Creation of C4 and C2 activators (91)
- Cristae formation (28)
- Cross-presentation of particulate exogenous antigens (phagosomes) (8)
- Cross-presentation of soluble exogenous antigens (endosomes) (51)
- Crosslinking of collagen fibrils (10)
- Cyclin A/B1/B2 associated events during G2/M transition (25)
- Cyclin A:Cdk2-associated events at S phase entry (86)
- Cyclin D associated events in G1 (45)
- Cyclin E associated events during G1/S transition (84)
- Cysteine formation from homocysteine (3)
- Cytochrome P450 - arranged by substrate type (65)
- Cytochrome c-mediated apoptotic response (13)
- Cytokine Signaling in Immune system (922)
- Cytosolic iron-sulfur cluster assembly (13)
- Cytosolic sensors of pathogen-associated DNA (64)
- Cytosolic sulfonation of small molecules (24)
- Cytosolic tRNA aminoacylation (24)
- DAG and IP3 signaling (40)
- DAP12 interactions (92)
- DAP12 signaling (29)
- DARPP-32 events (24)
- DCC mediated attractive signaling (14)
- DDX58/IFIH1-mediated induction of interferon-alpha/beta (77)
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production (7)
- DNA Damage Bypass (47)
- DNA Damage Recognition in GG-NER (38)
- DNA Damage Reversal (8)
- DNA Damage/Telomere Stress Induced Senescence (61)
- DNA Double Strand Break Response (58)
- DNA Double-Strand Break Repair (146)
- DNA Repair (306)
- DNA Replication Pre-Initiation (86)
- DNA methylation (34)
- DNA replication initiation (8)
- DNA strand elongation (32)
- DSCAM interactions (11)
- Deactivation of the beta-catenin transactivating complex (42)
- Deadenylation of mRNA (22)
- Deadenylation-dependent mRNA decay (53)
- Death Receptor Signalling (141)
- Dectin-1 mediated noncanonical NF-kB signaling (63)
- Dectin-2 family (29)
- Defective ABCA1 causes Tangier disease (2)
- Defective ABCA12 causes autosomal recessive congenital ichthyosis type 4B (1)
- Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3) (1)
- Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) (1)
- Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2 (1)
- Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1 (1)
- Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7) (1)
- Defective ABCC2 causes Dubin-Johnson syndrome (1)
- Defective ABCC6 causes pseudoxanthoma elasticum (PXE) (1)
- Defective ABCC8 can cause hypoglycemias and hyperglycemias (2)
- Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia (2)
- Defective ABCD1 causes adrenoleukodystrophy (ALD) (1)
- Defective ABCD4 causes methylmalonic aciduria and homocystinuria, cblj type (MAHCJ) (1)
- Defective ABCG5 causes sitosterolemia (2)
- Defective ABCG8 causes gallbladder disease 4 and sitosterolemia (2)
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) (2)
- Defective ACY1 causes encephalopathy (1)
- Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) (1)
- Defective ALG1 causes ALG1-CDG (CDG-1k) (1)
- Defective ALG11 causes ALG11-CDG (CDG-1p) (1)
- Defective ALG12 causes ALG12-CDG (CDG-1g) (1)
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) (2)
- Defective ALG2 causes ALG2-CDG (CDG-1i) (1)
- Defective ALG3 causes ALG3-CDG (CDG-1d) (1)
- Defective ALG6 causes ALG6-CDG (CDG-1c) (1)
- Defective ALG8 causes ALG8-CDG (CDG-1h) (1)
- Defective ALG9 causes ALG9-CDG (CDG-1l) (1)
- Defective AMN causes hereditary megaloblastic anemia 1 (2)
- Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) (3)
- Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) (2)
- Defective B3GALT6 causes EDSP2 and SEMDJL1 (20)
- Defective B3GALTL causes Peters-plus syndrome (PpS) (38)
- Defective B3GAT3 causes JDSSDHD (20)
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) (8)
- Defective B4GALT7 causes EDS, progeroid type (20)
- Defective BTD causes biotidinase deficiency (1)
- Defective Base Excision Repair Associated with MUTYH (1)
- Defective Base Excision Repair Associated with NEIL1 (1)
- Defective Base Excision Repair Associated with NEIL3 (1)
- Defective Base Excision Repair Associated with NTHL1 (1)
- Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) (20)
- Defective CD320 causes methylmalonic aciduria (2)
- Defective CFTR causes cystic fibrosis (62)
- Defective CHST14 causes EDS, musculocontractural type (8)
- Defective CHST3 causes SEDCJD (8)
- Defective CHST6 causes MCDC1 (8)
- Defective CHSY1 causes TPBS (8)
- Defective CP causes aceruloplasminemia (ACERULOP) (2)
- Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) (8)
- Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) (8)
- Defective CUBN causes hereditary megaloblastic anemia 1 (2)
- Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) (4)
- Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) (1)
- Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) (1)
- Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) (1)
- Defective CYP19A1 causes Aromatase excess syndrome (AEXS) (1)
- Defective CYP1B1 causes Glaucoma (1)
- Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) (1)
- Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) (1)
- Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) (1)
- Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) (1)
- Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) (1)
- Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) (1)
- Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) (1)
- Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) (1)
- Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) (1)
- Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) (1)
- Defective DHDDS causes retinitis pigmentosa 59 (2)
- Defective DOLK causes DOLK-CDG (CDG-1m) (1)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 (1)
- Defective DPM1 causes DPM1-CDG (CDG-1e) (3)
- Defective DPM2 causes DPM2-CDG (CDG-1u) (3)
- Defective DPM3 causes DPM3-CDG (CDG-1o) (3)
- Defective EXT1 causes exostoses 1, TRPS2 and CHDS (14)
- Defective EXT2 causes exostoses 2 (14)
- Defective FMO3 causes Trimethylaminuria (TMAU) (1)
- Defective GALE can cause Epimerase-deficiency galactosemia (EDG) (1)
- Defective GALK1 can cause Galactosemia II (GALCT2) (1)
- Defective GALNT12 causes colorectal cancer 1 (CRCS1) (19)
- Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) (19)
- Defective GALT can cause Galactosemia (1)
- Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) (1)
- Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) (2)
- Defective GFPT1 causes CMSTA1 (1)
- Defective GGT1 causes Glutathionuria (GLUTH) (1)
- Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2 (1)
- Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) (1)
- Defective HEXA causes GM2G1 (1)
- Defective HEXB causes GM2G2 (1)
- Defective HK1 causes hexokinase deficiency (HK deficiency) (1)
- Defective HLCS causes multiple carboxylase deficiency (7)
- Defective LARGE causes MDDGA6 and MDDGB6 (2)
- Defective LFNG causes SCDO3 (5)
- Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF (1)
- Defective MAN1B1 causes MRT15 (1)
- Defective MAOA causes Brunner syndrome (BRUNS) (1)
- Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) (1)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a) (1)
- Defective MMAA causes methylmalonic aciduria type cblA (1)
- Defective MMAB causes methylmalonic aciduria type cblB (1)
- Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC (1)
- Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD (2)
- Defective MOGS causes MOGS-CDG (CDG-2b) (1)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f) (1)
- Defective MPI causes MPI-CDG (CDG-1b) (1)
- Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (2)
- Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (2)
- Defective MUT causes methylmalonic aciduria mut type (1)
- Defective MUTYH substrate binding (1)
- Defective MUTYH substrate processing (1)
- Defective Mismatch Repair Associated With MLH1 (2)
- Defective Mismatch Repair Associated With MSH2 (3)
- Defective Mismatch Repair Associated With MSH3 (2)
- Defective Mismatch Repair Associated With MSH6 (2)
- Defective Mismatch Repair Associated With PMS2 (2)
- Defective NEU1 causes sialidosis (3)
- Defective NTHL1 substrate binding (1)
- Defective NTHL1 substrate processing (1)
- Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) (1)
- Defective PAPSS2 causes SEMD-PA (1)
- Defective PGM1 causes PGM1-CDG (CDG1t) (1)
- Defective PMM2 causes PMM2-CDG (CDG-1a) (1)
- Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 (2)
- Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 (3)
- Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 (3)
- Defective RFT1 causes RFT1-CDG (CDG-1n) (1)
- Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) (1)
- Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF) (1)
- Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) (1)
- Defective SLC12A1 causes Bartter syndrome 1 (BS1) (1)
- Defective SLC12A3 causes Gitelman syndrome (GS) (1)
- Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) (1)
- Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) (2)
- Defective SLC17A5 causes Salla disease (SD) and ISSD (1)
- Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) (1)
- Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) (1)
- Defective SLC1A3 causes episodic ataxia 6 (EA6) (1)
- Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) (1)
- Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) (1)
- Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) (1)
- Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) (1)
- Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) (1)
- Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) (1)
- Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) (1)
- Defective SLC26A2 causes chondrodysplasias (1)
- Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) (1)
- Defective SLC26A4 causes Pendred syndrome (PDS) (1)
- Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) (1)
- Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) (1)
- Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) (1)
- Defective SLC2A10 causes arterial tortuosity syndrome (ATS) (1)
- Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) (1)
- Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) (1)
- Defective SLC33A1 causes spastic paraplegia 42 (SPG42) (1)
- Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1) (1)
- Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) (1)
- Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) (1)
- Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) (1)
- Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) (1)
- Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) (1)
- Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) (1)
- Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) (1)
- Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) (1)
- Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) (1)
- Defective SLC3A1 causes cystinuria (CSNU) (2)
- Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) (2)
- Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) (2)
- Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) (1)
- Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) (1)
- Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM) (1)
- Defective SLC5A2 causes renal glucosuria (GLYS1) (1)
- Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) (1)
- Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) (1)
- Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria (1)
- Defective SLC6A19 causes Hartnup disorder (HND) (1)
- Defective SLC6A2 causes orthostatic intolerance (OI) (1)
- Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) (1)
- Defective SLC6A5 causes hyperekplexia 3 (HKPX3) (1)
- Defective SLC7A7 causes lysinuric protein intolerance (LPI) (2)
- Defective SLC7A9 causes cystinuria (CSNU) (2)
- Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) (1)
- Defective SLC9A9 causes autism 16 (AUTS16) (1)
- Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) (2)
- Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) (2)
- Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) (1)
- Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ (1)
- Defective ST3GAL3 causes MCT12 and EIEE15 (8)
- Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) (1)
- Defective TCN2 causes hereditary megaloblastic anemia (1)
- Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) (1)
- Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) (32)
- Defective UGT1A1 causes hyperbilirubinemia (1)
- Defective UGT1A4 causes hyperbilirubinemia (1)
- Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS) (1)
- Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS) (1)
- Defects in biotin (Btn) metabolism (8)
- Defects in cobalamin (B12) metabolism (12)
- Defects in vitamin and cofactor metabolism (20)
- Defensins (45)
- Degradation of AXIN (56)
- Degradation of DVL (58)
- Degradation of GABA (2)
- Degradation of GLI1 by the proteasome (61)
- Degradation of GLI2 by the proteasome (61)
- Degradation of beta-catenin by the destruction complex (85)
- Degradation of cysteine and homocysteine (13)
- Degradation of the extracellular matrix (111)
- Deletions in the AMER1 gene destabilize the destruction complex (1)
- Deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling (1)
- Depolymerisation of the Nuclear Lamina (16)
- Deposition of new CENPA-containing nucleosomes at the centromere (52)
- Depurination (37)
- Depyrimidination (42)
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (22)
- Dermatan sulfate biosynthesis (11)
- Detoxification of Reactive Oxygen Species (37)
- Deubiquitination (278)
- Developmental Biology (1055)
- Digestion (21)
- Digestion and absorption (26)
- Digestion of dietary carbohydrate (9)
- Digestion of dietary lipid (7)
- Dimerization of procaspase-8 (11)
- Disassembly of the destruction complex and recruitment of AXIN to the membrane (31)
- Disease (1105)
- Diseases associated with N-glycosylation of proteins (17)
- Diseases associated with O-glycosylation of proteins (71)
- Diseases associated with glycosaminoglycan metabolism (41)
- Diseases associated with glycosylation precursor biosynthesis (18)
- Diseases associated with surfactant metabolism (10)
- Diseases associated with the TLR signaling cascade (25)
- Diseases associated with visual transduction (13)
- Diseases of Base Excision Repair (4)
- Diseases of Cellular Senescence (4)
- Diseases of Immune System (25)
- Diseases of Mismatch Repair (MMR) (5)
- Diseases of carbohydrate metabolism (35)
- Diseases of glycosylation (146)
- Diseases of metabolism (103)
- Diseases of signal transduction (387)
- Disinhibition of SNARE formation (5)
- Disorders of transmembrane transporters (178)
- Displacement of DNA glycosylase by APEX1 (9)
- Dissolution of Fibrin Clot (13)
- Dopamine Neurotransmitter Release Cycle (23)
- Dopamine clearance from the synaptic cleft (5)
- Dopamine receptors (5)
- Downregulation of ERBB2 signaling (29)
- Downregulation of ERBB2:ERBB3 signaling (13)
- Downregulation of ERBB4 signaling (9)
- Downregulation of SMAD2/3:SMAD4 transcriptional activity (23)
- Downregulation of TGF-beta receptor signaling (26)
- Downstream TCR signaling (117)
- Downstream signal transduction (29)
- Downstream signaling events of B Cell Receptor (BCR) (82)
- Downstream signaling of activated FGFR1 (31)
- Downstream signaling of activated FGFR2 (30)
- Downstream signaling of activated FGFR3 (25)
- Downstream signaling of activated FGFR4 (27)
- Dual Incision in GG-NER (41)
- Dual incision in TC-NER (65)
- E2F mediated regulation of DNA replication (22)
- E2F-enabled inhibition of pre-replication complex formation (9)
- E3 ubiquitin ligases ubiquitinate target proteins (110)
- ECM proteoglycans (56)
- EGFR Transactivation by Gastrin (9)
- EGFR downregulation (31)
- EGFR interacts with phospholipase C-gamma (9)
- EPH-Ephrin signaling (92)
- EPH-ephrin mediated repulsion of cells (49)
- EPHA-mediated growth cone collapse (15)
- EPHB-mediated forward signaling (34)
- ER Quality Control Compartment (ERQC) (21)
- ER to Golgi Anterograde Transport (136)
- ER-Phagosome pathway (153)
- ERBB2 Activates PTK6 Signaling (13)
- ERBB2 Regulates Cell Motility (15)
- ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression (45)
- ERK/MAPK targets (22)
- ERKs are inactivated (13)
- ESR-mediated signaling (189)
- Early Phase of HIV Life Cycle (14)
- Effects of PIP2 hydrolysis (27)
- Eicosanoid ligand-binding receptors (15)
- Eicosanoids (12)
- Elastic fibre formation (41)
- Electric Transmission Across Gap Junctions (5)
- Electron transport from NADPH to Ferredoxin (3)
- Elevation of cytosolic Ca2+ levels (16)
- Endogenous sterols (27)
- Endosomal Sorting Complex Required For Transport (ESCRT) (31)
- Endosomal/Vacuolar pathway (79)
- Energy dependent regulation of mTOR by LKB1-AMPK (28)
- Entry of Influenza Virion into Host Cell via Endocytosis (2)
- Enzymatic degradation of Dopamine by monoamine oxidase (2)
- Enzymatic degradation of dopamine by COMT (4)
- Ephrin signaling (19)
- Epigenetic regulation of gene expression (118)
- Erythrocytes take up carbon dioxide and release oxygen (12)
