GRADE & PURITY ≥85%(HPLC)

Synonyms

C8X | SCHEMBL26378 | Terephthalic acid, bis(2-hydroxyethyl) ester | ETHYLENE GLYCOL, TEREPHTHALATE (2:1) | TEREPHTHALICACIDBIS(2-HYDROXYETHYL)ESTER | 1,4-bis(hydroxyethyl) terephthalate | BS-49322 | J61IL5R964 | Bis(2-hydroxyethyl) terephthalate # | bis(2

Storage

Room temperature,Argon charged

Shipped In

Normal

Overview

Bis(2-hydroxyethyl) Terephthalate is used in the synthesis of branched polyethylene terephthalate.

Bis(2-hydroxyethyl) terephthalate belongs to a class of monomers known as diols or ethylene glycol derivatives. It's widely used in the synthesis of unsaturated polyester resins, polyethylene terephthalate (PET), and new biocompatible polymer systems. BHET can also be used as a plasticizer for polyester resins and rigid or flexible polyurethanes. Additionally, due to its excellent biocompatibility and mechanical properties, BHET and its derivatives are being researched for biomedical applications, including drug delivery and tissue engineering.

Specifications

Synonyms

C8X | SCHEMBL26378 | Terephthalic acid, bis(2-hydroxyethyl) ester | ETHYLENE GLYCOL, TEREPHTHALATE (2:1) | TEREPHTHALICACIDBIS(2-HYDROXYETHYL)ESTER | 1, 4-bis(hydroxyethyl) terephthalate | BS-49322 | J61IL5R964 | Bis(2-hydroxyethyl) terephthalate # | bis(2

Specifications & Purity

≥85%(HPLC)

Biochemical and Physiological Mechanisms

Ester of ethylene glycol and terephthalic acid. Used in the synthesis of branched polyethylene terephthalate.

Storage

Room temperature, Argon charged

Shipped In

Normal

Note

Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥85%(HPLC)

Names and Identifiers

• Pubchem Sid: 488181901
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488181901
• Canonical Smiles: C1=CC(=CC=C1C(=O)OCCO)C(=O)OCCO
• IUPAC Name: bis(2-hydroxyethyl) benzene-1,4-dicarboxylate
• InChIKey: QPKOBORKPHRBPS-UHFFFAOYSA-N
• INCHI: 1S/C12H14O6/c13-5-7-17-11(15)9-1-2-10(4-3-9)12(16)18-8-6-14/h1-4,13-14H,5-8H2
• Isomeric SMILES: C1=CC(=CC=C1C(=O)OCCO)C(=O)OCCO
• Molecular Weight: 254.24
• Beilstein: 9(4)3310
• Reaxy-Rn: 1915096
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1915096&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Benzoic acids and derivatives
        • Level5 Phthalic acid and derivatives
          • Level6 Phthalate esters
            • Level7 p-Phthalate esters

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Benzoic acids and derivatives
• Intermediate Tree Nodes: Phthalic acid and derivatives - Phthalate esters
• Direct Parent: p-Phthalate esters
• Alternative Parents: P-phthalic acid and derivatives Benzoic acid esters Benzoyl derivatives Dicarboxylic acids and derivatives Carboxylic acid esters Primary alcohols Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Para-phthalic acid ester - Para_phthalic_acid - Benzoate ester - Benzoyl - Dicarboxylic acid or derivatives - Carboxylic acid ester - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Primary alcohol - Organooxygen compound - Alcohol - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as p-phthalate esters. These are ester derivatives of p-phthalic acids, which are based on a benzene 1,4-dicarboxylic acid skeleton.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Not miscible or difficult to mix in water；(soluble) in alcohol
• Sensitivity: Air sensitive
• Melt Point(°C): 106℃
• Molecular Weight: 254.240 g/mol
• XLogP3: 1.700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 8
• Exact Mass: 254.079 Da
• Monoisotopic Mass: 254.079 Da
• Topological Polar Surface Area: 93.100 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 242.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Bo Liu, Bing Liu, Zhangbin Liao, Jialin Zhang, Liying Guo.  (2023)  Preparation of functionalised heteropolyacid ionic liquids and their application in catalytic degradation of bottle-grade polyester.  NEW JOURNAL OF CHEMISTRY,  47  (43): (19943-19952).  [PMID:] [10.1039/D3NJ04367C]

