Determine the necessary mass, volume, or concentration for preparing a solution.
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Moligand™, 50 mg/mL in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 24 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
General Description
Clarithromycin is a macrolide antibiotic, which has both antibacterial and anti-inflammatory actions. It is a semi-synthetic 14-membered derivative of erythromycin A, which is resistant to degradation under acidic conditions.
Application
Clarithromycin may be used for- the study of the effects of clarithromycin on rate-dependent changes in QT, T p-e and proarrhythmic events performed on arterially perfused rabbit left ventricular wedge preparations the culture of parasites expressing GFP (green fluorescence protein) targeted to the apicoplast, to be further used for microscopy-based assays the study of the synergism of NAB741 with clarithromycin in microtiter plates.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids
| Canonical Smiles | CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)O)(C)O |
|---|---|
| IUPAC Name | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione |
| InChIKey | AGOYDEPGAOXOCK-KCBOHYOISA-N |
| INCHI | 1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1 |
| Isomeric SMILES | CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)O)(C)O |
| WGK Germany | 3 |
| RTECS | KF4997000 |
| Alternate CAS | 81103-11-9,116836-41-0 |
| NSC Number | 758704 |
| MeSH Entry Terms | 6-O-Methylerythromycin;A 56268;A-56268;A56268;Biaxin;Clarithromycin;TE 031;TE-031;TE031 |
| Molecular Weight | 747.95 |
| Reaxy-Rn | 24709380 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24709380&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic oxygen compounds |
| Class | Organooxygen compounds |
| Subclass | Carbohydrates and carbohydrate conjugates |
| Intermediate Tree Nodes | Aminosaccharides |
| Direct Parent | Aminoglycosides |
| Alternative Parents | Macrolides and analogues O-glycosyl compounds Oxanes Monosaccharides Tertiary alcohols Trialkylamines Secondary alcohols 1,2-aminoalcohols Amino acids and derivatives Carboxylic acid esters Cyclic ketones Lactones Oxacyclic compounds Acetals Monocarboxylic acids and derivatives Dialkyl ethers Organopnictogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aliphatic heteromonocyclic compounds |
| Substituents | Aminoglycoside core - Macrolide - Glycosyl compound - O-glycosyl compound - Oxane - Monosaccharide - Tertiary alcohol - 1,2-aminoalcohol - Amino acid or derivatives - Carboxylic acid ester - Ketone - Cyclic ketone - Tertiary aliphatic amine - Tertiary amine - Secondary alcohol - Lactone - Acetal - Carboxylic acid derivative - Dialkyl ether - Ether - Oxacycle - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Alcohol - Amine - Organopnictogen compound - Organonitrogen compound - Organic oxide - Aliphatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as aminoglycosides. These are molecules or a portion of a molecule composed of amino-modified sugars. |
| External Descriptors | Macrolides and lactone polyketides |
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| Specific Rotation[α] | -92°C |
|---|---|
| Melt Point(°C) | 225°C |
| Molecular Weight | 748.000 g/mol |
| XLogP3 | 3.200 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 14 |
| Rotatable Bond Count | 8 |
| Exact Mass | 747.477 Da |
| Monoisotopic Mass | 747.477 Da |
| Topological Polar Surface Area | 183.000 Ų |
| Heavy Atom Count | 52 |
| Formal Charge | 0 |
