2,2'-Bis(trifluoromethyl)benzidine（TFMB） - ≥98% , CAS No.341-58-2

CAS: 341-58-2 Cat. No.: B119981 Molecular Weight: 320.23 Beilstein Registry Number: 13(4)416 EC Number: 671-105-2

GRADE & PURITY ≥98%

Synonyms

InChI=1/C14H10F6N2/c15-13(16,17)11-5-7(21)1-3-9(11)10-4-2-8(22)6-12(10)14(18,19)20/h1-6H,21-22H2 | SY016481 | J-019470 | 4-[4-amino-2-(trifluoromethyl)phenyl]-3-(trifluoromethyl)aniline | AS-14398 | TFMB | 2,2'-BIS(TRIFLUOROMETHYL)BENZIDINE 2,2'-bis(trifl

Storage

Room temperature

Shipped In

Normal

Specifications

Synonyms

InChI=1/C14H10F6N2/c15-13(16, 17)11-5-7(21)1-3-9(11)10-4-2-8(22)6-12(10)14(18, 19)20/h1-6H, 21-22H2 | SY016481 | J-019470 | 4-[4-amino-2-(trifluoromethyl)phenyl]-3-(trifluoromethyl)aniline | AS-14398 | TFMB | 2, 2'-BIS(TRIFLUOROMETHYL)BENZIDINE 2, 2'-bis(trifl

Specifications & Purity

≥98%

Storage

Room temperature

Shipped In

Normal

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 488190811
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488190811
• Canonical Smiles: C1=CC(=C(C=C1N)C(F)(F)F)C2=C(C=C(C=C2)N)C(F)(F)F
• IUPAC Name: 4-[4-amino-2-(trifluoromethyl)phenyl]-3-(trifluoromethyl)aniline
• InChIKey: NVKGJHAQGWCWDI-UHFFFAOYSA-N
• INCHI: 1S/C14H10F6N2/c15-13(16,17)11-5-7(21)1-3-9(11)10-4-2-8(22)6-12(10)14(18,19)20/h1-6H,21-22H2
• Isomeric SMILES: C1=CC(=C(C=C1N)C(F)(F)F)C2=C(C=C(C=C2)N)C(F)(F)F
• Molecular Weight: 320.23
• Beilstein: 13(4)416
• Reaxy-Rn: 2770781
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2770781&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzidines
• Alternative Parents: Trifluoromethylbenzenes Aniline and substituted anilines Primary amines Organopnictogen compounds Organofluorides Hydrocarbon derivatives Alkyl fluorides
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Benzidine - Trifluoromethylbenzene - Aniline or substituted anilines - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Primary amine - Organonitrogen compound - Organofluoride - Organohalogen compound - Amine - Alkyl halide - Alkyl fluoride - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as benzidines. These are organic compounds containing the benzidine skeleton, made up of a biphenyl ring system substituted at the 4- and 4'-positions with a unsubstituted amine group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

Discover Target: TSHR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLB Tchem DNA polymerase beta (23632 Activities)

Discover Target: POLB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLA Tclin Alpha-galactosidase A (5444 Activities)

Discover Target: GLA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)

Discover Target: GAA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

Discover Target: TP53

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POLH Tchem DNA polymerase eta (21678 Activities)

Discover Target: POLH

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APOBEC3G Tchem DNA dC->dU-editing enzyme APOBEC-3G (12481 Activities)

Discover Target: APOBEC3G

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

Discover Target: IDH1

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Associated Targets(non-human)

Streptococcus (3973 Activities)

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Plasmodium falciparum (966862 Activities)

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Streptococcus sp. 'group A' (3417 Activities)

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ska Streptokinase A (5805 Activities)

Discover Target: ska

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NS1 Nonstructural protein 1 (33327 Activities)

Discover Target: NS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Insoluble in methanol.
• Melt Point(°C): 183°C
• Molecular Weight: 320.230 g/mol
• XLogP3: 4.000
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 1
• Exact Mass: 320.075 Da
• Monoisotopic Mass: 320.075 Da
• Topological Polar Surface Area: 52.000 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 345.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Siyu Wei, Xinyu Zhao, Ke Zhao, Meng Wang, LinZhe Xu, Yuanyuan Zhang, Xiujing Huang, Yingbo Chen.  (2023)  Flexible, foldable and transparent SERS film with high sensitivity and signal homogeneity via silver ion exchange and in-situ reduction.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:37948934] [10.1016/j.saa.2023.123624]

