4-Nitrophenyl α-D-glucopyranoside - ≥99% , CAS No.3767-28-0

CAS: 3767-28-0 Cat. No.: N109390 Molecular Weight: 301.25 Beilstein Registry Number: 92212 EC Number: 223-189-3

GRADE & PURITY ≥99%

Synonyms

4-nitrophenyl-alpha-D-glucopyranoside | p-Nitrophenyl-α-D-glucopyranoside

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

α-葡萄糖苷酶的显色底物。

Specifications

Synonyms

4-nitrophenyl-alpha-D-glucopyranoside | p-Nitrophenyl-α-D-glucopyranoside

Specifications & Purity

≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Pubchem Sid: 504756155
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504756155
• Canonical Smiles: OC[C@H]1O[C@H](OC2=CC=C(C=C2)[N+]([O-])=O)[C@H](O)[C@@H](O)[C@@H]1O
• IUPAC Name: (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-nitrophenoxy)oxane-3,4,5-triol
• InChIKey: IFBHRQDFSNCLOZ-ZIQFBCGOSA-N
• INCHI: 1S/C12H15NO8/c14-5-8-9(15)10(16)11(17)12(21-8)20-7-3-1-6(2-4-7)13(18)19/h1-4,8-12,14-17H,5H2/t8-,9-,10+,11-,12+/m1/s1
• Isomeric SMILES: C1=CC(=CC=C1[N+](=O)[O-])O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O
• WGK Germany: 3
• Molecular Weight: 301.25
• Beilstein: 92212
• Reaxy-Rn: 92212
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=92212&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Class Organooxygen compounds
      • Subclass Carbohydrates and carbohydrate conjugates
        • Level5 Glycosyl compounds
          • Level6 Phenolic glycosides

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Class: Organooxygen compounds
• Subclass: Carbohydrates and carbohydrate conjugates
• Intermediate Tree Nodes: Glycosyl compounds
• Direct Parent: Phenolic glycosides
• Alternative Parents: Hexoses O-glycosyl compounds Nitrobenzenes Nitroaromatic compounds Phenol ethers Phenoxy compounds Oxanes Secondary alcohols Oxacyclic compounds Organic oxoazanium compounds Propargyl-type 1,3-dipolar organic compounds Acetals Polyols Organopnictogen compounds Organonitrogen compounds Organic zwitterions Organic oxides Primary alcohols Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Phenolic glycoside - Hexose monosaccharide - O-glycosyl compound - Nitrobenzene - Phenoxy compound - Nitroaromatic compound - Phenol ether - Monocyclic benzene moiety - Monosaccharide - Oxane - Benzenoid - C-nitro compound - Organic nitro compound - Secondary alcohol - Propargyl-type 1,3-dipolar organic compound - Allyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Acetal - Oxacycle - Organic oxoazanium - Organoheterocyclic compound - Polyol - Organopnictogen compound - Organic oxide - Organonitrogen compound - Alcohol - Organic nitrogen compound - Hydrocarbon derivative - Primary alcohol - Organic zwitterion - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as phenolic glycosides. These are organic compounds containing a phenolic structure attached to a glycosyl moiety. Some examples of phenolic structures include lignans, and flavonoids. Among the sugar units found in natural glycosides are D-glucose, L-Fructose, and L rhamnose.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

GAA Alpha-glucosidase (25 Activities)

Discover Target: GAA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water (10 mg/ml), warm ethanol, and methanol.
• Sensitivity: Light Sensitive ，heat sensitive
• Specific Rotation[α]: 218.5 ° (C=0.5, H2O)
• Melt Point(°C): 204-218°C
• Molecular Weight: 301.250 g/mol
• XLogP3: -0.400
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 3
• Exact Mass: 301.08 Da
• Monoisotopic Mass: 301.08 Da
• Topological Polar Surface Area: 145.000 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 354.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Qu-Jing Luo, Wen-Chao Zhou, Xin-Yi Liu, Ya-Jie Li, Qing-Ling Xie, Bin Wang, Chao Liu, Wen-Mao Wang, Wei Wang, Xu-Dong Zhou.  (2023)  Chemical Constituents and α-Glucosidase Inhibitory, Antioxidant and Hepatoprotective Activities of Ampelopsis grossedentata.  MOLECULES,  28  (24): (7956).  [PMID:38138447] [10.3390/molecules28247956]

2. Weidong Xu, Jiameng Zhang, Yanfang Wu, Zichen Zhang, Xinsheng Wang, Junying Ma.  (2023)  Influence of Five Drying Methods on Active Compound Contents and Bioactivities of Fresh Flowers from Syringa pubescens Turcz.  MOLECULES,  28  (23): (7803).  [PMID:38067533] [10.3390/molecules28237803]

3. Hui-Ting Cao, Tiansheng Zhao, Wei Liu, Cai-Ying Xu, Yi-Jing Liao, Xi-Luan Yan, Xi Mai, Na Li.  (2023)  Smartphone-assisted ratiometric fluorescence sensor for sensitive and portable α-glucosidase activity detection and inhibitor screening.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2023.109723]