- Erythrocytes take up oxygen and release carbon dioxide (8)
- Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (12)
- Erythropoietin activates Phospholipase C gamma (PLCG) (7)
- Erythropoietin activates RAS (14)
- Erythropoietin activates STAT5 (7)
- Essential fructosuria (1)
- Essential pentosuria (1)
- Establishment of Sister Chromatid Cohesion (11)
- Estrogen biosynthesis (6)
- Estrogen-dependent gene expression (119)
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling (24)
- Estrogen-stimulated signaling through PRKCZ (6)
- Ethanol oxidation (12)
- Eukaryotic Translation Elongation (96)
- Eukaryotic Translation Initiation (121)
- Eukaryotic Translation Termination (95)
- Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 (3)
- Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 (4)
- Evasion of Oncogene Induced Senescence Due to p16INK4A Defects (4)
- Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 (3)
- Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 (4)
- Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects (4)
- Events associated with phagocytolytic activity of PMN cells (2)
- Export of Viral Ribonucleoproteins from Nucleus (33)
- Expression and Processing of Neurotrophins (4)
- Extension of Telomeres (30)
- Extra-nuclear estrogen signaling (74)
- Extracellular matrix organization (297)
- Extrinsic Pathway of Fibrin Clot Formation (5)
- FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (56)
- FBXW7 Mutants and NOTCH1 in Cancer (5)
- FCERI mediated Ca+2 mobilization (102)
- FCERI mediated MAPK activation (103)
- FCERI mediated NF-kB activation (153)
- FCGR activation (89)
- FGFR1 ligand binding and activation (16)
- FGFR1 mutant receptor activation (32)
- FGFR1b ligand binding and activation (6)
- FGFR1c and Klotho ligand binding and activation (3)
- FGFR1c ligand binding and activation (12)
- FGFR2 alternative splicing (26)
- FGFR2 ligand binding and activation (20)
- FGFR2 mutant receptor activation (33)
- FGFR2b ligand binding and activation (10)
- FGFR2c ligand binding and activation (13)
- FGFR3 ligand binding and activation (13)
- FGFR3 mutant receptor activation (12)
- FGFR3b ligand binding and activation (7)
- FGFR3c ligand binding and activation (13)
- FGFR4 ligand binding and activation (14)
- FGFR4 mutant receptor activation (1)
- FGFRL1 modulation of FGFR1 signaling (13)
- FLT3 Signaling (264)
- FMO oxidises nucleophiles (3)
- FOXO-mediated transcription (68)
- FOXO-mediated transcription of cell cycle genes (17)
- FOXO-mediated transcription of cell death genes (18)
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (30)
- FRS-mediated FGFR1 signaling (23)
- FRS-mediated FGFR2 signaling (25)
- FRS-mediated FGFR3 signaling (20)
- FRS-mediated FGFR4 signaling (22)
- Factors involved in megakaryocyte development and platelet production (139)
- FasL/ CD95L signaling (5)
- Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (8)
- Fatty acids (15)
- Fatty acyl-CoA biosynthesis (37)
- Fc epsilon receptor (FCERI) signaling (206)
- Fcgamma receptor (FCGR) dependent phagocytosis (163)
- Fertilization (26)
- Fibronectin matrix formation (6)
- Ficolins bind to repetitive carbohydrate structures on the target cell surface (5)
- Folding of actin by CCT/TriC (10)
- Formation of ATP by chemiosmotic coupling (17)
- Formation of Fibrin Clot (Clotting Cascade) (39)
- Formation of HIV elongation complex in the absence of HIV Tat (48)
- Formation of HIV-1 elongation complex containing HIV-1 Tat (47)
- Formation of Incision Complex in GG-NER (43)
- Formation of RNA Pol II elongation complex (61)
- Formation of Senescence-Associated Heterochromatin Foci (SAHF) (17)
- Formation of TC-NER Pre-Incision Complex (53)
- Formation of a pool of free 40S subunits (103)
- Formation of annular gap junctions (9)
- Formation of apoptosome (11)
- Formation of editosomes by ADAR proteins (2)
- Formation of the Early Elongation Complex (33)
- Formation of the Editosome (8)
- Formation of the HIV-1 Early Elongation Complex (33)
- Formation of the active cofactor, UDP-glucuronate (3)
- Formation of the beta-catenin:TCF transactivating complex (61)
- Formation of the cornified envelope (75)
- Formation of the ternary complex, and subsequently, the 43S complex (53)
- Formation of tubulin folding intermediates by CCT/TriC (26)
- Formation of xylulose-5-phosphate (5)
- Formyl peptide receptors bind formyl peptides and many other ligands (9)
- Free fatty acid receptors (5)
- Free fatty acids regulate insulin secretion (11)
- Frs2-mediated activation (10)
- Fructose biosynthesis (2)
- Fructose catabolism (5)
- Fructose metabolism (7)
- G alpha (12/13) signalling events (80)
- G alpha (i) signalling events (408)
- G alpha (q) signalling events (219)
- G alpha (s) signalling events (577)
- G alpha (z) signalling events (51)
- G beta:gamma signalling through BTK (18)
- G beta:gamma signalling through CDC42 (20)
- G beta:gamma signalling through PI3Kgamma (25)
- G beta:gamma signalling through PLC beta (20)
- G protein gated Potassium channels (25)
- G-protein activation (28)
- G-protein beta:gamma signalling (32)
- G-protein mediated events (53)
- G0 and Early G1 (27)
- G1 Phase (45)
- G1/S DNA Damage Checkpoints (69)
- G1/S Transition (132)
- G1/S-Specific Transcription (29)
- G2 Phase (5)
- G2/M Checkpoints (150)
- G2/M DNA damage checkpoint (76)
- G2/M DNA replication checkpoint (5)
- G2/M Transition (184)
- GAB1 signalosome (17)
- GABA B receptor activation (39)
- GABA receptor activation (56)
- GABA synthesis (2)
- GABA synthesis, release, reuptake and degradation (19)
- GDP-fucose biosynthesis (6)
- GLI proteins bind promoters of Hh responsive genes to promote transcription (7)
- GLI3 is processed to GLI3R by the proteasome (61)
- GP1b-IX-V activation signalling (10)
- GPCR downstream signalling (1152)
- GPCR ligand binding (460)
- GPVI-mediated activation cascade (32)
- GRB2 events in EGFR signaling (13)
- GRB2 events in ERBB2 signaling (16)
- GRB2:SOS provides linkage to MAPK signaling for Integrins (15)
- GRB7 events in ERBB2 signaling (5)
- GTP hydrolysis and joining of the 60S ribosomal subunit (114)
- Galactose catabolism (5)
- Gamma carboxylation, hypusine formation and arylsulfatase activation (39)
- Gamma-carboxylation of protein precursors (10)
- Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (11)
- Gap junction assembly (19)
- Gap junction degradation (10)
- Gap junction trafficking (28)
- Gap junction trafficking and regulation (30)
- Gap-filling DNA repair synthesis and ligation in GG-NER (25)
- Gap-filling DNA repair synthesis and ligation in TC-NER (64)
- Gastrin-CREB signalling pathway via PKC and MAPK (18)
- Gene Silencing by RNA (106)
- Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (37)
- Gene expression (Transcription) (1452)
- Generation of second messenger molecules (51)
- Generic Transcription Pathway (1195)
- Global Genome Nucleotide Excision Repair (GG-NER) (84)
- Glucagon signaling in metabolic regulation (36)
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (45)
- Glucagon-type ligand receptors (36)
- Glucocorticoid biosynthesis (9)
- Gluconeogenesis (34)
- Glucose metabolism (92)
- Glucuronidation (58)
- Glutamate Neurotransmitter Release Cycle (24)
- Glutamate and glutamine metabolism (13)
- Glutamate binding, activation of AMPA receptors and synaptic plasticity (31)
- Glutathione conjugation (37)
- Glutathione synthesis and recycling (13)
- Glycerophospholipid biosynthesis (129)
- Glycerophospholipid catabolism (7)
- Glycine degradation (4)
- Glycogen breakdown (glycogenolysis) (15)
- Glycogen metabolism (28)
- Glycogen storage disease type 0 (liver GYS2) (2)
- Glycogen storage disease type 0 (muscle GYS1) (2)
- Glycogen storage disease type II (GAA) (2)
- Glycogen storage disease type IV (GBE1) (3)
- Glycogen storage disease type Ia (G6PC) (1)
- Glycogen storage disease type Ib (SLC37A4) (1)
- Glycogen storage disease type XV (GYG1) (2)
- Glycogen storage diseases (17)
- Glycogen synthesis (17)
- Glycoprotein hormones (10)
- Glycosaminoglycan metabolism (122)
- Glycosphingolipid metabolism (46)
- Glyoxylate metabolism and glycine degradation (31)
- Golgi Associated Vesicle Biogenesis (56)
- Golgi Cisternae Pericentriolar Stack Reorganization (14)
- Golgi-to-ER retrograde transport (117)
- Growth hormone receptor signaling (24)
- HATs acetylate histones (107)
- HCN channels (4)
- HDACs deacetylate histones (60)
- HDL assembly (8)
- HDL clearance (5)
- HDL remodeling (10)
- HDMs demethylate histones (25)
- HDR through Homologous Recombination (HRR) (66)
- HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (112)
- HDR through MMEJ (alt-NHEJ) (10)
- HDR through Single Strand Annealing (SSA) (37)
- HHAT G278V abrogates palmitoylation of Hh-Np (4)
- HIV Infection (256)
- HIV Life Cycle (153)
- HIV Transcription Elongation (47)
- HIV Transcription Initiation (47)
- HIV elongation arrest and recovery (36)
- HS-GAG biosynthesis (31)
- HS-GAG degradation (21)
- HSF1 activation (29)
- HSF1-dependent transactivation (36)
- HSP90 chaperone cycle for steroid hormone receptors (SHR) (38)
- Hedgehog 'off' state (104)
- Hedgehog 'on' state (87)
- Hedgehog ligand biogenesis (66)
- Heme degradation (5)
- Hemostasis (666)
- Heparan sulfate/heparin (HS-GAG) metabolism (54)
- Hereditary fructose intolerance (1)
- Hh mutants abrogate ligand secretion (60)
- Hh mutants that don't undergo autocatalytic processing are degraded by ERAD (57)
- Highly calcium permeable nicotinic acetylcholine receptors (9)
- Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (11)
- Highly sodium permeable acetylcholine nicotinic receptors (7)
- Histamine receptors (4)
- Histidine catabolism (8)
- Homologous DNA Pairing and Strand Exchange (42)
- Homology Directed Repair (118)
- Hormone ligand-binding receptors (13)
- Host Interactions of HIV factors (153)
- Host Interactions with Influenza Factors (43)
- HuR (ELAVL1) binds and stabilizes mRNA (10)
- Hyaluronan biosynthesis and export (5)
- Hyaluronan metabolism (17)
- Hyaluronan uptake and degradation (12)
- Hydrolysis of LPC (9)
- Hydrolysis of LPE (2)
- Hydroxycarboxylic acid-binding receptors (3)
- Hypusine synthesis from eIF5A-lysine (4)
- IGF1R signaling cascade (53)
- IKBKB deficiency causes SCID (3)
- IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) (3)
- IKK complex recruitment mediated by RIP1 (23)
- IL-6-type cytokine receptor ligand interactions (17)
- IRAK1 recruits IKK complex (10)
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (10)
- IRAK2 mediated activation of TAK1 complex (10)
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (15)
- IRAK4 deficiency (TLR2/4) (12)
- IRAK4 deficiency (TLR5) (4)
- IRE1alpha activates chaperones (50)
- IRF3 mediated activation of type 1 IFN (5)
- IRF3-mediated induction of type I IFN (13)
- IRS activation (5)
- IRS-mediated signalling (48)
- IRS-related events triggered by IGF1R (52)
- ISG15 antiviral mechanism (74)
- IkBA variant leads to EDA-ID (7)
- Immune System (2246)
- Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (275)
- Import of palmitoyl-CoA into the mitochondrial matrix (12)
- Inactivation of APC/C via direct inhibition of the APC/C complex (20)
- Inactivation of CDC42 and RAC1 (8)
- Inactivation, recovery and regulation of the phototransduction cascade (33)
- Incretin synthesis, secretion, and inactivation (23)
- Infectious disease (408)
- Inflammasomes (20)
- Influenza Infection (157)
- Influenza Life Cycle (146)
- Influenza Viral RNA Transcription and Replication (137)
- Influenza Virus Induced Apoptosis (2)
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (25)
- Inhibition of Host mRNA Processing and RNA Silencing (2)
- Inhibition of PKR (1)
- Inhibition of Signaling by Overexpressed EGFR (8)
- Inhibition of TSC complex formation by PKB (3)
- Inhibition of replication initiation of damaged DNA by RB1/E2F1 (13)
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (20)
- Initial triggering of complement (98)
- Initiation of Nuclear Envelope Reformation (14)
- InlA-mediated entry of Listeria monocytogenes into host cells (9)
- InlB-mediated entry of Listeria monocytogenes into host cell (15)
- Innate Immune System (1188)
- Inositol transporters (3)
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (23)
- Insulin effects increased synthesis of Xylulose-5-Phosphate (2)
- Insulin processing (27)
- Insulin receptor recycling (26)
- Insulin receptor signalling cascade (54)
- Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA (7)
- Integration of energy metabolism (111)
- Integration of provirus (9)
- Integration of viral DNA into host genomic DNA (3)
- Integrin alphaIIb beta3 signaling (27)
- Integrin cell surface interactions (66)
- Integrin signaling (27)
- Interaction With Cumulus Cells And The Zona Pellucida (11)
- Interaction between L1 and Ankyrins (29)
- Interaction between PHLDA1 and AURKA (2)
- Interactions of Rev with host cellular proteins (37)
- Interactions of Tat with host cellular proteins (3)
- Interactions of Vpr with host cellular proteins (37)
- Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (3)
- Interconversion of nucleotide di- and triphosphates (30)
- Interconversion of polyamines (3)
- Interferon Signaling (280)
- Interferon alpha/beta signaling (136)
- Interferon gamma signaling (172)
- Interleukin receptor SHC signaling (27)
- Interleukin-1 family signaling (140)
- Interleukin-1 processing (8)
- Interleukin-1 signaling (103)
- Interleukin-10 signaling (45)
- Interleukin-12 family signaling (56)
- Interleukin-12 signaling (46)
- Interleukin-15 signaling (14)
- Interleukin-17 signaling (71)
- Interleukin-18 signaling (8)
- Interleukin-2 family signaling (44)
- Interleukin-2 signaling (12)
- Interleukin-20 family signaling (26)
- Interleukin-21 signaling (10)
- Interleukin-23 signaling (9)
- Interleukin-27 signaling (11)
- Interleukin-3, Interleukin-5 and GM-CSF signaling (44)
- Interleukin-33 signaling (3)
- Interleukin-35 Signalling (12)
- Interleukin-36 pathway (7)
- Interleukin-37 signaling (21)
- Interleukin-38 signaling (4)
- Interleukin-4 and Interleukin-13 signaling (111)
- Interleukin-6 family signaling (24)
- Interleukin-6 signaling (11)
- Interleukin-7 signaling (25)
- Interleukin-9 signaling (9)
- Intestinal absorption (5)
- Intestinal hexose absorption (4)
- Intestinal infectious diseases (2)
- Intestinal lipid absorption (1)
- Intestinal saccharidase deficiencies (2)
- Intra-Golgi and retrograde Golgi-to-ER traffic (187)
- Intra-Golgi traffic (45)
- Intracellular metabolism of fatty acids regulates insulin secretion (3)
- Intracellular oxygen transport (3)
- Intracellular signaling by second messengers (305)
- Intraflagellar transport (41)
- Intrinsic Pathway for Apoptosis (52)
- Intrinsic Pathway of Fibrin Clot Formation (22)
- Invadopodia formation (4)
- Inwardly rectifying K+ channels (31)
- Ion channel transport (179)
- Ion homeostasis (52)
- Ion influx/efflux at host-pathogen interface (4)
- Ion transport by P-type ATPases (55)
- Ionotropic activity of kainate receptors (10)
- Iron uptake and transport (59)
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (18)
- Josephin domain DUBs (11)
- KSRP (KHSRP) binds and destabilizes mRNA (17)
- Keratan sulfate biosynthesis (28)
- Keratan sulfate degradation (12)
- Keratan sulfate/keratin metabolism (33)
- Keratinization (217)
- Ketone body metabolism (10)
- Kinesins (44)
- L13a-mediated translational silencing of Ceruloplasmin expression (113)
- L1CAM interactions (100)
- LDL clearance (19)
- LDL remodeling (4)
- LGI-ADAM interactions (14)
- LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production (5)
- Lactose synthesis (3)
- Lagging Strand Synthesis (20)
- Laminin interactions (23)
- Late Phase of HIV Life Cycle (140)
- Latent infection - Other responses of Mtb to phagocytosis (4)
- Leading Strand Synthesis (14)
- Lectin pathway of complement activation (8)
- Leukotriene receptors (5)
- Lewis blood group biosynthesis (18)
- Ligand-receptor interactions (8)
- Linoleic acid (LA) metabolism (8)
- Lipid particle organization (6)
- Lipophagy (9)
- Listeria monocytogenes entry into host cells (20)
- Localization of the PINCH-ILK-PARVIN complex to focal adhesions (4)
- Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling (5)
- Loss of Function of SMAD2/3 in Cancer (7)
- Loss of Function of SMAD4 in Cancer (3)
- Loss of Function of TGFBR1 in Cancer (7)
- Loss of Function of TGFBR2 in Cancer (3)
- Loss of MECP2 binding ability to 5hmC-DNA (1)
- Loss of MECP2 binding ability to 5mC-DNA (4)
- Loss of MECP2 binding ability to the NCoR/SMRT complex (7)
- Loss of Nlp from mitotic centrosomes (69)
- Loss of function of MECP2 in Rett syndrome (13)
- Loss of phosphorylation of MECP2 at T308 (4)
- Loss of proteins required for interphase microtubule organization from the centrosome (69)
- Lysine catabolism (12)
- Lysosomal oligosaccharide catabolism (4)
- Lysosome Vesicle Biogenesis (35)
- Lysosphingolipid and LPA receptors (14)
- M Phase (350)
- MAP kinase activation (63)
- MAP2K and MAPK activation (38)