2. Siyu Wei, Xinfang Wang, Xinyu Zhao, Ke Zhao, Linzhe Xu, Yingbo Chen.  (2023)  Detection of pesticide residues on flexible and transparent fluorinated polyimide film based on surface-enhanced Raman spectroscopy technology.  ANALYTICA CHIMICA ACTA,      [PMID:37977783] [10.1016/j.aca.2023.341958]

3. Congcong Zhai, Wenchao Zhang, Rongjie Yang.  (2023)  Synthesis of a novel bis(diphenylphosphinyl)-containing pyromellitimide and its application in epoxy resins.  POLYMER DEGRADATION AND STABILITY,      [PMID:] [10.1016/j.polymdegradstab.2023.110574]

4. Junhao Xin, Xiaowei Zhou, Guolong Huo, Zhiguang Zhang, Yuchen Zhang, Shuanyan Kang, Zhongde Dai, Nanwen Li.  (2023)  Development of high performance carbon molecular sieve membranes via tuning the side groups on PI precursors.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2023.122124]

5. Wei Xie, Peijun Zheng, Yiwen Chen, Hongjun Zhang, Qi Wu, Hongyan Liu, Ying Sun, Haitao Wang, Shuangjiang Luo.  (2023)  Direct Thermal Oxidative Cross-Linking in Air toward Hierarchically Microporous Polymer Membranes for Advanced Molecular Sieving.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.3c02227]

6. Xinzuo Huang, Rongxiang Hu, Fenghua Zhang, Yanju Liu, Jinsong Leng.  (2023)  Transparent shape memory polyimide enables OLED for smart deformation.  COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING,      [PMID:] [10.1016/j.compositesa.2023.107781]

7. Guolong Huo, Zhiyong Guo, Zhiguang Zhang, Xiaowei Zhou, Junhao Xin, Yuchen Zhang, Shuanyan Kang, Yanqin Yang, Nanwen Li.  (2023)  Effect of uniaxial stretching on gas separation performance of polyimide membranes.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2023.122046]

8. Xiaowei Zhou, Yuchen Zhang, Guolong Huo, Zhiguang Zhang, Junhao Xin, Shuanyan Kang, Zhenggong Wang, Nanwen Li.  (2023)  Rationally designed fluorinated aromatic polyamide membrane for stable air dehumidification.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2023.122042]

9. Ke Zhao, Siyu Wei, Meng Wang, Yingbo Chen.  (2023)  Alkylated modified boron nitride nanosheets/polyimide composite films with advanced thermal conductivity and low dielectric constant.  CERAMICS INTERNATIONAL,      [PMID:] [10.1016/j.ceramint.2023.07.224]

10. Chang-Heng Li, Zhengyong Huang, Junping Lin, Tingting Hou, Yunlong Zi, Jian Li.  (2023)  Excellent-Moisture-Resistance Fluorinated Polyimide Composite Film and Self-Powered Acoustic Sensing.  ACS Applied Materials & Interfaces,      [PMID:37432932] [10.1021/acsami.3c05154]

11. Zhigang Yuan, Lei Wang, Mingming Sun, Xugang Zhang, Mehdi Derradji, Bin Zhang, Jianhui Li, Gang Xue, Ming Zhao, Caizhao Liu.  (2023)  The effect of the vanillin-derived diene compound on the thermal, dielectric and mechanical properties of epoxy resins.  Materials Today Communications,      [PMID:] [10.1016/j.mtcomm.2023.106119]

12. Yuhang Han, Yingyi Ma, Junming Zhang, Shun Yao, Kaizheng Xu.  (2022)  Overall Improvement in Dielectric, Water Resistance and Mechanical Properties of Polyimide Film via Synergy between GO and Sandwich-type Porous Structure.  Chemistry-An Asian Journal,  18  (3): (e202201130).  [PMID:36504338] [10.1002/asia.202201130]

13. Guolong Huo, Shan Xu, Lei Wu, Shuanyan Kang, Zhiguang Zhang, Yanfang Fan, Nanwen Li.  (2021)  Structural engineering on copolyimide membranes for improved gas separation performance.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2021.119989]

14. Guohan Gao, Danbo Mao, Renkui Jiang, Zhiwei Li, Xin Liu, Baiping Lei, Jiang Bian, Shibin Wu, Bin Fan.  (2020)  Investigation of Photoelastic Property and Stress Analysis for Optical Polyimide Membrane through Stress Birefringence Method.  Coatings,  10  (1): (56).  [PMID:] [10.3390/coatings10010056]