4. Abdulbaset Al-Romaima, Guilin Hu, Yanbing Wang, Chenxi Quan, Haopeng Dai, Minghua Qiu.  (2023)  Identification of New Diterpenoids from the Pulp of Coffea arabica and Their α-Glucosidase Inhibition Activity.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:38157425] [10.1021/acs.jafc.3c05619]

5. Haiping Xiang, Weiyi Wen, Ping Xu, Huiyun Qiu, Chu Chu, Qingsong Shao, Shengqiang Tong.  (2023)  Inhibition mechanism of α-glucosidase by three geranylated compounds: Kinetic, spectroscopic and molecular docking.  PROCESS BIOCHEMISTRY,      [PMID:] [10.1016/j.procbio.2023.11.034]

6. Si-Lu Wang, Jie Yu, Jian-Xi Song, Qing-Fan Meng, Zhuo-Rui Zhang, Gui-Quan Jiang.  (2023)  Isolation, purification, structural analysis and in vitro activity of polysaccharides from Amelanchier alnifolia Nutt..  PROCESS BIOCHEMISTRY,      [PMID:] [10.1016/j.procbio.2023.12.002]

7. Kumaravel Kaliaperumal, Linyan Zhang, Liangliang Gao, Qin Xiong, Yan Liang, Yueming Jiang, Jun Zhang.  (2023)  Insight into the Inhibitory Mechanisms of Hesperidin on α-Glucosidase through Kinetics, Fluorescence Quenching, and Molecular Docking Studies.  Foods,  12  (22): (4142).  [PMID:38002199] [10.3390/foods12224142]

8. Na Li, Baijian Feng, Yongguang Bi, Fansheng Kong, Zhong Wang, Shaofan Tan.  (2023)  Sulfobutyl ether cyclodextrin inclusion complexes containing tea polyphenols: Preparation, characterization, antioxidant activity, α-glucosidase inhibition, and in vitro release property.  JOURNAL OF MOLECULAR STRUCTURE,      [PMID:] [10.1016/j.molstruc.2023.136686]

9. Qinhao Guan, Lihua Tang, Liangliang Zhang, Lixin Huang, Man Xu, Yuan Wang, Meng Zhang.  (2023)  Molecular insights into α-glucosidase inhibition and antiglycation properties affected by the galloyl moiety in (−)-epigallocatechin-3-gallate.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,  103  (15): (7381-7392).  [PMID:37390299] [10.1002/jsfa.12818]

10. Xiang Wang, Yejun Deng, Yang Zhang, Caihong Zhang, Lujie Liu, Yong Liu, Jianxin Jiang, Pujun Xie, Lixin Huang.  (2023)  Screening and Evaluation of Novel α-Glucosidase Inhibitory Peptides from Ginkgo biloba Seed Cake Based on Molecular Docking Combined with Molecular Dynamics Simulation.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:37288757] [10.1021/acs.jafc.3c00826]

11. Yichen Yin, Shiwei Sun, Hui Wang, Mengru Guo, Zhizhou Li, Chaoyi Lv, Zhao Yang, Wei Wang.  (2023)  Mechanism of interaction between urolithin A and α-glucosidase: Analysis by inhibition kinetics, fluorescence spectroscopy, isothermal titration calorimetry and molecular docking.  JOURNAL OF MOLECULAR STRUCTURE,      [PMID:] [10.1016/j.molstruc.2023.135567]

12. Yao Wen, Caimei Su.  (2023)  Optimization of Ultrasonic Assisted Extraction and Bioactivity of Ophiopogon japonicus Polysaccharides by Response Surface Methodology.  STARCH-STARKE,      [PMID:] [10.1002/star.202200213]

13. Jing Zhang.  (2023)  Hydroxylated polycyclic aromatic hydrocarbons possess inhibitory activity against alpha-glucosidase: An in vitro study using multispectroscopic techniques and molecular docking.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:36689906] [10.1016/j.saa.2023.122366]

14. Da-Shuang Fang, Chun-Ru Cheng, Ming-Hua Qiu, Xing-Rong Peng.  (2022)  Diverse meroterpenoids with α-glucosidase inhibitory activity from Ganoderma cochlear.  FITOTERAPIA,      [PMID:36586625] [10.1016/j.fitote.2022.105420]

15. Huihui Liu, Chang Zheng, Ziliang Li, Xiaoyang Xia, Dan Jiang, Wen Wang, Ruiying Zhang, Xia Xiang.  (2022)  Inhibitory mechanism of phenolic compounds in rapeseed oil on α-amylase and α-glucosidase: Spectroscopy, molecular docking, and molecular dynamic simulation.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:36542921] [10.1016/j.saa.2022.122251]

