Chenodeoxycholic Acid(CDCA) - Moligand™, 10mM in DMSO , Bile acid receptor FXR agonist, CAS No.474-25-9, Bile acid receptor FXR agonist

CAS: 474-25-9 Cat. No.: C408499 Molecular Weight: 392.58 EC Number: 207-481-8

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Chenodiol | (3α,​5β,​7α)​-3,​7-​dihydroxy-cholan-​24-​oic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Chenodeoxycholic Acid Chenodeoxycholic Acid (Chenodiol) is a naturally occurring human bile acid, and inhibits production of cholesterol in the liver and absorption in the intestines. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activat
In vitro

Chenodeoxycholic acid (CDCA) and Deoxycholic acid (DCA) both inhibits 11 beta HSD2 with IC(50) values of 22 mM and 38 mM, respectively and causes cortisol-dependent nuclear translocation and increases transcriptionalactivity of mineralocorticoid receptor (MR). Chenodeoxycholic acid is able to stimulate Ishikawa cell growth by inducing a significant increase in Cyclin D1 protein and mRNA expression through the activation of the membrane G protein-coupled receptor (TGR5)-dependent pathway. Chenodeoxycholic acid (CDCA) induces LDL receptor mRNA levels approximately 4 fold and mRNA levels for HMG-CoA reductase and HMG-CoA synthase two fold in a cultured human hepatoblastoma cell line, Hep G2. Chenodeoxycholic acid-induced Isc is inhibited (≥67%) by Bumetanide, BaCl2, and the cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor CFTRinh-172. Chenodeoxycholic acid-stimulated Isc is decreased 43% by the adenylate cyclase inhibitor MDL12330A and Chenodeoxycholic acid increases intracellular cAMP concentration. Chenodeoxycholic acid treatment activates C/EBPβ, as shown by increases in its phosphorylation, nuclear accumulation, and expression in HepG2 cells. Chenodeoxycholic acid enhances luciferase gene transcription from the construct containing -1.65-kb GSTA2 promoter, which contains C/EBP response element (pGL-1651). Chenodeoxycholic acid treatment activates AMP-activated protein kinase (AMPK), which leads to extracellular signal-regulated kinase 1/2 (ERK1/2) activation, as evidenced by the results of experiments using a dominant-negative mutant of AMPKα and chemical inhibitor.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Chenodiol | (3α, ​5β, ​7α)​-3, ​7-​dihydroxy-cholan-​24-​oic acid

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Chenodeoxycholic Acid (Chenodiol) is a naturally occurring human bile acid, and inhibits production of cholesterol in the liver and absorption in the intestines. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FX

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Bile acid receptor FXR agonist

Product Properties

• ALogP: 4.9

Names and Identifiers

• Isomeric SMILES: C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C
• Molecular Weight: 392.58
• Reaxy-Rn: 2820380
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2820380&ln=

Associated Targets(Human)

FPR1 Tchem fMet-Leu-Phe receptor (1 Activities)

Discover Target: FPR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR1H4 Tclin Bile acid receptor (1 Activities)

Discover Target: NR1H4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GPBAR1 Tchem G-protein coupled bile acid receptor 1 (1 Activities)

Discover Target: GPBAR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro

References

1. Shuaijun Peng, Ruiqin Sun, Hui Liu, Baoying Wang, Yucheng Li.  (2025)  Chenodeoxycholic acid triggers gastric mucosal injury by inducing apoptosis and FXR activation.  PLoS One,  20  (7): (e0328000).  [PMID:40663543] [10.1371/journal.pone.0328000]

2. Yong Ding, Xi Luo, Jiasheng Guo, Baiying Xing, Haoyu Lin, Haohan Ma, Yicun Wang, Meng Li, Chuan Ye, Sen Yan, Kangjie Lin, Jinxin Zhang, Yingying Zhuo, Qixing Nie, Donghui Yang, Zhipeng Zhang, Yanli Pang, Kai Wang, Ming Ma, Luhua Lai, Changtao Jiang.  (2025)  Identification of gut microbial bile acid metabolic enzymes via an AI-assisted pipeline.  CELL,      [PMID:40780197] [10.1016/j.cell.2025.07.017]

