GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

1H-Indol-5-ol, 3-(1-methyl-4-piperidinyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

BRL 54443 is a5-HT1Eand5-HT1Freceptor agonist withpKiof 8.7 and 9.25, respectively, with a weak binding affinity for 5-HT1A, 5-HT1B, 5-HT1D receptors.
In vitro

BRL 54443 has also measurable affinity for the 5-HT_2A receptor. BRL 54443 induces contraction with a −logEC50 of 6.52. Contraction caused by BRL 54443 is likely mediated through stimulation of 5-HT5-HT_2A receptors.

In vivo

BRL 54443 induces an immediate dose-dependent maximal intragastric volume increase vs. saline.
Cell Data

cell lines：Renca or 786-O cells, mouse endothelial cells and splenic CD11b⁺/c^-myeloid cells, HUVECs

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

1H-Indol-5-ol, 3-(1-methyl-4-piperidinyl)-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

BRL 54443 is a 5-HT1E and 5-HT1F receptor agonist with pK_i of 8.7 and 9.25, respectively, with a weak binding affinity for 5-HT1A, 5-HT1B, 5-HT1D receptors.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of 5-ht 1e receptor;Agonist of 5-HT 1F receptor

Names and Identifiers

• Isomeric SMILES: CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)O
• Alternate CAS: 57477-39-1
• Molecular Weight: 230.31
• Reaxy-Rn: 749183
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=749183&ln=

Associated Targets(Human)

HTR1E Tchem 5-hydroxytryptamine receptor 1E (1 Activities)

Discover Target: HTR1E

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR1F Tclin 5-hydroxytryptamine receptor 1F (1 Activities)

Discover Target: HTR1F

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 38 mg/mL (204.04 mM); Ethanol: 15 mg/mL (80.54 mM); Water: Insoluble