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Metabolic Disease Targets

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  1. Hydroxocobalamin monohydrochloride - ≥98%, used for , CAS No. 59461-30-2, by Aladdin Scientific
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    Hydroxocobalamin monohydrochloride
    CAS: 58288-50-9 EC Number: 261-200-3 PubChem CID: 46783759 Formula: C62H89CoN13O15P · HCl Molecular Weight: 1382.82
    Solid ≥98%
    Out of Stock Item #: H304094
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    Technical Identifiers
    IUPAC Name
    cobalt(3+);[5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 1-[3-[(4Z,9Z,14Z)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(show more
    SMILES
    CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=N6)C(=C7C(C(C(=N7)C=C8C(C(C(=N8)C(=C4[N-]5)C)CCC(=O)N)(C)C)CCC(=O)N)(Cshow more
    InChIKey
    KEHNCSYXYMMUCO-UHFFFAOYSA-K
    InChI
    1S/C62H90N13O14P.ClH.Co.H2O/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80show more
    Synonyms
    cobalt(3+);[5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 1-[3-[(4Z,9Z,14Z)-2,13,18-tris(...
  2. Recombinant Mouse Leptin Protein
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    Recombinant Mouse Leptin Protein
    CAS: 181030-10-4 Formula: NA
    Lyophilized Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Bioactive ? Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure. ActiBioPure™ ? ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required. PBS Only ? PBS-only formulation — supplied in phosphate-buffered saline with no other additives. Use when you need a clean PBS buffer free of stabilizers/carriers. ≥95%(SDS-PAGE)
    In Stock Item #: L329647
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    Pricing & Pack Sizes
    Technical Identifiers
    Species
    Mouse
    Accession #
    Q544U0
    Expression system
    E. coli
    Protein Day
    No tag
    Endotoxin Concentration
    <1.0 EU/μg
    Bioactivity
    Immobilized Recombinant Mouse LEPR (C-10His) at 5μg/ml (100 μl/well) can bind Recombinant Mouse Leptin Biotinylated by NHS-biotin prior to testing.The ED50 of Recombinant Mouse Leptin is 1.16 ng/ml. Loaded Recombinant Mouse LEPR (C-10His) on HIS1K Biosensor, can bind Recombinant Mouse Leptin with an affinity constant of 0.196 nM as determined in BLI assay.
    Synonyms
    FLJ94114 | LEP | leptin (murine obesity homolog) | leptin (obesity homolog, mouse) | Leptin | OB | Obese protein | ob...
  3. Linderane - analytical standard,≥98%, used for , CAS No. 13476-25-0, by Aladdin Scientific
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    Linderane
    CAS: 13476-25-0 Formula: C15H16O4 Molecular Weight: 260.285
    Solid Analytical standard ? Analytical standard — certified-purity material for quantitative calibration. Use to prepare calibration standards and validate analytical methods. Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: L115734
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    Technical Identifiers
    IUPAC Name
    (1S,4E,12S,13S)-5,10-dimethyl-8,14,16-trioxatetracyclo[10.2.2.01,13.07,11]hexadeca-4,7(11),9-trien-15-one
    SMILES
    CC1=CCCC23C(O2)C(C4=C(C1)OC=C4C)OC3=O
    InChIKey
    KBMSVODXFLAQNJ-DXGHHDSJSA-N
    InChI
    1S/C15H16O4/c1-8-4-3-5-15-13(19-15)12(18-14(15)16)11-9(2)7-17-10(11)6-8/h4,7,12-13H,3,5-6H2,1-2H3/b8-4+/t12-,13-,15-/m0/s1
  4. Recombinant Mouse TNF-alpha Protein - by
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    Recombinant Mouse TNF-alpha Protein
    Lyophilized Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Bioactive ? Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure. ActiBioPure™ ? ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. High Performance ? High-performance grade with optimized purity and performance characteristics. Use for sensitive analyses where ordinary grades fall short. PBS Only ? PBS-only formulation — supplied in phosphate-buffered saline with no other additives. Use when you need a clean PBS buffer free of stabilizers/carriers. ≥97%(SDS-PAGE&HPLC)
    In Stock Item #: rp154759
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    Pricing & Pack Sizes
    Technical Identifiers
    Species
    Mouse
    Accession #
    P06804
    Expression system
    E. coli
    Protein Day
    No tag
    Endotoxin Concentration
    <0.01 EU/μg
    Bioactivity
    Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D (Catalog # A113142). The ED₅₀ for this effect is typically <0.1 ng/mL.
    Synonyms
    Recombinant Murine Tumor Necrosis Factor alpha (rMuTNF-α) | APC1 protein | Cachectin | Cachetin | DIF | TNF | TNF, mo...