3. Lei Tang, Yinan Feng, Yifei Bian, Zhixiong Sun, Qiaoce Ding, Dongying Chen, Jian-Rong Wang, Xuefeng Mei.  (2025)  Bile Acid-based Microcapsule-Like Cocrystals of Phytosterols with Enhanced Solubility, Bioavailability, and Bioactivity.  MOLECULAR PHARMACEUTICS,      [PMID:40923148] [10.1021/acs.molpharmaceut.5c00851]

4. Mu-Qiang Wang, Zhi-Neng You, Bing-Yi Yang, Zi-Wei Xia, Qi Chen, Jiang Pan, Chun-Xiu Li, Jian-He Xu.  (2023)  Machine-Learning-Guided Engineering of an NADH-Dependent 7β-Hydroxysteroid Dehydrogenase for Economic Synthesis of Ursodeoxycholic Acid.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:38016669] [10.1021/acs.jafc.3c06339]

5. Qing-Lin Li, Hua Zheng, Zhi Luo, Li-Xiang Wu, Peng-Cheng Xu, Jia-Cheng Guo, Yu-Feng Song, Xiao-Ying Tan.  (2023)  Characterization and expression analysis of seven lipid metabolism-related genes in yellow catfish Pelteobagrus fulvidraco fed high fat and bile acid diet.  GENE,      [PMID:37944648] [10.1016/j.gene.2023.147972]

6. Hua Zheng, Yi-Chuang Xu, Tao Zhao, Zhi Luo, Dian-Guang Zhang, Chang-Chun Song, An-Gen Yu, Xiaoying Tan.  (2023)  Dietary chenodeoxycholic acid attenuates high-fat diet-induced growth retardation, lipid accumulation and bile acid metabolism disorder in the liver of yellow catfish Pelteobagrus fulvidraco.  BRITISH JOURNAL OF NUTRITION,      [PMID:37905695] [10.1017/S0007114523002489]

7. Jiang-Tao Xue, Zhi-Neng You, Bing-Yi Yang, Zheng-Yu Huang, Jiang Pan, Chun-Xiu Li, Jian-He Xu.  (2023)  Efficient synthesis of 7-oxo-lithocholic acid using a newly identified 7α-hydroxysteroid dehydrogenase.  Molecular Catalysis,      [PMID:] [10.1016/j.mcat.2023.113739]

8. Zhiyuan Meng, Sen Yan, Wei Sun, Jin Yan, Miaomiao Teng, Ming Jia, Sinuo Tian, Zhiqiang Zhou, Wentao Zhu.  (2023)  Chlorothalonil induces obesity in mice by regulating host gut microbiota and bile acids metabolism via FXR pathways.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:37003002] [10.1016/j.jhazmat.2023.131310]

9. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv.  (2023)  Biotransformation of Penindolone, an Influenza A Virus Inhibitor.  MOLECULES,  28  (3): (1479).  [PMID:36771146] [10.3390/molecules28031479]

10. Bing-Yi Yang, Zhi-Neng You, Jiang-Tao Xue, Jiang Pan, Chun-Xiu Li, Jian-He Xu.  (2023)  Clean enzymatic production of ursodeoxycholic acid enabled by a newly identified NADH-dependent 7β-hydroxysteroid dehydrogenase.  Molecular Catalysis,      [PMID:] [10.1016/j.mcat.2023.112946]

11. Jia Xu, Chaozhong Zheng, Shuyan Chi, Shuang Zhang, Junming Cao, Beiping Tan, Shiwei Xie.  (2022)  Clostridium autoethanogenum protein substitution and bile acids addition altered intestinal health and transcriptome profiles of hepatopancreas in Litopenaeus vannamei.  Aquaculture Reports,      [PMID:] [10.1016/j.aqrep.2022.101432]

