3'-Azido-3'-deoxy-5-methylcytidine - ≥99% , CAS No.1282040-14-5

CAS: 1282040-14-5 Cat. No.: A648274 Molecular Weight: 282.26 PubChem CID: 101644650

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus ( XMRV ) inhibitor with a CC 50 of 43.5 μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibits HIV-1 reverse transcriptase with an EC 50 of 0.06 μM in peripheral blood mononuclear (PBM) cells

Form:Solid

IC50& Target:HIV-1 0.06 μM (EC 50 , in PBM cells) XMRV 43.5 μM (CC 50 , in MCF-7 cells)

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus ( XMRV ) inhibitor with a CC 50 of 43.5 μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibits HIV-1 reverse transcriptase with an EC 50 of 0

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CC1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)N=[N+]=[N-])O
• IUPAC Name: 4-amino-1-[(2R,3R,4S,5S)-4-azido-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one
• InChIKey: HQIDXEHGLJUNPT-JXOAFFINSA-N
• INCHI: 1S/C10H14N6O4/c1-4-2-16(10(19)13-8(4)11)9-7(18)6(14-15-12)5(3-17)20-9/h2,5-7,9,17-18H,3H2,1H3,(H2,11,13,19)/t5-,6-,7-,9-/m1/s1
• Isomeric SMILES: CC1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)N=[N+]=[N-])O
• PubChem CID: 101644650
• Molecular Weight: 282.26

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Nucleosides, nucleotides, and analogues
    • Class Pyrimidine nucleosides
      • Subclass Pyrimidine 3'-deoxyribonucleosides

• Kingdom: Organic compounds
• Superclass: Nucleosides, nucleotides, and analogues
• Class: Pyrimidine nucleosides
• Subclass: Pyrimidine 3'-deoxyribonucleosides
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyrimidine 3'-deoxyribonucleosides
• Alternative Parents: Glycosylamines Pentoses Aminopyrimidines and derivatives Pyrimidones Hydropyrimidines Imidolactams Heteroaromatic compounds Oxolanes Secondary alcohols Azo imides Azo compounds Azacyclic compounds Oxacyclic compounds Organic salts Organic oxides Primary alcohols Hydrocarbon derivatives Primary amines Organic zwitterions
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyrimidine 3'-deoxyribonucleoside - Glycosyl compound - N-glycosyl compound - Pentose monosaccharide - Aminopyrimidine - Pyrimidone - Hydropyrimidine - Monosaccharide - Pyrimidine - Imidolactam - Heteroaromatic compound - Oxolane - Secondary alcohol - Azo compound - Azo imide - Azacycle - Oxacycle - Organoheterocyclic compound - Organic zwitterion - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Amine - Alcohol - Organic oxide - Organic oxygen compound - Primary alcohol - Primary amine - Organic salt - Organic nitrogen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as pyrimidine 3'-deoxyribonucleosides. These are compounds consisting of a pyrimidine linked to a ribose which lacks a hydroxyl group at position 3.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: DMSO : 83.33 mg/mL (295.22 mM; Need ultrasonic)