15. Danbo Mao, Gang Lv, Guohan Gao, Bin Fan.  (2019)  Fabrication of polyimide films with imaging quality using a spin-coating method for potential optical applications.  JOURNAL OF POLYMER ENGINEERING,  39  (10): (917-925).  [PMID:] [10.1515/polyeng-2019-0177]

16. Xinyuan Che, Shiming Gong, Heng Zhang, Bin Liu, Yinghan Wang.  (2015)  The effect of junction modes between backbones and side chains of polyimides on the stability of liquid crystal vertical alignment.  PHYSICAL CHEMISTRY CHEMICAL PHYSICS,  18  (5): (3884-3892).  [PMID:26766667] [10.1039/C5CP06488K]

17. Jianing Zhang, Jian Zhou, Yuanpeng Deng, Hongxuan Yu, Han Zhao, Jingran Guo, Pengyu Zhang, Shixuan Dang, Dizhou Liu, Duola Wang, Yingde Zhao, Chuanyun Song, Cong Li, Zhengli Yan, Jiali Chen, Hui Li, Xiang Xu.  (2024)  Self-contact-electrification aerogel for all-in-one triboelectricity generation.  Nano Energy,      [PMID:] [10.1016/j.nanoen.2024.109693]

18. Jun Hu, Jiangzhou Luo, Yuxuan Zhao, Min Chen, Honglei Ling, Xiaoting Zhou, Song Xue.  (2024)  Tailoring the gas transport properties of network polyimide membranes by bromination/debromination.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2024.113318]

19. Hong Chen, Wei Ou, Yu Huang, Hongchang Huang, Junlan Li, Juncheng Liu.  (2024)  UiO-66 uniformly assembled foldable polyimide films with high transmittance and excellent ultraviolet resistance.  COMPOSITES SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.compscitech.2024.110590]

20. Changchun Qi, Xiong Yang, Jiufeng Dong, Guangyu Sun, Wenrui Li, Fangzheng Zou, Ruitong Zhou, Xiaogang Qin, Baipeng Song, Guanjun Zhang.  (2025)  Trap State Modulation via Strong Electron-Withdrawing Groups for Enhanced Vacuum Surface Insulation of All-Organic Polyimide.  ACS Applied Materials & Interfaces,      [PMID:40811861] [10.1021/acsami.5c10530]

21. Fuxing Zhai, Lixin Xu, Huijian Ye.  (2025)  Chain Topology Engineering in Amphiphilic Block Copolymers: Crosslinking-Induced Nanodomain Refinement for Ultrahigh Energy Density under Extreme Conditions.  Advanced Science,      [PMID:40953367] [10.1002/advs.202510046]

22. Zhiguang Zhang, Xiaolong Ren, Guolong Huo, Xiaowei Zhou, Hao Chen, Hongjun Zhang, Shuanyan Kang, Xiuling Chen, Nanwen Li.  (2024)  Effect of free volume and hydrophilicity on dehumidification performance of 6FDA-Based polyimide membranes.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2024.122876]

23. Xinbin Ji, Yulong Xiang, Jing Guo, Fucheng Guan, Xiaoqing Xiong, Da Bao, Qiang Yang, Minghan Li, Yihang Zhang, Zheng Li, Jianbin Sun.  (2024)  Polyacrylonitrile In-Situ reinforced polyimide superhydrophobic porous fibers: A miraculous thermal insulation and flame-retardant material.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.152641]

24. Yanna Zhao, Yingying Zhang, Xiaowei Bai, Yuqi Wang, Yiqing Li, Shuai Yang.  (2024)  Sustainable poly(imide-imide) vitrimer based on multiple dynamic covalent bonds.  JOURNAL OF APPLIED POLYMER SCIENCE,  141  (48): (e56281).  [PMID:] [10.1002/app.56281]

25. Shengrui Zhou, Li Zhang, Guan Wang, Bilal Iqbal Ayubi, Yiwei Wang.  (2025)  Mechanisms of Enhanced Durability in Fluorinated Polyimide Based on POSS during Electro-Thermal Aging.  POLYMER DEGRADATION AND STABILITY,      [PMID:] [10.1016/j.polymdegradstab.2025.111402]

