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187-1, N-WASP inhibitor TFA, CAS No.380488-27-7(free)
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
224,000+ research products · Triple ISO certified · COA & SDS available for every product · Same-day shipping on in-stock items
Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Protected from light,Store at -20°C,Argon charged,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
187-1, N-WASP inhibitor TFA, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor TFA potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor TFA prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein.
Specifications
Product Name
187-1, N-WASP inhibitor TFA, CAS No.380488-27-7(free)
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4, 5-bisphosphate (PIP2)-stimulated actin assembly (IC50~ 2μM) but does not directly inhibit actin polymerization.
Sequence
KFPFFPQ KFPFFPQ(Modifications: Phe-2 = D-Phe, Pro-3 = D-Pro, Phe-4 = D-Phe, Pro-6 = D-Pro, Cyclized)
Action Type
INHIBITOR
CAS
380488-27-7(free)
Molecule Type
Peptide
Storage and Shipping
Storage
Protected from light,Store at -20°C,Argon charged,Desiccated
Shipped In
Ice chest + Ice pads
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 G2411404 | Certificate of Analysis | Mar 21, 2024 | N287721 |
| G2411405 | Certificate of Analysis | Mar 21, 2024 | N287721 |
| G2411406 | Certificate of Analysis | Mar 21, 2024 | N287721 |
| G2411407 | Certificate of Analysis | Mar 21, 2024 | N287721 |
| G2411433 | Certificate of Analysis | Mar 21, 2024 | N287721 |
| G2411434 | Certificate of Analysis | Mar 21, 2024 | N287721 |
| G2411435 | Certificate of Analysis | Mar 21, 2024 | N287721 |
| G2411436 | Certificate of Analysis | Mar 21, 2024 | N287721 |
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