Ciprofloxacin Hydrochloride Monohydrate - 10mM in DMSO , CAS No.86393-32-0

CAS: 86393-32-0 Cat. No.: C426423 Molecular Weight: 367.81(as Anhydrous) EC Number: 617-845-1

GRADE & PURITY 10mM in DMSO

Synonyms

86393-32-0|Ciloxan|Ciprofloxacin hydrochloride hydrate|Ciprofloxacin hydrochloride monohydrate|Ceprimax|Oftacilox|Proquin XR|Cipropol|Cipro|Flociprin|Proquin|Ciflox|Bay o 9867 monohydrate|Cetraxal|Bay-o-9867 monohydrate|Ciprofloxacin HCl monohydrate|Cipro

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Specifications

Synonyms

86393-32-0 | Ciloxan | Ciprofloxacin hydrochloride hydrate | Ciprofloxacin hydrochloride monohydrate | Ceprimax | Oftacilox | Proquin XR | Cipropol | Cipro | Flociprin | Proquin | Ciflox | Bay o 9867 monohydrate | Cetraxal | Bay-o-9867 monohydrate | Ciprofloxacin HCl monohydrate | Cipro

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Fluoroquinolone antibiotic. Bacteriostatic agent. Interferes with DNA gyrase causing DNA rewinding stopping DNA and protein synthesis. Active in vivo and in vitro.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O.O.Cl
• IUPAC Name: 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrate;hydrochloride
• InChIKey: ARPUHYJMCVWYCZ-UHFFFAOYSA-N
• INCHI: 1S/C17H18FN3O3.ClH.H2O/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;;/h7-10,19H,1-6H2,(H,23,24);1H;1H2
• Isomeric SMILES: C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O.O.Cl
• WGK Germany: 3
• Molecular Weight: 367.81(as Anhydrous)
• Reaxy-Rn: 13474821
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13474821&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Quinolines and derivatives
      • Subclass Quinoline carboxylic acids

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Quinolines and derivatives
• Subclass: Quinoline carboxylic acids
• Intermediate Tree Nodes: Not available
• Direct Parent: Quinoline carboxylic acids
• Alternative Parents: N-arylpiperazines Fluoroquinolones Aminoquinolines and derivatives Hydroquinolones Haloquinolines Hydroquinolines Pyridinecarboxylic acids Dialkylarylamines Aryl fluorides Benzenoids Vinylogous amides Heteroaromatic compounds Amino acids Azacyclic compounds Carboxylic acids Dialkylamines Monocarboxylic acids and derivatives Organooxygen compounds Organic oxides Organofluorides Organopnictogen compounds Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Quinoline-3-carboxylic acid - Fluoroquinolone - N-arylpiperazine - Aminoquinoline - Haloquinoline - Dihydroquinolone - Dihydroquinoline - Pyridine carboxylic acid - Pyridine carboxylic acid or derivatives - Dialkylarylamine - Tertiary aliphatic/aromatic amine - Benzenoid - Aryl fluoride - Aryl halide - Pyridine - 1,4-diazinane - Piperazine - Heteroaromatic compound - Vinylogous amide - Tertiary amine - Amino acid - Amino acid or derivatives - Azacycle - Secondary amine - Carboxylic acid derivative - Carboxylic acid - Secondary aliphatic amine - Monocarboxylic acid or derivatives - Organopnictogen compound - Organic oxygen compound - Amine - Hydrocarbon derivative - Organic nitrogen compound - Organic oxide - Hydrochloride - Organohalogen compound - Organofluoride - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as quinoline carboxylic acids. These are quinolines in which the quinoline ring system is substituted by a carboxyl group at one or more positions.
• External Descriptors: hydrate

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Chemical and Physical Properties

• Molecular Weight: 385.800 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 3
• Exact Mass: 385.12 Da
• Monoisotopic Mass: 385.12 Da
• Topological Polar Surface Area: 73.900 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 571.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