- MAP3K8 (TPL2)-dependent MAPK1/3 activation (16)
- MAPK family signaling cascades (293)
- MAPK targets/ Nuclear events mediated by MAP kinases (31)
- MAPK1 (ERK2) activation (9)
- MAPK1/MAPK3 signaling (252)
- MAPK3 (ERK1) activation (10)
- MAPK6/MAPK4 signaling (92)
- MASTL Facilitates Mitotic Progression (10)
- MECP2 regulates neuronal receptors and channels (18)
- MECP2 regulates transcription factors (5)
- MECP2 regulates transcription of genes involved in GABA signaling (3)
- MECP2 regulates transcription of neuronal ligands (8)
- MET Receptor Activation (6)
- MET activates PI3K/AKT signaling (6)
- MET activates PTK2 signaling (18)
- MET activates PTPN11 (5)
- MET activates RAP1 and RAC1 (11)
- MET activates RAS signaling (11)
- MET activates STAT3 (3)
- MET interacts with TNS proteins (5)
- MET promotes cell motility (29)
- MET receptor recycling (10)
- MGMT-mediated DNA damage reversal (1)
- MHC class II antigen presentation (120)
- MPS I - Hurler syndrome (1)
- MPS II - Hunter syndrome (1)
- MPS IIIA - Sanfilippo syndrome A (1)
- MPS IIIB - Sanfilippo syndrome B (1)
- MPS IIIC - Sanfilippo syndrome C (1)
- MPS IIID - Sanfilippo syndrome D (1)
- MPS IV - Morquio syndrome A (1)
- MPS IV - Morquio syndrome B (1)
- MPS IX - Natowicz syndrome (1)
- MPS VI - Maroteaux-Lamy syndrome (1)
- MPS VII - Sly syndrome (1)
- MTF1 activates gene expression (3)
- Macroautophagy (90)
- Major pathway of rRNA processing in the nucleolus and cytosol (183)
- Meiosis (88)
- Meiotic recombination (56)
- Meiotic synapsis (60)
- Melanin biosynthesis (5)
- Membrane Trafficking (612)
- Membrane binding and targetting of GAG proteins (14)
- Metabolic disorders of biological oxidation enzymes (36)
- Metabolism (2112)
- Metabolism of Angiotensinogen to Angiotensins (18)
- Metabolism of RNA (686)
- Metabolism of amine-derived hormones (18)
- Metabolism of amino acids and derivatives (373)
- Metabolism of carbohydrates (293)
- Metabolism of cofactors (19)
- Metabolism of fat-soluble vitamins (48)
- Metabolism of folate and pterines (17)
- Metabolism of ingested H2SeO4 and H2SeO3 into H2Se (4)
- Metabolism of ingested MeSeO2H into MeSeH (1)
- Metabolism of ingested SeMet, Sec, MeSec into H2Se (8)
- Metabolism of lipids (740)
- Metabolism of nitric oxide: eNOS activation and regulation (15)
- Metabolism of non-coding RNA (53)
- Metabolism of nucleotides (100)
- Metabolism of polyamines (60)
- Metabolism of porphyrins (16)
- Metabolism of proteins (2050)
- Metabolism of serotonin (2)
- Metabolism of steroid hormones (35)
- Metabolism of steroids (151)
- Metabolism of vitamin K (3)
- Metabolism of vitamins and cofactors (188)
- Metabolism of water-soluble vitamins and cofactors (122)
- Metal ion SLC transporters (26)
- Metal sequestration by antimicrobial proteins (6)
- Metalloprotease DUBs (28)
- Metallothioneins bind metals (11)
- Methionine salvage pathway (6)
- Methylation (14)
- Methylation of MeSeH for excretion (1)
- MicroRNA (miRNA) biogenesis (24)
- Microautophagy (28)
- Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane (1)
- Mineralocorticoid biosynthesis (6)
- Minus-strand DNA synthesis (1)
- Miscellaneous substrates (12)
- Miscellaneous transport and binding events (24)
- Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (14)
- Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (14)
- Misspliced GSK3beta mutants stabilize beta-catenin (15)
- Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling (6)
- Mitochondrial ABC transporters (4)
- Mitochondrial Fatty Acid Beta-Oxidation (37)
- Mitochondrial Uncoupling Proteins (5)
- Mitochondrial biogenesis (89)
- Mitochondrial calcium ion transport (22)
- Mitochondrial iron-sulfur cluster biogenesis (13)
- Mitochondrial protein import (65)
- Mitochondrial tRNA aminoacylation (21)
- Mitochondrial transcription initiation (3)
- Mitochondrial transcription termination (1)
- Mitochondrial translation (96)
- Mitochondrial translation elongation (90)
- Mitochondrial translation initiation (90)
- Mitochondrial translation termination (90)
- Mitophagy (28)
- Mitotic Anaphase (183)
- Mitotic G1-G1/S phases (151)
- Mitotic G2-G2/M phases (186)
- Mitotic Metaphase and Anaphase (184)
- Mitotic Metaphase/Anaphase Transition (2)
- Mitotic Prometaphase (183)
- Mitotic Prophase (113)
- Mitotic Spindle Checkpoint (109)
- Mitotic Telophase/Cytokinesis (14)
- Molecules associated with elastic fibres (30)
- Mtb iron assimilation by chelation (1)
- Mucopolysaccharidoses (11)
- Multifunctional anion exchangers (9)
- Muscarinic acetylcholine receptors (5)
- Muscle contraction (202)
- MyD88 cascade initiated on plasma membrane (84)
- MyD88 deficiency (TLR2/4) (11)
- MyD88 deficiency (TLR5) (2)
- MyD88 dependent cascade initiated on endosome (91)
- MyD88-independent TLR4 cascade (97)
- MyD88:MAL(TIRAP) cascade initiated on plasma membrane (95)
- Myoclonic epilepsy of Lafora (10)
- Myogenesis (29)
- N-Glycan antennae elongation (15)
- N-glycan antennae elongation in the medial/trans-Golgi (26)
- N-glycan trimming and elongation in the cis-Golgi (5)
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle (35)
- NADE modulates death signalling (6)
- NADPH regeneration (1)
- NCAM signaling for neurite out-growth (59)
- NCAM1 interactions (38)
- NEIL3-mediated resolution of ICLs (1)
- NEP/NS2 Interacts with the Cellular Export Machinery (32)
- NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (12)
- NF-kB is activated and signals survival (13)
- NFG and proNGF binds to p75NTR (3)
- NGF processing (4)
- NGF-independant TRKA activation (5)
- NIK-->noncanonical NF-kB signaling (60)
- NOD1/2 Signaling Pathway (31)
- NOSIP mediated eNOS trafficking (2)
- NOSTRIN mediated eNOS trafficking (5)
- NOTCH1 Intracellular Domain Regulates Transcription (47)
- NOTCH2 Activation and Transmission of Signal to the Nucleus (22)
- NOTCH2 intracellular domain regulates transcription (12)
- NOTCH3 Activation and Transmission of Signal to the Nucleus (25)
- NOTCH3 Intracellular Domain Regulates Transcription (25)
- NOTCH4 Activation and Transmission of Signal to the Nucleus (11)
- NOTCH4 Intracellular Domain Regulates Transcription (20)
- NR1D1 (REV-ERBA) represses gene expression (4)
- NRAGE signals death through JNK (59)
- NRIF signals cell death from the nucleus (16)
- NS1 Mediated Effects on Host Pathways (41)
- NTF3 activates NTRK2 (TRKB) signaling (2)
- NTF3 activates NTRK3 signaling (2)
- NTF4 activates NTRK2 (TRKB) signaling (2)
- NTRK2 activates RAC1 (5)
- NTRK3 as a dependence receptor (3)
- Na+/Cl- dependent neurotransmitter transporters (19)
- Nectin/Necl trans heterodimerization (7)
- Neddylation (234)
- Nef Mediated CD4 Down-regulation (9)
- Nef Mediated CD8 Down-regulation (7)
- Nef and signal transduction (8)
- Nef mediated downregulation of CD28 cell surface expression (2)
- Nef mediated downregulation of MHC class I complex cell surface expression (30)
- Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (41)
- Negative epigenetic regulation of rRNA expression (79)
- Negative feedback regulation of MAPK pathway (6)
- Negative regulation of FGFR1 signaling (33)
- Negative regulation of FGFR2 signaling (34)
- Negative regulation of FGFR3 signaling (29)
- Negative regulation of FGFR4 signaling (31)
- Negative regulation of MAPK pathway (40)
- Negative regulation of MET activity (21)
- Negative regulation of NMDA receptor-mediated neuronal transmission (21)
- Negative regulation of NOTCH4 signaling (55)
- Negative regulation of TCF-dependent signaling by DVL-interacting proteins (5)
- Negative regulation of TCF-dependent signaling by WNT ligand antagonists (15)
- Negative regulation of activity of TFAP2 (AP-2) family transcription factors (10)
- Negative regulation of the PI3K/AKT network (110)
- Negative regulators of DDX58/IFIH1 signaling (34)
- Nephrin family interactions (21)
- Netrin mediated repulsion signals (8)
- Netrin-1 signaling (49)
- Neurexins and neuroligins (60)
- Neurodegenerative Diseases (22)
- Neurofascin interactions (7)
- Neuronal System (398)
- Neurophilin interactions with VEGF and VEGFR (4)
- Neurotoxicity of clostridium toxins (10)
- Neurotransmitter clearance (11)
- Neurotransmitter receptors and postsynaptic signal transmission (186)
- Neurotransmitter release cycle (51)
- Neurotransmitter uptake and metabolism In glial cells (4)
- Neutrophil degranulation (543)
- Nicotinamide salvaging (19)
- Nicotinate metabolism (31)
- Nitric oxide stimulates guanylate cyclase (21)
- NoRC negatively regulates rRNA expression (76)
- Non-integrin membrane-ECM interactions (43)
- Noncanonical activation of NOTCH3 (8)
- Nonhomologous End-Joining (NHEJ) (50)
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (117)
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (97)
- Nonsense-Mediated Decay (NMD) (117)
- Norepinephrine Neurotransmitter Release Cycle (18)
- Notch-HLH transcription pathway (28)
- NrCAM interactions (7)
- Nuclear Envelope Breakdown (54)
- Nuclear Envelope Reassembly (14)
- Nuclear Events (kinase and transcription factor activation) (25)
- Nuclear Pore Complex (NPC) Disassembly (36)
- Nuclear Receptor transcription pathway (53)
- Nuclear import of Rev protein (34)
- Nuclear signaling by ERBB4 (32)
- Nucleobase biosynthesis (15)
- Nucleobase catabolism (36)
- Nucleosome assembly (52)
- Nucleotide salvage (23)
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (50)
- Nucleotide-like (purinergic) receptors (16)
- O-glycosylation of TSR domain-containing proteins (39)
- O-linked glycosylation (114)
- O-linked glycosylation of mucins (65)
- O2/CO2 exchange in erythrocytes (12)
- OAS antiviral response (9)
- Olfactory Signaling Pathway (431)
- Oligomerization of connexins into connexons (3)
- Oncogene Induced Senescence (34)
- Oncogenic MAPK signaling (79)
- Opioid Signalling (89)
- Opsins (9)
- Orc1 removal from chromatin (72)
- Orexin and neuropeptides FF and QRFP bind to their respective receptors (8)
- Organelle biogenesis and maintenance (276)
- Organic anion transport (5)
- Organic anion transporters (10)
- Organic cation transport (10)
- Organic cation/anion/zwitterion transport (15)
- Other interleukin signaling (287)
- Other semaphorin interactions (19)
- Ovarian tumor domain proteases (38)
- Oxidative Stress Induced Senescence (94)
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (67)
- P2Y receptors (12)
- PAOs oxidise polyamines to amines (2)
- PCNA-Dependent Long Patch Base Excision Repair (21)
- PCP/CE pathway (93)
- PD-1 signaling (42)
- PDE3B signalling (2)
- PECAM1 interactions (12)
- PERK regulates gene expression (32)
- PI Metabolism (83)
- PI and PC transport between ER and Golgi membranes (1)
- PI-3K cascade:FGFR1 (21)
- PI-3K cascade:FGFR2 (23)
- PI-3K cascade:FGFR3 (18)
- PI-3K cascade:FGFR4 (20)
- PI3K Cascade (44)
- PI3K events in ERBB2 signaling (16)
- PI3K events in ERBB4 signaling (10)
- PI3K/AKT Signaling in Cancer (102)
- PI3K/AKT activation (9)
- PI5P Regulates TP53 Acetylation (8)
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (103)
- PIP3 activates AKT signaling (266)
- PIWI-interacting RNA (piRNA) biogenesis (29)
- PKA activation (17)
- PKA activation in glucagon signalling (20)
- PKA-mediated phosphorylation of CREB (19)
- PKA-mediated phosphorylation of key metabolic factors (5)
- PKB-mediated events (2)
- PKMTs methylate histone lysines (47)
- PLC beta mediated events (52)
- PLC-gamma1 signalling (3)
- PLCG1 events in ERBB2 signaling (4)
- POLB-Dependent Long Patch Base Excision Repair (8)
- POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation (13)
- POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation (10)
- PP2A-mediated dephosphorylation of key metabolic factors (7)
- PPARA activates gene expression (117)
- PRC2 methylates histones and DNA (42)
- PTEN Loss of Function in Cancer (1)
- PTEN Regulation (141)
- PTK6 Activates STAT3 (4)
- PTK6 Down-Regulation (3)
- PTK6 Expression (5)
- PTK6 Regulates Cell Cycle (6)
- PTK6 Regulates Proteins Involved in RNA Processing (5)
- PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (14)
- PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (9)
- PTK6 promotes HIF1A stabilization (6)
- Packaging Of Telomere Ends (33)
- Paradoxical activation of RAF signaling by kinase inactive BRAF (43)
- Passive transport by Aquaporins (13)
- Pausing and recovery of HIV elongation (36)
- Pausing and recovery of Tat-mediated HIV elongation (35)
- Pentose phosphate pathway disease (2)
- Peptide chain elongation (91)
- Peptide hormone biosynthesis (12)
- Peptide hormone metabolism (88)
- Peptide ligand-binding receptors (189)
- Peroxisomal lipid metabolism (29)
- Peroxisomal protein import (63)
- Pervasive developmental disorders (13)
- Phase 0 - rapid depolarisation (44)
- Phase 1 - inactivation of fast Na+ channels (7)
- Phase 2 - plateau phase (27)
- Phase 3 - rapid repolarisation (8)
- Phase 4 - resting membrane potential (19)
- Phase I - Functionalization of compounds (105)
- Phase II - Conjugation of compounds (109)
- Phenylalanine and tyrosine metabolism (11)
- Phenylketonuria (1)
- Phosphate bond hydrolysis by NTPDase proteins (8)
- Phosphate bond hydrolysis by NUDT proteins (7)
- Phospholipase C-mediated cascade: FGFR1 (16)
- Phospholipase C-mediated cascade; FGFR2 (18)
- Phospholipase C-mediated cascade; FGFR3 (13)
- Phospholipase C-mediated cascade; FGFR4 (15)
- Phospholipid metabolism (211)
- Phosphorylation of CD3 and TCR zeta chains (41)
- Phosphorylation of Emi1 (6)
- Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes (4)
- Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes (3)
- Phosphorylation of the APC/C (19)
- Physiological factors (12)
- Pink/Parkin Mediated Mitophagy (21)
- Plasma lipoprotein assembly (19)
- Plasma lipoprotein assembly, remodeling, and clearance (71)
- Plasma lipoprotein clearance (33)
- Plasma lipoprotein remodeling (32)
- Plasmalogen biosynthesis (3)
- Platelet Adhesion to exposed collagen (13)
- Platelet Aggregation (Plug Formation) (37)
- Platelet activation, signaling and aggregation (258)
- Platelet calcium homeostasis (28)
- Platelet degranulation (128)
- Platelet homeostasis (88)
- Platelet sensitization by LDL (17)
- Plus-strand DNA synthesis (1)
- Polo-like kinase mediated events (16)
- Polymerase switching (14)
- Polymerase switching on the C-strand of the telomere (14)
- Positive epigenetic regulation of rRNA expression (76)
- Post NMDA receptor activation events (62)
- Post-chaperonin tubulin folding pathway (23)
- Post-transcriptional silencing by small RNAs (7)
- Post-translational modification: synthesis of GPI-anchored proteins (94)
- Post-translational protein modification (1450)
- Post-translational protein phosphorylation (107)
- Postsynaptic nicotinic acetylcholine receptors (14)
- Potassium Channels (99)
- Potassium transport channels (3)
- Pre-NOTCH Expression and Processing (78)
- Pre-NOTCH Processing in Golgi (18)
- Pre-NOTCH Processing in the Endoplasmic Reticulum (6)
- Pre-NOTCH Transcription and Translation (62)
- Prefoldin mediated transfer of substrate to CCT/TriC (28)
- Pregnenolone biosynthesis (13)
- Presynaptic depolarization and calcium channel opening (13)
- Presynaptic function of Kainate receptors (21)
- Presynaptic nicotinic acetylcholine receptors (12)
- Presynaptic phase of homologous DNA pairing and strand exchange (39)
- Processing and activation of SUMO (10)
- Processing of Capped Intron-Containing Pre-mRNA (241)
- Processing of Capped Intronless Pre-mRNA (28)
- Processing of DNA double-strand break ends (79)
- Processing of Intronless Pre-mRNAs (19)
- Processing of SMDT1 (15)
- Processive synthesis on the C-strand of the telomere (11)
- Processive synthesis on the lagging strand (15)
- Programmed Cell Death (180)
- Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 (3)
- Prolactin receptor signaling (15)
- Proline catabolism (3)
- Prolonged ERK activation events (12)
- Propionyl-CoA catabolism (4)
- Prostacyclin signalling through prostacyclin receptor (22)
- Prostanoid ligand receptors (9)
- Protein folding (102)
- Protein localization (165)
- Protein methylation (15)
- Protein repair (6)
- Protein ubiquitination (130)
- Protein-protein interactions at synapses (91)
- Proton-coupled monocarboxylate transport (6)
- Proton-coupled neutral amino acid transporters (2)
- Proton/oligopeptide cotransporters (4)
- Purine catabolism (18)
- Purine ribonucleoside monophosphate biosynthesis (12)
- Purine salvage (13)
- Pyrimidine biosynthesis (3)
- Pyrimidine catabolism (12)
- Pyrimidine salvage (11)
- Pyrophosphate hydrolysis (2)
- Pyruvate metabolism and Citric Acid (TCA) cycle (55)
- RA biosynthesis pathway (22)
- RAB GEFs exchange GTP for GDP on RABs (90)
- RAB geranylgeranylation (66)
- RAF activation (30)
- RAF-independent MAPK1/3 activation (23)
- RAF/MAP kinase cascade (246)
- RAS signaling downstream of NF1 loss-of-function variants (4)
- RET signaling (41)
- RHO GTPase Effectors (273)
- RHO GTPases Activate Formins (120)
- RHO GTPases Activate NADPH Oxidases (24)
- RHO GTPases Activate ROCKs (19)
