3,5-Bis(2-fluorobenzylidene)piperidin-4-one - Moligand™, ≥98% , CAS No.342808-40-6

CAS: 342808-40-6 Cat. No.: B343498 Molecular Weight: 311.33 EC Number: 686-985-3

GRADE & PURITY Moligand™, ≥98%

Synonyms

3,5-Bis[(2-fluorophenyl)methylene]-4-piperidinone | (3E,5E)-3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one;hydrochloride | EF24 | 3,5-bis((E)-2-fluorobenzylidene)piperidin-4-one hydrochloride | (3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinon

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

EF24 is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK.

Specifications

Synonyms

3, 5-Bis[(2-fluorophenyl)methylene]-4-piperidinone | (3E, 5E)-3, 5-bis[(2-fluorophenyl)methylidene]piperidin-4-one;hydrochloride | EF24 | 3, 5-bis((E)-2-fluorobenzylidene)piperidin-4-one hydrochloride | (3E, 5E)-3, 5-bis[(2-fluorophenyl)methylene]-4-piperidinon

Specifications & Purity

Moligand™, ≥98%

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ACTIVATOR

Purity

≥98%

Names and Identifiers

• Canonical Smiles: C1C(=CC2=CC=CC=C2F)C(=O)C(=CC3=CC=CC=C3F)CN1.Cl
• IUPAC Name: (3E,5E)-3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one;hydrochloride
• InChIKey: ILMJCEBAMHGBAA-XETSTSIRSA-N
• INCHI: 1S/C19H15F2NO.ClH/c20-17-7-3-1-5-13(17)9-15-11-22-12-16(19(15)23)10-14-6-2-4-8-18(14)21;/h1-10,22H,11-12H2;1H/b15-9+,16-10+
• Isomeric SMILES: C\1NC/C(=C\C2=CC=CC=C2F)/C(=O)/C1=C/C3=CC=CC=C3F.Cl
• Molecular Weight: 311.33
• Reaxy-Rn: 32927881
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32927881&ln=

Chemical and Physical Properties

• Solubility: DMSO: ≥10 mg/mL