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· · COA & SDS available for every product · Same-day shipping on in-stock items ACT 462206 - Moligand™, ≥99%(HPLC) , Antagonist of OX 1 receptor;Antagonist of OX 2 receptor, CAS No.1361321-96-1, Antagonist of OX 1 receptor;Antagonist of OX 2 receptor
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%(HPLC) Synonyms
ACT 462206 | MS-26450 | NCGC00387479-01 | (S)-N-(3,5-dimethylphenyl)-1-((4-methoxyphenyl)sulfonyl)-pyrrolidine-2-carboxamide | ACT462206 | ACT-462206 | ACT-462206, >=98% (HPLC) | (2~{S})-~{N}-(3,5-dimethylphenyl)-1-(4-methoxyphenyl)sulfonyl-pyrrolidine-2-
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Why this grade Moligand™, ≥99%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
ACT 462206 | MS-26450 | NCGC00387479-01 | (S)-N-(3, 5-dimethylphenyl)-1-((4-methoxyphenyl)sulfonyl)-pyrrolidine-2-carboxamide | ACT462206 | ACT-462206 | ACT-462206, >=98% (HPLC) | (2~{S})-~{N}-(3, 5-dimethylphenyl)-1-(4-methoxyphenyl)sulfonyl-pyrrolidine-2-
Specifications & Purity
Moligand™, ≥99%(HPLC)
Biochemical and Physiological Mechanisms
Potent, dual orexin receptor antagonist (IC50values are 11 and 60 nM for OX2and OX1receptors respectively). Exhibits anxiolytic-like propertiesin vivo. Brain penetrant.ACT-462206 is a orally active, brain penetrant, potent and selective dual orexin1/2 rec
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
Antagonist of OX 1 receptor;Antagonist of OX 2 receptor
Names and Identifiers Pubchem Sid 504770170 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504770170 Canonical Smiles CC1=CC(=CC(=C1)NC(=O)C2CCCN2S(=O)(=O)C3=CC=C(C=C3)OC)C IUPAC Name (2S)-N-(3,5-dimethylphenyl)-1-(4-methoxyphenyl)sulfonylpyrrolidine-2-carboxamide InChIKey NHPQGZOBHSVTAQ-IBGZPJMESA-N INCHI 1S/C20H24N2O4S/c1-14-11-15(2)13-16(12-14)21-20(23)19-5-4-10-22(19)27(24,25)18-8-6-17(26-3)7-9-18/h6-9,11-13,19H,4-5,10H2,1-3H3,(H,21,23)/t19-/m0/s1 Isomeric SMILES CC1=CC(=CC(=C1)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=C(C=C3)OC)C Alternate CAS 1361321-96-1 PubChem CID 40924317 MeSH Entry Terms ACT-462206 Molecular Weight 388.48
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organic acids and derivatives Class Carboxylic acids and derivatives Subclass Amino acids, peptides, and analogues Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives Direct Parent Proline and derivatives Alternative Parents Alpha amino acid amides Benzenesulfonamides Anilides Benzenesulfonyl compounds m-Xylenes Anisoles Pyrrolidinecarboxamides Methoxybenzenes N-arylamides Phenoxy compounds Alkyl aryl ethers Organosulfonamides Sulfonyls Secondary carboxylic acid amides Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides Molecular Framework Aromatic heteromonocyclic compounds Substituents Proline or derivatives - Alpha-amino acid amide - Benzenesulfonamide - Benzenesulfonyl group - Anilide - Phenoxy compound - Anisole - M-xylene - Xylene - Phenol ether - Methoxybenzene - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - N-arylamide - Alkyl aryl ether - Monocyclic benzene moiety - Benzenoid - Organosulfonic acid amide - Organic sulfonic acid or derivatives - Pyrrolidine - Organosulfonic acid or derivatives - Sulfonyl - Secondary carboxylic acid amide - Carboxamide group - Organoheterocyclic compound - Azacycle - Ether - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Carbonyl group - Organosulfur compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Aromatic heteromonocyclic compound Description This compound belongs to the class of organic compounds known as proline and derivatives. These are compounds containing proline or a derivative thereof resulting from reaction of proline at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 38.85, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 38.85, Max Conc. mM: 100 Molecular Weight 388.500 g/mol XLogP3 3.200 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 5 Rotatable Bond Count 5 Exact Mass 388.146 Da Monoisotopic Mass 388.146 Da Topological Polar Surface Area 84.100 Ų Heavy Atom Count 27 Formal Charge 0 Complexity 600.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 1 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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