2. Wankui Jiang, Jingxiang Sun, Weiliang Dong, Jie Zhou, Yujia Jiang, Wenming Zhang, Fengxue Xin, Min Jiang.  (2023)  Characterization of a novel esterase and construction of a Rhodococcus-Burkholderia consortium capable of catabolism bis (2-hydroxyethyl) terephthalate.  ENVIRONMENTAL RESEARCH,      [PMID:37783328] [10.1016/j.envres.2023.117240]

3. Xiaoyan Qi, Mukan Ji, Chao-Fan Yin, Ning-Yi Zhou, Yongqin Liu.  (2023)  Glacier as a source of novel polyethylene terephthalate hydrolases.  ENVIRONMENTAL MICROBIOLOGY,  25  (12): (2822-2833).  [PMID:37775503] [10.1111/1462-2920.16516]

4. Haitao Yu, Yang Wang, Lan Chen, Chenyang Wei, Tiancheng Mu, Zhimin Xue.  (2023)  Biobased dimethyl isosorbide as an efficient solvent for alkaline hydrolysis of waste polyethylene terephthalate to terephthalic acid.  GREEN CHEMISTRY,  25  (19): (7807-7816).  [PMID:] [10.1039/D3GC02308G]

5. Ling-Xia Yun, Yan Wei, Qian Sun, Yu-Ting Li, Bin Zhang, Hang-Tian Zhang, Zhi-Gang Shen, Jie-Xin Wang.  (2023)  Magnetic hollow micro-sized nanoaggregates for synergistically accelerating PET glycolysis.  GREEN CHEMISTRY,  25  (17): (6901-6913).  [PMID:] [10.1039/D3GC01762A]

6. Hongjie Chen, Haoquan Hu.  (2023)  Solvent System with Improved Hydroxide Reactivity for Mild and High-Efficiency PET Alkaline Hydrolysis.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.3c01424]

7. Renwen Tian, Yan Sun.  (2023)  α-Synuclein: A fusion chaperone significantly boosting the enzymatic performance of PET hydrolase.  CHINESE JOURNAL OF CHEMICAL ENGINEERING,      [PMID:] [10.1016/j.cjche.2023.06.015]

8. Zhangbin Liao, Yunlong Duan, Liying Guo, Rongrong Zheng, Liyan Wang, Yanming Chen, Linnan Zhang, Xin Qian.  (2023)  Preparation of a heteropoly acid ionic liquid and its application in the catalytic degradation of bottle-grade PET.  NEW JOURNAL OF CHEMISTRY,  47  (9): (4337-4345).  [PMID:] [10.1039/D2NJ05985A]

9. Qing-Song Huang, Zheng-Fei Yan, Xiao-Qian Chen, Yan-Yi Du, Juan Li, Zhan-Zhi Liu, Wei Xia, Sheng Chen, Jing Wu.  (2021)  Accelerated biodegradation of polyethylene terephthalate by Thermobifida fusca cutinase mediated by Stenotrophomonas pavanii.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:34864034] [10.1016/j.scitotenv.2021.152107]

10. Kun Chen, Mingqin Quan, Xiaoyan Dong, Qinghong Shi, Yan Sun.  (2021)  Low modification of PETase enhances its activity toward degrading PET: Effect of conjugate monomer property.  BIOCHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.bej.2021.108151]

11. Zishuai Wang, Yaoqiang Wang, Shengnan Xu, Yu Jin, Zequn Tang, Gang Xiao, Haijia Su.  (2021)  A pseudo-homogeneous system for PET glycolysis using a colloidal catalyst of graphite carbon nitride in ethylene glycol.  POLYMER DEGRADATION AND STABILITY,      [PMID:] [10.1016/j.polymdegradstab.2021.109638]

12. Qiuli Cheng, Danfeng Cao, Xiuju Liu, Yan Zheng, Zuosen Shi, Song Zhu, Zhanchen Cui.  (2019)  Superhydrophobic coatings with self-cleaning and antibacterial adhesion properties for denture base.  Journal of the Mechanical Behavior of Biomedical Materials,      [PMID:31229907] [10.1016/j.jmbbm.2019.06.006]

13. Lulu Deng, Shuang Yang, Hailong He, Jie Chen, Chenyuan Zhang, Zhongqi Liu, Lei Wang.  (2025)  A “polymer-to-polymer” recycling of PET by the dissolution-precipitation strategy.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2025.115684]

