Cabotegravir (GSK1265744) - Moligand™, 10mM in DMSO , Human immunodeficiency virus type 1 integrase inhibitor, CAS No.1051375-10-0, Human immunodeficiency virus type 1 integrase inhibitor

CAS: 1051375-10-0 Cat. No.: C409179 Molecular Weight: 405.3522 EC Number: 855-453-4

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

GSK744, S/GSK1265744 | (3S,11aR)- N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Cabotegravir (GSK1265744) Cabotegravir (GSK744, GSK1265744, S/GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, and inhibits the HIV-1 integrase catalyzed strand transfer reaction with IC50 of 3.0 nM. Phase 2.
In vitro

GSK1265744 inhibits HIV replication with EC50 of 0.22 nM and 0.34-1.3 nM against HIV-1 Ba-L and NL432, respectively. GSK1265744 produces cytotoxicity with CC50 of 6.4, 5.0, 9.2, and 13 μM in proliferating IM-9, U-937, MT-4, and Molt-4 cell lines, respectively.

In vivo

GSK1265744 (50 mg/kg) treatment protects rhesus macaques against three high-dose SHIV challenges.
Cell Data

cell lines：Primary cortical neuron of fetal Sprague-Dawley rats\n(embryonic day 17)\n

Concentrations：~20 μM

Incubation Time：--

Powder Purity:≥99%

Specifications

Synonyms

GSK744, S/GSK1265744 | (3S, 11aR)- N-[(2, 4-difluorophenyl)methyl]-2, 3, 5, 7, 11, 11a-hexahydro-6-hydroxy-3-methyl-5, 7-dioxo-oxazolo[3, 2-a]pyrido[1, 2-d]pyrazine-8-carboxamide

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Cabotegravir (GSK744, GSK1265744, S/GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, and inhibits the HIV-1 integrase catalyzed strand transfer reaction with IC50 of 3.0 nM. Phase 2.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Human immunodeficiency virus type 1 integrase inhibitor

Product Properties

• ALogP: 2.1

Names and Identifiers

• Isomeric SMILES: C[C@H]1CO[C@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O
• Molecular Weight: 405.3522
• Reaxy-Rn: 31661431
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31661431&ln=

Chemical and Physical Properties

• Melt Point(°C): 248-251ºC