16. Xinlin Chen, Ying Wu, Yucheng Gu, Jianguang Luo, Lingyi Kong.  (2022)  Efficient discovery of potent α-glucosidase inhibitors from Paeoniae lactiflora using enzyme–MOF nanocomposites and competitive indicators.  Food & Function,  14  (1): (171-180).  [PMID:36477546] [10.1039/D2FO02783F]

17. Xue Lin, Yousheng Shi, Pan Wen, Xiaoping Hu, Lu Wang.  (2022)  Free, Conjugated, and Bound Phenolics in Peel and Pulp from Four Wampee Varieties: Relationship between Phenolic Composition and Bio-Activities by Multivariate Analysis.  Antioxidants,  11  (9): (1831).  [PMID:36139905] [10.3390/antiox11091831]

18. Fanshan Feng, Wei Xiang, Han Gao, Yanan Jia, Yuansong Zhang, Lingshu Zeng, Jiaxin Chen, Xianzhi Huang, Li Xu.  (2022)  Rapid Screening of Nonalkaloid α-Glucosidase Inhibitors from a Mulberry Twig Extract Using Enzyme-Functionalized Magnetic Nanoparticles Coupled with UPLC-MS/MS.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:36107153] [10.1021/acs.jafc.2c03435]

19. Jiahe Fan, Chaoyi Lv, Zhizhou Li, Mengru Guo, Yichen Yin, Hui Wang, Wei Wang, Shiwei Sun.  (2022)  α-Glucosidase inhibitory effect of an anthraquinonoid produced by Fusarium incarnatum GDZZ-G2.  JOURNAL OF BASIC MICROBIOLOGY,  62  (11): (1360-1370).  [PMID:35736630] [10.1002/jobm.202200166]

20. Ying Zhang, Yanna Pan, Jiaqi Li, Zeng Zhang, Yanming He, Hongjie Yang, Ping Zhou.  (2022)  Inhibition on α-Glucosidase Activity and Non-Enzymatic Glycation by an Anti-Oxidative Proteoglycan from Ganoderma lucidum.  MOLECULES,  27  (5): (1457).  [PMID:35268560] [10.3390/molecules27051457]

21. Hui Wang, Xiaoli Kang, Shiwei Sun, Yichen Yin, Kun Jiang, Guodong Tang, Xinning Tang, Wei Wang.  (2022)  Discovery of pyrogallol thermal reaction products from a model process of roasting coffee beans as potent α-glucosidase inhibitors.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2022.101583]

22. De-Fu Hong, Gui-Lin Hu, Xing-Rong Peng, Xiao-Yuan Wang, Yan-Bing Wang, Abdulbaset Al-Romaima, Zhong-Rong Li, Ming-Hua Qiu.  (2022)  Unusual ent-Kaurane Diterpenes from the Coffea Cultivar S288 Coffee Beans and Molecular Docking to α-Glucosidase.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:35005957] [10.1021/acs.jafc.1c06524]

23. Jia-Bin Wang, Le-Yi Yu, Xu Zeng, Jun-Wei Zheng, Bin Wang, Li Pan.  (2021)  Screening of probiotics with efficient α-glucosidase inhibitory ability and study on the structure and function of its extracellular polysaccharide.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2021.101452]

24. Li Tang, Xiaomin Luo, Meiyuan Wang, Zhong Wang, Juan Guo, Fansheng Kong, Yongguang Bi.  (2021)  Synthesis, characterization, in vitro antioxidant and hypoglycemic activities of selenium nanoparticles decorated with polysaccharides of Gracilaria lemaneiformis.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:34728301] [10.1016/j.ijbiomac.2021.10.189]

25. Jichen Yang, Huan Li, Xiaoli Wang, Chuanying Zhang, Guo Feng, Xin Peng.  (2021)  Inhibition Mechanism of α-Amylase/α-Glucosidase by Silibinin, Its Synergism with Acarbose, and the Effect of Milk Proteins.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:34463509] [10.1021/acs.jafc.1c01765]

26. Shouye Han, Yu Liu, Wan Liu, Fan Yang, Jia Zhang, Ruifeng Liu, Fenqin Zhao, Wei Xu, Zhongbin Cheng.  (2021)  Chromone Derivatives with α-Glucosidase Inhibitory Activity from the Marine Fungus Penicillium thomii Maire.  MOLECULES,  26  (17): (5273).  [PMID:34500706] [10.3390/molecules26175273]

27. Limin Wang, Yunsen Zhang, I. Agbaka Johnpaul, Kai Hong, Yumei Song, Xiao Yang, Chenyan Lv, Changwei Ma.  (2021)  Exploring two types of prenylated bitter compounds from hop plant (Humulus lupulus L.) against α-glucosidase in vitro and in silico.  FOOD CHEMISTRY,      [PMID:34543921] [10.1016/j.foodchem.2021.130979]

28. Ke Zhao, Shiwei Sun, Hui Wang, Lin Wang, Guoqing Qin, Jiahe Fan, Mengru Guo, Wei Wang.  (2021)  α-Glucosidase inhibitory triterpenoids from Euonymus fortunei.  BIOORGANIC CHEMISTRY,      [PMID:34004587] [10.1016/j.bioorg.2021.104980]

