Cefaclor monohydrate - ≥99% , Bacterial penicillin-binding protein inhibitor, CAS No.70356-03-5, Bacterial penicillin-binding protein inhibitor

CAS: 70356-03-5 Cat. No.: C412704 Molecular Weight: 385.83 EC Number: 641-991-5 PubChem CID: 51038

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Cefaclor monohydrate - ≥99% CAS No(70356-03-5) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥99%

Synonyms

(6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate | AS-57307 | Prestwick_783 | CEFACLOR MONOHYDRATE [MI] | NSC-757422 | CCG-220485 | HMS2096B11 | SR-01000000152 | Compound 99638 | J

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Citations of This Product References Solution Calculators Reviews

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Why this grade

≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 4 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

Cefaclor (Cefachlor, Cefaclorum) is a cephalosporin antibiotic.

Specifications

Synonyms

(6R, 7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate | AS-57307 | Prestwick_783 | CEFACLOR MONOHYDRATE [MI] | NSC-757422 | CCG-220485 | HMS2096B11 | SR-01000000152 | Compound 99638 | J

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Cefaclor (Cefachlor, Cefaclorum) is a cephalosporin antibiotic.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Bacterial penicillin-binding protein inhibitor

Purity

≥99%

Names and Identifiers

Pubchem Sid	504753661
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504753661
Canonical Smiles	C1C(=C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)Cl.O
IUPAC Name	(6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate
InChIKey	WKJGTOYAEQDNIA-IOOZKYRYSA-N
INCHI	1S/C15H14ClN3O4S.H2O/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7;/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23);1H2/t9-,10-,14-;/m1./s1
Isomeric SMILES	C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)N)C(=O)O)Cl.O
PubChem CID	51038
Molecular Weight	385.83

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Lactams
    - Subclass Beta lactams
      - Level5 Cephems
        Level6 Cephalosporins

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Lactams
Subclass	Beta lactams
Intermediate Tree Nodes	Cephems
Direct Parent	Cephalosporins
Alternative Parents	N-acyl-alpha amino acids and derivatives Alpha amino acid amides Phenylacetamides Aralkylamines 1,3-thiazines Vinylogous halides Tertiary carboxylic acid amides Azetidines Amino acids Secondary carboxylic acid amides Monocarboxylic acids and derivatives Vinyl chlorides Azacyclic compounds Dialkylthioethers Thiohemiaminal derivatives Carboxylic acids Chloroalkenes Carbonyl compounds Hydrocarbon derivatives Monoalkylamines Organic oxides Organochlorides Organopnictogen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Cephalosporin - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Alpha-amino acid or derivatives - Phenylacetamide - Aralkylamine - Meta-thiazine - Monocyclic benzene moiety - Benzenoid - Vinylogous halide - Tertiary carboxylic acid amide - Amino acid or derivatives - Amino acid - Azetidine - Carboxamide group - Secondary carboxylic acid amide - Azacycle - Chloroalkene - Carboxylic acid derivative - Carboxylic acid - Haloalkene - Monocarboxylic acid or derivatives - Dialkylthioether - Vinyl halide - Vinyl chloride - Thioether - Hemithioaminal - Primary aliphatic amine - Organic oxide - Amine - Hydrocarbon derivative - Organohalogen compound - Organochloride - Organonitrogen compound - Organooxygen compound - Primary amine - Organic nitrogen compound - Carbonyl group - Organic oxygen compound - Organopnictogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as cephalosporins. These are compounds containing a 1,2-thiazine fused to a 2-azetidinone to for a oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid moiety or a derivative thereof.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(non-human)

Streptococcus pneumoniae (31063 Activities)

Lot Number	Certificate Type	Date	Item
A2309316	Certificate of Analysis	Oct 13, 2025	C412704
A2309329	Certificate of Analysis	Oct 13, 2025	C412704
A2309330	Certificate of Analysis	Oct 13, 2025	C412704
A2309341	Certificate of Analysis	Oct 13, 2025	C412704

Solubility	Solubility (25°C) In vitro DMSO: 11 mg/mL (28.51 mM); Water: Insoluble; Ethanol: Insoluble;
Melt Point(°C)	>180° C (dec.)
Molecular Weight	385.800 g/mol
XLogP3
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	385.05 Da
Monoisotopic Mass	385.05 Da
Topological Polar Surface Area	139.000 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	606.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

1. Zhenbin Chen, Haohan Cai, Feng Huang, Zongping Wang, Yiqun Chen, Zizheng Liu, Pengchao Xie. (2024) Degradation of β-lactam antibiotics by Fe(III)/HSO3− system and their quantitative structure-activity relationship. ENVIRONMENTAL RESEARCH, [PMID:38986801] [10.1016/j.envres.2024.119577]
2. Yaowei Zhu, Ruijie Tang, Jun Zhao, Changlong Jiang, Lingfei Li, Bianhua Liu. (2025) Design and application of metal-organic framework based chemo-fluorescent sensor for selective sensing of the full spectrum of tetracyclines in complex samples. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.160281]
3. Xiaona Fang, Tian Gao, Zhaofeng Luo, Renjun Pei. (2025) Efficient selection of vancomycin-specific aptamers via particle display and development of a high-sensitivity fluorescent apta-sensor for vancomycin detection. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2025.137681]
4. Ruijie Tang, Lingfei Li, Yaowei Zhu, Minghui Zhan, Jun Zhao, Changlong Jiang, Bianhua Liu. (2025) Ratiometric fluorescent sensor for sensitive visualization of full-spectrum fluoroquinolone antibiotic residues in the environment. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2025.113260]