  5. Recombinant Human TNF-alpha Protein
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    Recombinant Human TNF-alpha Protein
    Liquid Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Bioactive ? Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure. ActiBioPure™ ? ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required. High Performance ? High-performance grade with optimized purity and performance characteristics. Use for sensitive analyses where ordinary grades fall short. ≥95%(SDS-PAGE) See COA
    In Stock Item #: rp152506
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    Pricing & Pack Sizes
    Technical Identifiers
    Species
    Human
    Accession #
    P01375
    Expression system
    E. coli
    Protein Day
    No tag
    Endotoxin Concentration
    <0.1 EU/μg
    Bioactivity
    Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D (Catalog # A113142). The ED₅₀ for this effect is typically <0.05 ng/mL.
    Synonyms
    APC1 protein | Cachectin | Cachetin | DIF | TNF | TNF, monocyte-derived | TNFA | TNF-A | TNFalpha | TNF-alpha | TNF-a...
  6. Recombinant Human IL-2 Protein
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    Recombinant Human IL-2 Protein
    Lyophilized Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Bioactive ? Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure. ActiBioPure™ ? ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. High Performance ? High-performance grade with optimized purity and performance characteristics. Use for sensitive analyses where ordinary grades fall short. His Tag ? His tag grade — recombinant protein bearing a His tag for affinity purification/detection. Use to purify, immobilize, or detect the tagged protein. ≥95%(SDS-PAGE)
    In Stock Item #: rp147476
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    Pricing & Pack Sizes
    Technical Identifiers
    Species
    Human
    Accession #
    P60568
    Expression system
    CHO-K1
    Protein Day
    His
    Endotoxin Concentration
    <1.0 EU/μg
    Bioactivity
    1、Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. The ED50 for this effect is typically less than 2.5 ng/mL. 2、Measured in a cell proliferation assay using mouse splenocytes. The ED50 for this effect is typically less than 30.0 ng/mL.
    Synonyms
    IL-2 | T-cell growth factor | TCGF
  7. Recombinant Human Leptin Protein - , expressed in , from , ＞97%(SDS-PAGE and HPLC), used for , CAS No.
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    Recombinant Human Leptin Protein
    Lyophilized Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Bioactive ? Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure. ActiBioPure™ ? ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. High Performance ? High-performance grade with optimized purity and performance characteristics. Use for sensitive analyses where ordinary grades fall short. ≥97%(SDS-PAGE&HPLC)
    In Stock Item #: rp148245
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    Pricing & Pack Sizes
    Technical Identifiers
    Species
    Human
    Accession #
    P41159
    Expression system
    E. coli
    Protein Day
    No tag
    Endotoxin Concentration
    <1.0 EU/μg
    Bioactivity
    Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human Leptin R transfected BaF3 murine proB cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg.
    Synonyms
    FLJ94114 | LEP | Leptin (murine obesity homolog) | Leptin (obesity homolog, mouse) | Leptin | OB | Obese protein | ob...
  8. Recombinant Rat TNF-alpha Protein
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    Recombinant Rat TNF-alpha Protein
    Lyophilized Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Bioactive ? Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure. ActiBioPure™ ? ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. High Performance ? High-performance grade with optimized purity and performance characteristics. Use for sensitive analyses where ordinary grades fall short. His Tag ? His tag grade — recombinant protein bearing a His tag for affinity purification/detection. Use to purify, immobilize, or detect the tagged protein. ≥95%(SDS-PAGE)
    In Stock Item #: rp155241
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    Pricing & Pack Sizes
    Technical Identifiers
    Species
    Rat
    Accession #
    P16599
    Expression system
    HEK293
    Protein Day
    C-His
    Endotoxin Concentration
    <0.1 EU/μg
    Bioactivity
    Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D (Catalog # A113142). The EC50 for this effect is typically <5 pg/mL.
    Synonyms
    APC1 protein | Cachectin | Cachetin | RATTNF | DIF | TNF | TNF, monocyte-derived | TNFA | TNF-A | TNFalpha | TNF-alph...
  9. Recombinant Human Osteoprotegerin Protein - by
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    Recombinant Human Osteoprotegerin Protein
    Lyophilized Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Bioactive ? Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure. ActiBioPure™ ? ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. High Performance ? High-performance grade with optimized purity and performance characteristics. Use for sensitive analyses where ordinary grades fall short. PBS Only ? PBS-only formulation — supplied in phosphate-buffered saline with no other additives. Use when you need a clean PBS buffer free of stabilizers/carriers. ≥95%(SDS-PAGE)
    In Stock Item #: rp149600
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    Pricing & Pack Sizes
    Technical Identifiers
    Species
    Human
    Accession #
    O00300
    Expression system
    E. coli
    Protein Day
    No tag
    Endotoxin Concentration
    <1.0 EU/μg
    Bioactivity
    Fully biologically active when compared to standard. The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10 ng/ml in the presence of 10 ng/mL soluble rHuRANKL (sRANKL).