29. Xie Zhike, He Ming, Zhai Yuhan, Xin Feifei, Yu Shuyan, Yu Shaoxuan, Xiao Haifang, Song Yuanda.  (2021)  Inhibitory kinetics and mechanism of oleanolic acid on α-glucosidase.  Journal of Food Measurement and Characterization,  15  (4): (3408-3418).  [PMID:] [10.1007/s11694-021-00920-y]

30. Junwei He, Liangfa Wu, Li Yang, Boyuan Zhao, Chunlong Li.  (2020)  Extraction of Phenolics and Flavonoids from Four Hosta Species Using Reflux and Ultrasound-Assisted Methods with Antioxidant and α-Glucosidase Inhibitory Activities.  Biomed Research International,      [PMID:33415149] [10.1155/2020/6124153]

31. GuiLin Hu, XingRong Peng, Ding Dong, Yin Nian, Ya Gao, XiaoYuan Wang, DeFu Hong, MingHua Qiu.  (2020)  New ent-kaurane diterpenes from the roasted arabica coffee beans and molecular docking to α-glucosidase.  FOOD CHEMISTRY,      [PMID:33341560] [10.1016/j.foodchem.2020.128823]

32. Halah Aalim, Di Wang, Zisheng Luo.  (2020)  Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.  FOOD RESEARCH INTERNATIONAL,      [PMID:33641947] [10.1016/j.foodres.2020.109898]

33. Minghao Fan, Junxiang Zhu, Yilin Qian, Wei Yue, Ying Xu, Dandan Zhang, Yuqi Yang, Xiaoya Gao, Haiyue He, Dongfeng Wang.  (2020)  Effect of purity of tea polysaccharides on its antioxidant and hypoglycemic activities.  JOURNAL OF FOOD BIOCHEMISTRY,  44  (8): (e13277).  [PMID:32557675] [10.1111/jfbc.13277]

34. Yejun Deng, Lixin Huang, Caihong Zhang, Pujun Xie, Jiang Cheng, Xiang Wang, Lujie Liu.  (2020)  Novel polysaccharide from Chaenomeles speciosa seeds: Structural characterization, α-amylase and α-glucosidase inhibitory activity evaluation.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:32169457] [10.1016/j.ijbiomac.2020.03.057]

35. Wang Le, Tan Nana, Wang Huan, Hu Jingbo, Diwu Wenbo, Wang Xiaoling.  (2020)  A systematic analysis of natural α-glucosidase inhibitors from flavonoids of Radix scutellariae using ultrafiltration UPLC-TripleTOF-MS/MS and network pharmacology.  BMC Complementary Medicine and Therapies,  20  (1): (1-17).  [PMID:32143602] [10.1186/s12906-020-2871-3]

36. Mengting Ni, Xing Hu, Deming Gong, Guowen Zhang.  (2020)  Inhibitory mechanism of vitexin on α-glucosidase and its synergy with acarbose.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2020.105824]

37. Yuxue Zheng, Jinhu Tian, Wenhan Yang, Shiguo Chen, Donghong Liu, Haitian Fang, Huiling Zhang, Xingqian Ye.  (2020)  Inhibition mechanism of ferulic acid against α-amylase and α-glucosidase.  FOOD CHEMISTRY,      [PMID:32070843] [10.1016/j.foodchem.2020.126346]

38. Taotao Dai, Ti Li, Xiaohong He, Xin Li, Chengmei Liu, Jun Chen, David Julian McClements.  (2020)  Analysis of inhibitory interaction between epigallocatechin gallate and alpha-glucosidase: A spectroscopy and molecular simulation study.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:31927512] [10.1016/j.saa.2019.118023]

39. Yu Zhang, Yixin Dong, Jinhua Zhou, Ying’ao Hu, Xun Li, Fei Wang.  (2019)  Peptide-Mediated Immobilization on Magnetoferritin for Enzyme Recycling.  Nanomaterials,  9  (11): (1558).  [PMID:31684120] [10.3390/nano9111558]

40. Sen Guo, Li Liu, Shanshan Zhang, Chuang Yang, Wenping Yue, Haoan Zhao, Chi-Tang Ho, Junfeng Du, Hai Zhang, Naisheng Bai.  (2019)  Chemical characterization of the main bioactive polyphenols from the roots of Morus australis (mulberry).  Food & Function,  10  (10): (6915-6926).  [PMID:31588440] [10.1039/C9FO01457H]

41. Mengting Ni, Junhui Pan, Xing Hu, Deming Gong, Guowen Zhang.  (2019)  Inhibitory effect of corosolic acid on α-glucosidase: kinetics, interaction mechanism, and molecular simulation.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,  99  (13): (5881-5889).  [PMID:31206698] [10.1002/jsfa.9862]

