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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Moligand™,10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 29 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Alizarin (Anthraquinonic) strongly inhibits P450 isoform CYP1A1, CYP1A2 andCYP1B1withIC50of 6.2 μM, 10.0 μM and 2.7 μM, respectively; weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5.
In vitro
Alizarin weakly inhibits CYP2A6 and CYP2E1. Alizarin shows competitive inhibition against CYP1B1 with Ki of 0.5 μM. Alizarin reduces the mutagenicity of MeIQx, which induced by each CYP1A2 or CYP1B1, while does not effectively reduce the mutation induced by B[a]P. Alizarin exhibits antioxidants against iodophenol-derived phenoxyl radicals, superoxide anion radicals and lipid peroxidation in rat liver microsomes.
In vivo
Alizarin also reduces the hepatic content of thiobarbituric acid-reactive substances and the serum level of alanine aminotransferase in poisoned animals.
Cell Data
cell lines:
Concentrations:
Incubation Time:
Powder Purity:≥97%
| Isomeric SMILES | C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C(=C(C=C3)O)O |
|---|---|
| WGK Germany | 3 |
| RTECS | CB6580000 |
| Molecular Weight | 240.21 |
| Beilstein | 1914037 |
| Reaxy-Rn | 1914037 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1914037&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Solubility | Solubility (25°C) In vitro |
|---|---|
| Boil Point(°C) | 430°C |
| Melt Point(°C) | 290°C |
| 1. Jin-jing Hu, Zeng-hui Sun, Zi-wei Wu, Chao Tu, Li Cui, Yao-jun Tan. (2023) One-Step Preparation of Ph-Sensitive and Antibacterial Calcium Alginate Fibers: In Situ Reduction Method and Original Solution Dyeing. MACROMOLECULAR CHEMISTRY AND PHYSICS, 225 (4): (2300255). [PMID:] [10.1002/macp.202300255] |
| 2. Jun Jiang, Baixiu Zhao, Jianpeng Xiao, Liang Shi, Wei Shang, Ye Shu, Zhiming Zhao, Junyi Shen, Jingjuan Xu, Hui Cai. (2023) Exploring the boost of steaming with wine on Ligustri Lucidi Fructus in treating postmenopausal osteoporosis based on superior “multi-component structure” and iron/bone metabolism coregulation. PHYTOMEDICINE, [PMID:38142661] [10.1016/j.phymed.2023.155275] |
| 3. Meimei Yu, Yuanyou Peng, Yu Wang, Facai Guo, Fen Ran. (2023) All-in-one membrane micro-supercapacitors for implantable devices. JOURNAL OF MEMBRANE SCIENCE, [PMID:] [10.1016/j.memsci.2023.122084] |
| 4. Wanmei Lin, Yifan Zhang, Jihong Huang, Zhonghong Li. (2023) pH-responsive double-layer film based on chitosan/curcumin-β-cyclodextrin complex/cinnamaldehyde and zein/alizarin for pork freshness monitoring and maintaining. FOOD RESEARCH INTERNATIONAL, [PMID:37803785] [10.1016/j.foodres.2023.113460] |
| 5. Shaochi Wang, Ting Du, Ying Zhu, Sijie Liu, Junqi Huangmin, Liang Zhang, Daize Shi, Minghui Zhang, Jing Sun, Daohong Zhang, Jianlong Wang. (2023) Natural needle microstructure-based immunochromatographic assay for sensitively detecting streptomycin in food products. FOOD CHEMISTRY, [PMID:37696155] [10.1016/j.foodchem.2023.137413] |
| 6. Yukun Wang, Zhiyu Jin, Zijun Zhang, Changkai Zhou, Zhe Sun, Feng Yan. (2023) pH-Responsive Polymer Films Based on Click Polymerization for Food Freshness Monitoring: Non-Toxic, Non-Leaking, and Antibacterial. ACS Applied Materials & Interfaces, [PMID:37403437] [10.1021/acsami.3c04050] |
| 7. Weiya Zeng, Yuan Fang, Suifen Mo, Caihong Shen, Huiling Yang, Guihua Luo, Luhua Xiao, Ruoting Zhan, Ping Yan. (2023) The Underling Mechanisms Exploration of Rubia cordifolia L. Extract Against Rheumatoid Arthritis by Integrating Network Pharmacology and Metabolomics. Drug Design Development and Therapy, [PMID:36818604] [10.2147/DDDT.S388932] |
