(1R,2R)-2-PCCA hydrochloride - ≥98% , CAS No.1609563-71-4

CAS: 1609563-71-4 Cat. No.: P648097 Molecular Weight: 528.56

GRADE & PURITY ≥98%

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC 50 of 3 nM in cell-free assay, and 603 nM in cell assay.

In Vitro

(1R,2R)-2-PCCA (Example 3) is a potent GPR88 receptor agonist, with an EC 50 of 3 nM in cell-free assay, and 603 nM in cell assay . (1R,2R)-2-PCCA inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC 50 of 56 nM in HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:EC50: 3 nM (GPR88 receptor), 603 nM (GPR88 receptor, in GPR88-22F cells)

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

(1R, 2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC 50 of 3 nM in cell-free assay, and 603 nM in cell assay.

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CCCC1=CC=C(C2=CC=C(N(C[C@@H](N)[C@@H](C)CC)C([C@H]3[C@H](C4=CC=CC=N4)C3)=O)C=C2)C=C1.[H]Cl.[H]Cl
• Molecular Weight: 528.56

Chemical and Physical Properties

• Solubility: DMSO : 50 mg/mL (94.60 mM; Need ultrasonic)