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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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3-TYP - Moligand™,≥99% , CAS No.120241-79-4
AVAILABLE TO ORDER
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Why this grade
Moligand™,≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 4 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Information
3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selectiveSIRT3inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.
Targets
SIRT3 (cell-free); SIRT1 (cell-free); SIRT2 (cell-free) 16 nM; 88 nM; 92 nM
In vitro
Melatonin-induced increases in deacetylated-SOD2 expression and SOD2 activity are significantly attenuated by 3-TYP in HepG2 cells exposed to Cd (cadmium).
Cell Research(from reference)
Cell lines：HepG2 cells
Concentrations：50 μM
Incubation Time：12 h
Specifications
Synonyms
3-(1H-1, 2, 3-triazol-4-yl) pyridinePyridine
Specifications & Purity
Moligand™, ≥99%
Biochemical and Physiological Mechanisms
3-TYP (3-(1H-1, 2, 3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Purity
≥99%
Product Properties
| ALogP | 0.602 |
|---|---|
| HBD Count | 1 |
| Rotatable Bond | 1 |
Names and Identifiers
| Pubchem Sid | 504764934 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504764934 |
| Canonical Smiles | C1=CC(=CN=C1)C2=NNN=C2 |
| IUPAC Name | 3-(2H-triazol-4-yl)pyridine |
| InChIKey | VYXFEFOIYPNBFK-UHFFFAOYSA-N |
| INCHI | 1S/C7H6N4/c1-2-6(4-8-3-1)7-5-9-11-10-7/h1-5H,(H,9,10,11) |
| Isomeric SMILES | C1=CC(=CN=C1)C2=NNN=C2 |
| PubChem CID | 9833992 |
| Molecular Weight | 146.15 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Taxonomic Classification
Taxonomy Tree
- Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
- Class Pyridines and derivatives
- Subclass Pyridyltriazoles
- Class Pyridines and derivatives
- Superclass Organoheterocyclic compounds
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Pyridines and derivatives |
| Subclass | Pyridyltriazoles |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Pyridyl-1,2,3-triazoles |
| Alternative Parents | Triazoles Heteroaromatic compounds Azacyclic compounds Organonitrogen compounds Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Pyridyl-1,2,3-triazole - Heteroaromatic compound - 1,2,3-triazole - Triazole - Azole - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as pyridyl-1,2,3-triazoles. These are organic compounds containing a pyridine ring attached to a 1,2,3-triazole ring. |
| External Descriptors | Not available |
3D Structure
Interactive Chemical Structure Model
Associated Targets(Human)
METAP2 Tchem Methionine aminopeptidase 2 (1 Activities)
METAP2 Tchem Methionine aminopeptidase 2 (1512 Activities)
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A498 (42825 Activities)
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ACHN (49357 Activities)
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CAKI-1 (44928 Activities)
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CCRF-CEM (65223 Activities)
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COLO 205 (50209 Activities)
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DU-145 (51482 Activities)
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HT-29 (80576 Activities)
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K562 (73714 Activities)
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KM12 (47707 Activities)
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M14 (47487 Activities)
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MCF7 (126967 Activities)
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MDA-MB-468 (9477 Activities)
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MOLT-4 (49676 Activities)
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OVCAR-3 (48710 Activities)
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OVCAR-4 (44535 Activities)
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OVCAR-5 (45555 Activities)
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OVCAR-8 (47708 Activities)
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PC-3 (62116 Activities)
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RPMI-8226 (44974 Activities)
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RXF 393 (41971 Activities)
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SF-295 (48000 Activities)
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SK-MEL-2 (46422 Activities)
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SK-MEL-28 (48833 Activities)
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SK-MEL-5 (47095 Activities)
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SK-OV-3 (52876 Activities)
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SN12C (47755 Activities)
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SNB-19 (46794 Activities)
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TK-10 (45540 Activities)
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U-251 (51189 Activities)