| 8. Binjie Wang, Tianyi Chen, Anli Wang, Jiakai Fang, Jiye Wang, Weixuan Yao, Yuanzhao Wu. (2021) Anisodamine affects the pigmentation, mineral density, craniofacial area, and eye development in zebrafish embryos. JOURNAL OF APPLIED TOXICOLOGY, 42 (6): (1067-1077). [PMID:34967033] [10.1002/jat.4278] |
| 9. Yu Wang, Xing-yi Huang, Joshua Aheto, Yi Ren, Xiaorui Zhang, Li Wang. (2021) Novel colorimetric sensor array for Chinese rice wine evaluation based on color reactions of flavor compounds. JOURNAL OF FOOD PROCESS ENGINEERING, 44 (12): (e13889). [PMID:] [10.1111/jfpe.13889] |
| 10. Song Zhi-Man, Zhang Jun-Liang, Zhou Kun, Yue Lu-Ming, Zhang Yu, Wang Chang-Yun, Wang Kai-Ling, Xu Ying. (2021) Anthraquinones as Potential Antibiofilm Agents Against Methicillin-Resistant Staphylococcus aureus. Frontiers in Microbiology, [PMID:34539607] [10.3389/fmicb.2021.709826] |
| 11. Wen Wang, Jiaxing Zhang, Wei Qi, Rongxin Su, Zhimin He, Xin Peng. (2021) Alizarin and Purpurin from Rubia tinctorum L. Suppress Insulin Fibrillation and Reduce the Amyloid-Induced Cytotoxicity. ACS Chemical Neuroscience, [PMID:34033711] [10.1021/acschemneuro.1c00177] |
| 12. Zhen Deshuai, Shi Sisi, Gao Chan, Kang Qing, Xiao Xilin, Grimes Craig A., Cai Qingyun. (2020) Bi, Fe, and Ti ternary co-doped ZrO2 nanocomposites as a mass spectrometry matrix for the determination of bisphenol A and tetrabromobisphenol A in tea. MICROCHIMICA ACTA, 187 (10): (1-10). [PMID:32980997] [10.1007/s00604-020-04544-9] |
| 13. Meichen Li, Yaru Li, Jingyu Zhao, Mingcheng Li, Yongchuan Wu, Ping Na. (2020) Alizarin-TiO2 LMCT Complex with Oxygen Vacancies: An Efficient Visible Light Photocatalyst for Cr(VI) Reduction. CHINESE JOURNAL OF CHEMISTRY, 38 (11): (1332-1338). [PMID:] [10.1002/cjoc.202000080] |
| 14. Hao Tang, Hong Zhou. (2019) A novel nitrogen, phosphorus, and boron ionic pair compound toward fire safety and mechanical enhancement effect for epoxy resin. POLYMERS FOR ADVANCED TECHNOLOGIES, 31 (4): (885-897). [PMID:] [10.1002/pat.4823] |
| 15. Kai-Yuan Huang, Hong-Xing He, Shao-Bin He, Xiang-Ping Zhang, Hua-Ping Peng, Zhen Lin, Hao-Hua Deng, Xing-Hua Xia, Wei Chen. (2019) Gold nanocluster-based fluorescence turn-off probe for sensing of doxorubicin by photoinduced electron transfer. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2019.126656] |
| 16. Xiao-Fei Shang, Zhong-Min Zhao, Jun-Cai Li, Guan-Zhou Yang, Ying-Qian Liu, Li-Xia Dai, Zhi-Jun Zhang, Zhi-Gang Yang, Xiao-Lou Miao, Cheng-Jie Yang, Ji-Yu Zhang. (2019) Insecticidal and antifungal activities of Rheum palmatum L. anthraquinones and structurally related compounds. INDUSTRIAL CROPS AND PRODUCTS, [PMID:] [10.1016/j.indcrop.2019.05.055] |
| 17. Bing Zhang, Xuehua Yin, Deshuai Zhen, Wenhong Gu, Yingju Liu, Qingyun Cai. (2017) Au nanoparticle-modified WO3 nanoflowers/TiO2 nanotubes used for the SERS detection of dyes. NEW JOURNAL OF CHEMISTRY, 41 (22): (13968-13973). [PMID:] [10.1039/C7NJ02998E] |
| 18. Wang Qianqian, Xu Yixiang, Xu Jiaqi, Wang Xudong, Shen Chen, Zhang Yan, Liu Xiufeng, Yu Boyang, Zhang Jian. (2017) Molecular cloning and expression of a glycosyltransferase from Bacillus subtilis for modification of morin and related polyphenols. BIOTECHNOLOGY LETTERS, 39 (8): (1229-1235). [PMID:28484911] [10.1007/s10529-017-2352-z] |
