Aloin - 10mM in DMSO , CAS No.1415-73-2

CAS: 1415-73-2 Cat. No.: A408967 Formula: C₂₁H₂₂O₉ Molecular Weight: 418.39 Beilstein Registry Number: 6077558 EC Number: 215-808-0

GRADE & PURITY 10mM in DMSO

Synonyms

Barbaloin, Barbalin | 9(10H)-Anthracenone, 10-β-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-, (10S)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Aloin Aloin (Barbaloin, Barbalin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.
In vitro

Aloin, a natural anthracycline from Aloe vera, is a tyrosinase inhibitor with inhibitory rates of 2mM. Aloin shows a pronounced antiproliferative effect at physiological concentration (IC50 = 97 μM), causes cell cycle arrest in the S phase and markedly increases HeLaS3 cell apoptosis (to 24%). Aloin causes a reduction in the proportion of cells undergoing mitosis by induction of apoptosis, inhibition of topo II alpha protein expression and downregulation of cyclin B1 protein expression in MCF-7 cell line.

In vivo

Cell Data

cell lines：HF1A3, HF4.9 and HF28RA cells

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyms

Barbaloin, Barbalin | 9(10H)-Anthracenone, 10-β-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-, (10S)-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Aloin (Barbaloin, Barbalin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

Isomeric SMILES

C1=CC2=C(C(=C1)O)C(=O)C3=C([C@H]2[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C=C(C=C3O)CO

WGK Germany

3

RTECS

LZ6520000

Molecular Weight

418.39

Beilstein

6077558

Reaxy-Rn

25113924

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25113924&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 177 mg/mL (199.94 mM); Water: 177 mg/mL (199.94 mM); Ethanol: 177 mg/mL (199.94 mM)
• Melt Point(°C): 148-149°C

Frequently Asked Questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1415-73-2, the molecular formula is C21H22O9, and the molecular weight is 418.39 g/mol.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.