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UACC-257 (46019 Activities)
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UACC-62 (47335 Activities)
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UO-31 (46270 Activities)
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786-0 (47912 Activities)
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A549 (127892 Activities)
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T47D (39041 Activities)
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EKVX (44102 Activities)
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NCI-H322M (45589 Activities)
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HCC 2998 (41480 Activities)
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HCT-116 (91556 Activities)
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HOP-92 (41141 Activities)
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NCI-H460 (60772 Activities)
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SF-268 (49410 Activities)
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IGROV-1 (47897 Activities)
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LOX IMVI (44321 Activities)
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HOP-62 (47048 Activities)
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MDA-MB-435 (38290 Activities)
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HeLa (62764 Activities)
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Malme-3M (44254 Activities)
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MDA-MB-231 (73002 Activities)
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Associated Targets(non-human)
rep Replicase polyprotein 1ab (378 Activities)
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Mechanisms of Action
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 F2303735 | Certificate of Analysis | Mar 13, 2026 | T414087 |
| F2303677 | Certificate of Analysis | Mar 13, 2026 | T414087 |
| F2303678 | Certificate of Analysis | Mar 13, 2026 | T414087 |
| F2303726 | Certificate of Analysis | Mar 13, 2026 | T414087 |
| F2303680 | Certificate of Analysis | Mar 13, 2026 | T414087 |
| F2303710 | Certificate of Analysis | Mar 13, 2026 | T414087 |
| L2512659 | Certificate of Analysis | Nov 21, 2025 | T414087 |
| L2512658 | Certificate of Analysis | Nov 21, 2025 | T414087 |
| B2309527 | Certificate of Analysis | Oct 30, 2025 | T414087 |
| L2220148 | Certificate of Analysis | Oct 11, 2025 | T414087 |
| I2306829 | Certificate of Analysis | Aug 24, 2023 | T414087 |
| I2306869 | Certificate of Analysis | Aug 24, 2023 | T414087 |
| F2303679 | Certificate of Analysis | May 19, 2023 | T414087 |
| F2303737 | Certificate of Analysis | May 19, 2023 | T414087 |
| B2309545 | Certificate of Analysis | Jan 05, 2023 | T414087 |
| B2309537 | Certificate of Analysis | Jan 05, 2023 | T414087 |
| G2221460 | Certificate of Analysis | Jun 11, 2022 | T414087 |
| L2220147 | Certificate of Analysis | Jun 11, 2022 | T414087 |
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Chemical and Physical Properties
| Solubility | Solubility (25°C) In vitro DMSO: 29 mg/mL (198.42 mM); Ethanol: 29 mg/mL (198.42 mM); Water: 1.25 mg/mL warmed with 50ºC Water: bath (8.55 mM); |
|---|---|
| DMSO(mg / mL) Max Solubility | 29 |
| DMSO(mM) Max Solubility | 198.4262744 |
| Water(mg / mL) Max Solubility | 5 |
| Water(mM) Max Solubility | 34.21142662 |
| Molecular Weight | 146.150 g/mol |
| XLogP3 | 0.200 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 146.059 Da |
| Monoisotopic Mass | 146.059 Da |
| Topological Polar Surface Area | 54.500 Ų |
| Heavy Atom Count | 11 |
| Formal Charge | 0 |
| Complexity | 128.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
Citations of This Product
References
| 1. Zhen Qin, Qiang-qiang Chu, An-lan Ding, Chuan-Ying Li, Mao-yan Zhang. (2024) Sirtuin 3 ameliorates inflammatory bowel disease via inhibiting intestinal inflammation and oxidative stress. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, [PMID:38799140] [10.3164/jcbn.23-42] |
| 2. Mingyue Tan, Yunfei Yin, Weixiang Chen, Jun Zhang, Yifeng Jin, Yue Zhang, Lei Zhang, Tingbo Jiang, Bin Jiang, Hongxia Li. (2024) Trimetazidine attenuates Ischemia/Reperfusion-Induced myocardial ferroptosis by modulating the Sirt3/Nrf2-GSH system and reducing Oxidative/Nitrative stress. BIOCHEMICAL PHARMACOLOGY, [PMID:39134283] [10.1016/j.bcp.2024.116479] |
| 3. Siyuan Liu, Jincheng Lv, Peng Peng, Xianshu Song, Pengyu Dai, Fangle Liu, Yufeng Yao, Chenchen Zhu, Chaozhan Lin. (2025) LianZhiXiaoYan Formula alleviates LPS-induced chronic pneumonia via regulating metabolic reprogramming through SIRT3-SDH-SUCNR1 signaling pathway. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:41005468] [10.1016/j.jep.2025.120646] |
| 4. Shushu Jiang, Cheng Wang, Yin Dong, Long Chen, Menghao Shi, Fengxiao Zhang, Zhaohui Wang, Minglu Liang. (2025) Erucin Alleviates Cardiac Hypertrophy by Improving Mitochondrial Function via Nrf2-Sirt3 Pathway. PHYTOTHERAPY RESEARCH, [PMID:40415605] [10.1002/ptr.8458] |
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