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Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selective PTHR1 activator. Abaloparatide TFA enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide TFA enhances bone formation
Appearance:Solid
IC50& Target:Parathyroid hormone receptor 1 (PTHR1)
In Vitro:Abaloparatide TFA (0-100 nM; 40 min) enhances Gs/cAMP signaling and β-arrestin recruitment in MC3T3-E1 cells. Abaloparatide TFA (0-100 nM) efficiently induces PTHR1 internalization in a dose-dependen manner with an EC 50 value of 0.8 nM in U2OS Cell
In Vivo:Abaloparatide TFA (20-80 µg/kg; s.c.; daily for 30 days) enhances bone formation and cortical structure in mouse. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female Sprague-Dawley rats
Biological Activity:Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selective PTHR1 activator. Abaloparatide TFA enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide TFA enhances bone formation
| Molecular Weight | 4074.61 |
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View spec sheet →| Solubility | H2O : ≥ 50 mg/mL (12.27 mM) |
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