26. Haodong Lin, Xu Zhang, Bilin Zhang, Liangkang Huang, Jun Fang, Xinhai He, Jianwei Li.  (2025)  Triboelectric mechanism enhances piezoelectric performance of polyimide composite nanofibrous membrane.  COMPOSITES SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.compscitech.2025.111231]

27. Yuan Pan, Kaifeng Chen, Yi Liu, Yuxuan Liu, Mengting He, Zhite Xie, Zongrong Wang.  (2025)  High-Sensitivity All-Fiber Sensor Smart Gloves for Hand Perception.  ACS Applied Materials & Interfaces,      [PMID:40374328] [10.1021/acsami.5c04794]

28. Zhengsheng Yang, Huanyong Liu, Peiheng Zhou, Haolan Li, Zhiheng Zou, Guang Yang.  (2025)  Thermally Stable, Hydrophobic Colorless Polyimides With High Strength and Excellent Dimensional Stability for Flexible Optoelectronics and Electronics.  JOURNAL OF POLYMER SCIENCE,      [PMID:] [10.1002/pol.20250363]

29. Xinbin Ji, Yulong Xiang, Jing Guo, Fucheng Guan, Da Bao, Qiang Yang, Zheng Li, Yihang Zhang, Xin Zhang, Jiahao He.  (2025)  Polyimide porous thermoelectric fibers based on sheath core structure: A new self-powered material for early fire warning and flame retardant protection.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.169714]

30. Yu Zhang, Lian Xia, Xiaolong Wu, Jinjun Liu, Hongzhen Xie, Haiping Xia, Zhongbin Pan.  (2025)  Hydrogen-bonded crosslinked alicyclic poly(amide-imide) for enhanced high-temperature capacitive energy storage.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.170259]

31. Yifan Hu, Qiuyue Zuo, Haowei Li, Lan Lei, Chunjie Xie, Hui Li.  (2025)  Fluorine-containing meta-aramid modified low dielectric, hydrophobic aramid paper.  COMPOSITES SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.compscitech.2025.111444]

32. Jin Wang, Tianlong Zhou, Jie Zou, Jianhang Hai, Yunqing Lu.  (2025)  High Output Power Density Triboelectric Nanogenerator Based on Surface-Patterned PI/UIO-66-NH2 Mixed Matrix Membranes.  Nanoscale,      [PMID:41313268] [10.1039/D5NR03339J]

33. Guangyu Duan, Fengying Hu, Yiran He, Zuming Hu, Ming Tian, Junwei Zha.  (2025)  Polymer dielectrics enabled by molecular engineering design and charge trap regulation for high-temperature energy storage.  Journal of Materials Chemistry A,      [PMID:] [10.1039/D5TA07395B]

34. Yu Zhang, Xiaolong Wu, Lian Xia, Jinjun Liu, Lingmin Yao, Hongzhen Xie, Junfei Luo, Zhongbin Pan.  (2025)  Molecular engineering of polyamide-imide copolymers for high-temperature energy storage.  Journal of Materials Chemistry A,      [PMID:] [10.1039/D5TA07559A]

35. Xinbin Ji, Yulong Xiang, Da Bao, Zheng Li, Jing Guo, Fucheng Guan, Jiahao He.  (2025)  Molecular Design Enables Dope-Dyed Porous Polyimide Fibers with Thermal Insulation and Flame Retardancy.  ACS Applied Polymer Materials,      [PMID:] [10.1021/acsapm.5c03548]

36. Peipei Wang, Fan Ding, Zhaokun Ma, Juan Zhang, Yuhong Liu, Beibei Chen, Zihan Chen, Wei Li.  (2026)  High thermal conductivity graphite film/polyimide composites based on enhanced interfacial bonding.  COMPOSITES COMMUNICATIONS,      [PMID:] [10.1016/j.coco.2026.102754]

37. Wenji Zheng, Yuliang Tao, Fengting Yao, Zhixu Yun, Miao Yu, Xiaobin Jiang, Gaohong He.  (2026)  Interfacial fusion engineered fluorinated UiO-66-based mixed matrix membranes: Enhanced He/CH4 separation.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2026.125300]

38. Jikang Liu, Yao Wang, Guoli Tu.  (2026)  Research on the Synthesis and Characterization of Colorless Polyimide Based on a Novel Asymmetric Dianhydride Monomer.  ACS Omega,      [PMID:] [10.1021/acsomega.6c00472]