≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature Ships Normal Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
4-Hydroxy-3-methoxybenzonitrile on treatment with sodium perborate yields 4-hydroxy-3-methoxybenzamide.
| Pubchem Sid | 488185518 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488185518 |
| Canonical Smiles | COC1=C(C=CC(=C1)C#N)O |
| IUPAC Name | 4-hydroxy-3-methoxybenzonitrile |
| InChIKey | QJRWLNLUIAJTAD-UHFFFAOYSA-N |
| INCHI | 1S/C8H7NO2/c1-11-8-4-6(5-9)2-3-7(8)10/h2-4,10H,1H3 |
| Isomeric SMILES | COC1=C(C=CC(=C1)C#N)O |
| Molecular Weight | 149.15 |
| Beilstein | 10398 |
| Reaxy-Rn | 2691571 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2691571&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Phenols |
| Subclass | Methoxyphenols |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Methoxyphenols |
| Alternative Parents | Phenoxy compounds Methoxybenzenes Benzonitriles Anisoles Alkyl aryl ethers 1-hydroxy-2-unsubstituted benzenoids Nitriles Organopnictogen compounds Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Methoxyphenol - Phenoxy compound - Anisole - Benzonitrile - Methoxybenzene - Phenol ether - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - Monocyclic benzene moiety - Ether - Nitrile - Carbonitrile - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organopnictogen compound - Organic oxygen compound - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as methoxyphenols. These are compounds containing a methoxy group attached to the benzene ring of a phenol moiety. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 C2208299 | Certificate of Analysis | Dec 10, 2025 | H156992 |
| C2208300 | Certificate of Analysis | Dec 10, 2025 | H156992 |
| C2209038 | Certificate of Analysis | Dec 10, 2025 | H156992 |
| C2209051 | Certificate of Analysis | Dec 10, 2025 | H156992 |
| L2123112 | Certificate of Analysis | Oct 11, 2025 | H156992 |
| L2107334 | Certificate of Analysis | Sep 09, 2025 | H156992 |
| J1925046 | Certificate of Analysis | Aug 04, 2023 | H156992 |
| G2321075 | Certificate of Analysis | Dec 24, 2021 | H156992 |
| Melt Point(°C) | 87 °C |
|---|---|
| Molecular Weight | 149.150 g/mol |
| XLogP3 | 0.500 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 149.048 Da |
| Monoisotopic Mass | 149.048 Da |
| Topological Polar Surface Area | 53.300 Ų |
| Heavy Atom Count | 11 |
| Formal Charge | 0 |
| Complexity | 172.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Qianqian Fan, Jiahui Li, Qi Cao, Chengwen Gu, Qian Liu, Xigao Jian, Zhihuan Weng. (2024) Bio-based liquid crystal epoxy resins: Toughening and strengthening of conventional epoxy resins with strategically extended spacer layers. COMPOSITES COMMUNICATIONS, [PMID:] [10.1016/j.coco.2024.102068] |
| 2. Ge-liang Xie, Yang Cao, Sheng-ren Li, Qian-qian Lu, Wei Chen, Shuai Gao, Wei Qiu, Chao He, Zhen Fang, Lujiang Xu. (2025) BDE-Driven Sustainable Synthesis of Lignin-Derived Hydroxybenzonitriles via Tandem Green Cyanation and Gas-Phase Hydrodeoxygenation. ACS Sustainable Chemistry & Engineering, [PMID:] [10.1021/acssuschemeng.5c04554] |
