GRADE & PURITY 10mM in DMSO

Synonyms

MK-401 | 4-​amino-​6-​(1,​2,​2-​trichloroethenyl)​-1,​3-​benzenedisulfonamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Clorsulon (MK-401) is used in the treatment of Fasciola hepatica infections in calves and sheep.
In vitro

Clorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a K_i of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro.

In vivo

Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation.
Cell Data

cell lines：NHEK, A431, MCF-7, and MDA-468

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

MK-401 | 4-​amino-​6-​(1, ​2, ​2-​trichloroethenyl)​-1, ​3-​benzenedisulfonamide

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Clorsulon (MK-401) is used in the treatment of Fasciola hepatica infections in calves and sheep.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C1=C(C(=CC(=C1N)S(=O)(=O)N)S(=O)(=O)N)C(=C(Cl)Cl)Cl
• Molecular Weight: 380.66
• Reaxy-Rn: 2821757
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2821757&ln=

Chemical and Physical Properties

• Melt Point(°C): 194-203°C