    Synonyms
    OCIF | OCIFMGC29565 | OPG | OPGtumor necrosis factor receptor superfamily member 11B | Osteoclastogenesis inhibitory ...
  10. Recombinant Human IL-2 Receptor Alpha Protein
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    Recombinant Human IL-2 Receptor Alpha Protein
    Lyophilized Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Bioactive ? Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure. ActiBioPure™ ? ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. High Performance ? High-performance grade with optimized purity and performance characteristics. Use for sensitive analyses where ordinary grades fall short. His Tag ? His tag grade — recombinant protein bearing a His tag for affinity purification/detection. Use to purify, immobilize, or detect the tagged protein. ≥97%(SDS-PAGE)
    In Stock Item #: rp147480
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    Pricing & Pack Sizes
    Technical Identifiers
    Species
    Human
    Accession #
    P01589
    Expression system
    HEK293
    Protein Day
    C-His
    Endotoxin Concentration
    <1.0 EU/μg
    Bioactivity
    1. Measured by its ability to inhibit the IL-2-dependent proliferation of MO7e human megakaryocytic leukemic cells. The ED50 for this effect is 0.2 ‑1.2 µg/mL in the presence of 30 ng/mL of recombinant human IL-2. 2. Immobilized Recombinant Human IL-2 Protein (rp156004) at 1 μg/mL can bind biotinylated Recombinant Human IL-2 Receptor Alpha Protein (rp147480).
    Synonyms
    Interleukin 2 receptor alpha chain | CD25 | CD25 antigen | IDDM10 | IL 2 receptor alpha subunit | IL-2 receptor subun...
  11. Recombinant Human IL-6R Protein
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    Recombinant Human IL-6R Protein
    Lyophilized Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Bioactive ? Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure. ActiBioPure™ ? ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. High Performance ? High-performance grade with optimized purity and performance characteristics. Use for sensitive analyses where ordinary grades fall short. His Tag ? His tag grade — recombinant protein bearing a His tag for affinity purification/detection. Use to purify, immobilize, or detect the tagged protein. ≥90%(SDS-PAGE)
    In Stock Item #: rp147628
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    Pricing & Pack Sizes
    Technical Identifiers
    Species
    Human
    Accession #
    P08887
    Expression system
    HEK293
    Protein Day
    C-His
    Endotoxin Concentration
    <1.0 EU/μg
    Bioactivity
    1. Immobilized Recombinant Human IL-6 Protein at 2 μg/mL can bind Recombinant Human IL-6R Protein (rp147628) the EC50 is 8.0 - 24.0 ng/mL. 2. Measured by its ability to enhance the IL-6 activity on M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 10.0 - 60.0 ng/mL.3. Using the Octet RED System, the affinity constant (Kd) of Recombinant Human IL-6R Protein (rp147628) bound Anti-IL6R Antibody was 0.1 nM.
    Synonyms
    CD126 | gp80 | IL-6 R alpha | IL6Q | IL6R alpha | IL-6R alpha | IL6R | IL-6R-1 | IL6RA | IL-6Ra | IL6RQ | interleukin...
  12. Recombinant Mouse IL-2 Protein
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    Recombinant Mouse IL-2 Protein
    Lyophilized Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Bioactive ? Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure. ActiBioPure™ ? ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. High Performance ? High-performance grade with optimized purity and performance characteristics. Use for sensitive analyses where ordinary grades fall short. His Tag ? His tag grade — recombinant protein bearing a His tag for affinity purification/detection. Use to purify, immobilize, or detect the tagged protein. ≥98%(SDS-PAGE)
    In Stock Item #: rp154174
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    Pricing & Pack Sizes
    Technical Identifiers
    Species
    Mouse
    Accession #
    P04351
    Expression system
    HEK293
    Protein Day
    N-His
    Endotoxin Concentration
    <1.0 EU/μg
    Bioactivity
    Recombinant Mouse IL-2 stimulates cell proliferation of the CTLL-2 mouse cytotoxic T cell line. The ED50 for this effect is typically less than 2.5 ng/mL.
    Synonyms
    Aldesleukin | IL2 | IL-2 | IL-2lymphokine | interleukin 2 | interleukin-2 | involved in regulation of T-cell clonal e...
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