12. Jiating Zheng, Xiaoru Peng, Taifeng Zhu, Shuyao Huang, Chao Chen, Guosheng Chen, Shuqin Liu, Gangfeng Ouyang.  (2022)  Detection of bile acids in small volume human bile samples via an amino metal-organic framework composite based solid-phase microextraction probe.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:36345074] [10.1016/j.chroma.2022.463634]

13. Wei Xu, Yingying Kong, Tuo Zhang, Zhihua Gong, Wenjun Xiao.  (2022)  L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,  103  (3): (1283-1293).  [PMID:36087337] [10.1002/jsfa.12222]

14. Ma Wen, Yang Bingxin, Li Jun, Liu Mingxia, Li Xianjiang, Liu Huwei.  (2022)  Maltose-functional metal–organic framework assisted laser desorption/ionization mass spectrometry for small biomolecule determination.  MICROCHIMICA ACTA,  189  (7): (1-8).  [PMID:35689150] [10.1007/s00604-022-05338-x]

15. Xiaoxu Cheng, Zifeng Pi, Zhong Zheng, Shu Liu, Fengrui Song, Zhiqiang Liu.  (2022)  Combined 16S rRNA gene sequencing and metabolomics to investigate the protective effects of Wu-tou decoction on rheumatoid arthritis in rats.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,      [PMID:35447521] [10.1016/j.jchromb.2022.123249]

16. Hai-Peng Li, Zhi-Neng You, Yuan-Yang Liu, Gao-Wei Zheng, Heng Gong, Yiming Mo, Ning Zhu, Yun-Peng Bai, Jian-He Xu.  (2021)  Continuous-Flow Microreactor-Enhanced Clean NAD+ Regeneration for Biosynthesis of 7-Oxo-lithocholic Acid.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.1c06730]

17. Ding Shen, Wei Hu, Suqing Zhao, Chuanbin Mao.  (2021)  Rapid Naked-Eye Detection of a Liver Disease Biomarker by Discovering Its Monoclonal Antibody to Functionalize Engineered Red-Colored Bacteria Probes.  ACS Omega,      [PMID:34870023] [10.1021/acsomega.1c04779]

18. Cui Xiping, He Qiyi, Yang Huiyi, Chen Yingshan, Shen Ding, Eremin Sergei A., Mu Yunping, Zhao Suqing.  (2021)  Development of enzyme-free single-step immunoassays for glycocholic acid based on palladium nanoparticle-mediated signal generation.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  413  (23): (5733-5742).  [PMID:34476526] [10.1007/s00216-021-03548-5]

19. Qiyi He, Yanxiong Fang, Huiyi Yang, Ding Shen, Yingshan Chen, Yingying Zhong, Xiangguang Li, Sergei A. Eremin, Xiping Cui, Suqing Zhao.  (2021)  Enhanced performance of a surface plasmon resonance-based immunosensor for the detection of glycocholic acid.  Analytical Methods,  13  (16): (1919-1924).  [PMID:33913980] [10.1039/D1AY00357G]

20. Min Wen, Yubei Liu, Ruiying Chen, Ping He, Feihua Wu, Rui Li, Yining Lin.  (2021)  Geniposide suppresses liver injury in a mouse model of DDC-induced sclerosing cholangitis.  PHYTOTHERAPY RESEARCH,  35  (7): (3799-3811).  [PMID:33763888] [10.1002/ptr.7086]

21. Zifei Qin, Peile Wang, Shuyi Duan, Xiaoying Wan, Han Xing, Jing Yang, Xiaojian Zhang, Zhihong Yao, Xinsheng Yao.  (2021)  Potential Determinants for Metabolic Fates and Inhibitory Effects of Isobavachalcone Involving in Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Efflux Transporters.  JOURNAL OF PHARMACEUTICAL SCIENCES,      [PMID:33610566] [10.1016/j.xphs.2021.02.013]