- RHO GTPases Activate Rhotekin and Rhophilins (9)
- RHO GTPases Activate WASPs and WAVEs (36)
- RHO GTPases activate CIT (19)
- RHO GTPases activate IQGAPs (11)
- RHO GTPases activate KTN1 (11)
- RHO GTPases activate PAKs (21)
- RHO GTPases activate PKNs (63)
- RHO GTPases regulate CFTR trafficking (3)
- RIP-mediated NFkB activation via ZBP1 (17)
- RIPK1-mediated regulated necrosis (16)
- RMTs methylate histone arginines (49)
- RNA Pol II CTD phosphorylation and interaction with CE (27)
- RNA Pol II CTD phosphorylation and interaction with CE during HIV infection (27)
- RNA Polymerase I Promoter Clearance (80)
- RNA Polymerase I Promoter Escape (61)
- RNA Polymerase I Promoter Opening (32)
- RNA Polymerase I Transcription (80)
- RNA Polymerase I Transcription Initiation (48)
- RNA Polymerase I Transcription Termination (31)
- RNA Polymerase II HIV Promoter Escape (47)
- RNA Polymerase II Pre-transcription Events (84)
- RNA Polymerase II Promoter Escape (47)
- RNA Polymerase II Transcription (1314)
- RNA Polymerase II Transcription Elongation (61)
- RNA Polymerase II Transcription Initiation (47)
- RNA Polymerase II Transcription Initiation And Promoter Clearance (47)
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening (47)
- RNA Polymerase II Transcription Termination (66)
- RNA Polymerase III Abortive And Retractive Initiation (42)
- RNA Polymerase III Chain Elongation (19)
- RNA Polymerase III Transcription (42)
- RNA Polymerase III Transcription Initiation (37)
- RNA Polymerase III Transcription Initiation From Type 1 Promoter (29)
- RNA Polymerase III Transcription Initiation From Type 2 Promoter (28)
- RNA Polymerase III Transcription Initiation From Type 3 Promoter (29)
- RNA Polymerase III Transcription Termination (24)
- RNA polymerase II transcribes snRNA genes (71)
- RNF mutants show enhanced WNT signaling and proliferation (8)
- ROBO receptors bind AKAP5 (9)
- RORA activates gene expression (18)
- ROS and RNS production in phagocytes (36)
- RPIA deficiency: failed conversion of R5P to RU5P (1)
- RPIA deficiency: failed conversion of RU5P to R5P (1)
- RSK activation (7)
- RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) (10)
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (37)
- RUNX1 regulates estrogen receptor mediated transcription (6)
- RUNX1 regulates expression of components of tight junctions (5)
- RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (66)
- RUNX1 regulates transcription of genes involved in BCR signaling (6)
- RUNX1 regulates transcription of genes involved in WNT signaling (6)
- RUNX1 regulates transcription of genes involved in differentiation of HSCs (100)
- RUNX1 regulates transcription of genes involved in differentiation of keratinocytes (8)
- RUNX1 regulates transcription of genes involved in differentiation of myeloid cells (7)
- RUNX1 regulates transcription of genes involved in interleukin signaling (5)
- RUNX2 regulates bone development (31)
- RUNX2 regulates chondrocyte maturation (5)
- RUNX2 regulates genes involved in cell migration (8)
- RUNX2 regulates genes involved in differentiation of myeloid cells (4)
- RUNX2 regulates osteoblast differentiation (24)
- RUNX3 Regulates Immune Response and Cell Migration (6)
- RUNX3 regulates BCL2L11 (BIM) transcription (5)
- RUNX3 regulates CDKN1A transcription (7)
- RUNX3 regulates NOTCH signaling (14)
- RUNX3 regulates RUNX1-mediated transcription (3)
- RUNX3 regulates WNT signaling (8)
- RUNX3 regulates YAP1-mediated transcription (8)
- RUNX3 regulates p14-ARF (11)
- Rab regulation of trafficking (123)
- Rap1 signalling (16)
- Ras activation upon Ca2+ influx through NMDA receptor (20)
- Reactions specific to the complex N-glycan synthesis pathway (10)
- Reactions specific to the hybrid N-glycan synthesis pathway (1)
- Receptor Mediated Mitophagy (11)
- Receptor-type tyrosine-protein phosphatases (20)
- Recognition and association of DNA glycosylase with site containing an affected purine (37)
- Recognition and association of DNA glycosylase with site containing an affected pyrimidine (42)
- Recognition of DNA damage by PCNA-containing replication complex (30)
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (57)
- Recruitment of NuMA to mitotic centrosomes (80)
- Recruitment of mitotic centrosome proteins and complexes (81)
- Recycling of bile acids and salts (16)
- Recycling of eIF2:GDP (8)
- Recycling pathway of L1 (28)
- Reduction of cytosolic Ca++ levels (12)
- Reelin signalling pathway (5)
- Regulated Necrosis (16)
- Regulated proteolysis of p75NTR (11)
- Regulation by TREX1 (1)
- Regulation by c-FLIP (11)
- Regulation of APC/C activators between G1/S and early anaphase (81)
- Regulation of Apoptosis (54)
- Regulation of Complement cascade (122)
- Regulation of FOXO transcriptional activity by acetylation (10)
- Regulation of FZD by ubiquitination (21)
- Regulation of Glucokinase by Glucokinase Regulatory Protein (32)
- Regulation of HSF1-mediated heat shock response (82)
- Regulation of IFNA signaling (25)
- Regulation of IFNG signaling (14)
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (124)
- Regulation of KIT signaling (16)
- Regulation of MECP2 expression and activity (31)
- Regulation of PAK-2p34 activity by PS-GAP/RHG10 (2)
- Regulation of PLK1 Activity at G2/M Transition (87)
- Regulation of PTEN gene transcription (60)
- Regulation of PTEN localization (9)
- Regulation of PTEN mRNA translation (11)
- Regulation of PTEN stability and activity (70)
- Regulation of RAS by GAPs (69)
- Regulation of RUNX1 Expression and Activity (17)
- Regulation of RUNX2 expression and activity (74)
- Regulation of RUNX3 expression and activity (57)
- Regulation of TLR by endogenous ligand (16)
- Regulation of TNFR1 signaling (33)
- Regulation of TP53 Activity (160)
- Regulation of TP53 Activity through Acetylation (29)
- Regulation of TP53 Activity through Association with Co-factors (14)
- Regulation of TP53 Activity through Methylation (19)
- Regulation of TP53 Activity through Phosphorylation (92)
- Regulation of TP53 Degradation (37)
- Regulation of TP53 Expression (2)
- Regulation of TP53 Expression and Degradation (38)
- Regulation of actin dynamics for phagocytic cup formation (138)
- Regulation of activated PAK-2p34 by proteasome mediated degradation (51)
- Regulation of beta-cell development (42)
- Regulation of cholesterol biosynthesis by SREBP (SREBF) (55)
- Regulation of commissural axon pathfinding by SLIT and ROBO (10)
- Regulation of cortical dendrite branching (4)
- Regulation of cytoskeletal remodeling and cell spreading by IPP complex components (8)
- Regulation of expression of SLITs and ROBOs (174)
- Regulation of gap junction activity (3)
- Regulation of gene expression by Hypoxia-inducible Factor (11)
- Regulation of gene expression in beta cells (21)
- Regulation of gene expression in early pancreatic precursor cells (8)
- Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells (5)
- Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells (16)
- Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (12)
- Regulation of innate immune responses to cytosolic DNA (15)
- Regulation of insulin secretion (81)
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (119)
- Regulation of localization of FOXO transcription factors (12)
- Regulation of mRNA stability by proteins that bind AU-rich elements (90)
- Regulation of mitotic cell cycle (87)
- Regulation of necroptotic cell death (14)
- Regulation of ornithine decarboxylase (ODC) (52)
- Regulation of pyruvate dehydrogenase (PDH) complex (16)
- Regulation of signaling by CBL (18)
- Regulation of signaling by NODAL (12)
- Regulation of the apoptosome activity (11)
- Regulation of thyroid hormone activity (3)
- Relaxin receptors (8)
- Release of Hh-Np from the secreting cell (8)
- Release of apoptotic factors from the mitochondria (5)
- Removal of aminoterminal propeptides from gamma-carboxylated proteins (10)
- Removal of the Flap Intermediate (14)
- Removal of the Flap Intermediate from the C-strand (10)
- Repression of WNT target genes (14)
- Reproduction (114)
- Resolution of AP sites via the multiple-nucleotide patch replacement pathway (25)
- Resolution of AP sites via the single-nucleotide replacement pathway (4)
- Resolution of Abasic Sites (AP sites) (38)
- Resolution of D-Loop Structures (33)
- Resolution of D-loop Structures through Holliday Junction Intermediates (32)
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) (26)
- Resolution of Sister Chromatid Cohesion (106)
- Respiratory electron transport (101)
- Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (123)
- Response to elevated platelet cytosolic Ca2+ (133)
- Response to metal ions (14)
- Retinoid cycle disease events (13)
- Retinoid metabolism and transport (44)
- Retinoid metabolism disease events (1)
- Retrograde neurotrophin signalling (14)
- Retrograde transport at the Trans-Golgi-Network (49)
- Reuptake of GABA (4)
- Rev-mediated nuclear export of HIV RNA (35)
- Reversal of alkylation damage by DNA dioxygenases (7)
- Reverse Transcription of HIV RNA (1)
- Reversible hydration of carbon dioxide (12)
- Rhesus blood group biosynthesis (2)
- Rhesus glycoproteins mediate ammonium transport. (3)
- Rho GTPase cycle (139)
- Ribosomal scanning and start codon recognition (60)
- Role of ABL in ROBO-SLIT signaling (8)
- Role of LAT2/NTAL/LAB on calcium mobilization (87)
- Role of phospholipids in phagocytosis (102)
- Role of second messengers in netrin-1 signaling (10)
- S Phase (162)
- S33 mutants of beta-catenin aren't phosphorylated (15)
- S37 mutants of beta-catenin aren't phosphorylated (15)
- S45 mutants of beta-catenin aren't phosphorylated (15)
- SCF(Skp2)-mediated degradation of p27/p21 (61)
- SCF-beta-TrCP mediated degradation of Emi1 (56)
- SDK interactions (2)
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (14)
- SHC-mediated cascade:FGFR1 (21)
- SHC-mediated cascade:FGFR2 (23)
- SHC-mediated cascade:FGFR3 (18)
- SHC-mediated cascade:FGFR4 (20)
- SHC-related events triggered by IGF1R (9)
- SHC1 events in EGFR signaling (14)
- SHC1 events in ERBB2 signaling (22)
- SHC1 events in ERBB4 signaling (14)
- SIRT1 negatively regulates rRNA expression (37)
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs (11)
- SLBP independent Processing of Histone Pre-mRNAs (10)
- SLC transporter disorders (100)
- SLC-mediated transmembrane transport (250)
- SLIT2:ROBO1 increases RHOA activity (4)
- SMAC (DIABLO) binds to IAPs (7)
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes (7)
- SMAC, XIAP-regulated apoptotic response (8)
- SMAD2/3 MH2 Domain Mutants in Cancer (3)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer (6)
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (32)
- SMAD4 MH2 Domain Mutants in Cancer (3)
- SOS-mediated signalling (7)
- SRP-dependent cotranslational protein targeting to membrane (114)
- STAT5 Activation (7)
- STAT6-mediated induction of chemokines (3)
- STING mediated induction of host immune responses (16)
- SUMO E3 ligases SUMOylate target proteins (170)
- SUMO is conjugated to E1 (UBA2:SAE1) (5)
- SUMO is proteolytically processed (6)
- SUMO is transferred from E1 to E2 (UBE2I, UBC9) (7)
- SUMOylation (176)
- SUMOylation of DNA damage response and repair proteins (78)
- SUMOylation of DNA methylation proteins (16)
- SUMOylation of DNA replication proteins (46)
- SUMOylation of RNA binding proteins (47)
- SUMOylation of SUMOylation proteins (35)
- SUMOylation of chromatin organization proteins (58)
- SUMOylation of immune response proteins (11)
- SUMOylation of intracellular receptors (30)
- SUMOylation of transcription cofactors (44)
- SUMOylation of transcription factors (21)
- SUMOylation of ubiquitinylation proteins (39)
- Scavenging by Class A Receptors (19)
- Scavenging by Class B Receptors (6)
- Scavenging by Class F Receptors (6)
- Scavenging by Class H Receptors (4)
- Scavenging of heme from plasma (87)
- Selenoamino acid metabolism (119)
- Selenocysteine synthesis (95)
- Sema3A PAK dependent Axon repulsion (16)
- Sema4D in semaphorin signaling (24)
- Sema4D induced cell migration and growth-cone collapse (20)
- Sema4D mediated inhibition of cell attachment and migration (8)
- Semaphorin interactions (64)
- Senescence-Associated Secretory Phenotype (SASP) (80)
- Sensing of DNA Double Strand Breaks (6)
- Separation of Sister Chromatids (171)
- Serotonin Neurotransmitter Release Cycle (18)
- Serotonin clearance from the synaptic cleft (3)
- Serotonin receptors (12)
- Severe congenital neutropenia type 4 (G6PC3) (1)
- Sialic acid metabolism (33)
- Signal Transduction (2704)
- Signal amplification (32)
- Signal attenuation (10)
- Signal regulatory protein family interactions (13)
- Signal transduction by L1 (21)
- Signaling by Activin (13)
- Signaling by BMP (28)
- Signaling by BRAF and RAF fusions (63)
- Signaling by EGFR (49)
- Signaling by EGFR in Cancer (25)
- Signaling by EGFRvIII in Cancer (15)
- Signaling by ERBB2 (50)
- Signaling by ERBB4 (58)
- Signaling by Erythropoietin (25)
- Signaling by FGFR (87)
- Signaling by FGFR in disease (64)
- Signaling by FGFR1 (50)
- Signaling by FGFR1 amplification mutants (1)
- Signaling by FGFR1 in disease (39)
- Signaling by FGFR2 (73)
- Signaling by FGFR2 IIIa TM (19)
- Signaling by FGFR2 amplification mutants (1)
- Signaling by FGFR2 fusions (1)
- Signaling by FGFR2 in disease (43)
- Signaling by FGFR3 (40)
- Signaling by FGFR3 fusions in cancer (10)
- Signaling by FGFR3 in disease (22)
- Signaling by FGFR3 point mutants in cancer (22)
- Signaling by FGFR4 (41)
- Signaling by FGFR4 in disease (11)
- Signaling by GPCR (1212)
- Signaling by Hedgehog (141)
- Signaling by Hippo (20)
- Signaling by Insulin receptor (78)
- Signaling by Interleukins (619)
- Signaling by Leptin (11)
- Signaling by Ligand-Responsive EGFR Variants in Cancer (19)
- Signaling by MET (67)
- Signaling by MST1 (5)
- Signaling by NODAL (21)
- Signaling by NOTCH (205)
- Signaling by NOTCH1 (73)
- Signaling by NOTCH1 HD Domain Mutants in Cancer (15)
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (58)
- Signaling by NOTCH1 PEST Domain Mutants in Cancer (58)
- Signaling by NOTCH1 in Cancer (58)
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant (7)
- Signaling by NOTCH2 (33)
- Signaling by NOTCH3 (49)
- Signaling by NOTCH4 (83)
- Signaling by NTRK1 (TRKA) (78)
- Signaling by NTRK2 (TRKB) (25)
- Signaling by NTRK3 (TRKC) (17)
- Signaling by NTRKs (99)
- Signaling by Non-Receptor Tyrosine Kinases (54)
- Signaling by Nuclear Receptors (232)
- Signaling by Overexpressed Wild-Type EGFR in Cancer (8)
- Signaling by PDGF (53)
- Signaling by PTK6 (54)
- Signaling by RAS mutants (56)
- Signaling by ROBO receptors (220)
- Signaling by Receptor Tyrosine Kinases (455)
- Signaling by Retinoic Acid (43)
- Signaling by Rho GTPases (402)
- Signaling by SCF-KIT (43)
- Signaling by TGF-beta Receptor Complex (73)
- Signaling by TGF-beta Receptor Complex in Cancer (8)
- Signaling by TGF-beta family members (102)
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (54)
- Signaling by VEGF (103)
- Signaling by WNT (299)
- Signaling by WNT in cancer (34)
- Signaling by activated point mutants of FGFR1 (11)
- Signaling by activated point mutants of FGFR3 (12)
- Signaling by cytosolic FGFR1 fusion mutants (19)
- Signaling by high-kinase activity BRAF mutants (34)
- Signaling by moderate kinase activity BRAF mutants (43)
- Signaling by plasma membrane FGFR1 fusions (3)
- Signaling by the B Cell Receptor (BCR) (173)
- Signalling to ERK5 (2)
- Signalling to ERKs (32)
- Signalling to RAS (20)
- Signalling to STAT3 (3)
- Signalling to p38 via RIT and RIN (5)
- Small interfering RNA (siRNA) biogenesis (9)
- Smooth Muscle Contraction (37)
- Sodium-coupled phosphate cotransporters (5)
- Sodium-coupled sulphate, di- and tri-carboxylate transporters (5)
- Sodium/Calcium exchangers (11)
- Sodium/Proton exchangers (9)
- Sperm Motility And Taxes (9)
- Sphingolipid de novo biosynthesis (44)
- Spry regulation of FGF signaling (16)
- Stabilization of p53 (58)
- Sterols are 12-hydroxylated by CYP8B1 (2)
- Stimulation of the cell death response by PAK-2p34 (2)
- Stimuli-sensing channels (102)
- Striated Muscle Contraction (34)
- Sulfide oxidation to sulfate (5)
- Sulfur amino acid metabolism (27)
- Surfactant metabolism (29)
- Switching of origins to a post-replicative state (91)
- Synaptic adhesion-like molecules (21)
- Syndecan interactions (20)
- Synthesis And Processing Of GAG, GAGPOL Polyproteins (14)
- Synthesis and processing of ENV and VPU (1)
- Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (9)
- Synthesis of 12-eicosatetraenoic acid derivatives (7)
- Synthesis of 15-eicosatetraenoic acid derivatives (6)
- Synthesis of 5-eicosatetraenoic acids (9)
- Synthesis of CL (1)
- Synthesis of DNA (120)
- Synthesis of Dolichyl-phosphate (6)
- Synthesis of GDP-mannose (5)
- Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1)
- Synthesis of IP2, IP, and Ins in the cytosol (14)
- Synthesis of IP3 and IP4 in the cytosol (26)
- Synthesis of IPs in the ER lumen (1)