42. Hang Zhang, Jing Zhong, Qian Zhang, Degang Qing, Chunyan Yan.  (2019)  Structural elucidation and bioactivities of a novel arabinogalactan from Coreopsis tinctoria.  CARBOHYDRATE POLYMERS,      [PMID:31151520] [10.1016/j.carbpol.2019.05.019]

43. Mengting Wang, Jing Jiang, Jinhu Tian, Shiguo Chen, Xingqian Ye, Yaqin Hu, Jianchu Chen.  (2019)  Inhibitory mechanism of novel allosteric inhibitor, Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves proanthocyanidins against α-glucosidase.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2019.03.026]

44. Halah Aalim, Tarun Belwal, Lei Jiang, Hao Huang, Xianghe Meng, Zisheng Luo.  (2019)  Extraction optimization, antidiabetic and antiglycation potentials of aqueous glycerol extract from rice (Oryza sativa L.) bran.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2019.01.006]

45. Li Zeng, Huafang Ding, Xing Hu, Guowen Zhang, Deming Gong.  (2018)  Galangin inhibits α-glucosidase activity and formation of non-enzymatic glycation products.  FOOD CHEMISTRY,      [PMID:30236734] [10.1016/j.foodchem.2018.07.148]

46. Xiaqing Wu, Huafang Ding, Xing Hu, Junhui Pan, Yijing Liao, Deming Gong, Guowen Zhang.  (2018)  Exploring inhibitory mechanism of gallocatechin gallate on a-amylase and a-glucosidase relevant to postprandial hyperglycemia.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2018.07.022]

47. Huafang Ding, Xiaqing Wu, Junhui Pan, Xing Hu, Deming Gong, Guowen Zhang.  (2018)  New Insights into the Inhibition Mechanism of Betulinic Acid on α-Glucosidase.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:29902001] [10.1021/acs.jafc.8b02992]

48. Minghao Fan, Xun Sun, Yilin Qian, Ying Xu, Dongfeng Wang, Yanping Cao.  (2018)  Effects of metal ions in tea polysaccharides on their in vitro antioxidant activity and hypoglycemic activity.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:29329813] [10.1016/j.ijbiomac.2018.01.041]

49. Huafang Ding, Xing Hu, Ximing Xu, Guowen Zhang, Deming Gong.  (2017)  Inhibitory mechanism of two allosteric inhibitors, oleanolic acid and ursolic acid on α-glucosidase.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:29030193] [10.1016/j.ijbiomac.2017.10.040]

50. Jian-Qiang Zhao, Yan-Ming Wang, Yan-Long Yang, Ying Zeng, Li-Juan Mei, Yan-Ping Shi, Yan-Duo Tao.  (2017)  Antioxidants and α-glucosidase inhibitors from “Liucha” (young leaves and shoots of Sibiraea laevigata).  FOOD CHEMISTRY,      [PMID:28407891] [10.1016/j.foodchem.2017.03.024]

51. Yingxian Guan, Tong Zhao, Anrong Zhang, Di Zhang, Xiaoxiao Huang, Xiao Fang, Jiajun Geng, Jie Gang.  (2024)  A Potential Diabetic-Friendly Food Material: Optimization, Nutritional Quality, Structural Characteristics, and Functional Properties of Oat and Purple Potato Fermented by Ganoderma lucidum Mycelium.  Fermentation-Basel,  10  (12): (618).  [PMID:] [10.3390/fermentation10120618]

52. Huafang Ding, Shouhe Huang, Chui Yiu Chook, Erika Kwek, Chi Yan, Kaying Ma, Jianhui Liu, Hanyue Zhu, Zhenyu Chen.  (2024)  Blood glucose-lowering activity of protocatechuic acid is mediated by inhibiting α-glucosidase.  Food Science and Human Wellness,      [PMID:] [10.26599/FSHW.2022.9250101]

53. Rundong Yang, Siyan Liu, Feifei Wang, Shuyi Li, Na Zhang, Zhenzhou Zhu.  (2024)  Construction and characterization of Laminaria polysaccharide functionalized selenium nanoparticles based on an activity-oriented approach.  PROCESS BIOCHEMISTRY,      [PMID:] [10.1016/j.procbio.2024.11.004]

54. Zhizhou Li, Hui Wang, Shiwei Sun, Zhongbai Shao, Chaoyi Lv, Xiaoyue Dong, Lu Wang, Wei Wang.  (2024)  Ellagitannins from pomegranate (Punica granatum L.) flower with xanthine oxidase and α-glucosidase inhibitory activities.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2024.106153]

55. Yucheng Yan, Safdar Ali Amur, Hong Liu, Ruoyao Shen, Huaiqing Sun, Yunlin Pei, Chaowan Guo, Hao Liang.  (2024)  Endogenous crude Scutellaria baicalensis polysaccharide robustly enhances one-pot extraction and deglycosylation of baicalin.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38387634] [10.1016/j.ijbiomac.2024.130349]