22. Qin Ni, Chunfang Cai, Shengjie Ren, Junbiao Zhang, Yijun Zhao, Xinyi Wei, Yiyang Ge, Chengrui Wang, Wenjian Li, Ping Wu, Yuantu Ye, Xiamin Cao.  (2021)  Pectin and soybean meal induce stronger inflammatory responses and dysregulation of bile acid (BA) homeostasis than cellulose and cottonseed meal, respectively, in largemouth bass (Micropterus salmoides), which might be attributed to their BA binding capacity.  AQUACULTURE RESEARCH,  52  (7): (2963-2979).  [PMID:] [10.1111/are.15140]

23. Yufei Sun, Zhiqiang Liu, Zifeng Pi, Fengrui Song, Jianlin Wu, Shu Liu.  (2021)  Poria cocos could ameliorate cognitive dysfunction in APP/PS1 mice by restoring imbalance of Aβ production and clearance and gut microbiota dysbiosis.  PHYTOTHERAPY RESEARCH,  35  (5): (2678-2690).  [PMID:33432644] [10.1002/ptr.7014]

24. Zhimin Mao, Weiqing Liu, Hongfeng Cai, Jing Shi, Zongjian Wu, Yan Yang, Junhong Duan.  (2020)  A kinetic/thermodynamic study of transparent co-adsorbents and colored dye molecules in visible light based on microgravimetric quartz-crystal microbalance on porous TiO2 films for dye-sensitized solar cells.  PHYSICAL CHEMISTRY CHEMICAL PHYSICS,  22  (46): (26828-26837).  [PMID:33232401] [10.1039/D0CP05403H]

25. Xiaofen Zhang, Ziyao Yang, Ziyu Shi, Zijia Zhu, Cai Li, Zhicheng Du, Yiding Zhang, Zipeng Wang, Zhenrui Jiao, Xin Tian, Ji Zhang, Wenlong Zhai, Quancheng Kan.  (2020)  Analysis of bile acid profile in plasma to differentiate cholangiocarcinoma from benign biliary diseases and healthy controls.  JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY,      [PMID:33130021] [10.1016/j.jsbmb.2020.105775]

26. Qiyi He, Huiyi Yang, Yingshan Chen, Ding Shen, Xiping Cui, Chunguo Zhang, Huanxin Xiao, Sergei A. Eremin, Yanxiong Fang, Suqing Zhao.  (2020)  Prussian blue nanoparticles with peroxidase-mimicking properties in a dual immunoassays for glycocholic acid.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:32416340] [10.1016/j.jpba.2020.113317]

27. Weiqing Liu, Haiyan Jiang, Jing Shi, Bingjun Lu, Hongfeng Cai, Zhimin Mao, Fantai Kong.  (2020)  In Situ Evaluation of Kinetics and Interaction Mechanism between Chenodeoxycholic Acid and N719 on Dye-Sensitized Nanofilm Surface.  ACS Applied Energy Materials,      [PMID:] [10.1021/acsaem.9b02321]

28. Xia Lu, Zhefeng Fan.  (2019)  Determination of cholic acid in body fluids by β‑cyclodextrin-modified N-doped carbon dot fluorescent probes.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:30921656] [10.1016/j.saa.2019.03.066]

29. Sinan Wang, Wenxiao Dong, Li Liu, Mengque Xu, Yu Wang, Tianyu Liu, Yujie Zhang, Bangmao Wang, Hailong Cao.  (2019)  Interplay between bile acids and the gut microbiota promotes intestinal carcinogenesis.  MOLECULAR CARCINOGENESIS,  58  (7): (1155-1167).  [PMID:30828892] [10.1002/mc.22999]

30. Li Wang, Xiaodan Hong, Zhihong Yao, Yi Dai, Guoping Zhao, Zifei Qin, Baojian Wu, Frank J. Gonzalez, Xinsheng Yao.  (2018)  Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes.  XENOBIOTICA,      [PMID:28443723] [10.1080/00498254.2017.1323139]

