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AMG 18 hydrochloride - ≥98%(HPLC) , CAS No.2250019-92-0

CAS: 2250019-92-0 Cat. No.: A288841 Molecular Weight: 637.58 PubChem CID: 134160238
COA
AMG 18 hydrochloride - ≥98%(HPLC) CAS No(2250019-92-0) by Aladdin Scientific
AVAILABLE TO ORDER
GRADE & PURITY ≥98%(HPLC)
Synonyms
2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
1mg
A288841-1mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$209.90
5mg
A288841-5mg
2
$459.90
10mg
A288841-10mg
2
$699.90
25mg
A288841-25mg
2
$1,399.90
50mg
A288841-50mg
2
$2,039.90
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Overview Specifications Names and Identifiers Documentation Advanced Data 3D Structure Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews
🧪

Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Kira8 Hydrochloride (AMG-18 Hydrochloride) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.

Specifications

Synonyms
2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride
Specifications & Purity
≥98%(HPLC)
Biochemical and Physiological Mechanisms
Potent and selective IRE1α inhibitor (IC50values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥98%(HPLC)
Names and Identifiers
Canonical SmilesCC1=C(C2=C(C=C1)C(=CC=C2)NS(=O)(=O)C3=CC=CC=C3Cl)OC4=C(C=CC=N4)C5=NC(=NC=C5)NC6CCCNC6.Cl
IUPAC Name2-chloro-N-[6-methyl-5-[3-[2-[[(3S)-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxynaphthalen-1-yl]benzenesulfonamide;hydrochloride
InChIKeyCNWIPRHGMZTPSB-BOXHHOBZSA-N
INCHI1S/C31H29ClN6O3S.ClH/c1-20-13-14-22-23(8-4-11-27(22)38-42(39,40)28-12-3-2-10-25(28)32)29(20)41-30-24(9-6-17-34-30)26-15-18-35-31(37-26)36-21-7-5-16-33-19-21;/h2-4,6,8-15,17-18,21,33,38H,5,7,16,19H2,1H3,(H,35,36,37);1H/t21-;/m0./s1
PubChem CID 134160238
Molecular Weight 637.58

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

3D Structure
Interactive Chemical Structure Model





Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate TypeDateItem
A2417049Certificate of AnalysisDec 15, 2023 A288841
A2417050Certificate of AnalysisDec 15, 2023 A288841
A2417051Certificate of AnalysisDec 15, 2023 A288841
A2417052Certificate of AnalysisDec 15, 2023 A288841
A2417053Certificate of AnalysisDec 15, 2023 A288841
A2417055Certificate of AnalysisDec 15, 2023 A288841
A2417056Certificate of AnalysisDec 15, 2023 A288841
A2417057Certificate of AnalysisDec 15, 2023 A288841
Chemical and Physical Properties
SolubilitySolvent:water, Max Conc. mg/mL: 63.76, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 63.76, Max Conc. mM: 100
Solution Calculators
Reviews

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