4,4-Difluoro-L-prolinamide hydrochloride - ≥97% , CAS No.426844-51-1

CAS: 426844-51-1 Cat. No.: D170309 Molecular Weight: 186.59 EC Number: 670-268-7

GRADE & PURITY ≥97%

Synonyms

DTXSID70669800 | (2S)-4,4-DIFLUOROPYRROLIDINE-2-CARBOXAMIDE HYDROCHLORIDE | 4,4-Difluoro-L-prolinamide--hydrogen chloride (1/1) | (2S)-4,4-difluoropyrrolidine-2-carboxamide;hydrochloride | AKOS016844203 | 4,4-Difluoro-l-prolinamide HCl | (S)-4,4-Difluorop

Storage

Room temperature

Shipped In

Normal

Overview

 Product Application：
4,4-Difluoro-L-prolinamide hydrochloride can be used as a building block in the synthesis of cyanopyrrolidine based DPP-IV inhibitors.

Specifications

Synonyms

DTXSID70669800 | (2S)-4, 4-DIFLUOROPYRROLIDINE-2-CARBOXAMIDE HYDROCHLORIDE | 4, 4-Difluoro-L-prolinamide--hydrogen chloride (1/1) | (2S)-4, 4-difluoropyrrolidine-2-carboxamide;hydrochloride | AKOS016844203 | 4, 4-Difluoro-l-prolinamide HCl | (S)-4, 4-Difluorop

Specifications & Purity

≥97%

Storage

Room temperature

Shipped In

Normal

Purity

≥97%

Names and Identifiers

• Pubchem Sid: 488201159
• Canonical Smiles: C1C(NCC1(F)F)C(=O)N.Cl
• IUPAC Name: (2S)-4,4-difluoropyrrolidine-2-carboxamide;hydrochloride
• InChIKey: RRQDQYAEZGKHOB-DFWYDOINSA-N
• INCHI: 1S/C5H8F2N2O.ClH/c6-5(7)1-3(4(8)10)9-2-5;/h3,9H,1-2H2,(H2,8,10);1H/t3-;/m0./s1
• Isomeric SMILES: C1[C@H](NCC1(F)F)C(=O)N.Cl
• WGK Germany: 3
• Alternate CAS: 719267-96-6（Free Base）
• Molecular Weight: 186.59
• Reaxy-Rn: 46884169
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=46884169&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Proline and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Proline and derivatives
• Alternative Parents: Alpha amino acid amides Pyrrolidinecarboxamides Primary carboxylic acid amides Dialkylamines Azacyclic compounds Organofluorides Organic oxides Hydrochlorides Hydrocarbon derivatives Carbonyl compounds Alkyl fluorides
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Proline or derivatives - Alpha-amino acid amide - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - Pyrrolidine - Carboxamide group - Primary carboxylic acid amide - Organoheterocyclic compound - Secondary amine - Azacycle - Secondary aliphatic amine - Hydrocarbon derivative - Organic oxygen compound - Alkyl fluoride - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Organic oxide - Carbonyl group - Amine - Organic nitrogen compound - Alkyl halide - Hydrochloride - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as proline and derivatives. These are compounds containing proline or a derivative thereof resulting from reaction of proline at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Sensitivity: Light sensitive
• Specific Rotation[α]: [α]/D −23±5°, c = 0.5 in H2O
• Melt Point(°C): 221 - 226 °C
• Molecular Weight: 186.590 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 186.037 Da
• Monoisotopic Mass: 186.037 Da
• Topological Polar Surface Area: 55.100 Ų
• Heavy Atom Count: 11
• Formal Charge: 0
• Complexity: 160.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3