31. Zifei Qin, Shishi Li, Zhihong Yao, Xiaodan Hong, Jinjin Xu, Pei Lin, Guoping Zhao, Frank J. Gonzalez, Xinsheng Yao.  (2018)  Metabolic profiling of corylin in vivo and in vitro.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:29631076] [10.1016/j.jpba.2018.03.047]

32. Xueke Liu, Peng Wang, Chang Liu, Yiran Liang, Zhiqiang Zhou, Donghui Liu.  (2017)  Absorption, Distribution, Metabolism, and in Vitro Digestion of Beta-Cypermethrin in Laying Hens.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:28793773] [10.1021/acs.jafc.7b02581]

33. Zhuo-Wei SHEN, Meng-Yue LUO, Hai-Hong HU, Hui ZHOU, Hui-Di JIANG, Lu-Shan YU, Su ZENG.  (2016)  Screening and verifying potential NTCP inhibitors from herbal medicinal ingredients using the LLC-PK1 cell model stably expressing human NTCP.  Chinese Journal of Natural Medicines,      [PMID:27507206] [10.1016/S1875-5364(16)30065-6]

34. Feng Li, Shuai Wang, Danyi Lu, Yifei Wang, Dong Dong, Baojian Wu.  (2016)  Identification of UDP-glucuronosyltransferases 1A1, 1A3 and 2B15 as the main contributors to glucuronidation of bakuchiol, a natural biologically active compound.  XENOBIOTICA,      [PMID:27314830] [10.1080/00498254.2016.1195523]

35. Shuai Zhang, Gong-Yu Dong, Bencai Lin, Jie Qu, Ning-Yi Yuan, Jian-Ning Ding, Zhongze Gu.  (2016)  Performance enhancement of aqueous dye-sensitized solar cells via introduction of a quasi-solid-state electrolyte with an inverse opal structure.  SOLAR ENERGY,      [PMID:] [10.1016/j.solener.2016.01.016]

36. Danyi Lu, Zhiguo Ma, Tianpeng Zhang, Xingwang Zhang, Baojian Wu.  (2015)  Metabolism of the anthelmintic drug niclosamide by cytochrome P450 enzymes and UDP-glucuronosyltransferases: metabolite elucidation and main contributions from CYP1A2 and UGT1A1.  XENOBIOTICA,      [PMID:26068521] [10.3109/00498254.2015.1047812]

37. Ma Xiaolei, Cao Xuejun.  (2014)  Separation of ursodeoxycholic acid by silylation crystallization.  Bioresources and Bioprocessing,  1  (1): (1-8).  [PMID:] [10.1186/s40643-014-0005-9]

38. Haigang Zhang, Lihua Qiu, Dan Xu, Wei Zhang, Feng Yan.  (2013)  Performance enhancement for water based dye-sensitized solar cells via addition of ionic surfactants.  Journal of Materials Chemistry A,  2  (7): (2221-2226).  [PMID:] [10.1039/C3TA14571A]

39. Shun Zhang, Ting Cai, Jing Lin, Jia-Juan Liu, Yong-Gang Zhao, Min-Yi Cao.  (2024)  Analysis of 15 bile acids in human plasma based on C18 functionalized magnetic organic polymer nanocomposite coupled with liquid chromatography-tandem mass spectrometry.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:38704923] [10.1016/j.chroma.2024.464962]

40. Xiaotang Guo, Jiming Xu, Xiyuan Lu, Xiaoyan Zheng, Xi Chen, Zhenning Sun, Beilei Shen, Hao Tang, Yiman Duan, Zhengwei Zhou, Xu Feng, Yang Chen, Junjie Wang, Jing Pang, Qin Jiang, Bin Huang, Ning Gu, Juxue Li.  (2024)  Chenodeoxycholic Acid-Modified Polyethyleneimine Nano-Composites Deliver Low-Density Lipoprotein Receptor Genes for Lipid-Lowering Therapy by Targeting the Liver.  Advanced Healthcare Materials,      [PMID:38857027] [10.1002/adhm.202400254]

