Clindamycin hydrochloride - ≥97% , Bacterial 70S ribosome inhibitor, CAS No.21462-39-5, Bacterial 70S ribosome inhibitor

CAS: 21462-39-5 Cat. No.: C168591 Molecular Weight: 461.44 EC Number: 244-398-6 PubChem CID: 16051951

GRADE & PURITY ≥97%

Synonyms

ClindaMed | (2S,4R)-N-[(1S,2S)-2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride | BenzaClin | CLINDAMYCIN HYDROCHLORIDE [USP MONOGRAPH] | HB4364 | L-threo-alpha-D-galac

Storage

Store at 2-8°C,Argon charged

Shipped In

Wet ice

Overview

Clindamycin hydrochloride inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.
Clindamycin is used to study bacterial infections, such as group B streptococcal disease, bacterial resistance and plasma protein binding.

Specifications

Synonyms

ClindaMed | (2S, 4R)-N-[(1S, 2S)-2-chloro-1-[(2R, 3R, 4S, 5R, 6R)-3, 4, 5-trihydroxy-6-methylsulanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride | BenzaClin | CLINDAMYCIN HYDROCHLORIDE [USP MONOGRAPH] | HB4364 | L-threo-alpha-D-galac

Specifications & Purity

≥97%

Biochemical and Physiological Mechanisms

Lincosamide antibiotic. Binds to the 23s portion of the 50S subunit of the bacterial ribosome inhibiting ribosomal translocation and protein synthesis.

Storage

Store at 2-8°C, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Bacterial 70S ribosome inhibitor

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥97%

Names and Identifiers

• Canonical Smiles: CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)Cl.Cl
• IUPAC Name: (2S,4R)-N-[(1S,2S)-2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride
• InChIKey: AUODDLQVRAJAJM-XJQDNNTCSA-N
• INCHI: 1S/C18H33ClN2O5S.ClH/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25);1H/t9-,10+,11-,12+,13-,14+,15+,16+,18+;/m0./s1
• Isomeric SMILES: CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@H](C)Cl.Cl
• PubChem CID: 16051951
• Molecular Weight: 461.44

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Class Organooxygen compounds
      • Subclass Carbohydrates and carbohydrate conjugates
        • Level5 Glycosyl compounds
          • Level6 Thioglycosides

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Class: Organooxygen compounds
• Subclass: Carbohydrates and carbohydrate conjugates
• Intermediate Tree Nodes: Glycosyl compounds
• Direct Parent: Thioglycosides
• Alternative Parents: Oxanes N-alkylpyrrolidines Monosaccharides Monothioacetals Trialkylamines Secondary alcohols Sulfenyl compounds Propargyl-type 1,3-dipolar organic compounds Polyols Oxacyclic compounds Azacyclic compounds Carboximidic acids Hydrochlorides Hydrocarbon derivatives Organochlorides Organopnictogen compounds Alkyl chlorides
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: S-glycosyl compound - Monosaccharide - Oxane - N-alkylpyrrolidine - Monothioacetal - Pyrrolidine - Tertiary aliphatic amine - Tertiary amine - Secondary alcohol - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Oxacycle - Sulfenyl compound - Azacycle - Carboximidic acid - Polyol - Carboximidic acid derivative - Hydrocarbon derivative - Organosulfur compound - Organonitrogen compound - Organochloride - Organohalogen compound - Alcohol - Organic nitrogen compound - Organopnictogen compound - Amine - Alkyl halide - Alkyl chloride - Hydrochloride - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as thioglycosides. These are glycoside in which a sugar group is bonded through one carbon to another group via a S-glycosidic bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

HEK293 (82097 Activities)

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

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Associated Targets(non-human)

ftsZ Cell division protein ftsZ (97 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Streptococcus pyogenes (16140 Activities)

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Enterococcus faecalis (29875 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Mechanisms of Action

Chemical and Physical Properties

• Solubility: H2O: 50 mg/mL；≥15.35 mg/mL in DMSO; ≥2.95 mg/mL in EtOH with gentle warming and ultrasonic; ≥53.1 mg/mL in H2O
• Sensitivity: Moisture sensitive
• Molecular Weight: 461.400 g/mol
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 7
• Exact Mass: 460.157 Da
• Monoisotopic Mass: 460.157 Da
• Topological Polar Surface Area: 128.000 Ų
• Heavy Atom Count: 28
• Formal Charge: 0
• Complexity: 502.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 9
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Tong Shao, Xiaoshuang Wang, Rentian Guan, Suyuan Zeng, Rui Li, Min Hong, Qiaoli Yue.  (2023)  Carbonized polymer dots for the sensitive and selective analysis of chlortetracycline based on the aggregation induced emission.  NEW JOURNAL OF CHEMISTRY,  47  (37): (17293-17302).  [PMID:] [10.1039/D3NJ02474A]

2. Wei Xinjie, Luo Xuan, Xu Shuai, Xi Fengna, Zhao Tingting.  (2022)  A Flexible Electrochemiluminescence Sensor Equipped With Vertically Ordered Mesoporous Silica Nanochannel Film for Sensitive Detection of Clindamycin.  Frontiers in Chemistry,      [PMID:35464210] [10.3389/fchem.2022.872582]

3. Chang Liu, Diandian Deng, Di Xu, Kang Wu, Hong Yang, Kang Zhao, Jianguo Li, Anping Deng.  (2018)  Development of a monoclonal antibody based-ELISA for the detection of chloramphenicol in shrimp, feed and milk samples and validation by LC-MS/MS coupled with immunoaffinity clean-up.  Analytical Methods,  11  (4): (507-516).  [PMID:] [10.1039/C8AY02284D]