14. Kai Xue, Zhonghu Bai, Eric Fordour, Siqi Guo, Yuxuan Zhou, Yankun Yang, Xiuxia Liu, Ye Li, Chun-Li Liu.  (2024)  Bacterial surface display of PETase mutants and MHETase for an efficient dual-enzyme cascade catalysis.  BIORESOURCE TECHNOLOGY,      [PMID:39097240] [10.1016/j.biortech.2024.131177]

15. Haixia Wang, Jiahong Zhu, Meng Sun, Mengjie Gu, Xiya Xie, Tongtong Ying, Zeling Zhang, Weihong Zhong.  (2024)  Biodegradation of combined pollutants of polyethylene terephthalate and phthalate esters by esterase-integrated Pseudomonas sp. JY-Q with surface-co-displayed PETase and MHETase.  Synthetic and Systems Biotechnology,      [PMID:39206086] [10.1016/j.synbio.2024.08.001]

16. Taishun Yang, Hao He, Shiyu Yan, Jiaojiao Gao, Zixu Yang, Jing Xu.  (2024)  Catalytic depolymerization of poly(ethylene terephthalate) plastic into value-added monomers using metal-modified mesoporous silica.  FUEL,      [PMID:] [10.1016/j.fuel.2024.133858]

17. Zhongqing Shen, Zixian Jia, Kunpeng Yu, Jing Xie, Lijiao Qin, Lin Gao, Baozhong Li, Xuehai Wang, Jianzhong Yin.  (2024)  CO2-enhanced PET depolymerization by catalyst free methanolysis.  PROCESS SAFETY AND ENVIRONMENTAL PROTECTION,      [PMID:] [10.1016/j.psep.2024.05.054]

18. Zheng-Fei Yan, Chu-Qi Feng, Jian-Qiao Zhou, Qing-Song Huang, Xiao-Qian Chen, Wei Xia, Jing Wu.  (2024)  Complete degradation of PET waste using a thermophilic microbe-enzyme system.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38246467] [10.1016/j.ijbiomac.2024.129538]

19. Zhi Qu, Yan Sun.  (2024)  Computer-Aided Site-Specific PEGylation of PET Hydrolases for Enhanced PET Degradation.  ACS Applied Materials & Interfaces,      [PMID:39370989] [10.1021/acsami.4c12187]

20. Zhi Wang, Jiaxing Zhang, Shengping You, Rongxin Su, Wei Qi.  (2025)  Energy-Guided Accumulated Mutation Strategy Achieves a Highly Efficient Polyethylene Terephthalate-Degrading Enzyme.  BIOCHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.bej.2025.109708]

21. Qing-Song Huang, Si-Qi Chen, Xiao-Min Zhao, Li-Jun Song, Yu-Ming Deng, Ke-Wei Xu, Zheng-Fei Yan, Jing Wu.  (2024)  Enhanced degradation of polyethylene terephthalate (PET) microplastics by an engineered Stenotrophomonas pavanii in the presence of biofilm.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:39461526] [10.1016/j.scitotenv.2024.177129]

22. Guoqiang Zhang, Jieke Du, Chengsong Zhang, Zhiyi Zhao, Yuexing Chen, Mingyu Liu, Jianwei Chen, Guangyi Fan, Li Ma, Shengying Li, Kun Liu.  (2024)  Identification of a PET hydrolytic enzyme from the human gut microbiome unveils potential plastic biodegradation in human digestive tract.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39551294] [10.1016/j.ijbiomac.2024.137732]

23. Zhi Qu, Lin Zhang, Yan Sun.  (2024)  Molecular Insights into the Enhanced Activity and/or Thermostability of PET Hydrolase by D186 Mutations.  MOLECULES,  29  (6): (1338).  [PMID:38542974] [10.3390/molecules29061338]

24. Lizhu Aer, Qifa Jiang, Linling Zhong, Qiuyue Si, Xianghong Liu, Yan Pan, Juan Feng, Hongjuan Zeng, Lixia Tang.  (2024)  Optimization of polyethylene terephthalate biodegradation using a self-assembled multi-enzyme cascade strategy.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:38901251] [10.1016/j.jhazmat.2024.134887]

