AR7 - 10mM in DMSO , CAS No.80306-38-3

CAS: 80306-38-3 Cat. No.: A426075 Formula: C₁₅H₁₂ClNO Molecular Weight: 257.71 EC Number: 806-133-8

GRADE & PURITY 10mM in DMSO

Synonyms

MFCD27978377 | SCHEMBL12206685 | 7-chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine | AKOS032946191 | EX-A1249 | BCP25687 | HY-101106 | AR7 | AR-7 | 7-Chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine | 7-chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine | NCGC00347937-01 |

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

AR7 AR7 is a retinoic acid receptor α (RARα) antagonist.

application：

AR7 has been used:

• as chaperone-mediated autophagy (CMA) activator to study the activity of CMA in rat liver lysosomes

• as a CMA activator to study its effects on expression of DEAD-box helicase 3 X-linked (DDX3X), eukaryotic translation initiation factor 4A1 (EIF4A1), and eukaryotic translation initiation factor 4H (EIF4H) in cancer cells

• to study its effects on synuclein α (SNCA) oligomer levels in mature primary cortical neurons

Specifications

Synonyms

MFCD27978377 | SCHEMBL12206685 | 7-chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine | AKOS032946191 | EX-A1249 | BCP25687 | HY-101106 | AR7 | AR-7 | 7-Chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine | 7-chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine | NCGC00347937-01 |

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

AR7 is a retinoic acid receptor α (RARα) antagonist.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Names and Identifiers

Pubchem Sid

528763121

Canonical Smiles

CC1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)Cl)OC2

IUPAC Name

7-chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine

InChIKey

MVOZLTFXYGHZPM-UHFFFAOYSA-N

INCHI

1S/C15H12ClNO/c1-10-2-4-11(5-3-10)14-9-18-15-8-12(16)6-7-13(15)17-14/h2-8H,9H2,1H3

Isomeric SMILES

CC1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)Cl)OC2

WGK Germany

3

Molecular Weight

257.71

Reaxy-Rn

20039175

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20039175&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Benzoxazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Benzoxazines
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzoxazines
• Alternative Parents: Toluenes Alkyl aryl ethers Aryl chlorides Ketimines Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Azacyclic compounds Organochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzoxazine - Alkyl aryl ether - Toluene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Benzenoid - Ketimine - Oxacycle - Azacycle - Ether - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Hydrocarbon derivative - Imine - Organic oxygen compound - Organohalogen compound - Organochloride - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as benzoxazines. These are organic compounds containing a benzene fused to an oxazine ring (a six-membered aliphatic ring with four carbon atoms, one oxygen atom, and one nitrogen atom).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Chemical and Physical Properties

• Molecular Weight: 257.709 g/mol
• XLogP3: 4.100
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 257.061 Da
• Monoisotopic Mass: 257.061 Da
• Topological Polar Surface Area: 21.600 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 322.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1