References

1. Jian Zhang, Jia-Fang Xie, Jia-Cheng E. Yang, Ding Li, Lu-Bin Zhong, Yu-Ming Zheng.  (2023)  Ultra-fast degradation of ciprofloxacin by the peroxymonosulfate activation using a Co/Al-LDH decorated magnetic hydrochar: Structural design, catalytic performance and synergistic effects.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.146961]

2. Jie Meng, Peng Zhang, Qingjie Liu, Pan Ran, Shuang Xie, Junwu Wei, Xiaohong Li.  (2023)  Pyroelectric Janus nanomotors for synergistic electrodynamic-photothermal-antibiotic therapies of bacterial infections.  Acta Biomaterialia,      [PMID:36931421] [10.1016/j.actbio.2023.03.012]

3. Zhe Zhao, Yufei Zhang, Yijie Cheng, Jie Li, Wenbo Wang, Siyuan Huang, Xinlong Ma, Xinge Zhang.  (2023)  Thermosensitive Nanotherapeutics for Localized Photothermal Ablation of MRSA-Infected Osteomyelitis Combined with Chemotherapy.  ACS Applied Materials & Interfaces,      [PMID:36862542] [10.1021/acsami.2c23312]

4. Yuan Kaisong, Huang Rui, Gong Kaishuo, Xiao Ziyi, Chen Jialin, Cai Siyao, Shen Jiayi, Xiong Zuer, Lin Zhexuan.  (2023)  Smartphone-based hand-held polarized light microscope for on-site pharmaceutical crystallinity characterization.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  415  (18): (4401-4410).  [PMID:36786836] [10.1007/s00216-023-04582-1]

5. Weijie Hua, Yong Kang, Shuai Liu.  (2022)  Synergistic removal of aqueous ciprofloxacin hydrochloride by water surface plasma coupled with peroxymonosulfate activation.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2022.122301]

6. Pei Fan, Chunhua Liu, Zhen Ke, Wei Zhou, Zhonghua Wu.  (2022)  Growth and physiological responses in a submerged clonal aquatic plant and multiple-endpoint assessment under prolonged exposure to ciprofloxacin.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:35643032] [10.1016/j.ecoenv.2022.113690]

7. J. Lu, Y.-Y. Qin, Y.-L. Wu, Z. Zhu, M.-N. Chen, Y.-S. Yan, C.-X. Li.  (2022)  Bio-synthesis of molecularly imprinted membrane with photo-regeneration availability for selective separation applications.  Materials Today Chemistry,      [PMID:] [10.1016/j.mtchem.2022.100836]

8. Yi Hu, Nuzahat Habibul, Yan-Yun Hu, Fan-Li Meng, Guo-Ping Sheng.  (2021)  Chemical speciation of ciprofloxacin in aqueous solution regulates its phytotoxicity and uptake by rice (Oryza sativa L.).  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:33548726] [10.1016/j.scitotenv.2020.144787]

9. Mihebai Yilimulati, Longfei Wang, Xiaoli Ma, Chuanwang Yang, Nuzahat Habibul.  (2020)  Adsorption of ciprofloxacin to functionalized nano-sized polystyrene plastic: Kinetics, thermochemistry and toxicity.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:33182210] [10.1016/j.scitotenv.2020.142370]

10. Jing Liu, Bin Wang, Huachuan Huang, Dan Jian, Yunan Lu, Yanke Shan, Shouyu Wang, Fei Liu.  (2020)  Quantitative ciprofloxacin on-site rapid detections using quantum dot microsphere based immunochromatographic test strips.  FOOD CHEMISTRY,      [PMID:32745840] [10.1016/j.foodchem.2020.127596]

11. Ling Cao, Zheng Li, Rui Jia, Li Chen, Ying Wu, Junwei Di.  (2020)  Sensitive Photoelectrochemical Determination of Ciprofloxacin Using an Indium Tin Oxide Photoelectrode Modified with Small Gold Nanoparticles.  ANALYTICAL LETTERS,      [PMID:] [10.1080/00032719.2019.1709481]