56. Na Li, Kaiyue Liu, Yue Zhang, Zhenzhen Hui, Ping Wang, Shuyang Sun, Chao Du.  (2025)  Identification of novel α-glucosidase inhibitory peptides in Meretrix meretrix Linnaeus and their inhibitory kinetics using in silico and in vitro analyses.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40174823] [10.1016/j.ijbiomac.2025.142480]

57. Jun Dai, Zihan Liu, Lei Ma, Chunliu Yang, Ligai Bai, Dandan Han, Qi Song, Hongyuan Yan, Zhiqiang Wang.  (2024)  Identification of procyanidins as α-glucosidase inhibitors, pancreatic lipase inhibitors, and antioxidants from the bark of Cinnamomum cassia by multi-bioactivity-labeled molecular networking.  FOOD RESEARCH INTERNATIONAL,      [PMID:39147522] [10.1016/j.foodres.2024.114833]

58. Ying Gao, Juan Chen, Junjun Liu, Zijian Huang, Xiaogang Peng, Wanpeng Li, Chunlun Qin, Hanli Ruan.  (2024)  Incartrilactones A and B: Two schinortriterpenoids with a 14,15-seco-15,17-cyclolancifoartane skeleton from Schisandra incarnata.  PHYTOCHEMISTRY,      [PMID:39613276] [10.1016/j.phytochem.2024.114342]

59. Zhong Yuxiu, Ni Derang, Yang Yubo, Li Yuanyi, Wang Li, Tian Jinhu, Yang Fan, Ye Xingqian.  (2024)  Inhibitory effect and mechanism of tannic acid against two starch digestive enzymes.  Food Quality and Safety,      [PMID:] [10.1093/fqsafe/fyad057]

60. Yuqing Zhang, Yaping Li, Yuhan Zhai, Xing Zhao, Mingxing Lv, Shaoxuan Yu, Haifang Xiao, Yuanda Song.  (2024)  Inhibitory mechanism of chrysin and diosmetin to α-glucosidase: insights from kinetics, multispectroscopy and molecular docking investigations.  JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,      [PMID:38289727] [10.1080/07391102.2024.2310207]

61. Minglong Wang, Shunyu Li, Jiesheng Chen, Xiaoli Zhou, Yiming Zhou.  (2025)  Mechanistic insights into the influence of Tartary buckwheat flavonoids on the digestibility of starch.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2025.111185]

62. Lichun Guo, Mengqing Zhang, Ying Fei, Wei Zhao.  (2024)  Natural Sweetener, Glycyrrhetinic Acid 3-O-Mono-beta-d-glucuronide, for Postprandial Hyperglycemia Management.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:38335161] [10.1021/acs.jafc.3c07188]

63. Wu Zongzhan, Dou Wenyu, Yang Xiaolin, Niu Tengfei, Han Zhuzhen, Yang Li, Wang Rufeng, Wang Zhengtao.  (2024)  Novel glycosidase from Paenibacillus lactis 154 hydrolyzing the 28-O-β-d-glucopyranosyl ester bond of oleanane-type saponins.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,  108  (1): (1-13).  [PMID:38573330] [10.1007/s00253-024-13109-2]

64. Wendie Hu, Bing Liu, Yao Wen.  (2024)  Optimization of Ultrasound-Assisted Deep Eutectic Solvent Extraction and Bioactivities of Polysaccharide from Porphyra haitanensis.  STARCH-STARKE,      [PMID:] [10.1002/star.202300272]

65. Wen Yao, Chen Jiawen.  (2024)  Optimization of Ultrasound-Assisted Deep Eutectic Solvent Extraction, Characterization, and Bioactivities of Polysaccharide from Pericarpium Citri Reticulatae.  APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,      [PMID:38904917] [10.1007/s12010-024-04990-8]

66. Wen Yao, Chen Geping, Zhang Xiaobing.  (2024)  Optimization of ultrasound-assisted deep eutectic solvent extraction, characterization, and biological studies of polysaccharide from seeds of Toona sinensis.  Journal of Food Measurement and Characterization,      [PMID:] [10.1007/s11694-024-02400-5]

67. Xinlin Chen, Ying Wu, Sifang Wu, Yucheng Gu, Jianguang Luo, Lingyi Kong.  (2024)  Paper-based ligand fishing method for rapid screening and real-time capturing of α-glucosidase inhibitors from the Chinese herbs.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:38387130] [10.1016/j.jpba.2024.116037]

68. Chenlei Ma, Honglei Bao, Beibei Zhu, Junchao Zhu, Songlin Chen, Huawei Lv, Chu Chu, Shengqiang Tong.  (2025)  Separation of sesquiterpene glycosides with α-glucosidase inhibitory activity from Eriobotrya japonica (Thunb.) leaves by high-speed countercurrent chromatography.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:39970686] [10.1016/j.chroma.2025.465780]

69. Yu-Fei Hou, Lu Bai, Shao-Jing Liu, Sen Guo, Ya-Long Wang, Chi-Tang Ho, Nai-Sheng Bai.  (2024)  Simultaneous characterization and quantification of 25 flavonoid compounds in Actinidia arguta Miq. leaves by HPLC-DAD and screening for their inhibitory activity on α‑glucosidase.  Phytochemistry Letters,      [PMID:] [10.1016/j.phytol.2024.04.015]