- Synthesis of IPs in the nucleus (4)
- Synthesis of Ketone Bodies (8)
- Synthesis of Leukotrienes (LT) and Eoxins (EX) (21)
- Synthesis of Lipoxins (LX) (6)
- Synthesis of PA (39)
- Synthesis of PC (28)
- Synthesis of PE (13)
- Synthesis of PG (8)
- Synthesis of PI (5)
- Synthesis of PIPs at the ER membrane (5)
- Synthesis of PIPs at the Golgi membrane (18)
- Synthesis of PIPs at the early endosome membrane (16)
- Synthesis of PIPs at the late endosome membrane (11)
- Synthesis of PIPs at the plasma membrane (53)
- Synthesis of PIPs in the nucleus (3)
- Synthesis of PS (2)
- Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (15)
- Synthesis of UDP-N-acetyl-glucosamine (8)
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes (30)
- Synthesis of bile acids and bile salts (34)
- Synthesis of bile acids and bile salts via 24-hydroxycholesterol (14)
- Synthesis of bile acids and bile salts via 27-hydroxycholesterol (15)
- Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (24)
- Synthesis of diphthamide-EEF2 (8)
- Synthesis of dolichyl-phosphate mannose (3)
- Synthesis of dolichyl-phosphate-glucose (2)
- Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (8)
- Synthesis of glycosylphosphatidylinositol (GPI) (18)
- Synthesis of pyrophosphates in the cytosol (10)
- Synthesis of substrates in N-glycan biosythesis (63)
- Synthesis of very long-chain fatty acyl-CoAs (24)
- Synthesis of wybutosine at G37 of tRNA(Phe) (6)
- Synthesis, secretion, and deacylation of Ghrelin (19)
- Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (20)
- Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (13)
- T41 mutants of beta-catenin aren't phosphorylated (15)
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex (28)
- TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P (1)
- TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P (1)
- TBC/RABGAPs (45)
- TCF dependent signaling in response to WNT (204)
- TCF7L2 mutants don't bind CTBP (3)
- TCR signaling (137)
- TET1,2,3 and TDG demethylate DNA (4)
- TFAP2 (AP-2) family regulates transcription of cell cycle factors (5)
- TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (13)
- TFAP2 (AP-2) family regulates transcription of other transcription factors (4)
- TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation (5)
- TGF-beta receptor signaling activates SMADs (32)
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (16)
- TGFBR1 KD Mutants in Cancer (6)
- TGFBR1 LBD Mutants in Cancer (4)
- TGFBR2 Kinase Domain Mutants in Cancer (3)
- TGFBR2 MSI Frameshift Mutants in Cancer (2)
- TICAM1 deficiency - HSE (2)
- TICAM1, RIP1-mediated IKK complex recruitment (19)
- TICAM1,TRAF6-dependent induction of TAK1 complex (11)
- TICAM1-dependent activation of IRF3/IRF7 (12)
- TLR3 deficiency - HSE (1)
- TLR3-mediated TICAM1-dependent programmed cell death (6)
- TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (17)
- TNF signaling (43)
- TNFR1-induced NFkappaB signaling pathway (26)
- TNFR1-induced proapoptotic signaling (13)
- TNFR1-mediated ceramide production (6)
- TNFR2 non-canonical NF-kB pathway (101)
- TNFs bind their physiological receptors (28)
- TP53 Regulates Metabolic Genes (86)
- TP53 Regulates Transcription of Caspase Activators and Caspases (12)
- TP53 Regulates Transcription of Cell Cycle Genes (48)
- TP53 Regulates Transcription of Cell Death Genes (45)
- TP53 Regulates Transcription of DNA Repair Genes (65)
- TP53 Regulates Transcription of Death Receptors and Ligands (12)
- TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (21)
- TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (14)
- TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (18)
- TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (20)
- TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (14)
- TRAF3 deficiency - HSE (3)
- TRAF3-dependent IRF activation pathway (14)
- TRAF6 mediated IRF7 activation (28)
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (10)
- TRAF6 mediated NF-kB activation (24)
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (90)
- TRAF6-mediated induction of TAK1 complex within TLR4 complex (16)
- TRAIL signaling (8)
- TRIF(TICAM1)-mediated TLR4 signaling (97)
- TRIF-mediated programmed cell death (9)
- TRKA activation by NGF (2)
- TRP channels (25)
- TWIK related potassium channel (TREK) (3)
- TWIK-related alkaline pH activated K+ channel (TALK) (2)
- TWIK-related spinal cord K+ channel (TRESK) (1)
- TWIK-releated acid-sensitive K+ channel (TASK) (2)
- TYSND1 cleaves peroxisomal proteins (7)
- Tachykinin receptors bind tachykinins (5)
- Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) (3)
- Tandem pore domain halothane-inhibited K+ channel (THIK) (1)
- Tandem pore domain potassium channels (12)
- Tat-mediated HIV elongation arrest and recovery (35)
- Tat-mediated elongation of the HIV-1 transcript (47)
- Telomere C-strand (Lagging Strand) Synthesis (24)
- Telomere C-strand synthesis initiation (8)
- Telomere Extension By Telomerase (6)
- Telomere Maintenance (63)
- Terminal pathway of complement (8)
- Termination of O-glycan biosynthesis (26)
- Termination of translesion DNA synthesis (32)
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (10)
- The AIM2 inflammasome (3)
- The IPAF inflammasome (2)
- The NLRP1 inflammasome (3)
- The NLRP3 inflammasome (15)
- The activation of arylsulfatases (13)
- The canonical retinoid cycle in rods (twilight vision) (23)
- The citric acid (TCA) cycle and respiratory electron transport (174)
- The fatty acid cycling model (5)
- The phototransduction cascade (34)
- The proton buffering model (5)
- The retinoid cycle in cones (daylight vision) (7)
- The role of GTSE1 in G2/M progression after G2 checkpoint (61)
- The role of Nef in HIV-1 replication and disease pathogenesis (48)
- Threonine catabolism (5)
- Thrombin signalling through proteinase activated receptors (PARs) (32)
- Thromboxane signalling through TP receptor (23)
- Thyroxine biosynthesis (10)
- Tie2 Signaling (18)
- Tight junction interactions (30)
- Tolerance by Mtb to nitric oxide produced by macrophages (1)
- Toll Like Receptor 10 (TLR10) Cascade (84)
- Toll Like Receptor 2 (TLR2) Cascade (95)
- Toll Like Receptor 3 (TLR3) Cascade (93)
- Toll Like Receptor 4 (TLR4) Cascade (125)
- Toll Like Receptor 5 (TLR5) Cascade (84)
- Toll Like Receptor 7/8 (TLR7/8) Cascade (91)
- Toll Like Receptor 9 (TLR9) Cascade (95)
- Toll Like Receptor TLR1:TLR2 Cascade (95)
- Toll Like Receptor TLR6:TLR2 Cascade (95)
- Toll-like Receptor Cascades (151)
- Toxicity of botulinum toxin type A (BoNT/A) (4)
- Toxicity of botulinum toxin type B (BoNT/B) (3)
- Toxicity of botulinum toxin type C (BoNT/C) (3)
- Toxicity of botulinum toxin type D (BoNT/D) (5)
- Toxicity of botulinum toxin type E (BoNT/E) (3)
- Toxicity of botulinum toxin type F (BoNT/F) (5)
- Toxicity of botulinum toxin type G (BoNT/G) (3)
- Toxicity of tetanus toxin (TeNT) (1)
- Trafficking and processing of endosomal TLR (13)
- Trafficking of AMPA receptors (31)
- Trafficking of GluR2-containing AMPA receptors (17)
- Trafficking of myristoylated proteins to the cilium (5)
- Transcription from mitochondrial promoters (4)
- Transcription of E2F targets under negative control by DREAM complex (19)
- Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 (16)
- Transcription of the HIV genome (74)
- Transcription-Coupled Nucleotide Excision Repair (TC-NER) (78)
- Transcriptional activation of cell cycle inhibitor p21 (4)
- Transcriptional Regulation by E2F6 (34)
- Transcriptional Regulation by MECP2 (61)
- Transcriptional Regulation by TP53 (365)
- Transcriptional activation of mitochondrial biogenesis (53)
- Transcriptional activation of p53 responsive genes (4)
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (44)
- Transcriptional regulation by RUNX1 (208)
- Transcriptional regulation by RUNX2 (121)
- Transcriptional regulation by RUNX3 (98)
- Transcriptional regulation by small RNAs (76)
- Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (36)
- Transcriptional regulation of granulopoiesis (59)
- Transcriptional regulation of pluripotent stem cells (31)
- Transcriptional regulation of white adipocyte differentiation (84)
- Transfer of LPS from LBP carrier to CD14 (2)
- Transferrin endocytosis and recycling (31)
- Translation (297)
- Translation initiation complex formation (60)
- Translesion Synthesis by POLH (18)
- Translesion synthesis by POLI (17)
- Translesion synthesis by POLK (17)
- Translesion synthesis by REV1 (16)
- Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (38)
- Translocation of SLC2A4 (GLUT4) to the plasma membrane (51)
- Translocation of ZAP-70 to Immunological synapse (38)
- Transmission across Chemical Synapses (253)
- Transmission across Electrical Synapses (5)
- Transport and synthesis of PAPS (6)
- Transport of Mature Transcript to Cytoplasm (83)
- Transport of Mature mRNA Derived from an Intronless Transcript (42)
- Transport of Mature mRNA derived from an Intron-Containing Transcript (74)
- Transport of Mature mRNAs Derived from Intronless Transcripts (43)
- Transport of Ribonucleoproteins into the Host Nucleus (32)
- Transport of bile salts and organic acids, metal ions and amine compounds (86)
- Transport of connexins along the secretory pathway (3)
- Transport of connexons to the plasma membrane (2)
- Transport of fatty acids (8)
- Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus (9)
- Transport of glycerol from adipocytes to the liver by Aquaporins (2)
- Transport of inorganic cations/anions and amino acids/oligopeptides (106)
- Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (12)
- Transport of nucleotide sugars (9)
- Transport of organic anions (12)
- Transport of small molecules (725)
- Transport of the SLBP Dependant Mature mRNA (36)
- Transport of the SLBP independent Mature mRNA (35)
- Transport of vitamins, nucleosides, and related molecules (44)
- Transport to the Golgi and subsequent modification (167)
- Triglyceride biosynthesis (14)
- Triglyceride catabolism (24)
- Triglyceride metabolism (38)
- Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA (17)
- Truncations of AMER1 destabilize the destruction complex (14)
- Tryptophan catabolism (14)
- Type I hemidesmosome assembly (9)
- Type II Na+/Pi cotransporters (3)
- Tyrosine catabolism (5)
- UCH proteinases (97)
- UNC93B1 deficiency - HSE (2)
- Ub-specific processing proteases (205)
- Ubiquinol biosynthesis (8)
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (53)
- Ubiquitin-dependent degradation of Cyclin D (53)
- Unblocking of NMDA receptors, glutamate binding and activation (21)
- Uncoating of the HIV Virion (1)
- Unfolded Protein Response (UPR) (92)
- Unwinding of DNA (12)
- Uptake and actions of bacterial toxins (29)
- Uptake and function of anthrax toxins (11)
- Uptake and function of diphtheria toxin (6)
- Utilization of Ketone Bodies (4)
- VEGF binds to VEGFR leading to receptor dimerization (8)
- VEGF ligand-receptor interactions (8)
- VEGFA-VEGFR2 Pathway (95)
- VEGFR2 mediated cell proliferation (19)
- VEGFR2 mediated vascular permeability (27)
- VLDL assembly (5)
- VLDL clearance (6)
- VLDLR internalisation and degradation (12)
- Variant SLC6A14 may confer susceptibility towards obesity (1)
- Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) (1)
- Vasopressin regulates renal water homeostasis via Aquaporins (46)
- Vasopressin-like receptors (6)
- Vesicle-mediated transport (725)
- Vif-mediated degradation of APOBEC3G (55)
- Viral Messenger RNA Synthesis (44)
- Viral RNP Complexes in the Host Cell Nucleus (1)
- Viral mRNA Translation (91)
- Virus Assembly and Release (2)
- Visual phototransduction (100)
- Vitamin B1 (thiamin) metabolism (5)
- Vitamin B2 (riboflavin) metabolism (7)
- Vitamin B5 (pantothenate) metabolism (17)
- Vitamin C (ascorbate) metabolism (8)
- Vitamin D (calciferol) metabolism (11)
- Vitamin E (1)
- Vitamins (6)
- Vitamins B6 activation to pyridoxal phosphate (3)
- Voltage gated Potassium channels (43)
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization (3)
- Vpr-mediated nuclear import of PICs (34)
- Vpu mediated degradation of CD4 (53)
- VxPx cargo-targeting to cilium (21)
- WNT ligand biogenesis and trafficking (26)
- WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 (1)
- WNT mediated activation of DVL (8)
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2 (13)
- WNT5A-dependent internalization of FZD4 (15)
- Wax and plasmalogen biosynthesis (7)
- Wax biosynthesis (4)
- XAV939 inhibits tankyrase, stabilizing AXIN (2)
- XBP1(S) activates chaperone genes (48)
- Xenobiotics (24)
- YAP1- and WWTR1 (TAZ)-stimulated gene expression (15)
- ZBP1(DAI) mediated induction of type I IFNs (21)
- Zinc efflux and compartmentalization by the SLC30 family (7)
- Zinc influx into cells by the SLC39 gene family (10)
- Zinc transporters (17)
- activated TAK1 mediates p38 MAPK activation (19)
- alpha-linolenic (omega3) and linoleic (omega6) acid metabolism (13)
- alpha-linolenic acid (ALA) metabolism (13)
- betaKlotho-mediated ligand binding (3)
- cGMP effects (16)
- eNOS activation (11)
- mRNA 3'-end processing (57)
- mRNA Capping (29)
- mRNA Editing (10)
- mRNA Editing: A to I Conversion (2)
- mRNA Editing: C to U Conversion (8)
- mRNA Splicing - Major Pathway (180)
- mRNA Splicing - Minor Pathway (52)
- mRNA decay by 3' to 5' exoribonuclease (16)
- mRNA decay by 5' to 3' exoribonuclease (15)
- mTOR signalling (39)
- mTORC1-mediated signalling (22)
- mitochondrial fatty acid beta-oxidation of saturated fatty acids (11)
- mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (6)
- p130Cas linkage to MAPK signaling for integrins (15)
- p38MAPK events (13)
- p53-Dependent G1 DNA Damage Response (67)
- p53-Dependent G1/S DNA damage checkpoint (67)
- p53-Independent DNA Damage Response (53)
- p53-Independent G1/S DNA damage checkpoint (53)
- p75 NTR receptor-mediated signalling (97)
- p75NTR negatively regulates cell cycle via SC1 (6)
- p75NTR recruits signalling complexes (13)
- p75NTR regulates axonogenesis (9)
- p75NTR signals via NF-kB (16)
- phospho-PLA2 pathway (2)
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex (15)
- rRNA modification in the mitochondrion (8)
- rRNA modification in the nucleus and cytosol (59)
- rRNA processing (217)
- rRNA processing in the mitochondrion (24)
- rRNA processing in the nucleus and cytosol (193)
- snRNP Assembly (53)
- t(4;14) translocations of FGFR3 (1)
- tRNA Aminoacylation (42)
- tRNA modification in the mitochondrion (9)
- tRNA modification in the nucleus and cytosol (43)
- tRNA processing (123)
- tRNA processing in the mitochondrion (20)
- tRNA processing in the nucleus (58)
- trans-Golgi Network Vesicle Budding (72)
- truncated APC mutants destabilize the destruction complex (14)
- vRNP Assembly (2)
- FABP4 in ovarian cancer (1)
- Trans-sulfuration pathway (10)
- Nanoparticle triggered autophagic cell death (23)
- Benzene metabolism (6)
- Mammary gland development pathway - Embryonic development (Stage 1 of 4) (17)
- Codeine and Morphine Metabolism (15)
- Calcium Regulation in the Cardiac Cell (155)
- miR-517 relationship with ARCN1 and USP1 (5)
- Alanine and aspartate metabolism (13)
- MicroRNA network associated with chronic lymphocytic leukemia (5)
- White fat cell differentiation (37)
- EGF/EGFR Signaling Pathway (214)
- Vitamin B12 Metabolism (60)
- Angiopoietin Like Protein 8 Regulatory Pathway (206)
- DNA Damage Response (84)
- Oxidative Damage (66)
- Spinal Cord Injury (164)
- Phase I biotransformations, non P450 (8)
- Nicotine Activity on Dopaminergic Neurons (26)
- Benzo(a)pyrene metabolism (12)
- PI3K/AKT/mTOR - VitD3 Signalling (43)
- IL-1 signaling pathway (125)
- Gastric Cancer Network 1 (32)
- Cytosine methylation (10)
- Copper homeostasis (89)
- Kit receptor signaling pathway (166)
- Caffeine and Theobromine metabolism (4)
- Vitamin D Metabolism (14)
- Thyroxine (Thyroid Hormone) Production (6)
- Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors (4)
- miRNAs involvement in the immune response in sepsis (69)
- Prostaglandin Synthesis and Regulation (54)
- FTO Obesity Variant Mechanism (9)
- Serotonin Receptor 4/6/7 and NR3C Signaling (60)
- ID signaling pathway (31)
- Integrated Breast Cancer Pathway (324)
- Metastatic brain tumor (24)
- Type II interferon signaling (IFNG) (97)
- Development and heterogeneity of the ILC family (55)
- Mitochondrial LC-Fatty Acid Beta-Oxidation (17)
- Hematopoietic Stem Cell Differentiation (83)
- Methionine De Novo and Salvage Pathway (28)
- TP53 Network (66)
- GABA receptor Signaling (37)
- TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition (56)
- Valproic acid pathway (20)
- Glial Cell Differentiation (10)
- Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways (279)
- Histone Modifications (45)
- Pathways in clear cell renal cell carcinoma (145)
- miRNAs involved in DNA damage response (54)
- Zinc homeostasis (49)
- BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation (29)
- Alzheimers Disease (167)
- Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway (182)