12. Minghao Sun, Chune Zhu, Jieyu Long, Chao Lu, Xin Pan, Chuanbin Wu.  (2020)  PLGA microsphere-based composite hydrogel for dual delivery of ciprofloxacin and ginsenoside Rh2 to treat Staphylococcus aureus-induced skin infections.  DRUG DELIVERY,      [PMID:32329376] [10.1080/10717544.2020.1756985]

13. Lan-jia Pan, Jie Li, Chun-xing Li, Xiao-da Tang, Guang-wei Yu, Yin Wang.  (2017)  Study of ciprofloxacin biodegradation by a Thermus sp. isolated from pharmaceutical sludge.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:28941838] [10.1016/j.jhazmat.2017.09.009]

14. Pei Fan, Haihao Yu, Tian Lv, Huiyuan Wang, Dexiang Li, Chao Tong, Zhonghua Wu, Dan Yu, Chunhua Liu.  (2024)  Alien emergent aquatic plants develop better ciprofloxacin tolerance and metabolic capacity than one native submerged species.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:38719043] [10.1016/j.scitotenv.2024.173030]

15. Yi Hu, Fan-Li Meng, Jia-Heng Zhao, Guo-Ping Sheng.  (2024)  Environmental microbes alleviate antibiotic disturbance on plant endophytes in aquatic microcosms: Prospects for conferring fitness benefits.  WATER RESEARCH,      [PMID:39047453] [10.1016/j.watres.2024.122112]

16. Luzhan Huang, Yongchao Jiang, Pengcheng Zhang, Muhan Li, Bingrong Liu, Keyong Tang.  (2024)  Injectable Modified Sodium Alginate Microspheres for Enhanced Operative Efficiency and Safety in Endoscopic Submucosal Dissection.  BIOMACROMOLECULES,      [PMID:38652682] [10.1021/acs.biomac.4c00081]

17. Shilin Li, Yunhui Tian, Guangxin Zhang.  (2024)  Modulating of Bi2MoO6-based photocatalyst through manipulation of reactant ratios for enhanced visible light photocatalytic activity.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2024.133958]

18. Muhammad Noman, Guangwei Yu, Dinkayehu Tsegaye Awugichew, Xinlin Li.  (2024)  Synthesis of surficial-modified green biochar catalyst generated by biogas residue biochar and potential application for catalytic ozonation degradation of ciprofloxacin.  ENVIRONMENTAL RESEARCH,      [PMID:38824988] [10.1016/j.envres.2024.119314]

19. Rui Liu, Bolin Wu, Rijia Liu, Xin Zhang, Yuan Sun, Jing Ma.  (2025)  Development of Ag/ZIF-67/g-C3N4/GCE electrochemical sensor to detect chloramphenicol with the assistance of machine learning.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.113510]

20. Yue He, Shuang Xiao, Jiabin Zhou, Dan Liu, Zhipu Wang.  (2025)  Visible light-peroxomonosulfate coactivation via CuOx/Fe2O3 composites for efficient degradation of tetracycline and bimetallic mechanisms.  Journal of Water Process Engineering,      [PMID:] [10.1016/j.jwpe.2025.108363]

21. Shuai Dou, Qi-Jun Zhang, Peng Wu, Hui-Wen Huo, Lu-Bin Zhong, Yu-Ming Zheng.  (2025)  Facile preparation of hierarchical porous MOF-based hollow carbon nanofiber mats using a polymer-blend electrospinning strategy for efficient adsorption of ciprofloxacin.  Journal of Environmental Sciences,      [PMID:41177602] [10.1016/j.jes.2025.04.029]

22. Kaixin Sun, Bo Gong, Chang Xu, Shan Zhao, Shuguang Wang, Le Ren, Chao Song.  (2025)  Enhancing the degradation of ciprofloxacin and levofloxacin by peroxydisulfate (PDS): Multiple roles of co-existing copper ion.  Journal of Environmental Chemical Engineering,  13  (6): (120491).  [PMID:] [10.1016/j.jece.2025.120491]