70. Lin-Lin Tian, Yan-Xue Bi, Hua Zhang.  (2024)  Structurally Diverse Stilbenoids as Potent α-Glucosidase Inhibitors with Antidiabetic Effect from Morus alba.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:39092914] [10.1021/acs.jafc.4c01681]

71. Wenhao Zhou, Huixian Chen, Yinghan Tian, Jiachuan Lei, Jianqing Yu.  (2024)  Study on antioxidant and antidiabetic components of Cirsium setosum based on molecular networking.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2024.104774]

72. Yan-Yun Liu, Zheng-Ao Li, Yu-Zheng Zhou, Sen-Lin Wang, Zong-Peng Chen, Si-Xu Liu, Peng Zhan, Ying-Jun Zhou, Zan-Xian Xia, Xu Deng.  (2025)  TCM theory-inspired discovery of DNJ-flavonoid conjugates as broad-spectrum anti-SARS-CoV-2 agents by primarily targeting ER-associated glycoprotein folding process.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:40168909] [10.1016/j.ejmech.2025.117582]

73. Zhou Jian-Feng, Xu Hai-Xia, Yin Zhong-Ping, Chen Ji-Guang, Zhang Qing-Feng.  (2024)  The combination effects of quercetin on starch and digestive enzymes reduce postprandial blood glucose in rats.  EUROPEAN FOOD RESEARCH AND TECHNOLOGY,      [PMID:] [10.1007/s00217-023-04455-y]

74. Jing Zhang, Honghui Wang, Yingmin Liao, Yan Li.  (2024)  The combined effects of bisphenol S and hexavalent chromium on alpha-glucosidase: Intermolecular interaction, structural and functional changes.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39343258] [10.1016/j.ijbiomac.2024.136120]

75. Gang Li, Chunming Bao, Hao Zhang, Lu Bai.  (2025)  Ultrasound-assisted extraction of polyphenols from Lonicera japonica leaves and their α-glucosidase inhibition.  Frontiers in Nutrition,      [PMID:39944961] [10.3389/fnut.2025.1542217]

76. Qinqin Zhao, Liwei Gao, Nuo Xu, Xiuting Zhang, Yuqi Qin, Yinbo Qu, Guodong Liu.  (2025)  An l-fucose-responsive transcription factor cross-regulates the expression of a diverse array of carbohydrate-active enzymes in Trichoderma reesei.  PLoS Genetics,  21  (8): (e1011815).  [PMID:40788923] [10.1371/journal.pgen.1011815]

77. Jing Zhang, Qiang Ma, Honghui Wang, Bin Chen, Yan Li, Yingmin Liao.  (2025)  Molecular insights into the transport and toxicity of 6-PPD: Interactions with human serum albumin and alpha-glucosidase.  BIOPHYSICAL CHEMISTRY,      [PMID:41014659] [10.1016/j.bpc.2025.107529]

78. Wen Luan, Wu Zhou-Wei, Lin Li-Wu, Al-Romaima Abdulbaset, Peng Xing-Rong, Qiu Ming-Hua.  (2023)  Structural characterizations and α-glucosidase inhibitory activities of four Lepidium meyenii polysaccharides with different molecular weights.  Natural Products and Bioprospecting,  13  (1): (1-9).  [PMID:37278859] [10.1007/s13659-023-00384-1]

79. Nana Li, Liangqiang Chen, Wanqiu Huang, Mengdi Hao, Huabin Tu, Hao Shen, Fan Yang, Shaoning Yu.  (2024)  Enzyme-integrated metal-organic framework platform for cascade detection of α-amylase.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38670199] [10.1016/j.ijbiomac.2024.131870]

80. Zhang Hui, Chen Guilin, Zhang Yongli, Muema Felix Wambua, Ding Jun, Guo Mingquan.  (2024)  Screening for Bioactive Compounds from Mulberry Leaves Combining Bio-Affinity Ultrafiltration with α-Glucosidase and Pancreatic Lipase.  Journal of Analysis and Testing,      [PMID:] [10.1007/s41664-024-00305-2]

81. Deli Zou, Lei Liu, Fangshen Liu, Dahong Li, Huiming Hua.  (2024)  α-Glucosidase Inhibitory Components from Garcinia pedunculata Fruits.  CHEMISTRY & BIODIVERSITY,      [PMID:38459792] [10.1002/cbdv.202400409]

82. Jing Jing, Li Huizhen, Li Cheng, Xu Mengjie, Zhao Yana, Cui Jianlan, Zhang Zhijun.  (2025)  Physicochemical, rheological properties, and hypoglycemic activities of polysaccharides from Hemerocallis citrina Baroni leaves and stems.  Journal of Food Measurement and Characterization,      [PMID:] [10.1007/s11694-025-03287-6]