- Imatinib and Chronic Myeloid Leukemia (55)
- Eicosanoid Synthesis (37)
- Signaling of Hepatocyte Growth Factor Receptor (146)
- Signal Transduction of S1P Receptor (75)
- Selenium Micronutrient Network (195)
- Eukaryotic Transcription Initiation (62)
- Wnt Signaling Pathway and Pluripotency (197)
- NOTCH1 regulation of human endothelial cell calcification (27)
- Role of Osx and miRNAs in tooth development (26)
- Deregulation of Rab and Rab Effector Genes in Bladder Cancer (16)
- IL-5 Signaling Pathway (229)
- SRF and miRs in Smooth Muscle Differentiation and Proliferation (28)
- HIF1A and PPARG regulation of glycolysis (20)
- Sterol Regulatory Element-Binding Proteins (SREBP) signalling (150)
- Folate-Alcohol and Cancer Pathway Hypotheses (28)
- GPCRs, Class A Rhodopsin-like (295)
- IL1 and megakaryocytes in obesity (73)
- MECP2 and Associated Rett Syndrome (162)
- miRs in Muscle Cell Differentiation (89)
- Primary Focal Segmental Glomerulosclerosis FSGS (184)
- Genes targeted by miRNAs in adipocytes (22)
- mRNA Processing (134)
- Wnt/beta-catenin Signaling Pathway in Leukemia (104)
- RalA downstream regulated genes (45)
- Interleukin-1 Induced Activation of NF-kappa-B (35)
- EBV LMP1 signaling (116)
- Farnesoid X Receptor Pathway (33)
- Nicotine Activity on Chromaffin Cells (7)
- mir-124 predicted interactions with cell cycle and differentiation (10)
- Hepatitis C and Hepatocellular Carcinoma (266)
- Transcription factor regulation in adipogenesis (100)
- Pentose Phosphate Metabolism (8)
- miRNA Biogenesis (7)
- Electron Transport Chain (OXPHOS system in mitochondria) (109)
- Melatonin metabolism and effects (103)
- Dual hijack model of Vif in HIV infection (10)
- AGE/RAGE pathway (391)
- miR-509-3p alteration of YAP1/ECM axis (28)
- Nucleotide GPCRs (23)
- Translation Factors (57)
- Estrogen metabolism (41)
- miRNA regulation of p53 pathway in prostate cancer (87)
- G Protein Signaling Pathways (250)
- Differentiation Pathway (136)
- Nuclear Receptors Meta-Pathway (715)
- T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection (329)
- Overview of leukocyte-intrinsic Hippo pathway functions (99)
- TFs Regulate miRNAs related to cardiac hypertrophy (82)
- ATM Signaling Pathway (171)
- Interferon type I signaling pathways (268)
- Arylamine metabolism (20)
- Photodynamic therapy-induced AP-1 survival signaling. (279)
- NAD metabolism, sirtuins and aging (60)
- Corticotropin-releasing hormone signaling pathway (538)
- GPCRs, Class C Metabotropic glutamate, pheromone (15)
- Amplification and Expansion of Oncogenic Pathways as Metastatic Traits (62)
- Exercise-induced Circadian Regulation (70)
- PI3K-AKT-mTOR signaling pathway and therapeutic opportunities (212)
- LncRNA-mediated mechanisms of therapeutic resistance (34)
- Insulin signalling in human adipocytes (normal condition) (47)
- Neural Crest Differentiation (262)
- Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) (6)
- Apoptosis Modulation by HSP70 (108)
- Serotonin Transporter Activity (42)
- TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway (389)
- SCFA and skeletal muscle substrate metabolism (15)
- NRF2 pathway (444)
- Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) (113)
- RAC1/PAK1/p38/MMP2 Pathway (539)
- Synaptic Vesicle Pathway (76)
- Ovarian Infertility Genes (85)
- Metabolism of Spingolipids in ER and Golgi apparatus (11)
- TCA Cycle (aka Krebs or citric acid cycle) (23)
- Parkinsons Disease Pathway (115)
- Arrhythmogenic Right Ventricular Cardiomyopathy (170)
- MFAP5-mediated ovarian cancer cell motility and invasiveness (120)
- Type III interferon signaling (34)
- Peroxisomal beta-oxidation of tetracosanoyl-CoA (8)
- Hair Follicle Development: Cytodifferentiation (Part 3 of 3) (285)
- let-7 inhibition of ES cell reprogramming (38)
- Diclofenac Metabolic Pathway (10)
- Globo Sphingolipid Metabolism (25)
- Urea cycle and metabolism of amino groups (29)
- Non-homologous end joining (14)
- One Carbon Metabolism (55)
- H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity (63)
- Overview of nanoparticle effects (113)
- Glycolysis and Gluconeogenesis (110)
- Myometrial Relaxation and Contraction Pathways (569)
- Constitutive Androstane Receptor Pathway (156)
- Lung fibrosis (266)
- Simplified Depiction of MYD88 Distinct Input-Output Pathway (105)
- Nanomaterial induced apoptosis (119)
- Blood Clotting Cascade (43)
- Serotonin Receptor 2 and STAT3 Signaling (31)
- Ethanol metabolism resulting in production of ROS by CYP2E1 (88)
- Insulin Signaling (915)
- Sulfation Biotransformation Reaction (35)
- Interactome of polycomb repressive complex 2 (PRC2) (23)
- Serotonin Receptor 2 and ELK-SRF/GATA4 signaling (175)
- Robo4 and VEGF Signaling Pathways Crosstalk (43)
- Nanoparticle triggered regulated necrosis (85)
- Nuclear Receptors in Lipid Metabolism and Toxicity (114)
- TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) (43)
- Metabolism of Dichloroethylene by CYP450 (5)
- DNA IR-damage and cellular response via ATR (219)
- Leptin signaling pathway (752)
- DNA Damage Response (only ATM dependent) (849)
- Methylation Pathways (17)
- NLR Proteins (90)
- Cytoplasmic Ribosomal Proteins (124)
- Estrogen Receptor Pathway (99)
- Gastric Cancer Network 2 (103)
- Phytochemical activity on NRF2 transcriptional activation (102)
- IL-7 Signaling Pathway (321)
- Proprotein convertase subtilisin/kexin type 9 (PCSK9) mediated LDL receptor degradation (7)
- Gut-Liver Indole Metabolism (7)
- Sphingolipid pathway (39)
- Complement Activation (48)
- Alpha 6 Beta 4 signaling pathway (374)
- Colchicine Metabolic Pathway (10)
- Sleep regulation (109)
- Adipogenesis (592)
- Neovascularisation processes (186)
- ATR Signaling (27)
- TYROBP Causal Network (115)
- Supression of HMGB1 mediated inflammation by THBD (104)
- Glucocorticoid and Mineralcorticoid Metabolism (15)
- Serotonin and anxiety (69)
- ncRNAs involved in STAT3 signaling in hepatocellular carcinoma (122)
- Polyol Pathway (7)
- EV release from cardiac cells and their functional effects (41)
- Statin Pathway (70)
- Arachidonate Epoxygenase / Epoxide Hydrolase (19)
- Extracellular vesicle-mediated signaling in recipient cells (269)
- Leptin Insulin Overlap (158)
- ATM Signaling Network in Development and Disease (206)
- Bone Morphogenic Protein (BMP) Signalling and Regulation (42)
- Heroin metabolism (9)
- Initiation of transcription and translation elongation at the HIV-1 LTR (147)
- Tumor suppressor activity of SMARCB1 (61)
- miRNA Regulation of DNA Damage Response (454)
- Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds (85)
- GPR40 Pathway (51)
- Development of pulmonary dendritic cells and macrophage subsets (60)
- Cell Differentiation - Index (61)
- Photodynamic therapy-induced NF-kB survival signaling (292)
- ESC Pluripotency Pathways (807)
- NO/cGMP/PKG mediated Neuroprotection (289)
- BDNF-TrkB Signaling (359)
- Regulation of Apoptosis by Parathyroid Hormone-related Protein (183)
- Mammary gland development pathway - Involution (Stage 4 of 4) (119)
- Hfe effect on hepcidin production (18)
- IL-2 Signaling Pathway (578)
- Insulin signalling in human adipocytes (diabetic condition) (89)
- Leptin and adiponectin (37)
- NAD+ metabolism (27)
- Prader-Willi and Angelman Syndrome (201)
- Structural Pathway of Interleukin 1 (IL-1) (534)
- Mitochondrial Gene Expression (79)
- Canonical and Non-canonical Notch signaling (109)
- Mesodermal Commitment Pathway (425)
- PPAR Alpha Pathway (164)
- PTF1A related regulatory pathway (53)
- Striated Muscle Contraction Pathway (65)
- Aripiprazole Metabolic Pathway (4)
- ApoE and miR-146 in inflammation and atherosclerosis (71)
- Aflatoxin B1 metabolism (33)
- MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ (204)
- Selenium Metabolism and Selenoproteins (228)
- Vitamin A and Carotenoid Metabolism (142)
- PDGF Pathway (630)
- Liver X Receptor Pathway (79)
- EDA Signalling in Hair Follicle Development (37)
- Regulation of toll-like receptor signaling pathway (1089)
- Amino acid conjugation of benzoic acid (5)
- IL17 signaling pathway (421)
- TLR4 Signaling and Tolerance (300)
- Oncostatin M Signaling Pathway (957)
- ncRNAs involved in Wnt signaling in hepatocellular carcinoma (428)
- ERK Pathway in Huntington's Disease (212)
- miRNA targets in ECM and membrane receptors (58)
- Regulation of Microtubule Cytoskeleton (348)
- Pregnane X Receptor pathway (215)
- Non-genomic actions of 1,25 dihydroxyvitamin D3 (741)
- Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling (296)
- Amino Acid metabolism (241)
- Notch Signaling (177)
- Nanoparticle-mediated activation of receptor signaling (459)
- Toll-like Receptor Signaling (334)
- 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression (315)
- Ectoderm Differentiation (350)
- Physiological and Pathological Hypertrophy of the Heart (335)
- Integrin-mediated Cell Adhesion (804)
- exRNA mechanism of action and biogenesis (11)
- Preimplantation Embryo (142)
- Dopaminergic Neurogenesis (146)
- Human Complement System (292)
- Mammary gland development pathway - Puberty (Stage 2 of 4) (130)
- Novel intracellular components of RIG-I-like receptor (RLR) pathway (515)
- Monoamine GPCRs (105)
- Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway (84)
- Oxytocin signaling (17)
- Metapathway biotransformation Phase I and II (496)
- Vitamins A and D - action mechanisms (29)
- Cell-type Dependent Selectivity of CCK2R Signaling (49)
- Energy Metabolism (336)
- Endoderm Differentiation (552)
- Glycerophospholipid Biosynthetic Pathway (31)
- Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex (133)
- MAPK Cascade (522)
- Glycogen Synthesis and Degradation (128)
- Fatty Acid Beta Oxidation (106)
- Felbamate Metabolism (25)
- DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM (368)
- Osteoblast Signaling (65)
- Butyrate-induced histone acetylation (58)
- Nicotine Metabolism (43)
- Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway (162)
- Osteopontin Signaling (310)
- Cori Cycle (82)
- Circadian rhythm related genes (843)
- G13 Signaling Pathway (271)
- Biosynthesis and regeneration of tetrahydrobiopterin (BH4) and catabolism of phenylalanine, including diseases (2)
- Hypoxia-mediated EMT and Stemness (8)
- Tgif disruption of Shh signaling (38)
- Cholesterol Biosynthesis Pathway (31)
- Follicle Stimulating Hormone (FSH) signaling pathway (446)
- Heart Development (295)
- Irinotecan Pathway (72)
- Fluoropyrimidine Activity (117)
- Evolocumab Mechanism (11)
- Serotonin and anxiety-related events (94)
- Aryl Hydrocarbon Receptor Pathway (438)
- PDGFR-beta pathway (633)
- Folate Metabolism (513)
- Photodynamic therapy-induced unfolded protein response (71)
- Senescence and Autophagy in Cancer (928)
- Kennedy pathway from Sphingolipids (23)
- TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer (176)
- Dopamine metabolism (77)
- BMP Signaling Pathway in Eyelid Development (259)
- MicroRNAs in cardiomyocyte hypertrophy (1174)
- Secretion of Hydrochloric Acid in Parietal Cells (14)
- G1 to S cell cycle control (401)
- Integrated Cancer Pathway (557)
- Glucose Homeostasis (15)
- GPCRs, Other (191)
- AMP-activated Protein Kinase (AMPK) Signaling (587)
- Tamoxifen metabolism (156)
- T-Cell Receptor and Co-stimulatory Signaling (353)
- Hypothetical Craniofacial Development Pathway (43)
- Target Of Rapamycin (TOR) Signaling (328)
- Prion disease pathway (413)
- Signaling Pathways in Glioblastoma (1284)
- Degradation pathway of sphingolipids, including diseases (11)
- Proteasome Degradation (182)
- Acetylcholine Synthesis (17)
- Inflammatory Response Pathway (172)
- Association Between Physico-Chemical Features and Toxicity Associated Pathways (918)
- GPCRs, Class B Secretin-like (34)
- IL-9 Signaling Pathway (409)
- Oxidative Stress (308)
- Endochondral Ossification (416)
- Gene regulatory network modelling somitogenesis (62)
- Endothelin Pathways (315)
- Matrix Metalloproteinases (106)
- Oxidation by Cytochrome P450 (269)
- Common Pathways Underlying Drug Addiction (523)
- IL-6 signaling pathway (842)
- Nuclear Receptors (180)
- Iron metabolism in placenta (20)
- miR-222 in Exercise-Induced Cardiac Growth (24)
- Aryl Hydrocarbon Receptor (735)
- TNF alpha Signaling Pathway (1289)
- Nucleotide Metabolism (43)
- Apoptosis Modulation and Signaling (856)
- Influenza A virus infection (25)
- Differentiation of white and brown adipocyte (137)
- Drug Induction of Bile Acid Pathway (112)
- RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway (1126)
- DNA Mismatch Repair (39)
- Wnt Signaling (949)
- MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma (46)
- Sulindac Metabolic Pathway (28)
- Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation (485)
- Hypertrophy Model (129)
- Cannabinoid receptor signaling (438)
- Lidocaine metabolism (36)
- Effects of Nitric Oxide (42)
- Retinoblastoma Gene in Cancer (629)
- SREBF and miR33 in cholesterol and lipid homeostasis (148)
- ACE Inhibitor Pathway (83)
- Cardiac Progenitor Differentiation (374)
- Pathways Affected in Adenoid Cystic Carcinoma (565)
- miRNA regulation of prostate cancer signaling pathways (804)
- Human Thyroid Stimulating Hormone (TSH) signaling pathway (1163)
- Cardiac Hypertrophic Response (1147)
- Canonical and Non-Canonical TGF-B signaling (258)
- EPO Receptor Signaling (669)
- Apoptosis-related network due to altered Notch3 in ovarian cancer (581)
- eIF5A regulation in response to inhibition of the nuclear export system (5)
- DDX1 as a regulatory component of the Drosha microprocessor (52)
- Parkin-Ubiquitin Proteasomal System pathway (180)
- Brain-Derived Neurotrophic Factor (BDNF) signaling pathway (2081)
- Triacylglyceride Synthesis (57)
- Ebola Virus Pathway on Host (1141)
- Osteoclast Signaling (125)
- Microglia Pathogen Phagocytosis Pathway (357)
- Peptide GPCRs (222)
- Composition of Lipid Particles (56)
- Nucleotide-binding Oligomerization Domain (NOD) pathway (340)
- Wnt Signaling in Kidney Disease (391)
- Androgen receptor signaling pathway (1045)
- LTF danger signal response pathway (371)
- Mevalonate pathway (24)
- Cocaine metabolism (39)
- Splicing factor NOVA regulated synaptic proteins (142)
- NAD+ biosynthetic pathways (63)
- Biogenic Amine Synthesis (62)
- Photodynamic therapy-induced HIF-1 survival signaling (280)
- Macrophage markers (32)
- Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling (329)
- Trans-sulfuration and one carbon metabolism (133)
- Cytokines and Inflammatory Response (308)
- Hypothesized Pathways in Pathogenesis of Cardiovascular Disease (393)
- Ethanol effects on histone modifications (162)
- Interleukin-11 Signaling Pathway (1087)
- Fatty Acid Omega Oxidation (118)
- Vitamin D Receptor Pathway (903)
- Focal Adhesion-PI3K-Akt-mTOR-signaling pathway (2650)
- IL-4 Signaling Pathway (1252)
- IL-3 Signaling Pathway (1237)
- Glycine Metabolism (20)
- Cell Differentiation - Index expanded (163)
- Monoamine Transport (273)
- T-Cell antigen Receptor (TCR) Signaling Pathway (1763)
- Gastric acid production (11)
- One carbon metabolism and related pathways (238)
- Small Ligand GPCRs (63)
- VEGFA-VEGFR2 Signaling Pathway (2944)
- Ganglio Sphingolipid Metabolism (21)
- LncRNA involvement in canonical Wnt signaling and colorectal cancer (874)
- Pancreatic adenocarcinoma pathway (1992)
- Cells and Molecules involved in local acute inflammatory response (189)
- Ciliary landscape (642)
- Extracellular vesicles in the crosstalk of cardiac cells (260)
- Lamin A-processing pathway (7)
- Metabolism of Tetrahydrocannabinol (THC) (37)
- Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells (376)
- Breast cancer pathway (2555)
- Metabolic reprogramming in colon cancer (155)
- Methionine metabolism leading to Sulphur Amino Acids and related disorders (68)
- Somatroph axis (GH) and its relationship to dietary restriction and aging (210)
- Mevalonate arm of cholesterol biosynthesis pathway with inhibitors (13)
- Caloric restriction and aging (232)
- Fibrin Complement Receptor 3 Signaling Pathway (692)
- Resistin as a regulator of inflammation (927)
- Hormonal control of Pubertal Growth Spurt (6)
- Metabolic pathway of LDL, HDL and TG, including diseases (86)
- The human immune response to tuberculosis (171)
- The alternative pathway of fetal androgen synthesis (34)
- MET in type 1 papillary renal cell carcinoma (1558)
- Hereditary leiomyomatosis and renal cell carcinoma pathway (225)
- Tryptophan catabolism leading to NAD+ production (48)
- Transcriptional cascade regulating adipogenesis (99)
- Oxysterols derived from cholesterol (75)
- MTHFR deficiency (170)
- The effect of progerin on the involved genes in Hutchinson-Gilford Progeria Syndrome (187)
- Role Altered Glycolysation of MUC1 in Tumour Microenvironment (346)
- Chromosomal and microsatellite instability in colorectal cancer (1699)
- Rett syndrome causing genes (212)
- Neurotransmitter Disorders (31)
- Genotoxicity pathway (214)
- NRF2-ARE regulation (378)
- Lipid Metabolism Pathway (361)
- Phosphodiesterases in neuronal function (230)