25. Zishuai Wang, Jing Shi, Yu Jin, Gang Xiao, Haijia Su.  (2025)  Recyclable Zinc Cyanamide Dual-Site Catalyst Enables Efficient PET Glycolysis.  ACS Applied Polymer Materials,      [PMID:] [10.1021/acsapm.4c03337]

26. Si-Qi Chen, Qing-Song Huang, Yang Li, Jing Wu, Sheng Chen, Zheng-Fei Yan.  (2024)  Targeted aggregation of PETase towards surface of Stenotrophomonas pavanii for degradation of PET microplastics.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:39312844] [10.1016/j.jhazmat.2024.135895]

27. Lin Gao, Zixian Jia, Lijiao Qin, Haocheng Sun, Xinwei Zhang, Baozhong Li, Xuehai Wang, Jiquan Liu, Jinbo Bai.  (2024)  Using waste to treat waste: Catalysts from spent alkaline batteries for glycolysis of PET waste.  CATALYSIS TODAY,      [PMID:] [10.1016/j.cattod.2024.115143]

28. ZIXIAN JIA, JIE ZHANG, LIN GAO, LIJIAO QIN, HAOCHENG SUN, JIAXING CHEN, Jian-Zhong Yin.  (2025)  Unraveling the role of water on catalytic glycolysis of PET.  RSC Sustainability,      [PMID:] [10.1039/D5SU00528K]

29. Xueying Wen, Ran Niu, Tao Tang, Jiang Gong.  (2025)  Atmospheric, continuous degradation of poly(ethylene terephthalate) waste by ZnO.  APPLIED CATALYSIS B-ENVIRONMENTAL,      [PMID:] [10.1016/j.apcatb.2025.125485]

30. Yi-Mei Cai, Cui-Can Lu, Tian-Tian Wang, Li-Jun Song, Yu-Ming Deng, Han Xu, Sheng Chen, Wei Xia, Jing Wu, Zheng-Fei Yan.  (2025)  Engineering a thermophilic Bacillus thermoamylovorans for degradation of polyethylene terephthalate waste.  Journal of Cleaner Production,      [PMID:] [10.1016/j.jclepro.2025.145472]

31. Taishun Yang, Qingming Fan, Hao He, Chuang Gao, Zixu Yang, Jing Xu.  (2025)  Closed-loop recycling for poly(ethylene terephthalate) (PET) plastic: depolymerization, monomer separation, and recycled PET (rPET).  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.163038]

32. Zhe Bai, Zhixian Bao, Haoquan Hu.  (2025)  Chemical Recycling of Catalytic Glycolysis of Polyethylene Terephthalate with Potassium-Rich Biomass.  Recycling,  10  (3): (85).  [PMID:] [10.3390/recycling10030085]

33. Huijie Wang, Hongzhao Chen, Qingqiao Wan, Yuzhao Zheng, Yang Wan, Xin Liu, Xianghai Song, Wei Ma, Pengwei Huo.  (2025)  Catalytic degradation of polyethylene terephthalate microplastics by Co-N/C@CeO2 composite in thermal-assisted activation PMS system: Process mechanism and toxicological analysis.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.163192]

34. Jing Xie, Lin Li, Jianlei Qi, Xuehai Wang, Haocheng Sun, Jianzhong Yin.  (2025)  Methanolysis of Polyethylene Terephthalate (PET) Catalyzed by Ionic Liquid [Bmim]BF4.  JOURNAL OF POLYMER SCIENCE,      [PMID:] [10.1002/pol.20250074]

35. Lulu Deng, Yao Meng, Zhonghao Chen, Xinrui Li, Lei Wang.  (2026)  Tunable ether-functionalized protic ionic liquid for efficient glycolysis of polyethylene terephthalate.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2026.172817]

36. Haoling Yang, Qi Zhang, Kunyu Xu, Guang Wang, Yiqi Pan, Licheng Lu, Qi Mao, Zihao Yang, Zhaoxia Dong.  (2026)  Adjusting the GeO2 catalyst crystal system to enhance the efficiency of polyester catalysis.  JOURNAL OF CATALYSIS,      [PMID:] [10.1016/j.jcat.2026.116780]

37. Zhi Qu, Zongyang Tian, Zehui Guo, Yan Sun.  (2026)  Rational redesign of FAST-PETase via a “locking” strategy for efficient PET depolymerization.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:] [10.1016/j.jhazmat.2026.141883]