83. Wen Yao, Chen Geping.  (2025)  Optimization of ultrasound-assisted deep eutectic solvent extraction, characterization, and bioactivities of polysaccharide from the fruit of Rosa roxburghii Tratt.  Journal of Food Measurement and Characterization,      [PMID:] [10.1007/s11694-025-03424-1]

84. Kexin Du, Yapu Zhang, Xinya Liu, Yang Tian, Mengfan Wang, Xin Peng.  (2025)  Preparation of soybean 7S/11S proteins-quercetin nanocomplexes through heat treatment: Effects on stability, in vitro digestion and bioactivities of quercetin.  Journal of Future Foods,      [PMID:] [10.1016/j.jfutfo.2025.10.022]

85. Zhi-Wen Wan, Rui Meng, Hua-Yuan Yang, Xing Yang, Qin Zhou, Min Wu, Bin Li, Xia Zhang.  (2025)  Antioxidant and Hypoglycemic Activity of Polysaccharides With Different Tissues From Rosa roxburghii f. eseiosa Ku.  CHEMISTRY & BIODIVERSITY,      [PMID:41202184] [10.1002/cbdv.202501725]

86. Yanqu Cai, Haotian Chen, Yao Wen, Haiyun Chen.  (2025)  Optimization of Ultrasound-Assisted Water Solvent Extraction and Bioactivities of Polysaccharide From Eleusine indica (L.) Gaertn.  STARCH-STARKE,      [PMID:] [10.1002/star.70144]

87. Bin-Chun Li, Weijuan Dong, Bingbing Wu, Yanlong Liu, Na Han, Guo-Bin Ding.  (2025)  Characterization of a Thermophilic and Acidophilic GH78 α-L-Rhamnosidase from Thermotoga sp. 2812B Capable of Efficiently Hydrolyzing a Variety of Natural Flavonoid Diglycosides.  Biomolecules,  16  (1): (68).  [PMID:41594608] [10.3390/biom16010068]

88. Shi-Hui Lu, Xiu-Xia Li, Xiao-Yan Xia, Wei-Neng Li, Kai-Jie Luo, Jing Huang.  (2026)  Three New Glycosides from the Leaves of Ligustrum robustum and Their Antioxidant Activities and Inhibitory Effects on Fatty Acid Synthase, α-Glucosidase, and α-Amylase.  CHEMISTRY & BIODIVERSITY,  23  (1): (e03315).  [PMID:41494995] [10.1002/cbdv.202503315]

89. Mengli Geng, Dandan Ma, Zhaojun Wang, Qiuming Chen, Maomao Zeng, Jie Chen, Benu Adhikari, Hongyang Pan, Zhiyong He.  (2026)  Enzymatically synthesized kaempferol fatty acid esters enhance glycolipid metabolism regulation and α-glucosidase inhibition.  FOOD RESEARCH INTERNATIONAL,      [PMID:] [10.1016/j.foodres.2026.118422]

90. Qingfeng Guo, Xia Zhang, Hao Zhang, Mengxue Wang, Haoran Zhou, Meiru Chen, Zhenhua Yin, Juanjuan Zhang, Baocheng Yang, Li Wang, Lin Chen.  (2026)  α-Glucosidase and Pancreatic Lipase Inhibitory Activity of Chemical Constituents from Adzuki Bean (Vigna angularis).  Life-Basel,  16  (2): (235).  [PMID:41752872] [10.3390/life16020235]

91. Shan-Mei Zeng, Wu-Mei Jiang, Yan Lin, Ze-Lin Liao, Jia-Yi Liang, Ze-Dan Yang, Wen-Jing Wu, Jia-Yi Luo, Wei-Ming Chai.  (2026)  Inhibition of Hawthorn Leaf Condensed Tannins on α-Glucosidase and Nonenzymatic Glycosylation: Molecular Mechanisms of Action.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:41569292] [10.1021/acs.jafc.5c14159]

92. Hang Su, Wenjie Han, Hamed I. Hamouda, Huidan Zhang, Ming Lu.  (2026)  Characterization and Functional Mechanism Analysis of Two Glycoside Hydrolase Family-39 β-Xylosidases Identified from Caldicellulosiruptor saccharolyticus.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:41744459] [10.1021/acs.jafc.5c06093]

93. Huiqing Ma, Lijia Sun, Huaibo Yuan, Wenhong Liu.  (2026)  Synthesis and hypoglycemic efficacy assessment of epigallocatechin gallate-selenium nanoparticles (EGCG-Se NPs) nanocomposites.  PeerJ,      [PMID:] [10.7717/peerj.20939]

94. Siyang Mao, Chu Chu, Yanzhi Xiong, Mengjia Xu, Jian Yang, Mingquan Guo.  (2026)  Potential Hypoglycemic, Hypolipidemic, and Hypouricemic Bioactive Components From Ampelopsis grossedentata Explored by Affinity Ultrafiltration With Three Enzyme Targets.  eFood,  7  (2): (e70144).  [PMID:] [10.1002/efd2.70144]