22-(4′-py)-JA , CAS No.1178895-15-2

CAS: 1178895-15-2 Cat. No.: P1447378 Molecular Weight: 598.60

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

22-(4′-py)-JA is a semisynthetic derivative of junamycin A (JA) that can be isolated from the Thai blue sponge (Xestospongia sp.). 22-(4′-py)-JA has antimetastatic activity and can inhibit AKT/mTOR/p70S6K signaling. 22-(4′-py)-JA inhibits tumor cell invasion and tube formation in human umbilical vein endothelial cells (HUVEC), downregulates metalloproteinases ( MMP-2 and MMP-9 ), hypoxia-inducible factor 1α ( HIF-1α ) and vascular endothelial growth factor ( VEGF ). 22-(4′-py)-JA has potent anticancer activity against non-small cell lung cancer (NSCLC).

Specifications

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Molecular Weight: 598.60