10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Desiccated,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
BCI ((E)-BCI) hydrochloride is a DUSP6 ( dual specificity phosphatase 6 ) inhibitor. BCI hydrochloride shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI hydrochloride can be used in inflammatory disease research
In Vitro
BCI (100 ng/mL; 24 h) downregulats the expression of DUSP6 in RAW264.7 macrophage cells. BCI (0-1 nM; 24 h) inhibits the expression of IL-1β and IL-6 in lipopolysaccharide- (LPS-) activated macrophages. BCI (0-4 nM; 24 h) decreases ROS production and activates the Nrf2 Pathway in LPS-activated macrophages. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: RAW264.7 macrophage cells Concentration: 100 ng/mL Incubation Time: 24 hours Result: Showed DUSP6 protein downregulation. RT-PCRCell Line: RAW264.7 macrophage cells Concentration: 0-1 nM Incubation Time: 24 hours Result: Inhibited the expression of IL-1β and IL-6 mRNA in LPS-activated macrophages.
IC50& Target:DUSP6
Specifications
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
BCI ((E)-BCI) hydrochloride is a DUSP6 ( dual specificity phosphatase 6 ) inhibitor. BCI hydrochloride shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI hydrochloride can be used in inflammatory disease research
Storage
Desiccated, Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
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