41. Hao Zhi, Zhongyan Wang, Xinyue Zhu, Wenhan Wu, Lu Yang, Yidong Dai, Zehua Wang, Ling Jiang, Yongmei Tan, Xiaodong Liu, Li Liu.  (2025)  Chronic liver injury decreases levels of cerebral carnitine and acetylcarnitine in rats partly due to the downregulation of OCTs and OCTN2 at the blood-brain barrier.  DRUG METABOLISM AND DISPOSITION,      [PMID:40300306] [10.1016/j.dmd.2025.100072]

42. Miao Zheng, Qi Su, Haoqing Wu, Chenggang Cai, Le Thanh Ninh, Haiying Cai.  (2024)  Elucidating Bile Acid Tolerance in Saccharomyces cerevisiae: Effects on Sterol Biosynthesis and Transport Protein Expression.  Foods,  13  (21): (3405).  [PMID:39517189] [10.3390/foods13213405]

43. Yuan Li, Shu-Fang Li, Lin Zhang, Ya-Ping Xue, Yu-Guo Zheng.  (2024)  Engineering of a hydroxysteroid dehydrogenase with simultaneous enhancement in activity and thermostability for efficient biosynthesis of ursodeoxycholic acid.  APPLIED AND ENVIRONMENTAL MICROBIOLOGY,  90  (9):   [PMID:39207158] [10.1128/aem.01237-24]

44. Chen Song, Hu Zongren, Tang Jianbang, Zhu Haipeng, Zheng Yuhua, Xiao Jiedong, Xu Youhua, Wang Yao, Luo Yi, Mo Xiaoying, Wu Yalan, Guo Jianwen, Zhang Yongliang, Luo Huanhuan.  (2024)  High temperature and humidity in the environment disrupt bile acid metabolism, the gut microbiome, and GLP-1 secretion in mice.  Communications Biology,  7  (1): (1-13).  [PMID:38632312] [10.1038/s42003-024-06158-w]

45. Lei Zhang, Xu Liu, Tenghui Jin, Jing Dong, Xiaodong Li, Youyi Zhang, Dongyang Liu.  (2024)  Isomers-oriented separation of forty-five plasma bile acids with liquid chromatography-tandem mass spectrometry.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:38520985] [10.1016/j.chroma.2024.464827]

46. Yunfeng Hu, Jiahui Zou, Qianqian Wang, Yang Chen, Hui Wang, Jin Li.  (2024)  Lipoprotein-mimicking nanotherapeutics reconstituted with chenodeoxycholic acid modified protein for efficient tumor targeting.  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,      [PMID:38244896] [10.1016/j.ejpb.2024.114184]

47. SunHongzheng , HanLongsen , GuoYueshuai , AnHuiqing , WangBing , ZhangXiangzheng , LiJiashuo , JiangYingtong , WangYue , SunGuangyi , ZhuShuai , TangShoubin , GeJuan , ChenMinjian , GuoXuejiang , WangQiang.  (2024)  The global phosphorylation landscape of mouse oocytes during meiotic maturation.  EMBO JOURNAL,      [PMID:39256562] [10.1038/s44318-024-00222-1]

48. Dongping Li, Meijuan Wan, Lanfeng Xue, Zhelin Zhang, Yifeng Qiu, Fengyi Mei, Niexing Tang, Chunxiao Yu, Yao Yu, Tianqi Chen, Xing Ding, Qin Yang, Qiuyan Liu, Peng Gu, Wei Jia, Yu Chen, Peng Chen.  (2024)  Zinc promotes microbial p-coumaric acid production that protects against cholestatic liver injury.  Cell Host & Microbe,      [PMID:39610253] [10.1016/j.chom.2024.11.002]