| Complexity | 1190.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 18 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Xiaoyu Zhang, Peiran Meng, Wei Wang, Xiwen Li, Zuan Yang, Shaokai Du, Yue Sun. (2023) Simultaneous Electrochemical Determination of Erythromycin and Hemoglobin by Flexible Carbon Cloth Modified with ZnO Nanorod Arrays and Au Nanoparticles by Differential Pulse Voltammetry (DPV). ANALYTICAL LETTERS, [PMID:] [10.1080/00032719.2023.2292664] |
| 2. Qin Tang, Zhengcai Ma, Xiang Tang, Yan Liu, Huimin Wu, Yu Peng, Baihua Jiao, Rui Wang, Xiaoli Ye, Hang Ma, Xuegang Li. (2023) Coptisine inhibits Helicobacter pylori and reduces the expression of CagA to alleviate host inflammation in vitro and in vivo. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:37164257] [10.1016/j.jep.2023.116618] |
| 3. Ruoyu Deng, Dongxu Yang, Mengli Chen, Qiang He, Qingjuan He, Yi Chen. (2023) The enhancing energy efficiency of sulfadiazine degradation using a DBD-contact plasma treatment process. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2023.142491] |
| 4. Chong Yu, Chi Li, Ying Zhang, Xiang Du, Jing-Han Wang, Zhan-You Chi, Qian Zhang. (2023) Effects of environment-relevant concentrations of antibiotics on seawater Chlorella sp. biofilm in artificial mariculture effluent. Algal Research-Biomass Biofuels and Bioproducts, [PMID:] [10.1016/j.algal.2023.103008] |
| 5. Yu Wang, Yunxiang He, Qin Wang, Xiaoling Wang, Blaise L. Tardy, Joseph J. Richardson, Orlando J. Rojas, Junling Guo. (2022) Microporous membranes for ultrafast and energy-efficient removal of antibiotics through polyphenol-mediated nanointerfaces. Matter, [PMID:] [10.1016/j.matt.2022.09.021] |
| 6. Wan-Feng Xu, Yun Wang, Hai Huang, Jia-Wei Wu, Yuan Che, Chu-Jie Ding, Quan Zhang, Wei-Ling Cao, Li-Juan Cao. (2022) Octreotide-based therapies effectively protect mice from acute and chronic gastritis. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:35487253] [10.1016/j.ejphar.2022.174976] |
| 7. Ling Li, Yaoyao Du, Yang Wang, Ning He, Bing Wang, Tong Zhang. (2022) Atractylone Alleviates Ethanol-Induced Gastric Ulcer in Rat with Altered Gut Microbiota and Metabolites. Journal of Inflammation Research, [PMID:35996682] [10.2147/JIR.S372389] |
| 8. Shuting Zeng, Jing Sun, Ziwei Chen, Qiuxiang Xu, Wei Wei, Dongbo Wang, Bing-Jie Ni. (2021) The impact and fate of clarithromycin in anaerobic digestion of waste activated sludge for biogas production. ENVIRONMENTAL RESEARCH, [PMID:33545126] [10.1016/j.envres.2021.110792] |
| 9. Xueqing Guo, Yang Liu, Wenjuan Dong, Qin Hu, Yong Li, Shaomin Shuang, Chuan Dong, Lishuai Cai, Xiaojuan Gong. (2021) Azithromycin detection in cells and tablets by N,S co-doped carbon quantum dots. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:33561684] [10.1016/j.saa.2021.119506] |
| 10. Zhou Chen, Yanzeng Li, Yanyan Peng, Chengsong Ye, Shenghua Zhang. (2020) Effects of antibiotics on hydrolase activity and structure of microbial community during aerobic co-composting of food waste with sewage sludge. BIORESOURCE TECHNOLOGY, [PMID:33310386] [10.1016/j.biortech.2020.124506] |
| 11. Yuanna Shen, Yiqing Zou, Xiaonan Chen, Pengyu Li, Yiqin Rao, Xuan Yang, Yingying Sun, Haiyan Hu. (2020) Antibacterial self-assembled nanodrugs composed of berberine derivatives and rhamnolipids against Helicobacter pylori. JOURNAL OF CONTROLLED RELEASE, [PMID:32946873] [10.1016/j.jconrel.2020.09.025] |
| 12. Ziming Zhao, Yanzhu Guo, Tao Zhang, Jiliang Ma, Haiming Li, Jinghui Zhou, Zhiwei Wang, Runcang Sun. (2020) Preparation of carbon dots from waste cellulose diacetate as a sensor for tetracycline detection and fluorescence ink. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:32891644] [10.1016/j.ijbiomac.2020.08.243] |