- Ras Signaling (2526)
- Pyrimidine metabolism and related diseases (60)
- Vitamin B6-dependent and responsive disorders (9)
- Acrylamide Biotransformation and Exposure Biomarkers (15)
- Disorders of the Krebs cycle (22)
- Epithelial to mesenchymal transition in colorectal cancer (2193)
- Type 2 papillary renal cell carcinoma (305)
- Regulation of sister chromatid separation at the metaphase-anaphase transition (44)
- Vitamin D in inflammatory diseases (603)
- Thiamine metabolic pathways (26)
- Oligodendrocyte Specification and differentiation(including remyelination), leading to Myelin Components for CNS (234)
- Viral Acute Myocarditis (1425)
- Disorders of Folate Metabolism and Transport (76)
- Vitamin B12 Disorders (37)
- Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer (57)
- Mitochondrial complex I assembly model OXPHOS system (129)
- Canonical NF-KB pathway (295)
- Interactions between immune cells and microRNAs in tumor microenvironment (426)
- 22q11.2 Deletion Syndrome (389)
- Neural Crest Cell Migration in Cancer (711)
- Cysteine and methionine catabolism (101)
- Cell migration and invasion through p75NTR (487)
- Control of immune tolerance by vasoactive intestinal peptide (183)
- IL-10 Anti-inflammatory Signaling Pathway (214)
- Selective expression of chemokine receptors during T-cell polarization (275)
- Neural Crest Cell Migration during Development (758)
- Molybdenum cofactor (Moco) biosynthesis (20)
- FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma (239)
- Hepatitis B infection (3383)
- Bile Acids synthesis and enterohepatic circulation (251)
- Signal transduction through IL1R (914)
- Fragile X Syndrome (1471)
- Translation inhibitors in chronically activated PDGFRA cells (1336)
- Nonalcoholic fatty liver disease (1998)
- Platelet-mediated interactions with vascular and circulating cells (240)
- MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement (446)
- Cerebral Organic Acidurias, including diseases (18)
- Gamma-Glutamyl Cycle for the biosynthesis and degradation of glutathione, including diseases (51)
- Glycosylation and related congenital defects (28)
- Classical pathway of steroidogenesis, including diseases (61)
- Amino Acid Metabolism Pathway Excerpt (Histidine catabolism extension) (14)
- Hippo-Yap signaling pathway (92)
- Synaptic signaling pathways associated with autism spectrum disorder (1203)
- Hippo-Merlin Signaling Dysregulation (1092)
- Regulatory circuits of the STAT3 signaling pathway (1078)
- Transcription co-factors SKI and SKIL protein partners (106)
- Genes related to primary cilium development (based on CRISPR) (147)
- Intraflagellar transport proteins binding to dynein (65)
- Envelope proteins and their potential roles in EDMD physiopathology (896)
- Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms (580)
- Pathways Regulating Hippo Signaling (1184)
- Urea cycle and related diseases (25)
- Joubert Syndrome (340)
- Cancer immunotherapy by CTLA4 blockade (368)
- Biomarkers for pyrimidine metabolism disorders (67)
- Biomarkers for urea cycle disorders (50)
- Cancer immunotherapy by PD-1 blockade (386)
- Metabolism of alpha-linolenic acid (23)
- Major receptors targeted by epinephrine and norepinephrine (104)
- Urea cycle and associated pathways (106)
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- Lyase (24)
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- Transcription factor (124)
- Methyltransferase (45)
- Nucleic acid binding (122)
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- Membrane-bound signaling molecule (34)
- Cytokine (34)
- Extracellular matrix structural protein (12)
- Serine protease inhibitor (67)
- Transferase (88)
- Oxidase (65)
- Oxygenase (68)
- mRNA splicing factor (91)
- Calcium-binding protein (26)
- Growth factor (107)
- SLC44 choline transporter-like family (5)
- Non-motor actin binding protein (77)
- SLC7 family (13)
- cation channel sperm-associated family (4)
- Homeodomain transcription factor (95)
- Gap junction (21)
- Chemokine (48)
- chemokine receptor (6)
- C-X-C chemokine receptor (4)
- Ubiquitin-protein ligase (93)
- Oxidoreductase (28)
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- Reductase (40)
- phagocyte (gp91(phox)) nadph oxidase family (1)
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- Glycosyltransferase (115)
- Calmodulin (89)
- Chaperonin (13)
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- CNGA4 subfamily (1)
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- Phosphatase (72)
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- Acetyltransferase (53)
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- Serine protease (200)
- Nuclease (64)
- Isomerase (40)
- C-C chemokine receptor (12)
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- DNA methyltransferase (1)
- Endodeoxyribonuclease (8)
- Guanyl-nucleotide exchange factor (58)
- Phosphodiesterase (7)
- CNGB3 subfamily (1)
- Lipase (29)
- dopamine receptor (6)
- Nucleotide phosphatase (25)
- G-protein modulator (125)
- Eph family (14)
- Membrane trafficking regulatory protein (67)
- Protease inhibitor (108)
- class A rhodopsin like (107)
- IRE family (2)
- purinoceptor (8)
- Peroxidase (24)
- Ribosomal protein (151)
- Hydroxylase (2)
- Winged helix/forkhead transcription factor (76)
- CDKL family (5)
- CRK7 subfamily (1)
- CDK7 subfamily (1)
- CFTR transporter subfamily (1)
- DNA-directed DNA polymerase (22)
- DNA helicase (26)
- leukotriene receptor (5)
- angiotensin receptor (4)
- chemokine receptor-like (1)
- 3B. Estrogen-related receptors (3)
- 3A. Estrogen receptors (2)
- Acyltransferase (55)
- Enzyme modulator (66)
- Basic helix-loop-helix transcription factor (59)
- EGFR family (4)
- Hydrolase (131)
- galanin like (1)
- GABRR1 sub-subfamily (1)
- Exodeoxyribonuclease (4)
- KRAB box transcription factor (186)
- Mitochondrial amino acid transporter subfamily (15)
- Signaling (134)
- glucagon receptor (6)
- Cellular structure (72)
- Galactosidase (5)
- Hsp90 family chaperone (10)
- Rel homology transcription factor (27)
- Actin family cytoskeletal protein (55)
- DNA binding protein (80)
- Type I cytokine receptor (20)
- Translation release factor (4)
- GABRR3 sub-subfamily (1)
- Tight junction (36)
- Kinase activator (46)
- GABRA1 sub-subfamily (1)
- Cadherin (7)
- GABRD sub-subfamily (1)
- GABRG3 sub-subfamily (1)
- Non-motor microtubule binding protein (57)
- Translation elongation factor (6)
- Protein methyltransferase (9)
- Microtubule family cytoskeletal protein (31)
- Dyrk1 subfamily (2)
- Dyrk2 subfamily (3)
- PEK family (2)
- PEK subfamily (1)
- GCN2 subfamily (1)
- Glutamate transporter subfamily (5)
- 3C. 3-Ketosteroid receptors (4)
- Hormone (32)
- Mitochondrial di- and tri-carboxylic acid transporter subfamily (6)
- GEK subfamily (4)
- Aminoacyl-tRNA synthetase (24)
- Ligase (77)
- GABRG1 sub-subfamily (1)
- GABRG2 sub-subfamily (1)
- GABRA3 sub-subfamily (1)
- GABRA4 sub-subfamily (1)
- GABRA5 sub-subfamily (1)
- GABRB1 sub-subfamily (1)
- GABRB3 sub-subfamily (1)
- GABRP sub-subfamily (1)
- GABRQ sub-subfamily (1)
- Antibacterial response protein (8)
- Endoribonuclease (11)
- DCAMKL family (3)
- DCK/DGK family (3)
- DDR family (2)
- GABRE sub-subfamily (1)
- GABRR2 sub-subfamily (1)
- SGK496 family (1)
- Carbohydrate phosphatase (3)
- carbohydrate kinase (3)
- Nucleotidyltransferase (24)
- Histone (56)
- FAK family (2)
- Cell adhesion (58)
- Chaperone (45)
- Extracellular matrix glycoprotein (41)
- Cysteine protease inhibitor (2)
- Cyclase (4)
- Deaminase (28)
- Basic leucine zipper transcription factor (30)
- DNA ligase (2)
- DMPK family (1)
- corticotropin-releasing factor receptor (2)
- PDGFR family (5)
- Protein phosphatase (59)
- G-protein (7)
- DAPK family (5)
- Chromodomain (7)
- CDK9 subfamily (1)
- TAIRE subfamily (5)
- Bromodomain (14)
- CACNA1H subfamily (1)
- CACNA1A subfamily (1)
- calcium channel auxiliary subunit 1-8 (cca) family (8)
- cholecystokinin receptor (2)
- Kinase inhibitor (16)
- PITSLRE subfamily (2)
- adhesion class (26)
- Tumor necrosis factor family member (11)
- Aspartic protease (23)
- CACNG subfamily (1)
- CDK8 subfamily (2)
- CDK4 subfamily (2)
- Replication origin binding protein (8)
- Annexin (2)
- CDK10 subfamily (1)
- Microtubule binding motor protein (47)
- Neuropeptide (15)
- Diacylglycerol kinase family (3)
- Centromere DNA-binding protein (1)
- Decarboxylase (13)
- Phospholipase (44)
- SLC49 family of FLVCR-related heme transporters (4)
- GABRA2 sub-subfamily (1)
- Glycosidase (16)
- GABRA6 sub-subfamily (1)
- GABRB2 sub-subfamily (1)
- Immunoglobulin superfamily cell adhesion molecule (3)
- DNA photolyase (2)
- CCRK subfamily (1)
- CDC7 family (1)
- CDK5 subfamily (1)
- Vesicle coat protein (40)
- Aquaporins (12)
- Aldolase (1)
- Damaged DNA-binding protein (11)
- Phosphorylase (10)
- SLOB family (1)
- parathyroid hormone receptor (2)
- Phosphatase activator (1)
- RAF family (5)
- RET family (1)
- 1B. Retinoic acid receptors (3)
- Primase (1)
- Zinc finger transcription factor (33)
- SCY1 family (3)
- PAKB subfamily (3)
- Type II pantothenate kinase family (3)
- proteinase-activated receptor (4)
- mRNA processing factor (13)
- Translation factor (6)
- Phosphatase modulator (16)
- DNAPK subfamily (1)
- CCK4 family (1)
- Type I phosphatidylinositol-4-phosphate 5-kinase family (1)
- DNA-directed RNA polymerase (43)
- Mitochondrial nucleotide transporter subfamily (17)
- DYRK family (1)
- SRC family (13)
- BUD32 family (1)
- PKA family (5)
- Phosphatase inhibitor (32)
- GRK subfamily (5)
- Unclassified protein (2)
- SGK family (3)
- Atypical SLC22B subfamily (1)
- SLC50 sugar transporter (1)
- SRPK family (3)
- Runt transcription factor (3)
- Organic anion transporters (OATs) (6)
- SLC12 family of cation-coupled chloride transporters (9)
- SLC26A/SulP transporter family (2)
- SLC39 family of metal ion transporters (14)
- SLC35 family of nucleotide sugar transporters (31)
- SLC36 family of proton-coupled amino acid transporters (4)
- Apolipoprotein (13)
- Neutral amino acid transporter subfamily (6)
- Lambda repressor-like transcription factor (2)
- SCN4B family (1)
- RYR1 subfamily (1)
- Organic cation transporters (OCT) (3)
- SLC15 family of peptide transporters (4)
- Orphan or poorly characterized SLC22 family members (10)
- Type I sodium-phosphate co-transporters (4)
- SLC29 family (4)
- SLC46 family of folate transporters (3)
- SLC40 iron transporter (1)
- SLC28 family (3)
- SLC52 family of riboflavin transporters (3)
- Hexose transporter family (5)
- GABA transporter subfamily (6)
- SCNN1A subfamily (1)
- SCNN1G subfamily (1)
- Nav1.2/SCN2A subfamily (1)
- Urate transporter (1)
- Chloride/bicarbonate exchangers (2)
- Other SLC26 anion exchangers (4)
- System A-like transporters (3)
- SLC13 family of sodium-dependent sulphate/carboxylate transporters (5)
- Sodium-dependent HCO3- transporters (6)
- C2H2 zinc finger transcription factor (25)
- Helicase (2)
- RYR3 subfamily (1)
- System N-like transporters (2)
- SLC27 family of fatty acid transporters (6)
- SLC23 family of ascorbic acid transporters (3)
- Orphan SLC38 transporters (6)
- Tubulin (22)
- Sodium iodide symporter, sodium-dependent multivitamin transporter and sodium-coupled monocarboxylate transporters (4)
- Miscellaneous SLC25 mitochondrial transporters (8)
- SLC18 family of vesicular amine transporters (4)
- RYR2 subfamily (1)
- 2B. Retinoid X receptors (3)
- SLC41 family of divalent cation transporters (3)
- SLC45 family of putative sugar transporters (4)
- MADS box transcription factor (5)
- Ribonucleoprotein (26)
- RIO3 subfamily (1)
- ROR family (2)
- ROCK subfamily (2)
- NKF1 family (3)
- 1F. Retinoic acid-related orphans (3)
- other-UNIQUE family (3)
- MET family (2)
- RYK family (1)
- Selective sulphate transporters (1)
- SLC20 family of sodium-dependent phosphate transporters (2)
- SLC19 family of vitamin transporters (3)
- Transaminase (16)
- Heterotrimeric G-protein (39)
- RSKL family (2)
- SEV family (1)
- NDR family (4)
- Protein kinase receptor (2)
- YSK subfamily (3)
- SLK subfamily (2)
- 5A. Fushi tarazu F1-like receptors (2)
- NAK family (4)
- Protease (11)
- SLC37 family of phosphosugar/phosphate exchangers (4)
- SNARE protein (30)
- TRPM1 sub-subfamily (1)
- TRPM2 sub-subfamily (1)
- TRPM3 sub-subfamily (1)
- TRPM4 sub-subfamily (1)
- TRPM5 sub-subfamily (1)
- ChaK subfamily (1)
- TRPM7 sub-subfamily (1)
- HMG box transcription factor (14)
- YANK family (3)
- CAMK-UNIQUE family (2)
- FRAY subfamily (2)
- MST subfamily> (2)
- LKB subfamily (1)
- STE20 family (3)
- lipid kinase (9)
- SLC63 Sphingosine-phosphate transporters (3)
- NKF4 family (2)
- ULK family (5)
- SGK495 family (1)
- SGK071 family (1)
- transmembrane channel (TMC) family (6)
- TEC family (5)
- Mitochondrial uncoupling proteins (6)
- V-type ATPase (23)
- 1I. Vitamin D receptor-like receptors (3)
- SLC14 family of facilitative urea transporters (2)
- VEGFR family (3)
- Vesicular glutamate transporters (VGLUTs) (3)
- SLC32 vesicular inhibitory amino acid transporter (1)
- vomeronasal receptor (6)
- AXL family (3)
- JAKA family (4)
- TRPV3 sub-subfamily (1)
- IRAK family (4)
- histamine receptor (4)
- RCK family (3)
- HIPK subfamily (4)
- ILK subfamily (1)
- IKK family (4)
- ABCB subfamily (11)
- Inositol phosphokinase (IPK) family (3)
- Interleukin superfamily (4)
- Type II cytokine receptor (12)
- frizzled receptor (10)
- Storage (8)
- free fatty acid receptor (4)
- galanin receptor (3)
- formyl peptide receptor (3)
- fxyd family (5)
- GPR137 family (1)
- Class II transporters (8)
- Class I transporters (5)
- KCNJ4 subfamily (1)
- two pore domain potassium channel family (15)
- HASPIN family (1)
- KCNJ2 subfamily (1)
- KCNJ6 subfamily (1)
- RGC family (5)
- Mutase (5)
- 2A. Hepatocyte nuclear factor-4 receptors (2)
- Thymidine kinase family (1)
- hydroxycarboxylic acid receptor (3)
- cyclic nucleotide-gated cation channel family (4)
- Meta subfamily (2)
- HDAC class IIa (4)
- SET domain (9)
- HDAC class IIb (2)
- HDAC class I (4)
- kisspeptin receptor (1)
- HDAC class IV (1)
- GLRA2 sub-subfamily (1)
- FER family (2)
- glycoprotein hormone receptor (3)
- Phospholemman (plm) family (2)
- ghrelin receptor (1)
- endothelin receptor (1)
- FGFR family (4)
- FAST family (1)
- Hexokinase family (2)
- SLC48 heme transporter (1)
- HUNK subfamily (1)
- voltage-gated proton channel (vpc) family (1)
- AK1 subfamily (1)
- AK2 subfamily (1)
- CK1 family (7)
- voltage-gated potassium channel -subunit (kv) family (3)
- CAMK1 family (5)
- SLC60 Glucose transporters (2)
- INSR family (3)
- MELK subfamily (1)
- ITPK1 family (1)
- CAMK2 family (4)
- KCNJ14 subfamily (1)
- KCNJ15 subfamily (1)
- KCNJ16 subfamily (1)
- KCNJ12 subfamily (2)
- Kv1.6/KCNA6 sub-subfamily (1)
- Kv1.7/KCNA7 sub-subfamily (1)
- KCNMB/KCNMB1 subfamily (1)
- KCNMB/KCNMB3 subfamily (1)
- Kv3.1/KCNC1 sub-subfamily (1)
- Kv7.4/KCNQ4 sub-subfamily (1)
- Kv7.5/KCNQ5 sub-subfamily (1)
- Kv9.1/KCNS1 sub-subfamily (1)
- Actin binding motor protein (27)
- ryanodine-inositol 1,4,5-triphosphate receptor calcium channel (rir-cac) family (3)
- SLC30 zinc transporter family (10)
- taste 1 receptor (3)
- TSSK family (5)
- TTBK family (2)
- Tudor domain (2)
- TRPV6 sub-subfamily (1)
- TRPC3 sub-subfamily (1)
- TRPC4 sub-subfamily (1)
- TRPC5 sub-subfamily (1)
- TRPC6 sub-subfamily (1)
- TRPV1 sub-subfamily (1)
- TRPC7 sub-subfamily (1)
- TRPC1 sub-subfamily (1)
- MLCK family (5)
- Tumor necrosis factor receptor (2)
- two pore calcium channel subfamily (2)
- TLK family (2)
- DNA topoisomerase (4)
- SNRK subfamily (1)
- SLCO family of organic anion transporting polypeptides (11)
- ACK family (2)
- TRIO family (4)
- TOPK family (1)
- QIK subfamily (3)
- tmem38 family (2)
- SLC9 family of sodium/hydrogen exchangers (13)
- HDAC class III (7)
- MSN subfamily (3)
- MBT domain (5)
- class F frizzled-type (1)
- SLC10 family of sodium-bile acid co-transporters (7)
- Deacetylase (3)
- Monoamine transporter subfamily (3)
- Glycine transporter subfamily (4)
- SCNN1B subfamily (1)
- SCN7A subfamily (1)
- SCN2B family (1)
- NKF5 family (1)
- SCN3B family (1)
- Organic zwitterions/cation transporters (OCTN) (3)
- Choline transporter (1)
- Nav1.9/SCN11A subfamily (1)
- Sodium myo-inositol cotransporter transporters (2)
- Surfactant (5)
- SLC56 Sideroflexins (4)
- SCN1B family (1)
- SLC47 family of multidrug and toxin extrusion transporters (2)
- Nav1.5/SCN5A subfamily (1)
- Nav1.8/SCN10A subfamily (1)
- Nav1.3/SCN3A subfamily (1)
- Sialic acid transporter (1)
- Vesicular nucleotide transporter (1)
- SLC43 family of large neutral amino acid transporters (3)
- Alanine/serine/cysteine transporter subfamily (2)
- Anion channels (2)
- Nav1.7/SCN9A subfamily (1)
- Nav1.4/SCN4A subfamily (1)
- Nav1.1/SCN1A subfamily (1)
- SCNN1D subfamily (1)
- Nav1.6/SCN8A subfamily (1)
- TATA-binding transcription factor (3)
- TBCK family (1)
- taste 2 receptor (24)
- TAF1 family (1)
- TAO subfamily (3)
- class B secretin like (4)
- TESK subfamily (1)
- STKR Type 1 subfamily (7)
- STKR Type 2 subfamily (5)