49. Jun Lin, Qixing Nie, Jie Cheng, Ya-Ni Zhong, Tianyao Zhang, Xiuying Zhang, Xiaoyan Ge, Yong Ding, Canyang Niu, Yuhua Gao, Kai Wang, Mingxin Gao, Xuemei Wang, Weixuan Chen, Chuyu Yun, Chuan Ye, Jinkun Xu, Weike Shaoyong, Lijun Zhang, Pan Shang, Xi Luo, Zhiwei Zhang, Xin Zheng, Xueying Sha, Jinxin Zhang, Shaoping Nie, Xuguang Zhang, Fazheng Ren, Huiying Liu, Erdan Dong, Xiao Yu, Linong Ji, Yanli Pang, Jin-Peng Sun, Changtao Jiang.  (2025)  A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE.  CELL,      [PMID:40446798] [10.1016/j.cell.2025.05.010]

50. Shuai Xue, Jianli Yin, Jiawei Shao, Yuanhuan Yu, Linfeng Yang, Yidan Wang, Mingqi Xie, Martin Fussenegger, Haifeng Ye.  (2017)  A Synthetic-Biology-Inspired Therapeutic Strategy for Targeting and Treating Hepatogenous Diabetes.  MOLECULAR THERAPY,      [PMID:28153094] [10.1016/j.ymthe.2016.11.008]

51. Chunli Qi, Jiangnan Fu, Huinan Zhao, Huijie Xing, Dong Dong, Baojian Wu.  (2018)  Identification of UGTs and BCRP as potential pharmacokinetic determinants of the natural flavonoid alpinetin.  XENOBIOTICA,      [PMID:29436891] [10.1080/00498254.2018.1440657]

52. Yuan Li, Shu-Fang Li, Sen-Yu Fu, Xin-Ding Ren, Yi-Cheng Zhou, Ya-Ping Xue, Yu-Guo Zheng.  (2025)  Design of a Distal Site Saturation Test-Iterative Parallel Mutagenesis for Engineering Hydroxysteroid Dehydrogenase.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:40205835] [10.1021/acs.jafc.4c12812]

53. Zihong Shan, Chenghui He, Qingyao Yang, Jingjing Xiong, Meng Li, Mingyao Meng, Yongkun Huang.  (2025)  Chenodeoxycholic acid activates the TGR5/TRPA1-5-HT pathway to regulate intestinal motility in breastfed infants and mouse models.  Translational Pediatrics,  14  (6): (1213).  [PMID:40688229] [10.21037/tp-2025-100]

54. Yangzu Gao, Haoyu Li, Qian Wu, Bang Chen, Kangzhen Xu, Cong Li, Yehua Shen.  (2025)  Functions of Pugionium cornutum (L.) Gaertn Extracts: Investigating the Mechanism of Gastroparesis Amelioration from the Perspective of the Gut Microbiota and Its Metabolites.  Foods,  14  (16): (2800).  [PMID:40870711] [10.3390/foods14162800]

55. Jiayi Xu, Zhimin Mao, Weiqing Liu, Yan Yang, Yilei Lu, Ligang Yuan, Wenhao Chen.  (2025)  Thermally Modulated Quartz Crystal Microbalance for Multimolecular Adsorption Decoupling: A Selective Desorption Strategy for Precision Interface Engineering.  LANGMUIR,      [PMID:41198190] [10.1021/acs.langmuir.5c03872]

56. Hongyu Jiang, Wenyan Xiong, Yingna Feng, Xingjie Li, Jinzhuo Tan, Zongde Zhang.  (2026)  Bile acids enrichment fuel tumor aerobic glycolysis and immune evasion via stabilizing FXR-RARα.  Frontiers in Immunology,      [PMID:] [10.3389/fimmu.2026.1750358]

57. Danhua Zhu, Qingmiao Shi, Xiaoxi Ouyang, Yanhong Zhang, Xiaopeng Yu, Long Yang, Kunkai Su, Lanjuan Li.  (2026)  Integrative transcriptomic and metabolomic analyses of puerarin against cholestatic liver fibrosis.  Current Molecular Pharmacology,      [PMID:] [10.1016/j.cmp.2026.04.003]