| 13. Yunlei Zhou, Fei Li, Hanwen Wu, Yan Chen, Huanshun Yin, Shiyun Ai, Jun Wang. (2019) Electrochemical aptasensing strategy for kanamycin detection based on target-triggered single-strand DNA adsorption on MoS2 nanosheets and enzymatic signal amplification. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2019.126664] |
| 14. Pengyu Li, Xiaonan Chen, Yuanna Shen, Huatian Li, Yiqing Zou, Gang Yuan, Ping Hu, Haiyan Hu. (2019) Mucus penetration enhanced lipid polymer nanoparticles improve the eradication rate of Helicobacter pylori biofilm. JOURNAL OF CONTROLLED RELEASE, [PMID:30825476] [10.1016/j.jconrel.2019.02.039] |
| 15. Yaowei Zhu, Ruijie Tang, Jun Zhao, Changlong Jiang, Lingfei Li, Bianhua Liu. (2025) Design and application of metal-organic framework based chemo-fluorescent sensor for selective sensing of the full spectrum of tetracyclines in complex samples. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.160281] |
| 16. Wanjun Long, Huanhuan Lu, Yulong Han, Hengye Chen, Wei Lan, Yuanbin She, Haiyan Fu. (2025) Machine learning-assisted smartphone-based fluorescence visual sensing platform for ultrasensitive detection of chlortetracycline. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2025.137241] |
| 17. Yongze Liu, Mei Li, Genyuan Li, Lei He, Xiaofeng Ma, Zhaoxiang Zhang, Jun Zhang. (2025) Rapidly self-crosslinking sodium alginate hydrogel for infected wounds. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, [PMID:39760654] [10.1080/09205063.2024.2438497] |
| 18. Linqian Hou, Qiulan Li, Jitao Li, Dezhi Yang, Yaling Yang. (2025) Cu,Fe,B/Cur-CDs with peroxidase- and ascorbic acid oxidase-like catalytic activity for dual-signal fluorescence sensing of metronidazole. FOOD CHEMISTRY, [PMID:40774207] [10.1016/j.foodchem.2025.145757] |
| 19. Jiahong Zheng, Xiudan Shi, Pengzhan Li, Zhiguo Zhao, Guangqiang Ding. (2025) Preparation of a Cs4PbBr6 NCs@PCDs ratiometric fluorescent probe and detection of amoxicillin. NEW JOURNAL OF CHEMISTRY, [PMID:] [10.1039/D5NJ02499D] |
| 20. Wenjuan Dong, Lu Wang, Rongrong Zhang, Chaochao Wen, Ren Su, Xiaojuan Gong, Wenting Liang. (2023) High luminescent N,S,P co-doped carbon dots for the fluorescence sensing of extreme acidity and folic acid. DALTON TRANSACTIONS, 52 (19): (6551-6558). [PMID:37185994] [10.1039/D3DT00560G] |
| 21. Jian Zhang, Zhijun Bao, Jingjing Qian, Haibo Zhou, Kui Zhang. (2022) Copper doped zinc sulfide quantum dots as ratiometric fluorescent probes for rapid and specific detection of tetracycline residues in milk. ANALYTICA CHIMICA ACTA, [PMID:35691678] [10.1016/j.aca.2022.339991] |
| 22. Li Zhang, Huaizhong Xing, Wei Liu, Zihan Wang, Yumin Hao, Huiping Wang, Wenjuan Dong, Yang Liu, Shaomin Shuang, Chuan Dong, Xiaojuan Gong. (2021) 11-Mercaptoundecanoic Acid-Functionalized Carbon Dots As a Ratiometric Optical Probe for Doxorubicin Detection. ACS Applied Nano Materials, [PMID:] [10.1021/acsanm.1c03141] |
| 23. Pusheng Xu, Yi Li, Bihan Xu, Dan Cao, Xu Dong, Yanghui Xiang, Xiuzhi Jiang, Xin Yuan, Yuwei Qiu, Ying Zhang. (2025) Novel mutations in the marR gene (MAB_2648c) modify nitroxoline activity in Mycobacterium abscessus. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 69 (5): [PMID:40167421] [10.1128/aac.01744-24] |
| 24. Yukun Lin, Kunjing Liu, Jiahui Chen, Tingjie Li, Zijin Sun, Yifan Fan, Peng Zou, Yanting Liu, Chunyu Wang, Chongyang Ma, Xueqian Wang, Fang Lu, Fafeng Cheng, Changming Zhai. (2025) Pinellia ternata–Coptidis Rhizoma herb pair suppresses Helicobacter pylori colonization via NLRP3-mediated pyroptosis. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:41389884] [10.1016/j.jep.2025.121018] |
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
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