| 19. JinTao He, Qiong Peng, JingJing Wang, Jing Deng, Wen Li, QinLu Lin, FeiFei Zhong, Xu Xia. (2025) An intelligent thymol/alizarin-loaded polycaprolactone/gelatin/zein nanofibrous film with pH-responsive and antibacterial properties for shrimp freshness monitoring and preservation. FOOD CHEMISTRY, [PMID:39799688] [10.1016/j.foodchem.2025.142812] |
| 20. Ling Zhu, Yue-Ling Bai, Yongmei Zhao, Feifei Xing, Ming-Xing Li, Shourong Zhu. (2019) Bis(2-pyridylmethyl)amine-functionalized alizarin: an efficient and simple colorimetric sensor for fluoride and a fluorescence turn-on sensor for Al3+ in an organic solution. DALTON TRANSACTIONS, 48 (15): (5035-5047). [PMID:30916697] [10.1039/C9DT00859D] |
| 21. Yingran Xu, Kai Wang, Pan Liu, Zheng Wang, Wenya Liu, Zan Yang, Wanqi Jiang, Yibin Zhou, Mingming Zheng, Yaqing Xiao, Yingnan Liu. (2024) A novel dual-channel cassava starch/polyvinyl alcohol-based film for visual monitoring of shrimp freshness. CARBOHYDRATE POLYMERS, [PMID:38616081] [10.1016/j.carbpol.2024.122107] |
| 22. Guangmei Xia, Yingying Ma, Qiance Ma, Xiaohui Yao, Zhen Xu, Xingxiang Ji, Fengshan Zhang. (2024) Anti-ultraviolet, antioxidant and pH-responsive cellulose-based composite film incorporated with alizarin for intelligent packaging applications. Food Packaging and Shelf Life, [PMID:] [10.1016/j.fpsl.2024.101413] |
| 23. Shen Zhang, Zhuo Wang, Tianyu Miao. (2025) Tryptophan-functionalized gold nanoclusters used as a fluorescence sensor for alizarin determination. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:40054145] [10.1016/j.saa.2025.125963] |
| 24. Jianing Zhang, Junjun Zhang, Lei Zhou, Nurmymeti Yasen, Abudulekemu Abudinaibi, Xiaowei Huang, Xiaodong Zhai, Zhihua Li, Jiyong Shi, Remah Sobhy, Ibrahim Khalifa, Xiaobo Zou. (2025) Two different fabrication method of high-hydrophobic Bi-layer indicators based on sodium alginate-polyvinyl alcohol/chitosan-zein incorporated with alizarin@ZIF-8 for beef freshness visualization. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:40074125] [10.1016/j.ijbiomac.2025.141954] |
| 25. Yaping Huang, Botian Zhu, Xuyang Feng, Hualin Zhang, Haoyou Jiang, Yongfang Qian, Ying Wang. (2025) The Antibacterial and pH Responsive Dual-Function (Sc2O3-MgO)/Alizarin/Polycaprolactone/Polyvinylpyrrolidone Nanofiber Membranes for Fresh Shrimp Packaging. Journal of Macromolecular Science Part B-Physics, [PMID:] [10.1080/00222348.2025.2492969] |
| 26. Min Zhang, Enguang Zuo, Xiaoxi Wu, Yuanjia Wang, Wenxue Xiao, Huamao Wei, Ru Jia, Tao Huang, Wenge Yang, Zhaohui Qiao. (2025) An intelligent and active polyvinyl alcohol hydrogel packaging incorporating alizarin and Zn-MOF for shrimp freshness monitoring and preservation. FOOD CHEMISTRY, [PMID:41101017] [10.1016/j.foodchem.2025.146678] |
| 27. Shouyan Zhu, Huimin Wu, Rongrong Ma, Xiaoying Wang, Qin Wu. (2025) pH-responsive color indicator film based on sodium carboxymethylcellulose and natural acid buffering matrix for real-time beef sub-freshness monitoring. NEW JOURNAL OF CHEMISTRY, [PMID:] [10.1039/D5NJ04148A] |
| 28. Rui Chen, Yiwen Xie, Yunyan Bai, Kerang Huang, Xuemei Liao, Yulin Liu, Rong Wang. (2026) Dual-function photosensitive bacterial cellulose film for real-time meat freshness monitoring and rapid sterilization. FOOD CONTROL, [PMID:] [10.1016/j.foodcont.2026.112049] |
| 29. Jiaxing Zhang, Wen Wang, Zubiyan Yibula, Xin Peng, Rongxin Su, Wei Qi. (2026) Anthraquinones Inhibit Insulin Amyloidosis in Crowded Environments. MOLECULES, 31 (7): (1092). [PMID:] [10.3390/molecules31071092] |
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