- SLC64 Golgi Ca2+/H+ exchangers (1)
- transient receptor potential calcium channel (TRP-CC) family (1)
- TIE family (2)
- 1A. Thyroid Hormone Receptors (2)
- Reverse transcriptase (1)
- calcium-dependent chloride channel (ca-clc) family (5)
- Immunoglobulin (76)
- SLC3 family (2)
- RSKR family (1)
- PIKK family (2)
- TTK family (1)
- anion channel tweety (tweety) family (3)
- Thiamine pyrophosphokinase family (1)
- TRPV2 sub-subfamily (1)
- TRPV4 sub-subfamily (1)
- SLC58 MagT-like magnesium transporter family (2)
- NKF2 family (1)
- polycystin cation channel (pcc) family (6)
- PLK family (4)
- WEE family (3)
- PIM family (3)
- PKN family (3)
- PI3/PI4 kinase family (8)
- SGK493 family (1)
- Plant homeodomain (4)
- PHK family (2)
- VPS15 family (1)
- Cell-cell junction (4)
- Dehydratase (5)
- class C metabotropic glutamate/pheromone (6)
- Eukaryotic two domain clade "E" sub-subfamily (1)
- Phosphoglycerate kinase family (1)
- RIO2 subfamily (1)
- RIO1 subfamily (1)
- RIPK family (5)
- PDHK family (4)
- Actin and actin related protein (31)
- NKF3 family (2)
- Phosphoenolpyruvate carboxykinase [GTP] family (1)
- PLK2 subfamily (1)
- PDHK subfamily (1)
- mechanical nociceptor, piezo (piezo) family (2)
- Type III PI4K subfamily (1)
- DNA polymerase processivity factor (1)
- Pyridoxine kinase family (1)
- SLC24 family of sodium/potassium/calcium exchangers (6)
- tachykinin receptor (3)
- gap junction-forming innexin (innexin) family (3)
- SLC42 family of Rhesus glycoprotein ammonium transporters (3)
- ERK subfamily (5)
- Lysine-specific demethylase (3)
- Jumonji domain-containing (8)
- PKG family (2)
- PSK family (2)
- PKC iota subfamily (2)
- other small molecule kinase (2)
- p70 subfamily (2)
- MNK subfamily (2)
- Guanylate kinase family (1)
- PKC delta subfamily (2)
- RSK subfamily (4)
- SYK family (2)
- PKC alpha subfamily (3)
- PKD family (3)
- PKC eta subfamily (2)
- JNK subfamily (3)
- p38 subfamily (4)
- Erk7 subfamily (1)
- Cytokine receptor (2)
- MSK subfamily (2)
- Mevalonate kinase subfamily (1)
- STE11 family (8)
- NEK family (11)
- olfactory receptor (421)
- SLC16 family of monocarboxylate transporters (14)
- SLC54 Mitochondrial pyruvate carriers (3)
- MAST family (5)
- MARK subfamily (4)
- Mas proto-oncogene and Mas-related (MRGs) receptor (10)
- 4A. Nerve growth factor IB-like receptors (3)
- MOS family (1)
- STE7 family (7)
- MLK family (2)
- KHS subfamily (4)
- LZK subfamily (1)
- melanocortin receptor (5)
- DNA glycosylase (5)
- MCOLN2 sub-subfamily (1)
- TKL-UNIQUE family (1)
- MCOLN1 sub-subfamily (1)
- MCOLN3 sub-subfamily (1)
- MAPKAPK subfamily (3)
- LMR family (3)
- Phosphorylase b kinase regulatory chain family (2)
- lysophospholipid (LPA) receptor (6)
- SLC55 Mitochondrial cation/proton exchangers (3)
- LIMK subfamily (2)
- Glucosidase (7)
- MLK subfamily (4)
- TAK1 subfamily (1)
- ALK family (2)
- melanin-concentrating hormone receptor (6)
- STE-UNIQUE family (2)
- Methyl-CpG-binding domain (2)
- LRRK family (2)
- MCU family (1)
- ABCC subfamily (11)
- 0B. DAX-like receptors (2)
- 1D. Rev-Erb receptors (2)
- 1H. Liver X receptor-like receptors (3)
- 2C. Testicular receptors (2)
- SLC11 family of proton-coupled metal ion transporters (2)
- NRBP family (2)
- Mitochondrial phosphate transporters (1)
- calcium channel auxiliary subunit types 1-4 (cca-) family (4)
- calcium homeostasis modulator calcium channel (calhm-c) family (4)
- FAM26 family (2)
- CACNA1G subfamily (1)
- CACNA1I subfamily (1)
- CACNA1C subfamily (1)
- calcitonin receptor (2)
- calcium-sensing receptor (2)
- CACNA1B subfamily (1)
- anaphylatoxin receptor (3)
- calcium channel auxiliary subunit 2 types 1-4 (cca-2) family (4)
- Protein arginine methyltransferase (7)
- CACNA1D subfamily (1)
- CACNA1E subfamily (1)
- CACNA1F subfamily (1)
- anion channel-forming bestrophin (bestrophin) family (4)
- bombesin receptor (3)
- BUB family (2)
- BRSK subfamily (2)
- CACNA1S subfamily (1)
- BARK subfamily (2)
- bradykinin receptor (2)
- Neurotrophic factor (8)
- F-type ATPase (13)
- ATR subfamily (1)
- AUR family (3)
- ABC1-A subfamily (2)
- 2F. COUP-TF-like receptors (3)
- Anion exchangers (4)
- Phospholipid-transporting ATPases (14)
- Na+/K+-ATPases (8)
- ClC-1/CLCN1 subfamily (1)
- ClC-4/CLCN4 subfamily (1)
- ClC-5/CLCN5 subfamily (1)
- Ca2+-ATPases (9)
- intracellular chloride channel (clic) family (6)
- H+/K+-ATPases (3)
- chemerin receptor (1)
- SLC31 family of copper transporters (2)
- CDK family (1)
- CNGA1 subfamily (1)
- CNGA2 subfamily (1)
- VRK family (3)
- WNK family (4)
- SLC53 Phosphate carriers (1)
- TRPM8 sub-subfamily (1)
- neurotransmitter receptor, Cys loop, ligand-gated ion channel (LIC) family (1)
- TRPV5 sub-subfamily (1)
- Uridine kinase family (2)
- 5-HT1 receptor (5)
- ABCD subfamily of peroxisomal ABC transporters (3)
- beta-3/CHRNB3 sub-subfamily (1)
- alpha-5/CHRNA5 sub-subfamily (1)
- alpha-6/CHRNA6 sub-subfamily (1)
- delta/CHRND sub-subfamily (1)
- alpha-7/CHRNA7 sub-subfamily (1)
- beta adrenoceptor (3)
- ABCG subfamily (5)
- 5-HT5 receptor (1)
- ABCA subfamily (12)
- alpha-3/CHRNA3 sub-subfamily (1)
- gamma/CHRNG sub-subfamily (1)
- alpha-10/CHRNA10 sub-subfamily (1)
- acetylcholine receptor (muscarinic) (5)
- alpha-1/CHRNA1 sub-subfamily (1)
- alpha-9/CHRNA9 sub-subfamily (1)
- alpha adrenoceptor (6)
- 5-HT3 receptor sub-subfamily (5)
- 5-HT4 receptor (1)
- CAMKL family (2)
- ABL family (2)
- beta-2/CHRNB2 sub-subfamily (1)
- beta-4/CHRNB4 sub-subfamily (1)
- SLC62 Pyrophosphate transporters (1)
- apelin receptor (1)
- 5-HT2 receptor (3)
- adenosine receptor (4)
- alpha-4/CHRNA4 sub-subfamily (1)
- epsilon/CHRNE sub-subfamily (1)
- 5-HT7 receptor (1)
- SLC33 acetylCoA transporter (1)
- alpha-2/CHRNA2 sub-subfamily (1)
- beta-1/CHRNB1 sub-subfamily (1)
- ABC1-B subfamily (2)
- latrophilin receptor (4)
- AKT family (3)
- ABC1-C subfamily (1)
- Alpha family (3)
- nucleoside kinase (1)
- AMPK subfamily (2)
- 5-HT6 receptor (1)
- CHK1 subfamily (1)
- Choline/ethanolamine kinase family (2)
- RAD53 family (1)
- TK-UNIQUE family (1)
- TRBL family (3)
- UPF0359 family (1)
- KIS family (1)
- HH498 subfamily (1)
- LISK family (1)
- acid-sensing ion channel 4 (ASIC4) subfamily (1)
- acid-sensing ion channel 5 (ASIC5) subfamily (1)
- ClC-2/CLCN2 subfamily (1)
- Cu+-ATPases (2)
- epithelial chloride channel (e-clc) family (4)
- CLCNKB subfamily (1)
- ClC-3/CLCN3 subfamily (1)
- ClC-6/CLCN6 subfamily (1)
- ClC-7/CLCN7 subfamily (1)
- CLK family (4)
- acid-sensing ion channel 3 (ASIC3) subfamily (1)
- intracellular chloride channel (icc) family (1)
- CLCNKA subfamily (1)
- acid-sensing ion channel 1 (ASIC1) subfamily (1)
- acid-sensing ion channel 2 (ASIC2) subfamily (1)
- gonadotrophin-releasing hormone receptor (2)
- GABA-B receptor (3)
- bile acid receptor (1)
- golgi pH regulator family (2)
- Myelin protein (3)
- GRIA4 subfamily (1)
- GRID1 subfamily (1)
- GRID2 subfamily (1)
- metabotropic glutamate receptor (8)
- endothelin type A (1)
- endothelin type B (1)
- eEF2K subfamily (1)
- Ephrin family (1)
- KCNE subfamily (4)
- Kv6.1/KCNG1 sub-subfamily (1)
- Kv12.3/KCNH4 sub-subfamily (1)
- Kv11.3/KCNH7 sub-subfamily (1)
- KCNJ3 subfamily (1)
- KCNJ8 subfamily (1)
- KCNJ9 subfamily (1)
- ATP:guanido phosphotransferase family (1)
- Kv12.1/KCNH8 sub-subfamily (1)
- GRIK4 subfamily (1)
- GRIK5 subfamily (1)
- GRIK1 subfamily (1)
- Pyrophosphatase (4)
- GSK subfamily (2)
- Kv12.2/KCNH3 sub-subfamily (1)
- calcium-activated subfamily (4)
- Kv7.2/KCNQ2 sub-subfamily (1)
- Amylase (1)
- Kv10.1/KCNH1 sub-subfamily (1)
- Kv11.2/KCNH6 sub-subfamily (1)
- Kv7.1/KCNQ1 sub-subfamily (1)
- GRIA2 subfamily (1)
- GRIA3 subfamily (1)
- GRIK2 subfamily (1)
- GRIK3 subfamily (1)
- Kv4.3/KCND3 sub-subfamily (1)
- Kv6.3/KCNG3 sub-subfamily (1)
- Kv6.4/KCNG4 sub-subfamily (1)
- Kv6.2/KCNG2 sub-subfamily (1)
- Kv10.2/KCNH5 sub-subfamily (1)
- GLRA1 sub-subfamily (1)
- GLRA4 sub-subfamily (1)
- other 7TM proteins (1)
- adrenomedullin receptor (1)
- LU7TM family (1)
- GRIA1 subfamily (1)
- Kv5.1/KCNF1 sub-subfamily (1)
- Kv11.1/KCNH2 sub-subfamily (1)
- KCNJ1 subfamily (1)
- KCNJ5 subfamily (1)
- estrogen (G protein-coupled) receptor (1)
- GLRA3 sub-subfamily (1)
- GLRB sub-subfamily (1)
- FGGY kinase family (1)
- NuaK subfamily (2)
- atp-gated p2x receptor cation channel (p2x receptor) family (7)
- PASK subfamily (1)
- PAKA subfamily (3)
- PAN3 family (1)
- SLC51 family of steroid-derived molecule transporters (2)
- P2Y receptor (10)
- P53-like transcription factor (3)
- PI3K p85 subunit family (1)
- neuromedin U receptor (2)
- NR3A/GRIN3A subfamily (1)
- NR1/GRIN1 subfamily (1)
- neurotensin receptor (2)
- TRK family (3)
- 1C. Peroxisome proliferator-activated receptors (3)
- neuropeptide Y receptor (5)
- NR2A/GRIN2A subfamily (1)
- NR2B/GRIN2B subfamily (1)
- neuropeptide FF/neuropeptide AF receptor (2)
- SLC57 NiPA-like magnesium transporter family (6)
- protein kinase (2)
- NIM1 subfamily (1)
- NMO subfamily (1)
- SLC34 family of sodium phosphate co-transporters (3)
- neuropeptide S receptor (1)
- Kv1.8/KCNA10 sub-subfamily (1)
- the phagocyte (gp91(phox)) nadph oxidase family (1)
- KCNJ10 subfamily (1)
- KCNJ11 subfamily (1)
- KCNJ13 subfamily (1)
- Kv1.3/KCNA3 sub-subfamily (1)
- Kv1.4/KCNA4 sub-subfamily (1)
- KCNMB/KCNMB4 subfamily (1)
- Kv1.2/KCNA2 sub-subfamily (1)
- Kv3.2/KCNC2 sub-subfamily (1)
- Kv3.3/KCNC3 sub-subfamily (1)
- Kv9.2/KCNS2 sub-subfamily (1)
- KCa4.1/KCNT1 sub-subfamily (1)
- KCa4.2/KCNT2 sub-subfamily (1)
- KCa5.1/KCNU1 sub-subfamily (1)
- SLC59 Sodium-dependent lysophosphatidylcholine symporter family (2)
- AK3 subfamily (1)
- Kv1.5/KCNA5 sub-subfamily (1)
- KCa1.1/KCNMA1 sub-subfamily (1)
- KCNMB/KCNMB2 subfamily (1)
- Kv2.1/KCNB1 sub-subfamily (1)
- Kv1.1/KCNA1 sub-subfamily (1)
- Kv2.2/KCNB2 sub-subfamily (1)
- Kv7.3/KCNQ3 sub-subfamily (1)
- Kv3.4/KCNC4 sub-subfamily (1)
- Kv4.1/KCND1 sub-subfamily (1)
- Kv4.2/KCND2 sub-subfamily (1)
- Kv9.3/KCNS3 sub-subfamily (1)
- Kv8.1/KCNV1 sub-subfamily (1)
- Kv8.2/KCNV2 sub-subfamily (1)
- SLC61 Molybdate transporter family (1)
- carbohydrate kinase PfkB family (1)
- Thymidylate kinase family (1)
- Phosphoinositide 3-kinase (PI3K) family (1)
- 2E. Tailless-like receptors (2)
- 6A. Germ cell nuclear factor receptors (1)
- motilin receptor (1)
- membrane protein mlc1 family (1)
- melatonin receptor (2)
- SLC8 family of sodium/calcium exchangers (3)
- NinaC subfamily (2)
- SLC65 NPC-type cholesterol transporters (2)
- neuropeptide W/neuropeptide B receptor (2)
- NR3B/GRIN3B subfamily (1)
- NR2C/GRIN2C subfamily (1)
- NR2D/GRIN2D subfamily (1)
- MUSK family (1)
- cation-nonselective channel family (1)
- Proton-coupled inositol transporter (1)
- FRAP subfamily (1)
- Type II PI4K subfamily (1)
- PDK1 subfamily (1)
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Target Development Level
Panther Classes
- metalloprotease (185)
- protease (266)
- hydrolase (893)
- homeodomain transcription factor (108)
- DNA-directed RNA polymerase (43)
- RNA binding protein (654)
- membrane traffic protein (273)
- transcription factor (998)
- transporter (610)
- oxidoreductase (408)
- cell junction protein (96)
- tight junction (36)
- mRNA processing factor (149)
- mRNA splicing factor (109)
- nucleic acid binding (1536)
- signaling molecule (663)
- growth factor (121)
- microtubule family cytoskeletal protein (194)
- cytoskeletal protein (487)
- ligase (227)
- oxidase (94)
- oxygenase (68)
- transferase (846)
- kinase (363)
- chaperonin (13)
- chaperone (110)
- cation transporter (161)
- receptor (840)
- C4 zinc finger nuclear receptor (43)
- dehydrogenase (174)
- G-protein coupled receptor (260)
- ribosomal protein (157)
- cysteine protease (228)
- protease inhibitor (307)
- enzyme modulator (870)
- DNA binding protein (462)
- chromatin/chromatin-binding protein (118)
- small GTPase (80)
- G-protein (158)
- KRAB box transcription factor (187)
- zinc finger transcription factor (292)
- serine protease inhibitor (93)
- ion channel (189)
- voltage-gated sodium channel (22)
- sodium channel (22)
- voltage-gated ion channel (45)
- kinase modulator (132)
- kinase inhibitor (33)
- acyltransferase (86)
- HMG box transcription factor (19)
- microtubule binding motor protein (62)
- defense/immunity protein (343)
- actin family cytoskeletal protein (225)
- non-motor actin binding protein (91)
- methyltransferase (71)
- cell adhesion molecule (193)
- membrane-bound signaling molecule (105)
- extracellular matrix glycoprotein (81)
- extracellular matrix protein (187)
- basic leucine zipper transcription factor (30)
- CREB-related transcription factor (3)
- immunoglobulin receptor superfamily (109)
- cytokine receptor (157)
- immunoglobulin superfamily cell adhesion molecule (17)
- myelin protein (16)
- structural protein (83)
- guanyl-nucleotide exchange factor (74)
- G-protein modulator (280)
- protein kinase (253)
- non-receptor serine/threonine protein kinase (199)
- transfer/carrier protein (194)
- intracellular calcium-sensing protein (164)
- calmodulin (164)
- calcium-binding protein (236)
- annexin (90)
- extracellular matrix linker protein (26)
- immunoglobulin (88)
- transmembrane receptor regulatory/adaptor protein (60)
- P53-like transcription factor (8)
- Rel homology transcription factor (27)
- transcription cofactor (161)
- peptide hormone (70)
- helix-turn-helix transcription factor (88)
- decarboxylase (15)
- lyase (94)
- serine protease (246)
- ATP synthase (36)
- protein phosphatase (60)
- phosphatase (167)
- ubiquitin-protein ligase (99)
- lipase (73)
- phospholipase (44)
- viral protein (8)
- protein kinase receptor (22)
- serine/threonine protein kinase receptor (16)
- isomerase (81)
- non-motor microtubule binding protein (63)
- non-receptor tyrosine protein kinase (37)
- nuclease (136)
- basic helix-loop-helix transcription factor (77)
- glycosidase (24)
- aminoacyl-tRNA synthetase (24)
- membrane trafficking regulatory protein (83)
- ligand-gated ion channel (67)
- ionotropic glutamate receptor (5)
- endodeoxyribonuclease (14)
- winged helix/forkhead transcription factor (78)
- reductase (106)
- transaminase (18)
- DNA-directed DNA polymerase (22)
- nucleotidyltransferase (50)
- ATP-binding cassette (ABC) transporter (34)
- histone (56)
- carbohydrate transporter (20)
- calcium channel (21)
- voltage-gated calcium channel (21)
- type II cytokine receptor (12)
- type I cytokine receptor (32)
- acetyltransferase (68)
- peroxidase (24)
- neuropeptide (15)
- helicase (74)
- RNA helicase (44)
- cytokine (112)
- phosphatase modulator (49)
- aspartic protease (23)
- vesicle coat protein (40)
- deaminase (33)
- DNA helicase (37)
- acetylcholine receptor (47)
- GABA receptor (47)
- gap junction (21)
- C2H2 zinc finger transcription factor (25)
- extracellular matrix structural protein (29)
- esterase (40)
- nucleotide kinase (44)
- chemokine (48)
- phosphatase inhibitor (32)
- carbohydrate kinase (24)
- kinase activator (53)
- translation factor (77)
- translation elongation factor (28)
- antibacterial response protein (31)
- translation initiation factor (57)
- SNARE protein (30)
- transketolase (4)
- Hsp90 family chaperone (10)
- DNA glycosylase (5)
- glycosyltransferase (125)
- major histocompatibility complex antigen (21)
- heterotrimeric G-protein (44)
- endoribonuclease (23)
- replication origin binding protein (8)
- tyrosine protein kinase receptor (4)
- complement component (11)
- galactosidase (5)
- actin binding motor protein (27)
- apolipoprotein (13)
- amino acid kinase (5)
- phosphodiesterase (10)
- tubulin (22)
- surfactant (8)
- pyrophosphatase (21)
- nucleotide phosphatase (27)
- actin and actin related protein (31)
- intermediate filament binding protein (15)
- intermediate filament (15)
- phosphorylase (10)
- TGF-beta receptor (12)
- amino acid transporter (37)
- epimerase/racemase (30)
- hydratase (13)
- DNA methyltransferase (13)
- anion channel (19)
- mitochondrial carrier protein (16)
- Runt transcription factor (3)
- tumor necrosis factor receptor (2)
- mRNA polyadenylation factor (17)
- storage protein (18)
- hydroxylase (6)
- cyclase (9)
- ribonucleoprotein (45)
- dehydratase (23)
- Lambda repressor-like transcription factor (2)
- exoribonuclease (24)
- TATA-binding transcription factor (3)
- deacetylase (15)
- interleukin superfamily (4)
- neurotrophic factor (8)
- potassium channel (12)
- voltage-gated potassium channel (12)
- RNA methyltransferase (11)
- carbohydrate phosphatase (6)
- damaged DNA-binding protein (20)
- translation release factor (7)
- cadherin (10)
- glucosidase (7)
- exodeoxyribonuclease (7)
- mutase (5)
- DNA topoisomerase (4)
- DNA polymerase processivity factor (1)
- tumor necrosis factor family member (11)
- MADS box transcription factor (5)
- phosphatase activator (1)
- amylase (2)
- DNA photolyase (2)
- adenylate cyclase (5)
- guanylate cyclase (5)
- DNA ligase (2)
- primase (1)
- cysteine protease inhibitor (2)
- centromere DNA-binding protein (1)
- aldolase (1)
- reverse transcriptase (1)
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